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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林文澧(Win-Li Lin) | |
dc.contributor.author | Wei-Ran Chang | en |
dc.contributor.author | 張維仁 | zh_TW |
dc.date.accessioned | 2021-06-15T06:16:35Z | - |
dc.date.available | 2011-08-18 | |
dc.date.copyright | 2010-08-18 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-10 | |
dc.identifier.citation | [1] 行政院衛生署(2009)。中華民國97年死因統計(編號:2009502599)。臺北市。
[2] R. Lencioni and et al (2008). 'Image-guided thermal ablation of hepatocellular carcinoma.' Critical Reviews in Oncology/Hematology 66(3): 200-207. [3] H. Wu and et al (2004). 'A finite state model for respiratory motion analysis in image guided radiation therapy.' Physics in Medicine and Biology 49(23): 5357. [4] 許銘權(2006)。區間窗口治療策略應用於高強度聚焦超音波肝腫瘤熱治療。國立台灣大學醫學工程研究所碩士論文,未出版,台北市。 [5] A. Okada and et al (2006). 'A case of hepatocellular carcinoma treated by MR-guided focused ultrasound ablation with respiratory gating' Magn. Reson. Med. Sci. 5 (3):167–171 [6] Y. Kaneko and et al (2005). 'Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue.' Eur Radiol 15:1415–1420 [7] K. Takegami and et al (2005). 'Erythrocytes, as well as microbubble contrast agents, are important factors in improving thermal and therapeutic effects of high-intensity focused ultrasound.' Ultrasound in Medicine & Biology 31(3): 385-390. [8] J. E. Kennedy and et al (2004). 'High intensity focused ultrasound for the treatment of liver tumours ' Ultrasonics 42:931–935. [9] J. Song and et al (2010). 'Feasibility of Using Lateral Mode Coupling Method for a Large Scale Ultrasound Phased Array for Noninvasive Transcranial Therapy'IEEE Transactions on Biomedical Engineering, vol. 57, NO. 1. [10] HH. Pennes (1948). 'Analysis of tissue and arterial blood temperatures in the resting human forearm.' J. Appl. Phys, vol. 1: 93-122. [11] W. C. Dewey and et al (1977). 'Hyperthermia and radiation--A selective thermal effect on chronically hypoxic tumor cells in vivo.' International Journal of Radiation Oncology Biology Physics 2(1-2): 99-103. [12] K. Hynynen and et al (1995). 'MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies.' J Magn Reson Imaging vol. 5 (259): 66 [13] E. Ebbine (1989). 'Multiple-Focus Ultrasound Phased-Array Pattern Synthesis - Optimal Driving-Signal Distributions for Hyperthermia.' IEEE T ULTRASON FERR, vol. 36: 540-548. [14] A. Duck and et al (1998). 'Ultrasound in Medicine (Medical Sciences Series).' Institute of Physics :77 [15] J.C. Bamber and et al (1986). 'Physical Principles of Medical Ultrasonics.' Ellis Horwood :188-99 [16] C. Kolios and et al (1999). 'Temperature dependent tissue properties and ultrasonic lesion formation' HTD, Vol. 363 [17] E. Cochard and et al (2009). 'Ultrasonic focusing through the ribs using the DORT method' Med. Phys. 36:3495-3503 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/47753 | - |
dc.description.abstract | 現今肝腫瘤高溫熱治療手術,如射頻、雷射、微波等,為低侵入式手術,超音波做為肝腫瘤治療的最大優勢為非侵入式手術。而以往超音波肝腫瘤臨床手術上遇到的問題為肋骨聲窗口的限制與腫瘤的移動以及治療時間過長。
此研究的目的,為利用多個長條曲面超音波換能器,曲率半徑15cm,圓弧長度17.7cm,寬度1cm,利用共焦加熱策略,探討在皮膚下3、6、9公分處的聲壓情形,並且在腫瘤正常呼吸末區段移動以及腫瘤靜態情形下,在五次單元加熱達到約1cm3~5 cm3熱劑量累積。 在皮下9公分處,考慮被肋骨限制的擺放方式,由五個換能器個別相隔15o進行共焦,在模擬方面假設為無肋骨組織影響聚焦情形,並且以擬反矩陣(pseudo inverse)方法,找到互補的聚焦模式並且進行切換加熱,結果可以在腫瘤正常呼吸末區段移動以及腫瘤靜態情形下,形成呼吸移動方向上(X方向)的連續熱劑量累積,再藉由換能器另一個方向上(Y方向)的自由移動,可以形成熱劑量的疊加,五次的疊加體積約1cm3。而皮下3、6公分處,擺放方式受到肋骨影響,換能器數量減少,仍以共焦的方法取得高功率強度場,並且利用擬反矩陣方法,找到其他的互補性聚焦,並且在五次單元加熱下熱劑量可達約5cm3。從以上的結果來看,熱劑量可以在深度(Z方向)3到9公分處造成累積。 | zh_TW |
dc.description.abstract | The high temperature treatment for liver tumor, such as radiofrequency(RF) ablation、laser ablation、microwave ablation, are minimally invasive surgery. The advantage of focused ultrasound for liver tumor surgery is noninvasive. However, there are some problems of clinical surgery: the narrow ultrasound window due to ribs, the motion of tumor due to breath, and the long period of surgery time.
This study used multiple concaved strip-shaped ultrasound transducers with a radius of curvature of 15 cm, arc length of 17.7 cm, and width of 1 cm to arrange the foci at the same point. The sound pressure was investigated at the depth of 3, 6, and 9 cm below the skin. In the situation of end-of-exhale and breath hold, the thermal dose accumulated to a volume of about 1cm3 ~5cm3 after five thermal ablations with shifts of the focus location. For a target region at the depth of 9 cm, five transducers were used. To avoid the ribs from obstructing the ultrasound beam path, the transducers were placed 15o apart from each other. Thus the computer simulation didn’t considered the effect of ribs on sound pressure. The pseudo inverse method was applied to obtain complementary sound pressure patterns. These patterns was switched to ablate the target region with a frequency of 10Hz. The results showed that the thermal dose accumulated along the motion direction caused by the breath (X direction). Multiple heating with the transducers moved in the Y direction, the thermal lesion up to 1cm3 could be formed for both situations of end-of-exhale and breath hold. When the target regions were at the depth of 3 cm or 6 cm, the number of transducers reduced, so that the ribs did not block the beam path. The transducers were placed to form a focus at the desired depth. High intensity sound pressure was obtained. The pseudo inverse method was used to obtain complementary sound pressure and the thermal dose accumulated to a volume of about 5cm3 after five thermal ablations with shifts of the focus location. The simulation results, demonstrated that the thermal lesion can be accumulated at different depths from 3cm to 9cm by using appropriate number of transducers and sonication modes. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T06:16:35Z (GMT). No. of bitstreams: 1 ntu-99-R97548040-1.pdf: 2060223 bytes, checksum: 3ed3bfe5c123e583aaf0b863fea46c04 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 誌謝 I
摘要 II Abstract III 第一章 緒論 1 1.1 肝腫瘤高溫熱治療 1 1.2 肝腫瘤超音波高溫熱治療 4 1.3 研究動機與目的 5 第二章 超音波特性以及聚焦理論 6 2.1 雷利積分式計算壓力場(Rayleigh — Sommerfeld Diffraction Integral) 6 2.2 功率強度場、溫度場及熱劑量轉換 9 2.3 Pseudo Inverse 控制焦點 11 第三章 模擬方法與結果 13 3.1 功率強度場、方法策略 14 3.1.1 模擬參數 14 3.1.2 天然聚焦情形 15 3.1.3 互補性聚焦方法-Pseudo Inverse 22 3.2 熱劑量模擬結果-靜態加熱情形與呼吸末加熱情形 34 3.2.1 皮下9公分處 34 3.2.1.1 靜態加熱 34 3.2.1.2 呼吸末區段加熱 43 3.2.2 皮下6公分處 51 3.2.2.1 靜態加熱 57 3.2.2.2 呼吸末區段加熱 65 3.2.3 皮下3公分處 72 3.2.3.1 靜態加熱 77 3.2.3.2 呼吸末區段加熱 85 第四章 討論與未來工作 92 4.1結果討論 92 4.2 結論 93 4.3未來工作 94 4.3.1 肋骨限制以及其他組織造成的問題 94 4.3.2 系統的問題 94 參考文獻 95 | |
dc.language.iso | zh-TW | |
dc.title | 探討多個長條曲面超音波換能器於肝腫瘤熱治療之應用 | zh_TW |
dc.title | Investigation of Multiple Concaved Strip-shaped Ultrasound Transducers for Liver Tumor Thermal Therapy | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 陳永耀(Yung-Yaw Chen) | |
dc.contributor.oralexamcommittee | 陳景欣(Gin-Shin Chen),劉浩澧(Hao-Li Liu) | |
dc.subject.keyword | 超音波換能器,高溫熱治療,擬反矩陣, | zh_TW |
dc.subject.keyword | ultrasound transducer,high temperature hyperthermia,pseudo inverse, | en |
dc.relation.page | 96 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-08-11 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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