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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蔡元奮(Yuan-Feen Tsai) | |
dc.contributor.author | Yi-Ya Fang | en |
dc.contributor.author | 方怡雅 | zh_TW |
dc.date.accessioned | 2021-06-15T04:51:49Z | - |
dc.date.available | 2011-09-09 | |
dc.date.copyright | 2010-09-09 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-02 | |
dc.identifier.citation | Adams, J. P., Anderson, A. E., Varga, A. W., Dineley, K. T., Cook, R. G., Pfaffinger, P. J., & Sweatt, J. D. (2000). The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. Journal of Neurochemistry, 75, 2277-2287.
Adolphs, R., Tranel, D., & Damasio, A. R. (1998). The human amygdala in social judgment. Nature, 393, 470-474. Alcaro, A., Cabib, S., Ventura, R., & Puglisi-Allegra, S. (2002). Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test. Psychopharmacology, 164, 138-143. Alonso, M., Viola, H., Izquierdo, I., & Medina, J. H. (2002). Aversive experiences are associated with a rapid and transient activation of ERKs in the rat hippocampus. Neurobiology of Learning and Memory, 77, 119-124. Ambrogi Lorenzini, C., Bucherelli, C., Giachetti, A., & Tassoni, G. (1987). Spontaneous and conditioned behavior of Wistar and Long Evans rats. Archives Italiennes de Biologie, 125, 155-170. Anagnostaras, S. G., Maren, S., DeCola, J. P., Lane, N. I., Gale, G. D., Schlinger, B. A., & Fanselow, M. S. (1998). Testicular hormones do not regulate sexually dimorphic Pavlovian fear conditioning or perforant-path long-term potentiation in adult male rats. Behavioural Brain Research, 92, 1-9. Archer, J. (1975). Rodent sex differences in emotional and related behavior. Behavioral Biology, 14, 451-479. Arnold, A. P., & Gorski, R. A. (1984). Gonadal steroid induction of structural sex differences in the central nervous system. Annual Review of Neuroscience, 7, 413-442. Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998). The MAPK cascade is required for mammalian associative learning. Nature Neuroscience, 1, 602-609. Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A., & Bennett, D. A. (2005). Sex differences in the clinical manifestations of Alzheimer disease pathology. Archives of General Psychiatry, 62, 685-691. Beatty, W. W. (1979). Gonadal hormones and sex differences in nonreproductive behaviors in rodents: organizational and activational influences. Hormones and Behavior, 12, 112-163. Beatty, W. W., & Beatty, P. A. (1970). Hormonal determinants of sex differences in avoidance behavior and reactivity to electric shock in the rat. Journal of Comparative and Physiological Psychology, 73, 446-455. Becker, J. T., Walker, J. A., & Olton, D. S. (1980). Neuroanatomical bases of spatial memory. Brain Research, 200, 307-320. Berman, D. E., Hazvi, S., Rosenblum, K., Seger, R., & Dudai, Y. (1998). Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat. Journal of Neuroscience, 18, 10037-10044. Best, P. J., & Orr, J., Jr. (1973). Effects of hippocampal lesions on passive avoidance and taste aversion conditioning. Physiology and Behavior, 10, 193-196. Bi, R., Foy, M. R., Vouimba, R. M., Thompson, R. F., & Baudry, M. (2001). Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Proceedings of the National Academy of Sciences of the United States of America, 98, 13391-13395. Birnbaum, S. G., Varga, A. W., Yuan, L. L., Anderson, A. E., Sweatt, J. D., & Schrader, L. A. (2004). Structure and function of Kv4-family transient potassium channels. Physiological Reviews, 84, 803-833. Bjorklund, D. F., & Kipp, K. (1996). Parental investment theory and gender differences in the evolution of inhibition mechanisms. Psychological Bulletin, 120, 163-188. Blizard, D. A. (1971). Individual differences in autonomic responsivity in the adult rat. Neonatal influences. Psychosomatic Medicine, 33, 445-457. Blizard, D. A., Lippman, H. R., & Chen, J. J. (1975). Sex differences in open-field behavior in the rat: the inductive and activational role of gonadal hormones. Physiology and Behavior, 14, 601-608. Blum, S., Moore, A. N., Adams, F., & Dash, P. K. (1999). A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. Journal of Neuroscience, 19, 3535-3544. Bowman, R. E., Micik, R., Gautreaux, C., Fernandez, L., & Luine, V. N. (2009). Sex-dependent changes in anxiety, memory, and monoamines following one week of stress. Physiology and Behavior, 97, 21-29. Broadhurst, P. L. (1957). Determinants of emotionality in the rat. I. Situational factors. British Journal of Psychology, 48, 1-12. Bucci, D. J., Chiba, A. A., & Gallagher, M. (1995). Spatial learning in male and female Long-Evans rats. Behavioral Neuroscience, 109, 180-183. Cabib, S., & Bonaventura, N. (1997). Parallel strain-dependent susceptibility to environmentally-induced stereotypies and stress-induced behavioral sensitization in mice. Physiology and Behavior, 61, 499-506. Cabib, S., Orsini, C., Le Moal, M., & Piazza, P. V. (2000). Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience. Science, 289, 463-465. Cabib, S., Pascucci, T., Ventura, R., Romano, V., & Puglisi-Allegra, S. (2003). The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria. Behavior Genetics, 33, 301-310. Caldji, C., Francis, D., Sharma, S., Plotsky, P. M., & Meaney, M. J. (2000). The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology, 22, 219-229. Cammarota, M., Bevilaqua, L. R., Ardenghi, P., Paratcha, G., Levi de Stein, M., Izquierdo, I., & Medina, J. H. (2000). Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade. Brain Research. Molecular Brain Research, 76, 36-46. Campenot, R. B. (1969). Effect of amygdaloid lesions upon active avoidance acquisition and anticipatory responding in rats. Journal of Comparative and Physiological Psychology, 69, 492-497. Canli, T., Desmond, J. E., Zhao, Z., & Gabrieli, J. D. (2002). Sex differences in the neural basis of emotional memories. Proceedings of the National Academy of Sciences of the United States of America, 99, 10789-10794. Castellano, C., Brioni, J. D., Nagahara, A. H., & McGaugh, J. L. (1989). Post-training systemic and intra-amygdala administration of the GABA-B agonist baclofen impairs retention. Behavioral and Neural Biology, 52, 170-179. Chai, S. C., Holahan, M. R., Shyu, B. C., & Wang, C. C. (2006). Differential patterns of extracellular signal-regulated kinase-1 and -2 phosphorylation in rat limbic brain regions after short-term and long-term inhibitory avoidance learning. Neuroscience, 137, 1321-1330. Christianson, S.-å., & Loftus, E. F. (1987). Memory for traumatic events. Applied Cognitive Psychology, 1, 225-239. Cooke, B. M., & Woolley, C. S. (2005). Sexually dimorphic synaptic organization of the medial amygdala. Journal of Neuroscience, 25, 10759-10767. Costa, R. M., Federov, N. B., Kogan, J. H., Murphy, G. G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T., & Silva, A. J. (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415, 526-530. Critchlow, V., Liebelt, R. A., Bar-Sela, M., Mountcastle, W., & Lipscomb, H. S. (1963). Sex difference in resting pituitary-adrenal function in the rat. American Journal of Physiology, 205, 807-815. Cullen, P. J., & Lockyer, P. J. (2002). Integration of calcium and Ras signalling. Nature Reviews. Molecular Cell Biology, 3, 339-348. Dal Forno, G., Palermo, M. T., Donohue, J. E., Karagiozis, H., Zonderman, A. B., & Kawas, C. H. (2005). Depressive symptoms, sex, and risk for Alzheimer's disease. Annals of Neurology, 57, 381-387. Denti, A., & Epstein, A. (1972). Sex differences in the acquisition of two kinds of avoidance behavior in rats. Physiology and Behavior, 8, 611-615. Derkinderen, P., Enslen, H., & Girault, J. A. (1999). The ERK/MAP-kinases cascade in the nervous system. Neuroreport, 10, R24-34. Derntl, B., Habel, U., Windischberger, C., Robinson, S., Kryspin-Exner, I., Gur, R. C., & Moser, E. (2009). General and specific responsiveness of the amygdala during explicit emotion recognition in females and males. BMC Neuroscience, 10, 91. Desbonnet, L., Garrett, L., Daly, E., McDermott, K. W., & Dinan, T. G. (2008). Sexually dimorphic effects of maternal separation stress on corticotrophin-releasing factor and vasopressin systems in the adult rat brain. International Journal of Developmental Neuroscience, 26, 259-268. Di Cristo, G., Berardi, N., Cancedda, L., Pizzorusso, T., Putignano, E., Ratto, G. M., & Maffei, L. (2001). Requirement of ERK activation for visual cortical plasticity. Science, 292, 2337-2340. Doron, N. N., & Ledoux, J. E. (2000). Cells in the posterior thalamus project to both amygdala and temporal cortex: a quantitative retrograde double-labeling study in the rat. Journal of Comparative Neurology, 425, 257-274. Drago, F., Bohus, B., Scapagnini, U., & de Wied, D. (1980). Sexual dimorphism in passive avoidance behavior of rats: relation to body weight, age, shock intensity and retention interval. Physiology and Behavior, 24, 1161-1164. Edwards, H. E., MacLusky, N. J., & Burnham, W. M. (2000). The effect of seizures and kindling on reproductive hormones in the rat. Neuroscience and Biobehavioral Reviews, 24, 753-762. Einon, D. (1980). Spatial memory and response strategies in rats: age, sex and rearing differences in performance. Quarterly Journal of Experimental Psychology, 32, 473-489. Eisinger, D. A., & Ammer, H. (2008). Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases. Cellular Signalling, 20, 2324-2331. English, J. D., & Sweatt, J. D. (1996). Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. Journal of Biological Chemistry, 271, 24329-24332. English, J. D., & Sweatt, J. D. (1997). A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation. Journal of Biological Chemistry, 272, 19103-19106. Ferry, B., Roozendaal, B., & McGaugh, J. L. (1999). Basolateral amygdala noradrenergic influences on memory storage are mediated by an interaction between beta- and alpha1-adrenoceptors. Journal of Neuroscience, 19, 5119-5123. Fiore, R. S., Murphy, T. H., Sanghera, J. S., Pelech, S. L., & Baraban, J. M. (1993). Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. Journal of Neurochemistry, 61, 1626-1633. Galea, L. A., McEwen, B. S., Tanapat, P., Deak, T., Spencer, R. L., & Dhabhar, F. S. (1997). Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience, 81, 689-697. Gao, L., Chao, L., & Chao, J. (2010). A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor. Experimental Cell Research, 316, 376-389. Gonzalez-Lima, F., & Cada, A. (1994). Cytochrome oxidase activity in the auditory system of the mouse: a qualitative and quantitative histochemical study. Neuroscience, 63, 559-578. Gooney, M., Messaoudi, E., Maher, F. O., Bramham, C. R., & Lynch, M. A. (2004). BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events. Neurobiology of Aging, 25, 1323-1331. Gorkiewicz, T., Szczuraszek, K., Wyrembek, P., Michaluk, P., Kaczmarek, L., & Mozrzymas, J. W. (2009). Matrix metalloproteinase-9 reversibly affects the time course of NMDA-induced currents in cultured rat hippocampal neurons. Hippocampus. Graham, L. K., Yoon, T., Lee, H. J., & Kim, J. J. (2009). Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats. Psychology and Neuroscience, 2, 219-225. Gresack, J. E., Schafe, G. E., Orr, P. T., & Frick, K. M. (2009). Sex differences in contextual fear conditioning are associated with differential ventral hippocampal extracellular signal-regulated kinase activation. Neuroscience, 159, 451-467. Guzowski, J. F., & McGaugh, J. L. (1997). Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proceedings of the National Academy of Sciences of the United States of America, 94, 2693-2698. Hardingham, G. E., Arnold, F. J., & Bading, H. (2001). A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nature Neuroscience, 4, 565-566. Heinsbroek, R. P., van Oyen, H. G., & van de Poll, N. E. (1984). The pituitary-adrenocortical system is not involved in the sex difference in passive avoidance. Pharmacology, Biochemistry and Behavior, 20, 663-668. Herz, R. S., & Cupchik, G. C. (1992). An experimental characterization of odor-evoked memories in humans. Chemical Senses, 17, 519-528. Hines, M., Allen, L. S., & Gorski, R. A. (1992). Sex differences in subregions of the medial nucleus of the amygdala and the bed nucleus of the stria terminalis of the rat. Brain Research, 579, 321-326. Jarrard, L. E. (1993). On the role of the hippocampus in learning and memory in the rat. Behavioral and Neural Biology, 60, 9-26. Juraska, J. M., Fitch, J. M., Henderson, C., & Rivers, N. (1985). Sex differences in the dendritic branching of dentate granule cells following differential experience. Brain Research, 333, 73-80. Juraska, J. M., Fitch, J. M., & Washburne, D. L. (1989). The dendritic morphology of pyramidal neurons in the rat hippocampal CA3 area. II. Effects of gender and the environment. Brain Research, 479, 115-119. Kelleher, R. J., 3rd, Govindarajan, A., Jung, H. Y., Kang, H., & Tonegawa, S. (2004). Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell, 116, 467-479. Kelly, A., Laroche, S., & Davis, S. (2003). Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory. Journal of Neuroscience, 23, 5354-5360. Kemble, E. D., & Tapp, J. T. (1968). Passive and active avoidance performance following small amygdaloid lesions in rats. Physiology and Behavior, 3, 713-718. Killcross, S., Robbins, T. W., & Everitt, B. J. (1997). Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala. Nature, 388, 377-380. Kilts, C. D., Gross, R. E., Ely, T. D., & Drexler, K. P. (2004). The neural correlates of cue-induced craving in cocaine-dependent women. American Journal of Psychiatry, 161, 233-241. Kitay, J. I. (1963). Pituitary-Adrenal Function in the Rat after Gonadectomy and Gonadal Hormone Replacement. Endocrinology, 73, 253-260. Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H. A., Murison, R., Moser, E. I., & Moser, M. B. (2002). Reduced fear expression after lesions of the ventral hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 99, 10825-10830. Klüver, H., & Bucy, P. C. (1938). An analysis of certain effects of bilateral temporal lobectomy in the rhesus monkey, with special reference to 'psychic blindness.' Journal of Psychology, 5, 33-54. Kosten, T. A., Lee, H. J., & Kim, J. J. (2006). Early life stress impairs fear conditioning in adult male and female rats. Brain Research, 1087, 142-150. Kudo, K., Qiao, C. X., Kanba, S., & Arita, J. (2004). A selective increase in phosphorylation of cyclic AMP response element-binding protein in hippocampal CA1 region of male, but not female, rats following contextual fear and passive avoidance conditioning. Brain Research, 1024, 233-243. LaCroix-Fralish, M. L., Rutkowski, M. D., Weinstein, J. N., Mogil, J. S., & Deleo, J. A. (2005). The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex. Spine (Phila Pa 1976), 30, 1821-1827. LaBar, K. S., & Phelps, E. A. (1998). Arousal-Mediated Memory Consolidation: Role of the Medial TemporalLobe in Humans. Psychological Science, 9, 490-493. Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P.M. Long-term behavioral and neuroendocrine adaptations to adverse early experience. In: Mayer EA, Saper CB, editors. Progress in brain research: the biological basis for mind body interactions. Amsterdam: Elsevier, 2000. pp. 81–103. LeDoux, J. E., Iwata, J., Cicchetti, P., & Reis, D. J. (1988). Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. Journal of Neuroscience, 8, 2517-2529. Leshner, A. I., Brookshire, K. H., & Stewart, C. N. (1971). The effects of adrenal demedullation on conditioned fear. Hormones and Behavior, 2, 43-48. Liang, K. C., McGaugh, J. L., Martinez, J. L., Jr., Jensen, R. A., Vasquez, B. J., & Messing, R. B. (1982). Post-training amygdaloid lesions impair retention of an inhibitory avoidance response. Behavioural Brain Research, 4, 237-249. Lømo, T. (1966) Frequency potentiation of excitatory synaptic activity in the dentate area of the hippocampal formation. Acta Physiol. Scand. 68(Suppl. 277), 128. Lopez-Rubalcava, C., & Lucki, I. (2000). Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacology, 22, 191-199. Lynch, M. A. (2004). Long-term potentiation and memory. Physiological Reviews, 84, 87-136. Madeira, M. D., & Lieberman, A. R. (1995). Sexual dimorphism in the mammalian limbic system. Progress in Neurobiology, 45, 275-333. Maren, S., De Oca, B., & Fanselow, M. S. (1994). Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning. Brain Research, 661, 25-34. Marks, H. E., Fargason, B. D., & Hobbs, S. H. (1972). Reactivity to aversive stimuli as a function of alterations in body weight in normal and gonadectomized female rats. Physiology and Behavior, 9, 539-544. Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., Welzl, H., Wolfer, D. P., Pages, G., Valverde, O., Marowsky, A., Porrazzo, A., Orban, P. C., Maldonado, R., Ehrengruber, M. U., Cestari, V., Lipp, H. P., Chapman, P. F., Pouyssegur, J., & Brambilla, R. (2002). Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron, 34, 807-820. McCarty, R., & Kopin, I. J. (1978). Sympatho-adrenal medullary activity and behavior during exposure to footshock stress: a comparison of seven rat strains. Physiology and Behavior, 21, 567-572. McGaugh, J. L., Ferry, B., Vazdarjanova, A. and Roozendaal, B. Amygdala: role in modulation of memory storage. In The Amygdala: A Functional Analysis edited by J. Aggleton, New York: Oxford University Press, 2000, pp. 391-423. McIver, A. H., & Jeffrey, W. E. (1967). Strain differences in maternal behavior in rats. Behaviour, 28, 210-216. McNew, J. J., & Thompson, R. (1966). Role of the limbic system in active and passive avoidance conditioning in the rat. Journal of Comparative and Physiological Psychology, 61, 173-180. Mendez-Lopez, M., Mendez, M., Lopez, L., & Arias, J. L. (2009). Spatial working memory in Wistar rats: brain sex differences in metabolic activity. Brain Research Bulletin, 79, 187-192. Morris, R. G., Anderson, E., Lynch, G. S., & Baudry, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature, 319, 774-776. Moser, E., Moser, M. B., & Andersen, P. (1993). Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. Journal of Neuroscience, 13, 3916-3925. Nakajima, A., Yamakuni, T., Matsuzaki, K., Nakata, N., Onozuka, H., Yokosuka, A., Sashida, Y., Mimaki, Y., & Ohizumi, Y. (2007). Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling. Journal of Pharmacology and Experimental Therapeutics, 321, 784-790. O'Reilly, R. C., & Rudy, J. W. (2001). Conjunctive representations in learning and memory: principles of cortical and hippocampal function. Psychological Review, 108, 311-345. Orsini, C., Buchini, F., Conversi, D., & Cabib, S. (2004). Selective improvement of strain-dependent performances of cognitive tasks by food restriction. Neurobiology of Learning and Memory, 81, 96-99. Orton, R. J., Sturm, O. E., Vyshemirsky, V., Calder, M., Gilbert, D. R., & Kolch, W. (2005). Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochemical Journal, 392, 249-261. Palkovits, M., & Brownstein, M. J. (1988). Maps and guide to microdissection of the rat brain. New York: Elsevier. Pare, D., Quirk, G. J., & Ledoux, J. E. (2004). New vistas on amygdala networks in conditioned fear. Journal of Neurophysiology, 92, 1-9. Pavlov, I. P. (1927). Conditioned Reflexes. London: Oxford University Press. Parent, M. B., & McGaugh, J. L. (1994). Posttraining infusion of lidocaine into the amygdala basolateral complex impairs retention of inhibitory avoidance training. Brain Research, 661, 97-103. Paxinos, G., & Watson, C. (1986). The rat brain in stereotaxic coordinates. San Diego; London: Academic. Phillips, A. G., & Deol, G. S. (1977). Neonatal androgen levels and avoidance learning in prepubescent and adult male rats. Hormones and Behavior, 8, 22-29. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285. Podhorna, J., McCabe, S., & Brown, R. E. (2002). Male and female C57BL/6 mice respond differently to diazepam challenge in avoidance learning tasks. Pharmacology, Biochemistry and Behavior, 72, 13-21. Quadagno, D. M., Shryne, J., Anderson, C., & Gorski, R. A. (1972). Influence of gonadal hormones on social, sexual, emergence, and open field behaviour in the rat (Rattus norvegicus). Animal Behaviour, 20, 732-740. Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C., & Sweatt, J. D. (1999). The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. Journal of Neuroscience, 19, 4337-4348. Robinson, J. A. (1976). Sampling autobiographical memory. Cognitive Psychology, 8, 578-595. Roof, R. L., Zhang, Q., Glasier, M. M., & Stein, D. G. (1993). Gender-specific impairment on Morris water maze task after entorhinal cortex lesion. Behavioural Brain Research, 57, 47-51. Roozendaal, B., Nguyen, B. T., Power, A. E., & McGaugh, J. L. (1999). Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation. Proceedings of the National Academy of Sciences of the United States of America, 96, 11642-11647. Ross, M., & Holmberg, D. (2000). Recounting the past: Gender differences in the recall of events in the history of a closer relationship. Reprinted in U. Neisser & I. E. Hyman (Eds.) (2000), Memory observed: Remembering in natural contexts (pp. 183-196). New York: Worth. (article originally published in 1990) Sachs, B. D. (1996). Penile erection in response to remote cues from females: albino rats severely impaired relative to pigmented strains. Physiology and Behavior, 60, 803-808. Sachs, B. D., Akasofu, K., Citron, J. H., Daniels, S. B., & Natoli, J. H. (1994). Noncontact stimulation from estrous females evokes penile erection in rats. Physiology and Behavior, 55, 1073-1079. Salinas, J. A., Packard, M. G., & McGaugh, J. L. (1993). Amygdala modulates memory for changes in reward magnitude: reversible post-training inactivation with lidocaine attenuates the response to a reduction in reward. Behavioural Brain Research, 59, 153-159. Sarter, M., & Markowitsch, H. J. (1985). Involvement of the amygdala in learning and memory: a critical review, with emphasis on anatomical relations. Behavioral Neuroscience, 99, 342-380. Satinder, K. P., & Hill, K. D. (1974). Effects of genotype and postnatal experience on activity, avoidance, shock threshold, and open-field behavior of rats. Journal of Comparative and Physiological Psychology, 86, 363-374. Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000). Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning. Journal of Neuroscience, 20, 8177-8187. Scoville, W. B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery and Psychiatry, 20, 11-21. Seidlitz, L., & Diener, E. (1998). Sex differences in the recall of affective experiences. Journal of Personality and Social Psychology, 74, 262-271. Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R., & Sweatt, J. D. (1999). A necessity for MAP kinase activation in mammalian spatial learning. Learning and Memory, 6, 478-490. Silva, A. J., Frankland, P. W., Marowitz, Z., Friedman, E., Laszlo, G. S., Cioffi, D., Jacks, T., & Bourtchuladze, R. (1997). A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nature Genetics, 15, 281-284. Smith, M. D., Jones, L. S., & Wilson, M. A. (2002). Sex differences in hippocampal slice excitability: role of testosterone. Neuroscience, 109, 517-530. Sutherland, R. J., & McDonald, R. J. (1990). Hippocampus, amygdala, and memory deficits in rats. Behavioural Brain Research, 37, 57-79. Sweatt, J. D. (1999). Toward a molecular explanation for long-term potentiation. Learning and Memory, 6, 399-416. Sweatt, J. D. (2001). The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. Journal of Neurochemistry, 76, 1-10. Thiels, E., & Klann, E. (2001). Extracellular signal-regulated kinase, synaptic plasticity, and memory. Reviews in the Neurosciences, 12, 327-345. Trapold, M. A. (1970). Are expectancies based upon different positive reinforcing events discriminably different? Learning and Motivation, 1, 129-140. Trifilieff, P., Herry, C., Vanhoutte, P., Caboche, J., Desmedt, A., Riedel, G., Mons, N., & Micheau, J. (2006). Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation. Learning and Memory, 13, 349-358. Turner, B. B., & Weaver, D. A. (1985). Sexual dimorphism of glucocorticoid binding in rat brain. Brain Research, 343, 16-23. Uno, H., Tarara, R., Else, J. G., Suleman, M. A., & Sapolsky, R. M. (1989). Hippocampal damage associated with prolonged and fatal stress in primates. Journal of Neuroscience, 9, 1705-1711. van Haaren, F., & van de Poll, N. E. (1984). The number of pre-shock trials affects sex differences in passive avoidance behavior. Physiology and Behavior, 33, 269-272. van Haaren, F., & van de Poll, N. E. (1986). Effects of light intensity on passive avoidance behavior of male and female Wistar rats. Physiology and Behavior, 36, 123-125. van Oyen, H. G., van de Poll, N. E., & de Bruin, J. P. (1979). Sex, age and shock-intensity as factors in passive avoidance. Physiology and Behavior, 23, 915-918. van Oyen, H. G., van de Poll, N. E., & de Bruin, J. P. (1980). Effects of retention interval and gonadectomy on sex differences in passive avoidance behavior. Physiology and Behavior, 25, 859-862. Walz, R., Roesler, R., Quevedo, J., Sant'Anna, M. K., Madruga, M., Rodrigues, C., Gottfried, C., Medina, J. H., & Izquierdo, I. (2000). Time-dependent impairment of inhibitory avoidance retention in rats by posttraining infusion of a mitogen-activated protein kinase kinase inhibitor into cortical and limbic structures. Neurobiology of Learning and Memory, 73, 11-20. Wehrwein, E. A., Lujan, H. L., & DiCarlo, S. E. (2007). Gender differences in learning style preferences among undergraduate physiology students. Adv Physiol Educ, 31, 153-157. Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006). Learning induces long-term potentiation in the hippocampus. Science, 313, 1093-1097. Wilcock, J., & Bush, M. A. (1972). Heterosis for punishment-induced inhibition of drinking in laboratory rats. Life Sciences. Part 1, Physiology and Pharmacology, 11, 403-412. Wilensky, A. E., Schafe, G. E., & LeDoux, J. E. (2000). The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning. Journal of Neuroscience, 20, 7059-7066. Wimer, R. E., & Wimer, C. (1985). Three sex dimorphisms in the granule cell layer of the hippocampus in house mice. Brain Research, 328, 105-109. Zhang, J. J., Okutani, F., Inoue, S., & Kaba, H. (2003). Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway leading to cyclic AMP response element-binding protein phosphorylation is required for the long-term facilitation process of aversive olfactory learning in young rats. Neuroscience, 121, 9-16. Zhu, J. J., Qin, Y., Zhao, M., Van Aelst, L., & Malinow, R. (2002). Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell, 110, 443-455. Ziabreva, I., Poeggel, G., Schnabel, R., & Braun, K. (2003). Separation-induced receptor changes in the hippocampus and amygdala of Octodon degus: influence of maternal vocalizations. Journal of Neuroscience, 23, 5329-5336. Zimmerman, J. M., Rabinak, C. A., McLachlan, I. G., & Maren, S. (2007). The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learning and Memory, 14, 634-644. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46030 | - |
dc.description.abstract | 第一部分:
被動型躲避學習 (passive avoidance learning) 是將動物自發性的趨暗行為與嫌惡性的電擊刺激配對,而引發該趨暗行為產生抑制性現象的一種學習作業。過去的研究指出在被動型躲避學習作業中,訓練與測試間隔超過15分鐘以上即可以觀察到雄鼠的學習表現顯著優於雌鼠的現象。根據與自發行為、制約學習與生殖相關的研究指出,大鼠的探索行為、躲避型學習與性行為都會隨著動物品系的差異而有所不同。為釐清大鼠品系對被動型躲避學習作業中性別差異現象的影響,我們比較鼠齡為8週的Wistar及Long-Evans兩種品系的大鼠在該學習作業中的行為表現。在被動型躲避學習的訓練中,先讓大鼠學習暗箱和足部電擊的配對關係,並在訓練後30分鐘的測試中以大鼠之步入暗箱時間 (step-through latency) 來評估其學習行為的良莠。研究結果顯示Wistar雄鼠在被動型躲避學習作業中的行為表現明顯較Wistar雌鼠為佳,但Long-Evans雄鼠和雌鼠間則沒有顯著的差異。換言之,我們可以在Wistar品系大鼠被動型躲避學習中觀察到性別差異的現象,卻無法在Long-Evans品系的大鼠中發現。故研究性別差異時所使用之實驗動物品系也將是影響實驗結果的重要因子之一。 第二部分: 雄鼠和雌鼠在與生殖相關的行為模式上存在著顯著的性別差異。然而,在與生殖非相關的行為方面,性別差異的現象則被研究得較少。在自發性反應 (如: 趨暗行為、飲水行為等) 與嫌惡型刺激配對的連結學習中,如在訓練後立即給予測試,雌鼠的自發性反應受到較強的抑制,然而,當訓練與測試的間隔較長時,雄鼠則表現出較強的抑制性自發反應。本研究以鼠齡為8週的Wistar大鼠作為實驗材料,觀察被動型躲避學習 (passive avoidance learning) 中訓練和測試的時距間隔改變,是否導致雄、雌鼠的行為表現有所差異。實驗組的動物在步入暗箱後會接受足部電擊,而控制組的動物在由亮箱步入暗箱後並不會接受足部的電擊。在此學習作業訓練後的立即測試中,雌鼠的學習行為表現顯著較雄鼠為佳。然而,在訓練後30分鐘給予測試,雄鼠的學習表現則顯著優於雌鼠。若訓練和測試的時距間隔延長至120分鐘,則雄、雌鼠之間沒有顯著的差異。Extracellular signal-regulated kinase (ERK) 的活化在神經可塑性與記憶處理的相關過程中扮演著重要的角色,且發現動物在接受被動型躲避學習訓練之後其會產生活化的現象。為釐清雄、雌鼠在被動型躲避學習作業中的行為差異,我們於動物完成測試之後進行斷頭犧牲,以西方點墨法分析背側海馬迴 (dorsal hippocampus)、腹側海馬迴 (ventral hippocampus)、中央杏仁核 (central nucleus of amygdala) 與基側杏仁核 (basolateral nucleus of amygdala) 等腦區中ERK的活性。結果顯示在訓練後立即測試並犧牲的雄鼠腦中,其背側海馬、腹側海馬中ERK的活性並沒有改變,但在中央杏仁核與基側杏仁核則觀察到ERK的活性有顯著提升的現象;而在訓練後立即測試並犧牲的雌鼠上述各腦區中則沒有觀察到ERK活性的改變。若訓練和測試的間隔延長為30分鐘,則雄、雌鼠在上述各腦區之ERK活性皆未觀察到有顯著的變化。訓練後120分鐘測試並犧牲的雄鼠腦中,其基側杏仁核中的ERK活化量有顯著提升的現象,但在雌鼠上述各腦區中則未觀察到ERK活性的變化。 綜合上述的結果,改變訓練與測試的時距間隔可以發現到雄、雌鼠有不同的學習表現。雄鼠在訓練後的立即測試中,其基側杏仁核會產生快速且短暫的ERK活化現象,而該現象並未在雌鼠腦中發現。因此,雄、雌鼠在被動型躲避學習行為上的差異以及ERK表現的不同可能顯示雄、雌鼠在記憶處理過程中有不同的機制。 | zh_TW |
dc.description.abstract | First part:
Passive avoidance learning is a one-trial fear-motivated avoidance task in which the animal learns to refrain from stepping through a door to an apparently safer but previously punished dark compartment. Male rats have been observed to be more efficient than females in a passive avoidance situation once the duration of the interval exceeds 15 min. According to previous studies on spontaneous behavior, reproductive behavior and conditioned learning, it appears that differences in the rat strains may influence exploratory behavior, sexual behavior, and learning behavior. To address this question, passive avoidance tasks were given to rats of two strains, albono (Wistar) and pigmented (Long-Evans) strains. During passive avoidance learning, rats had to learn from the training procedures that paired the dark compartment with a mild footshock. Step-through latencies were measured to infer the animal’s memory for the fearful experience. The passive avoidance behavior of Wistar male rats were superior to that of Wistar female rats, but there was no significant difference in this behavior between the retenion of Long-Evans male and female rats. In conclusion, our data demonstrate that sex differences in passive avoidance learning exist in Wistar rats, but not in Long-Evans rats. Thus, choice of animal strains for studies on sex differences may be an important variable. Second part: Although there is extensive literature demonstrating that male and female rats differ in many behavioral patterns related to reproductive behavior, sex differences in non-reproductive behaviors have been investigated less. Female rats show more response suppression in aversively motivated learning when the effect of presentation of an aversive stimulus upon subsequent responding is measured immediately, whereas males show more suppression in procedures in which the effect of an aversive stimulus is measured after longer intervals. In the present study, we used both male and female Wistar rats aged 8 weeks which have been through passive avoidance learning to examine whether sexual divergence can indeed be attributed to temporal parameters. The step-through latencies were studied using various intervals between footshock and retention interval. During training, male and female rats received a footshock in the dark section of a conditioning chamber while control rats received the same training procedures but without the footshock. Female rats were superior to males in the retention of a step-through type passive avoidance response immediately after training. However, males performed better in the acquisition of a passive avoidance response 30 min after training. Males and females showed no sex differences in behavioral performance when they were tested 120 min after training. In order to examine whether the sex difference in the performance of passive avoidance conditioning is associated with a change in the activation of extracellular signal-regulated kinase (ERK), animals were decapitated immediately after testing, and we used western blot analysis to examine the activation of ERK in the dorsal hippocampus, ventral hippocampus, central nucleus of amygdale (CeA), and basolateral nucleus of amygdala (BLA). Our data demonstrated that phosphorylated ERK levels in the BLA and CeA, but not dorsal hippocampus, or ventral hippocampus, were higher in males than in females, relative to same sex controls, immediately after training. In both males and females, phosphorylation of ERK was not found in any brain regions at 30 min after training. When a shock-retest interval was 120 min, ERK activation in the BLA was observed only in males, but not in females. In summary, sex differences in passive avoidance learning depend on the time intervals between training and retention trial. ERK would be activated in the BLA only in males, immediately after training. Together, these findings suggest that there may be the existence of sexual dimorphism in memory process. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T04:51:49Z (GMT). No. of bitstreams: 1 ntu-99-R97441002-1.pdf: 1906783 bytes, checksum: f6233a4a6600d28ef913eac9458e3225 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 口委審定書 i
誌謝 ii 目錄 iii 圖目錄 v 表目錄 vi 縮寫表 vii 第一篇 品系對被動型躲避學習作業中的性別差異現象有所影響 中文摘要 2 英文摘要 3 第一章 緒論 1.1 情緒記憶與性別差異 5 1.2 被動型躲避學習作業 6 1.3 性別差異現象 7 1.4 品系差異現象 10 1.5 品系對性別差異現象的影響 12 1.6 研究目的 13 第二章 材料與方法 2.1 實驗動物及其分組 14 2.2 被動型躲避學習 14 2.3 統計方法 15 第三章 結果 3.1 Long-Evans大鼠之學習行為 17 3.2 Wistar大鼠之學習行為 17 第四章 討論 18 第二篇 被動型躲避學習中的性別差異現象與杏仁核中ERK的活化有關 中文摘要 24 英文摘要 26 第一章 緒論 1.1 訓練與測試之時距變化對性別差異的影響 28 1.2 與被動型躲避學習相關的腦區 28 1.3 ERK與制約學習和記憶的關係 31 1.4 研究目的 35 第二章 材料與方法 2.1 實驗動物及其分組 37 2.2 被動型躲避學習 37 2.3 腦中ERK的測定 37 2.4 統計方法 45 第三章 結果 3.1 「訓練」與「測試」之時距的改變對性別差異的影響 47 3.2 被動型躲避學習作業中「訓練」與「測試」的時距間隔不同對不同腦區中ERK活化量之影響 48 第四章 討論 4.1 行為結果 52 4.2 ERK的測定結果 55 4.3 結論 61 參考文獻 83 圖 目 錄 第一篇 品系對被動型躲避學習作業中的性別差異現象有所影響 圖1. Long-Evans大鼠在被動型躲避學習訓練後30分鐘的測試中之步入時間 21 圖2. Wistar大鼠在在被動型躲避學習訓練後30分鐘的測試中之步入時間 22 第二篇 被動型躲避學習中的性別差異現象與杏仁核中ERK的活化有關 圖1. 神經組織取樣 63 圖2. 動物在被動型躲避學習訓練後立即測試中的步入時間 64 圖3. 動物在被動型躲避學習訓練後30分鐘的測試中之步入時間 65 圖4. 動物在被動型躲避學習訓練後120分鐘的測試中之步入時間 66 圖5. 動物完成訓練後之立即測試其背側海馬pERK的表現 67 圖6. 動物完成訓練後之立即測試其腹側海馬pERK的表 68 圖7. 動物完成訓練後30分鐘之測試其背側海馬pERK的表現 69 圖8. 動物完成訓練後30分鐘之測試其腹側海馬pERK的表現 70 圖9. 動物完成訓練後120分鐘之測試其背側海馬pERK的表現 71 圖10. 動物完成訓練後120分鐘之測試其腹側海馬pERK的表現 72 圖11. 動物完成訓練後之立即測試其中央杏仁核pERK的表現 73 圖12. 動物完成訓練後之立即測試其基側杏仁核pERK的表現 74 圖13. 動物完成訓練後30分鐘之測試其中央杏仁核pERK的表現 75 圖14. 動物完成訓練後30分鐘之測試其基側杏仁核pERK的表現 76 圖15. 動物完成訓練後120分鐘之測試其中央杏仁核pERK的表現 77 圖16. 動物完成訓練後120分鐘之測試其基側杏仁核pERK的表現 78 表 目 錄 表1. 各組腦區中total ERK (tERK-44與tERK-42) 的表現 79 表2. 各組腦區中phospho ERK (pERK-44與pERK-42) 的表現 81 | |
dc.language.iso | zh-TW | |
dc.title | 被動型躲避學習中之性別差異 | zh_TW |
dc.title | Sex differences in passive avoidance learning | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 梁庚辰(Keng-Chen Liang),廖瑞銘(Ruey-Ming Liao),呂國棟(Kwok-Tung Lu) | |
dc.subject.keyword | 被動型躲避學習,性別差異,品系,大鼠,extracellular signal-regulated kinase (ERK),海馬迴,杏仁核, | zh_TW |
dc.subject.keyword | passive avoidance learning,sex differences,strain,rat,extracellular signal-regulated kinase (ERK),hippocampus,amygdala, | en |
dc.relation.page | 94 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-08-02 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 生理學研究所 | zh_TW |
顯示於系所單位: | 生理學科所 |
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