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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鄭謙仁 | |
| dc.contributor.author | Chuen-Chuen Cheng | en |
| dc.contributor.author | 鄭純純 | zh_TW |
| dc.date.accessioned | 2021-06-15T06:17:28Z | - |
| dc.date.available | 2012-08-16 | |
| dc.date.copyright | 2010-08-16 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-11 | |
| dc.identifier.citation | 李兆峯、林皓雯、徐志忠、黃純純、鄭育昇、劉玉文、王旭昌 2009. 2008台灣養豬統計手冊, 財團法人中央畜產會, ed. (台北市, 王政騰).
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Waldvogel, A., Broll, S., Rosskopf, M., Schwyzer, M., Pospischil, A., 1995b, Diagnosis of fetal infection with porcine parvovirus by in situ hybridization. Vet Microbiol. 47, 377-385. Wang, C., Huang, T., Huang, C., Tu, C., Jong, M., Lin, S., Lai, S., 2004, Characterization of porcine circovirus type 2 in Taiwan. J. Vet. Med. Sci. 66, 469. Wang, C., Lee, F., Huang, T., Pan, C., Jong, M., Chao, P., 2008, Genetic variation in open reading frame 5 gene of porcine reproductive and respiratory syndrome virus in Taiwan. Vet Microbiol. 131, 339-347. Wastling, J.M., Mattsson, J.G., 2003, Detection of toxoplasma gondii Methods in molecular biology, In: Sachse, K., Frey, J. (Eds.) PCR detection of microbial pathogens. Humana ;Blackwell, Totowa, N.J. Oxford, pp. 289-297. West, K., Bystrom, J., Wojnarowicz, C., Shantz, N., Jacobson, M., Allan, G., Haines, D., Clark, E., Krakowka, S., McNeilly, F., 1999, Myocarditis and abortion associated with intrauterine infection of sows with porcine circovirus 2. J Vet Diagn Invest. 11, 530-532. Wrathall, A., 1975, Reproductive disorders in pigs. Commonwealth Agricultural Bureaux. Wrathall, A., Mengeling, W., 1979a, Effect of inseminating seropositive gilts with semen containing porcine parvovirus. Br Vet J. 135, 420-425. Wrathall, A., Mengeling, W., 1979b, Effect of porcine parvovirus on development of fertilized pig eggs in vitro. Br Vet J 135, 249-254. Xue, J., Dial, G., Marsh, W., Davies, P., Momont, H., 1993, Influence of lactation length on sow productivity. Livestock Production Science 34, 253-265. Zimmerman, J.J., Benfield, D.A., Murtaugh, M.P., Osorio, F., Stevenson, G.W., Torremorell, M., 2006, Porcine Reproductive and Respiratory Syndrome Virus (Porcine Arterivirus), In: Straw, B.E., Zimmerman, J.J., D'Allaire, S., Taylor, D.J. (Eds.) Diseases of swine. Blackwell, Ames, pp. 387-417. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/47768 | - |
| dc.description.abstract | 胎兒的損失與仔豬離乳前死亡一直是商業化豬場重要的經濟損失。一般豬場胎兒損失 (死產、木乃伊胎) 的比率約為5-15％。而台灣商業化豬場其流產與死產比例佔胎兒死亡率的27.3％。為針對豬隻流死產胎進行傳染性病原的調查，並利用間接原位雜交反應 (indirect ISPCR) 了解豬第二型環狀病毒在胎兒組織中的親和性，本研究將以PCR與RT-PCR調查九種豬隻傳染性繁殖障礙病原；其中包含豬小病毒、豬第二型環狀病毒、假性狂犬病病毒、豬瘟、豬繁殖與呼吸道綜合症病毒、日本腦炎病毒、布氏桿菌、鉤端螺旋體、弓蟲等九種病原。在實驗期間共蒐集了52頭足月分娩的死產胎以及6頭懷孕日期小於109天的流產胎。在進行病理剖檢與採集冷凍檢體後進行核酸萃取，之後進行PCR與RT-PCR檢測，並觀察組織病變。其結果在肉眼與組織病變檢查無特異性病灶；九種病原的PCR/RT-PCR檢測，僅兩例有豬第二型環狀病毒陽性病例，其他八種病原的分子檢測皆為陰性。以間接原位聚合酶鏈鎖檢測，在PCV2陽性胎兒的心臟心肌細胞與血管內皮以及腸系膜淋巴結淋巴濾泡的淋巴細胞中偵測出棕黑色陽性訊號。此結果顯示PCV2在台灣可能是引起流死產的危險因子之一，而大部分的流死產多和非傳染性因子有關。而間接原位聚合酶鏈鎖反應結果則和現今文獻一致，顯示PCV2對胎兒心臟的心肌細胞具有親合性。 | zh_TW |
| dc.description.abstract | Fetal losses and pre-weaning mortality are among the most important causes of losses in commercial swine herds. Usually, fetal losses (mummified fetuses and stillborns) can vary from 5 to 15%. But the abortion and stillbirth in the fetal mortality rate was 27.3％ in Taiwan. The aims of the present study were pathogens surveillance in the field cases of swine abortions or stillbirths, and using indirect in situ PCR to define PCV2 tissue tropism in aborted or stillbirthed cases. Nine reproductive pathogens were included in this study which are porcine parvovirus, porcine circovirus 2 (PCV2) , pseudorabies, porcine respiratory and reproductive virus (PRRS) , Japanese encephalitis, classical swine fever, Brucella suis, Leptospira sp., and Toxoplasma gondii. Fifty two at term stillbirths and six middle term abortions were collected. Nuclear acid were extracted from the homogenized visceral organs and PCR or RT-PCR were subsequently performed for molecular screening. After gross and histopathologic examination, no specificly lesion was observed in these fetuses. The molecular screeing results showed none of the pathogens were detected in the collected samples except 2 stillbirths were positive for PCV2. The indirect in situ PCR revealed that the PCV2 signals distribute discretely in the myocardium and germinal center of mesentery lymph node. The result suggests that PCV2 is the potential risk factor in swine stillbirth, although noninfectious risk factors are the major causes of stillbirth. The indirect in situ PCR results are consistent with the current studies, the heart is the PCV2 primary replicated organ in fetus. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T06:17:28Z (GMT). No. of bitstreams: 1 ntu-99-R97629001-1.pdf: 8928991 bytes, checksum: bfc87f6ce73fb453a050e969aadfbd9d (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 第一章 序言 1
第二章 文獻回顧 3 2.1 母豬繁殖性能評估之總述 3 2.2 豬隻重要繁殖系統疾病之病原、背景、與研究現況 7 2.2.1 前言 7 2.2.2 豬小病毒之特性及病理變化 8 2.2.3 豬第二型環狀病毒之特性及病理變化 12 2.2.4 豬假性狂犬病之病毒特性及病理變化 14 2.2.5 豬生殖與呼吸綜合症病毒之特性及病理變化 15 2.2.6 豬瘟之病毒特性及病理變化 16 2.2.7 日本腦炎之病毒特性及病理變化 16 2.2.8 布氏桿菌之特性及病理變化 17 2.2.9 鉤端螺旋體之特性及病理變化 18 2.2.10 弓蟲之特性及病理變化 19 2.3 影響母豬繁殖障礙非病原性因子 19 2.4 免疫組織化學染色與原位雜交反應 20 2.4.1 免疫組織化學染色之原理 20 2.4.2 原位雜交反應 (in situ hybridization ,ISH) 之原理 23 2.4.3 免疫組織化學染色與原位雜交反應在仔豬流死產之診斷應用 25 2.5 原位聚合酶鏈鎖反應 (in situ PCR, ISPCR) 之原理與應用 25 第三章 材料與方法 27 3.1 實驗設計 27 3.2 實驗材料 28 3.3 實驗動物背景 28 3.4 材料處理 28 3.5 實驗方法 28 3.5.1 組織病理學診斷 28 3.5.2 病材核酸萃取 29 3.5.3 九種流產病原的分子生物學檢測診斷 30 3.5.4 間接原位聚合酶鏈鎖反應 (Indirect in situ PCR) 38 3.5.5 免疫組織化學染色 (Immunohistochemistry, IHC) 40 第四章 結果 41 4.1 肉眼病理學觀察 41 4.2 形態病理學檢查 41 4.3 九種流產病原診斷結果 41 4.3.1 DNA病毒聚合酶鏈鎖反應檢測結果 41 4.3.2 G3PDH之聚合酶連鎖反應結果 42 4.3.3 RNA病毒之聚合酶鏈鎖反應結果 42 4.3.4 細菌、原蟲檢測檢果 42 4.4 原位聚合酶鏈鎖反應結果 61 4.4.1 PCV2 原位聚合酶連鎖反應結果 61 4.5 免疫組織化學染色結果 64 4.5.1 PCV2免疫組織化學染色結果 64 第五章 討論 66 5.1 各地方傳染性流死產病因的流行病學概況 66 5.2 組織病理學、聚合酶鏈鎖反應、原位聚合酶鏈鎖反應與免疫組織化學染色等結果關連性探討 68 5.3 PCV2垂直傳播之致病機制探討 69 5.4 非傳染性因子對本實驗結果之影響 71 第六章 結論與未來展望 72 第七章 參考文獻 73 附錄 一 流死產豬隻檢體之肉眼病變 91 附錄 二 流死產胎樣材之組織病變 94 附錄 三 流死產豬隻PCR/ RT-PCR檢測結果 96 | |
| dc.language.iso | zh-TW | |
| dc.subject | 傳染性病原 | zh_TW |
| dc.subject | 鏈鎖反應 | zh_TW |
| dc.subject | 流死產 | zh_TW |
| dc.subject | 間接原位雜交反應 | zh_TW |
| dc.subject | 豬 | zh_TW |
| dc.subject | 聚合酶 | zh_TW |
| dc.subject | swine aboriton | en |
| dc.subject | infectious pathogens | en |
| dc.subject | PCR/ RT-PCR | en |
| dc.subject | indirect ISPCR | en |
| dc.title | 豬隻流死病原的調查 | zh_TW |
| dc.title | Pathogens Survey in Swine Abortion | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 龐飛,蕭世烜 | |
| dc.contributor.oralexamcommittee | 劉涓,張志成 | |
| dc.subject.keyword | 豬,流死產,傳染性病原,聚合酶,鏈鎖反應,間接原位雜交反應, | zh_TW |
| dc.subject.keyword | swine aboriton,infectious pathogens,PCR/ RT-PCR,indirect ISPCR, | en |
| dc.relation.page | 99 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-08-11 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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