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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蘇慧敏(Hui-Min Su) | |
| dc.contributor.author | Jian-Rong Lin | en |
| dc.contributor.author | 林建融 | zh_TW |
| dc.date.accessioned | 2021-06-15T06:45:31Z | - |
| dc.date.available | 2011-10-05 | |
| dc.date.copyright | 2011-10-05 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2011-06-27 | |
| dc.identifier.citation | Ahmad A, Moriguchi T, Salem N (2002a) Decrease in neuron size in docosahexaenoic acid-deficient brain. Pediatr Neurol 26:210-218.
Ahmad A, Murthy M, Greiner RS, Moriguchi T, Salem N, Jr. (2002b) A decrease in cell size accompanies a loss of docosahexaenoate in the rat hippocampus. Nutr Neurosci 5:103-113. Aid S, Vancassel S, Poumes-Ballihaut C, Chalon S, Guesnet P, Lavialle M (2003) Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. J Lipid Res 44:1545-1551. Anderson GJ, Neuringer M, Lin DS, Connor WE (2005) Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys. Pediatr Res 58:865-872. Angst J, Gamma A, Gastpar M, Lepine JP, Mendlewicz J, Tylee A (2002) Gender differences in depression. Epidemiological findings from the European DEPRES I and II studies. Eur Arch Psychiatry Clin Neurosci 252:201-209. Arnold AP, Breedlove SM (1985) Organizational and activational effects of sex steroids on brain and behavior: a reanalysis. Horm Behav 19:469-498. Baldwin D, Rudge S (1995) The role of serotonin in depression and anxiety. Int Clin Psychopharmacol 9 Suppl 4:41-45. Banasr M, Hery M, Brezun JM, Daszuta A (2001) Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus. Eur J Neurosci 14:1417-1424. Barrett-Connor E, Kritz-Silverstein D (1993) Estrogen replacement therapy and cognitive function in older women. JAMA 269:2637-2641. Bazan NG (2003) Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res 44:2221-2233. Behl C (2002) Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 3:433-442. Beltz BS, Tlusty MF, Benton JL, Sandeman DC (2007) Omega-3 fatty acids upregulate adult neurogenesis. Neurosci Lett 415:154-158. Bethea CL, Lu NZ, Gundlah C, Streicher JM (2002) Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol 23:41-100. Breckenridge WC, Gombos G, Morgan IG (1972) The lipid composition of adult rat brain synaptosomal plasma membranes. Biochim Biophys Acta 266:695-707. Burdge GC (2006) Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids 75:161-168. Burt VK, Stein K (2002) Epidemiology of depression throughout the female life cycle. J Clin Psychiatry 63 Suppl 7:9-15. Cameron HA, Woolley CS, McEwen BS, Gould E (1993) Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56:337-344. Cao D, Xue R, Xu J, Liu Z (2005) Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures. J Nutr Biochem 16:538-546. Carranza-Lira S, Valentino-Figueroa ML (1999) Estrogen therapy for depression in postmenopausal women. Int J Gynaecol Obstet 65:35-38. Caygill CP, Charlett A, Hill MJ (1996) Fat, fish, fish oil and cancer. Br J Cancer 74:159-164. Chalon S, Delion-Vancassel S, Belzung C, Guilloteau D, Leguisquet AM, Besnard JC, Durand G (1998) Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. J Nutr 128:2512-2519. Charney DS, Woods SW, Goodman WK, Heninger GR (1987) Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology (Berl) 92:14-24. Christiansen C, Christensen MS, McNair P, Hagen C, Stocklund KE, Transbol I (1980) Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur J Clin Invest 10:273-279. Chung WL, Chen JJ, Su HM (2008) Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. J Nutr 138:1165-1171. Colditz GA, Egan KM, Stampfer MJ (1993) Hormone replacement therapy and risk of breast cancer: results from epidemiologic studies. Am J Obstet Gynecol 168:1473-1480. Cordoba Montoya DA, Carrer HF (1997) Estrogen facilitates induction of long term potentiation in the hippocampus of awake rats. Brain Res 778:430-438. Coyle JT, Price DL, DeLong MR (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219:1184-1190. Decsi T, Campoy C, Koletzko B (2005) Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial. Adv Exp Med Biol 569:109-113. Delion S, Chalon S, Guilloteau D, Lejeune B, Besnard JC, Durand G (1997) Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet. J Lipid Res 38:680-689. DeMar JC, Jr., Ma K, Bell JM, Igarashi M, Greenstein D, Rapoport SI (2006) One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats. J Lipid Res 47:172-180. Deng W, Aimone JB, Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11:339-350. Deutsch JA (1971) The cholinergic synapse and the site of memory. Science 174:788-794. Ditkoff EC, Crary WG, Cristo M, Lobo RA (1991) Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol 78:991-995. Dohanich GP, ed (2002) Gonadal steroids, learning and memory. . San Diego: Academic press. Eison MS (1990) Serotonin: a common neurobiologic substrate in anxiety and depression. J Clin Psychopharmacol 10:26S-30S. El-Bakri NK, Islam A, Zhu S, Elhassan A, Mohammed A, Winblad B, Adem A (2004) Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: relationship to Morris water maze performance. J Cell Mol Med 8:537-544. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult human hippocampus. Nat Med 4:1313-1317. Favreliere S, Perault MC, Huguet F, De Javel D, Bertrand N, Piriou A, Durand G (2003) DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. Neurobiol Aging 24:233-243. Fibiger HC (1991) Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurosci 14:220-223. Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi L (2005) Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest 35:691-699. Foy MR (2001) 17beta-estradiol: effect on CA1 hippocampal synaptic plasticity. Neurobiol Learn Mem 76:239-252. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, Basun H, Faxen-Irving G, Garlind A, Vedin I, Vessby B, Wahlund LO, Palmblad J (2006) Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 63:1402-1408. Frick KM, Fernandez SM, Bulinski SC (2002) Estrogen replacement improves spatial reference memory and increases hippocampal synaptophysin in aged female mice. Neuroscience 115:547-558. Frye CA (1995) Estrus-associated decrements in a water maze task are limited to acquisition. Physiol Behav 57:5-14. Frye CA, Wawrzycki J (2003) Effect of prenatal stress and gonadal hormone condition on depressive behaviors of female and male rats. Horm Behav 44:319-326. Fujita S, Ikegaya Y, Nishikawa M, Nishiyama N, Matsuki N (2001) Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices. Br J Pharmacol 132:1417-1422. Gamoh S, Hashimoto M, Sugioka K, Shahdat Hossain M, Hata N, Misawa Y, Masumura S (1999) Chronic administration of docosahexaenoic acid improvesreference memory-related learning ability in young rats. Neuroscience 93:237-241. Ge S, Yang CH, Hsu KS, Ming GL, Song H (2007) A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 54:559-566. Gibbs RB (1998) Impairment of basal forebrain cholinergic neurons associated with aging and long-term loss of ovarian function. Exp Neurol 151:289-302. Gibbs RB, Aggarwal P (1998) Estrogen and basal forebrain cholinergic neurons: implications for brain aging and Alzheimer's disease-related cognitive decline. Horm Behav 34:98-111. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL (2004) Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr 80:1167-1174. Gould E, Woolley CS, Frankfurt M, McEwen BS (1990) Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci 10:1286-1291. Gould E, Tanapat P, Hastings NB, Shors TJ (1999) Neurogenesis in adulthood: a possible role in learning. Trends Cogn Sci 3:186-192. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320:134-139. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (1986) Sequence and expression of human estrogen receptor complementary DNA. Science 231:1150-1154. Grodin JM, Siiteri PK, MacDonald PC (1973) Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab 36:207-214. Hamazaki T, Hirayama S (2004) The effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder-a placebo-controlled double-blind study. Eur J Clin Nutr 58:838. Horrocks LA, Yeo YK (1999) Health benefits of docosahexaenoic acid (DHA). Pharmacol Res 40:211-225. Huang SY, Yang HT, Chiu CC, Pariante CM, Su KP (2008) Omega-3 fatty acids on the forced-swimming test. J Psychiatr Res 42:58-63. Jarrard LE (1993) On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 60:9-26. Kampen DL, Sherwin BB (1994) Estrogen use and verbal memory in healthy postmenopausal women. Obstet Gynecol 83:979-983. Kawakita E, Hashimoto M, Shido O (2006) Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 139:991-997. Kempermann G, Wiskott L, Gage FH (2004) Functional significance of adult neurogenesis. Curr Opin Neurobiol 14:186-191. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB (1993) Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence. J Affect Disord 29:85-96. Kimura D (1995) Estrogen replacement therapy may protect against intellectual decline in postmenopausal women. Horm Behav 29:312-321. Kimura Y, Kono S, Toyomura K, Nagano J, Mizoue T, Moore MA, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N (2007) Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Sci 98:590-597. Korol DL (2004) Role of estrogen in balancing contributions from multiple memory systems. Neurobiol Learn Mem 82:309-323. Korol DL, Gold PE, eds (2006) Modulation of learning and memory by andrenal and ovarian hormones. Burlington: Nikki Levy. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 93:5925-5930. Kuriki K, Hirose K, Wakai K, Matsuo K, Ito H, Suzuki T, Hiraki A, Saito T, Iwata H, Tatematsu M, Tajima K (2007) Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. Int J Cancer 121:377-385. Kuriki K, Wakai K, Hirose K, Matsuo K, Ito H, Suzuki T, Saito T, Kanemitsu Y, Hirai T, Kato T, Tatematsu M, Tajima K (2006) Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids. Cancer Epidemiol Biomarkers Prev 15:1791-1798. Lee I, Kesner RP (2003) Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay. Behav Neurosci 117:1044-1053. Li H, Liu D, Zhang E (2000) [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. Wei Sheng Yan Jiu 29:47-49. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC (1976) Long-term prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment. Lancet 1:1038-1041. Luine VN, McEwen BS (1977) Effect of oestradiol on turnover of type A monoamine oxidase in brain. J Neurochem 28:1221-1227. Luine VN, Richards ST, Wu VY, Beck KD (1998) Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. Horm Behav 34:149-162. Manly JJ, Merchant CA, Jacobs DM, Small SA, Bell K, Ferin M, Mayeux R (2000) Endogenous estrogen levels and Alzheimer's disease among postmenopausal women. Neurology 54:833-837. Marcondes FK, Miguel KJ, Melo LL, Spadari-Bratfisch RC (2001) Estrous cycle influences the response of female rats in the elevated plus-maze test. Physiol Behav 74:435-440. Marszalek JR, Lodish HF (2005) Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 21:633-657. Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120:S129-138. McDonald HY, Wojtowicz JM (2005) Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci Lett 385:70-75. McEntee WJ, Crook TH (1992) Cholinergic function in the aged brain: implications for treatment of memory impairments associated with aging. Behav Pharmacol 3:327-336. McEwen BS, Alves SE (1999) Estrogen actions in the central nervous system. Endocr Rev 20:279-307. McMillan PJ, Singer CA, Dorsa DM (1996) The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat. J Neurosci 16:1860-1865. McNamara RK, Able J, Liu Y, Jandacek R, Rider T, Tso P, Lipton JW (2009) Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. J Psychiatr Res 43:656-663. Meltzer HY (1990) Role of serotonin in depression. Ann N Y Acad Sci 600:486-499; discussion 499-500. Mendelsohn ME, Karas RH (1999) The protective effects of estrogen on the cardiovascular system. N Engl J Med 340:1801-1811. Minami M, Kimura S, Endo T, Hamaue N, Hirafuji M, Togashi H, Matsumoto M, Yoshioka M, Saito H, Watanabe S, Kobayashi T, Okuyama H (1997) Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. Pharmacol Biochem Behav 58:1123-1129. Moriguchi T, Greiner RS, Salem N, Jr. (2000) Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem 75:2563-2573. Morris RG, Garrud P, Rawlins JN, O'Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683. Morris RG, Schenk F, Tweedie F, Jarrard LE (1990) Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning. Eur J Neurosci 2:1016-1028. Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A 101:8491-8496. Naftolin F, Ryan KJ, Davies IJ, Reddy VV, Flores F, Petro Z, Kuhn M, White RJ, Takaoka Y, Wolin L (1975) The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res 31:295-319. Naliwaiko K, Araujo RL, da Fonseca RV, Castilho JC, Andreatini R, Bellissimo MI, Oliveira BH, Martins EF, Curi R, Fernandes LC, Ferraz AC (2004) Effects of fish oil on the central nervous system: a new potential antidepressant? Nutr Neurosci 7:91-99. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S (1986) Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci U S A 83:4021-4025. O'Connor DL et al. (2001) Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. Pediatrics 108:359-371. O'Neal MF, Means LW, Poole MC, Hamm RJ (1996) Estrogen affects performance of ovariectomized rats in a two-choice water-escape working memory task. Psychoneuroendocrinology 21:51-65. Olton DS (1990) Dementia: animal models of the cognitive impairments following damage to the basal forebrain cholinergic system. Brain Res Bull 25:499-502. Olton DS, Werz MA (1978) Hippocampal function and behavior: spatial discrimination and response inhibition. Physiol Behav 20:597-605. Ormerod BK, Galea LA (2001) Reproductive status influences cell proliferation and cell survival in the dentate gyrus of adult female meadow voles: a possible regulatory role for estradiol. Neuroscience 102:369-379. Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coodinates 2nd Edition: Elsevier Inc. Paxinos G, Watson C (2007) The Rat Brain in Stereotaxic Coodinates 6th Edition. Perry EK, Perry RH, Blessed G, Tomlinson BE (1978a) Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol 4:273-277. Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH (1978b) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 2:1457-1459. Prasad A, Prasad C (1996) Short-term consumption of a diet rich in fat decreases anxiety response in adult male rats. Physiol Behav 60:1039-1042. Rachman IM, Unnerstall JR, Pfaff DW, Cohen RS (1998) Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test. Proc Natl Acad Sci U S A 95:13941-13946. Rao MS, Hattiangady B, Shetty AK (2006) The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus. Aging Cell 5:545-558. Rapkin AJ, Mikacich JA, Moatakef-Imani B, Rasgon N (2002) The clinical nature and formal diagnosis of premenstrual, postpartum, and perimenopausal affective disorders. Curr Psychiatry Rep 4:419-428. Richardson AJ, Montgomery P (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115:1360-1366. Riediger ND, Azordegan N, Harris-Janz S, Ma DW, Suh M, Moghadasian MH (2009) 'Designer oils' low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice. Eur J Nutr 48:307-314. Rissman EF (2008) Roles of oestrogen receptors alpha and beta in behavioural neuroendocrinology: beyond Yin/Yang. J Neuroendocrinol 20:873-879. Robinson D, Friedman L, Marcus R, Tinklenberg J, Yesavage J (1994) Estrogen replacement therapy and memory in older women. J Am Geriatr Soc 42:919-922. Roesch DM (2006) Effects of selective estrogen receptor agonists on food intake and body weight gain in rats. Physiol Behav 87:39-44. Ross BM (2009) Omega-3 polyunsaturated fatty acids and anxiety disorders. Prostaglandins Leukot Essent Fatty Acids 81:309-312. Sakamoto T, Cansev M, Wurtman RJ (2007) Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res 1182:50-59. Salem N, Jr., Moriguchi T, Greiner RS, McBride K, Ahmad A, Catalan JN, Slotnick B (2001) Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids. J Mol Neurosci 16:299-307; discussion 317-221. Scharfman HE, MacLusky NJ (2006) Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS. Front Neuroendocrinol 27:415-435. Schinder AF, Gage FH (2004) A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology (Bethesda) 19:253-261. Schmidt PJ, Rubinow DR (2009) Sex hormones and mood in the perimenopause. Ann N Y Acad Sci 1179:70-85. Schmidt PJ, Nieman L, Danaceau MA, Tobin MB, Roca CA, Murphy JH, Rubinow DR (2000) Estrogen replacement in perimenopause-related depression: a preliminary report. Am J Obstet Gynecol 183:414-420. Schwartz NB (1964) Acute Effects of Ovariectomy on Pituitary Lh, Uterine Weight, and Vaginal Cornification. Am J Physiol 207:1251-1259. Schwellenbach LJ, Olson KL, McConnell KJ, Stolcpart RS, Nash JD, Merenich JA (2006) The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides. J Am Coll Nutr 25:480-485. Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21. Singer CA, McMillan PJ, Dobie DJ, Dorsa DM (1998) Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats. Brain Res 789:343-346. Singh J, Hamid R, Reddy BS (1997) Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. Cancer Res 57:3465-3470. Singh M, Meyer EM, Simpkins JW (1995) The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology 136:2320-2324. Singh M, Meyer EM, Millard WJ, Simpkins JW (1994) Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Res 644:305-312. Soares CN, Almeida OP, Joffe H, Cohen LS (2001) Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial. Arch Gen Psychiatry 58:529-534. Soderberg M, Edlund C, Kristensson K, Dallner G (1991) Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26:421-425. Song C, Manku MS, Horrobin DF (2008) Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. J Nutr 138:954-963. Steinbusch HWM, Nieuwenhuys R, eds (1983) The raphe nuclei of the rat brain stem: a cytoarchitectonic and immunohistochemical study. New York:: Raven. Stevens L, Zhang W, Peck L, Kuczek T, Grevstad N, Mahon A, Zentall SS, Arnold LE, Burgess JR (2003) EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 38:1007-1021. Stillwell W, Wassall SR (2003) Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids 126:1-27. Sumino H, Ichikawa S, Murakami M, Nakamura T, Kanda T, Sakamaki T, Mizunuma H, Kurabayashi M (2003) Effects of hormone replacement therapy oncirculating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. Endocr J 50:51-59. Takeuchi T, Fukumoto Y, Harada E (2002) Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. Behav Brain Res 131:193-203. Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M, Yamada K (2007) 17beta-estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience 146:60-68. Tanabe Y, Hashimoto M, Sugioka K, Maruyama M, Fujii Y, Hagiwara R, Hara T, Hossain SM, Shido O (2004) Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus. Clin Exp Pharmacol Physiol 31:700-703. Tanapat P, Hastings NB, Reeves AJ, Gould E (1999) Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci 19:5792-5801. Teague WE, Fuller NL, Rand RP, Gawrisch K (2002) Polyunsaturated lipids in membrane fusion events. Cell Mol Biol Lett 7:262-264. Theodoratou E, McNeill G, Cetnarskyj R, Farrington SM, Tenesa A, Barnetson R, Porteous M, Dunlop M, Campbell H (2007) Dietary fatty acids and colorectal cancer: a case-control study. Am J Epidemiol 166:181-195. Thomson J, Oswald I (1977) Effect of oestrogen on the sleep, mood, and anxiety of menopausal women. Br Med J 2:1317-1319. Valente T, Hidalgo J, Bolea I, Ramirez B, Angles N, Reguant J, Morello JR, Gutierrez C, Boada M, Unzeta M (2009) A Diet Enriched in Polyphenols and Polyunsaturated Fatty Acids, LMN Diet, Induces Neurogenesis in the Subventricular Zone and Hippocampus of Adult Mouse Brain. J Alzheimers Dis 18:849-865. Vancassel S, Aid S, Pifferi F, Morice E, Nosten-Bertrand M, Chalon S, Lavialle M (2005) Cerebral asymmetry and behavioral lateralization in rats chronically lacking n-3 polyunsaturated fatty acids. Biol Psychiatry 58:805-811. Vancassel S, Leman S, Hanonick L, Denis S, Roger J, Nollet M, Bodard S, Kousignian I, Belzung C, Chalon S (2008) n-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice. J Lipid Res 49:340-348. Wade GN (1972) Gonadal hormones and behavioral regulation of body weight. Physiol Behav 8:523-534. Wainwright PE, Huang YS, Coscina DV, Levesque S, McCutcheon D (1994) Brain and behavioral effects of dietary n-3 deficiency in mice: a three generational study. Dev Psychobiol 27:467-487. Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR,Karam EG, Lee CK, Lellouch J, Lepine JP, Newman SC, Rubio-Stipec M, Wells JE, Wickramaratne PJ, Wittchen H, Yeh EK (1996) Cross-national epidemiology of major depression and bipolar disorder. JAMA 276:293-299. Wenk GL (1997) The nucleus basalis magnocellularis cholinergic system: one hundred years of progress. Neurobiol Learn Mem 67:85-95. Whitehouse PJ, Struble RG, Hedreen JC, Clark AW, White CL, Parhad IM, Price DL (1983) Neuroanatomical evidence for a cholinergic deficit in Alzheimer's disease. Psychopharmacol Bull 19:437-440. Wilkinson P, Leach C, Ah-Sing EE, Hussain N, Miller GJ, Millward DJ, Griffin BA (2005) Influence of alpha- linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 181:115-124. Woolf NJ (1991) Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 37:475-524. Woolf NJ, Butcher LL (1985) Cholinergic systems in the rat brain: II. Projections to the interpeduncular nucleus. Brain Res Bull 14:63-83. Woolley CS, McEwen BS (1992) Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci 12:2549-2554. Woolley CS, McEwen BS (1993) Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol 336:293-306. Woolley CS, Weiland NG, McEwen BS, Schwartzkroin PA (1997) Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. JNeurosci 17:1848-1859. Wu A, Ying Z, Gomez-Pinilla F (2004) Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 21:1457-1467. Yaffe K, Sawaya G, Lieberburg I, Grady D (1998) Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. JAMA 279:688-695. Yamamoto H, Kitawaki J, Kikuchi N, Okubo T, Iwasa K, Kawata M, Honjo H (2007) Effects of estrogens on cholinergic neurons in the rat basal nucleus. J Steroid Biochem Mol Biol 107:70-79. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48068 | - |
| dc.description.abstract | 婦女停經後，體內雌激素 (estrogen) 含量下降，對某些婦女而言，容易造成認知功能及情緒上的障礙。雌激素補充療法雖能有效改善停經婦女的認知功能以及焦慮、憂鬱等情緒，然而卻也增加罹患乳癌的風險。因此發展其他方式改善停經婦女的認知功能下降及情緒障礙，便是一個重要的課題。
根據研究顯示，雌激素與二十二碳六烯酸 (DHA，docosahexaenoic acid) ，均能幫助學習記憶 (learning and memory) 並改善焦慮 (anxiety) 及憂鬱(depression) 等情緒。而雌激素與DHA 在體內含量似乎有某種程度的關聯。因此本論文探討，是否能藉由補充富含DHA 的魚油，進而改善去卵巢大鼠因雌激素缺造成的學習記憶功能下降，並降低大鼠焦慮憂鬱的程度。 本研究將出生後六個月的Wistar 大鼠分成四組： 假手術組(sham operation)、去卵巢組 (ovariectomy)、假手術魚油補組、去卵巢魚油補充組。手術4 個月後開始進行行為實驗，測試大鼠空間參考記憶(spatial reference memory) 、工作記憶 (working memory) 以及焦慮、憂鬱的程度，並於鼠齡為12個月時將大鼠犧牲，分別對與學習記憶功能相關的海馬 (hippocampus) 與基底前腦 (basal forebrain) 進行組織切片染色；觀察海馬齒狀回(dentate gyrus) 神經新生 (neurogenesis)，計算齒狀回體積及CA1 (cornu ammonis 1) 神經細胞面積，並計算基底前腦內膽鹼神經元 (cholinergic neuron) 的細胞數。另一方面對情緒相關的背側縫核 (dorsal raphe) 進行組織切片染色，計算其內血清素神經元(serotonergic neuron) 的細胞數。 實驗結果發現去卵巢大鼠相較於假手術大鼠，在工作記憶實驗的表現較差；給予魚油補充的大鼠相較於未補充魚油的大鼠，在空間參考記憶及工作記憶實驗的表現均較佳，且魚油補充能提高大鼠齒狀回的神經新生能力，且能減少齒狀回IV因去除卵巢後造成的體積下降。然而去除卵巢或補充魚油並未對大鼠CA1 神經細胞面積、基底前腦膽鹼神經元細胞數造成顯著的影響。而在焦慮、憂鬱程度及血清素神經元細胞數方面，去除卵巢或魚油補充也無顯著影響。 根據本論文的實驗結果，推測魚油補充可能藉由增加齒狀回神經新生的能力，避免齒狀回因去除卵巢而減少體積，進而增進大鼠的空間參考記憶及工作記憶，因此或許能利用魚油的補充，幫助缺乏雌激素之停經婦女的學習記憶能力。 | zh_TW |
| dc.description.abstract | Cognitive decline and mood disorder may happen in postmenopausal women. Estrogen replacement therapy can delay cognitive decline, reduce the risk of Alzheimer’s disease and prevent mood disorder. However the therapy increases the risk of breast cancer in postmenopausal women. Therefore, it is important to find an alternative way to ameliorate the cognition and mood in postmenopausal women.
Docosahexaenoic acid (DHA, 22:6n-3) and estrogen have similar effects on neurological function. According to some studies, the concentration of DHA is related to that of estrogen in human body. The aim of this thesis is to study whether DHA enriched fish oil supplementation would prevent the decline of learning and memory and ameliorate anxiety and depression in ovariectomized rats. Six-month- old female rats were ovariectomized or sham operated and then fed n-3 fatty acids deficient diet with or without fish oil supplementation for six months. We hypothesized that ovariectomy (OVX) may decrease the ability of learning and memory, dentate gyrus volume, CA1 neuron cell size, neurogenesis in hippocampus, the number of cholinergic neurons in basal forebrain. Moreover, OVX may decrease the number of serotonergic neurons in dorsal raphe leading to anxiety and depression. While, fish oil supplementation may retrieve back those changes. We found that ovariectomized rats showed significantly poorer working memory than sham operated rats and fish oil supplementation rescued the memory performance. In addition, fish oil supplementation increase hippocampal neurogenesis in ovariectomized rats. Decreasing size of dentate gyrus in ovariectomized rats was ameliorated by fish oil supplementation. In CA1 neuron size and the number of cholinergic neurons, there was no significant difference between ovariectomized and sham operated rats with or without fish oil supplementation. On the other hand, there was no significant effect of OVX or fish oil supplementation on anxiety, depression and the number of serotonergic neurons. According to our study, fish oil supplementation improves working memory and increases hippocampal neurogenesis in ovariectomized rats. These results suggest that fish oil supplementation has the benefit on learning and memory in postmenopausalwomen. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T06:45:31Z (GMT). No. of bitstreams: 1 ntu-99-R96441008-1.pdf: 11207152 bytes, checksum: 7817f08e33f7dcc154377a15ceb107c8 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 目錄
誌謝……………………………………………………………………Ⅰ 中文摘要………………………………………………………………Ⅲ 英文摘要……………………………………………………………..Ⅴ 目錄……………………………………………………………………Ⅶ 圖目錄………………………………………………………………ⅩⅠ 表目錄………………………………………………………………ⅩⅢ 第一章 引言……………………………………………………………1 第二章 文獻回顧……………………………………………………3 第一節 雌激素………………………………………………………3 第二節 雌激素與神經系統…………………………………………4 第三節 二十二碳六烯酸……………………………………………6 第四節 二十二碳六烯酸與神經系統………………………………7 第五節 雌激素與二十二碳六烯酸的關聯…………………………9 第三章 實驗目的與假設……………………………………………..10 第四章 材料與方法…………………………………………………..11 第一節 實驗設計……………………………………………......11 第二節 動物飼料……………………………………………………14 第三節 去卵巢手術及假手術………………………………………16 第四節 行為實驗……………………………………………………17 (一) 十字迷宮實驗…………….........…………………...17 (二) 強迫游泳實驗…..………………………………...…….18 (三) 被動閃避學習實驗..…………………...……………….19 (四) 雙向主動閃避學習實驗…..………………………………21 (五) 水迷宮實驗...……………..…………………………….22 5-1 空間參考記憶實驗...…………………………………23 5-2 工作記憶實驗...………………………………………23 第五節 BrdU 注射…...……………………………………………24 第六節 組織染色………………………..…………………………25 (一) 心臟灌流..…...………………………………………….25 1-1 藥品…………………………………………………….25 1-2 步驟…………………………………………………….26 (二) 免疫組織化學染色………..…………...……………….26 2-1 切片…………………………………………………….26 2-2 BrdU 免疫組織化學染色………………………………27 2-2.1.藥品……………………………………………….27 2-2.2.步驟……………………………………………….28 2-3 BrdU 免疫組織螢光染色………………………………29 2-4 ChAT、tryptophan hydroxylase免疫組織化學染色.30 2-4.1.藥品……………………………………………….30 2-4.2.步驟……………………………………………….31 (三) 尼氏染色………………..…………………………………32 3-1 藥品…………………………………………………….32 3-2 步驟…………………………………………………….32 第七節 細胞計數………………..………………………………..32 (一) BrdU 陽性反應細胞之計數……………………………….32 (二) ChAT 陽性反應細胞之計數……………………………….33 (三) Tryptophan hydroxylase 陽性反應細胞之計數……….34 第八節 海馬齒狀回體積的量測……………………………………34 第九節 海馬CA1 神經細胞細胞體面積的量測……………………35 第十節 統計分析……………………………………………………36 第五章 實驗結果….………………………………………………….37 第一節 子宮及體重變化……………………………………………37 第二節 水迷宮實驗..……………………………….…………….39 (一) 空間參考記憶實驗…………………………………………39 (二) 工作記憶實驗…………………….……………………….44 第三節 BrdU陽性反應細胞…………………………………………48 第四節 海馬齒狀回之體積..……………………………..………51 第五節 海馬CA1 神經細胞細胞體面積……………………………54 第六節 ChAT 陽性反應細胞……………………….………………58 第七節 十字迷宮實驗…..……………………………..…………63 第八節 強迫游泳實驗…………………………..…………………66 第九節 Tryptophan hydroxylase 陽性反應細胞……………...69 第六章 討論……………………………………………………………72 第一節 去除卵巢對大鼠學習記憶的影響……….……………….72 第二節 補充魚油對學習記憶的影響……………….…………….73 第三節 去除卵巢對海馬的影響……………………………………74 第四節 補充魚油對海馬的影響……………………………………76 第五節 去除卵巢對大鼠情緒的影響………………………………78 第六節 補充魚油對大鼠情緒的影響………………………………79 第七節 去除卵巢對不同神經傳導物質系統的影響………………80 第八節 補充魚油對不同神經傳導物質系統的影響………………81 第七章 結論……………………………………………………………83 Appendix……………………………………………………………….84 A、被動閃避學習實驗………………………………………………84 B、雙向主動閃避學習實驗…………………………………………85 C、免疫組織螢光染色………………………….………………….87 參考文獻……………………………………………………….………89 圖目錄 圖一、動物分組與實驗流程圖……………………………………….12 圖二、十字迷宮……………………………………………………….17 圖三、強迫游泳實驗之水缸………………………………………….18 圖四、Passive avoidance/active avoidance test 被、主動閃避學習系統…….............................................19 圖五、Shuttle Flex Test Chamber Model-SFLX 儀器…………..21 圖六、水迷宮………………………………………………………….22 圖七、各組大鼠子宮重量…………………………………………….37 圖八、各組大鼠於手術後體重變化………………………………….38 圖九、空間參考記憶折線圖……………………..………………….41 圖十、空間參考記憶實驗每天個別4 次訓練的逃脫時間………….42 圖十一、工作記憶折線圖…………………………………………….46 圖十二、免疫組織化學染色-背側海馬齒狀回顆粒下區BrdU陽性反應細胞…….................................................49 圖十三、大鼠背側海馬齒狀回顆粒下區BrdU 陽性反應細胞數……50 圖十四、尼氏染色-海馬齒狀回………………………………………52 圖十五、大鼠海馬齒狀回體積………………………………...……53 圖十六、尼氏染色-海馬CA1 神經元…………………………………55 圖十七、大鼠海馬CA1 神經細胞細胞體面積..…………………….56 圖十八、免疫組織化學染色-Basal nucleus of Myenert 的ChAT陽性反應細胞….............................................59 圖十九、大鼠basal nucleus of Myenert 內ChAT 陽性反應細胞數…………...............................................60 圖二十、免疫組織化學染色-HDB 的ChAT 陽性反應細胞………….61 圖二十一、大鼠HDB內ChAT陽性反應細胞數………………………..62 圖二十二、十字迷宮實驗結果-大鼠探索open arms 的時間總和…64 圖二十三、十字迷宮實驗結果-大鼠進入open arms 的次數………64 圖二十四、十字迷宮實驗結果-大鼠進出open arms 與closed arms 的次數總和….............................................65 圖二十五、強迫游泳實驗結果…………………………….........67 圖二十六、免疫組織化學染色-背側縫核tryptophan hydroxylase 陽性反應細胞…...........................................70 圖二十七、大鼠背側縫核內tryptophan hydroxylase 陽性反應細胞數…………….............................................71 圖A1、被動閃避學習實驗結果……………………………………….84 圖A2、雙向主動閃避學習實驗結果………………………………….86 圖A3-1、SD組OD組大鼠BrdU、NeuN免疫組織螢光染色….…..……87 圖A3-2、SDF組ODF組大鼠BrdU、NeuN免疫組織螢光染色……...…88 表目錄 表一、自製缺乏n-3 脂肪酸飼料之成分組成…………………..….14 表二、自製n-3 脂肪酸缺乏飼料及餵食魚油之脂肪酸組成…..….15 表三、空間參考記憶實驗統計分析結果…..…………..………….43 表四、工作記憶實驗統計分析結果……………………..………….47 表五、海馬染色統計分析…………………………………………….57 表六、ChAT 陽性反應細胞計數統計分析…………………………..62 表七、十字迷宮與強迫游泳實驗統計分析………………………….68 表八、Tryptophan hydroxylase 陽性反應細胞計數統計分析…..71 | |
| dc.language.iso | zh-TW | |
| dc.title | 探討魚油補充對去卵巢大鼠空間學習記憶及焦慮憂鬱之影響 | zh_TW |
| dc.title | Effects of fish oil supplementation on spatial learning,
anxiety and depression in ovariectomized rats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔡元奮(Yuan-Feen Tsai),盧國賢(Kuo-Shyan Lu),黃青真(Ching-jang Huang) | |
| dc.subject.keyword | 魚油,去卵巢大鼠,空間學習記憶,焦慮,憂鬱,海馬,神經新生, | zh_TW |
| dc.subject.keyword | fish oil,ovariectomized rats,spatial learning,anxiety,depression,hippocampus,neurogenesis, | en |
| dc.relation.page | 100 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-06-27 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 生理學研究所 | zh_TW |
| 顯示於系所單位： | 生理學科所 | |
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