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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 黃慧璧(Hui-Pi Huang) | |
dc.contributor.author | Tsai-Jung Wu | en |
dc.contributor.author | 吳采蓉 | zh_TW |
dc.date.accessioned | 2021-06-15T04:07:49Z | - |
dc.date.available | 2011-02-11 | |
dc.date.copyright | 2010-02-11 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-02-05 | |
dc.identifier.citation | Chapter 1
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J Am Soc Nephrol 2002;13:1230-1237. 8. Igarashi P, Somlo S. Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 2002;13:2384-2398. 9. Gabow PA, Johnson AM, Kaehny WD, Manco-Johnson ML, Duley IT, Everson GT. Risk factors for the development of hepatic cysts in autosomal dominant polycystic kidney disease. Hepatology 1990;11:1033-1037. 10. Danaci M, Akpolat T, Bastemir M, et al. The prevalence of seminal vesicle cysts in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant 1998;13:2825-2828. 11. Alpern MB, Dorfman RE, Gross BH, Gottlieb CA, Sandler MA. Seminal vesicle cysts: association with adult polycystic kidney disease. Radiology 1991;180:79-80. 12. Wijdicks EF, Torres VE, Schievink WI. Chronic subdural hematoma in autosomal dominant polycystic kidney disease. Am J Kidney Dis 2000;35:40-43. 13. Schievink WI, Huston J, 3rd, Torres VE, Marsh WR. Intracranial cysts in autosomal dominant polycystic kidney disease. J Neurosurg 1995;83:1004-1007. 14. Alehan FK, Gurakan B, Agildere M. Familial arachnoid cysts in association with autosomal dominant polycystic kidney disease. Pediatrics 2002;110:e13. 15. Nicolau C, Torra R, Bianchi L, et al. Abdominal sonographic study of autosomal dominant polycystic kidney disease. J Clin Ultrasound 2000;28:277-282. 16. Chapman AB, Johnson AM, Rainguet S, Hossack K, Gabow P, Schrier RW. Left ventricular hypertrophy in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1997;8:1292-1297. 17. Gabow PA, Chapman AB, Johnson AM, et al. Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney Int 1990;38:1177-1180. 18. Chapman AB, Johnson A, Gabow PA, Schrier RW. The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med 1990;323:1091-1096. 19. Loghman-Adham M, Soto CE, Inagami T, Cassis L. The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol 2004;287:F775-788. 20. Fick GM, Johnson AM, Hammond WS, Gabow PA. Causes of death in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995;5:2048-2056. 21. Gattone VH, 2nd, Grantham JJ. Understanding human cystic disease through experimental models. Semin Nephrol 1991;11:617-631. 22. Silvestro D. [On a case of bilateral polycystic kidney in a cat]. Acta Med Vet (Napoli) 1967;13:349-361. 23. Battershell D, Garcia JP. Polycystic kidney in a cat. J Am Vet Med Assoc 1969;154:665-666. 24. Biller DS, Chew DJ, DiBartola SP. Polycystic kidney disease in a family of Persian cats. J Am Vet Med Assoc 1990;196:1288-1290. 25. Biller DS, DiBartola SP, Eaton KA, Pflueger S, Wellman ML, Radin MJ. Inheritance of polycystic kidney disease in Persian cats. J Hered 1996;87:1-5. 26. Bonazzi M, Volta A, Gnudi G, Bottarelli E, Gazzola M, Bertoni G. Prevalence of the polycystic kidney disease and renal and urinary bladder ultrasonographic abnormalities in Persian and Exotic Shorthair cats in Italy. J Feline Med Surg 2007;9:387-391. 27. Barrs VR, Gunew M, Foster SF, Beatty JA, Malik R. Prevalence of autosomal dominant polycystic kidney disease in Persian cats and related-breeds in Sydney and Brisbane. Aust Vet J 2001;79:257-259. 28. Beck C, Lavelle RB. Feline polycystic kidney disease in Persian and other cats: a prospective study using ultrasonography. Aust Vet J 2001;79:181-184. 29. Cannon MJ, MacKay AD, Barr FJ, Rudorf H, Bradley KJ, Gruffydd-Jones TJ. Prevalence of polycystic kidney disease in Persian cats in the United Kingdom. Vet Rec 2001;149:409-411. 30. Barthez PY, Rivier P, Begon D. Prevalence of polycystic kidney disease in Persian and Persian related cats in France. J Feline Med Surg 2003;5:345-347. 31. Domanjko-Petric A, Cernec D, Cotman M. Polycystic kidney disease: a review and occurrence in Slovenia with comparison between ultrasound and genetic testing. J Feline Med Surg 2008;10:115-119. 32. Lyons LA, Biller DS, Erdman CA, et al. Feline polycystic kidney disease mutation identified in PKD1. J Am Soc Nephrol 2004;15:2548-2555. 33. Eaton KA, Biller DS, DiBartola SP, Radin MJ, Wellman ML. Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats. Vet Pathol 1997;34:117-126. 34. Pei Y, Obaji J, Dupuis A, et al. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 2009;20:205-212. 35. Helps CR, Tasker S, Barr FJ, Wills SJ, Gruffydd-Jones TJ. Detection of the single nucleotide polymorphism causing feline autosomal-dominant polycystic kidney disease in Persians from the UK using a novel real-time PCR assay. Mol Cell Probes 2007;21:31-34. 36. Grantham JJ, Nair V, Winklhofer F. Cystic Diseases of the Kidney. In: Brenner BM, ed. Brenner and Rector's the kidney. 6 ed. Philadelphia :: Saunders, 2000:1699-1730. 37. Mendelssohn DC, Harding ME, Cardella CJ, Cook GT, Uldall PR. Management of end-stage autosomal dominant polycystic kidney disease with hemodialysis and transplantation. Clin Nephrol 1988;30:315-319. 38. Elzinga LW, Barry JM, Torres VE, et al. Cyst decompression surgery for autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1992;2:1219-1226. 39. Zatelli A, D'Ippolito P, Bonfanti U, Zini E. Ultrasound-assisted drainage and alcoholization of hepatic and renal cysts: 22 cases. J Am Anim Hosp Assoc 2007;43:112-116. 40. Cowgill LD. Advanced therapeutic approaches for the management of uraemia--'the met and unmet needs'. J Feline Med Surg 2003;5:57-67. Chapter 2 1. Biller DS, Chew DJ, DiBartola SP. Polycystic kidney disease in a family of Persian cats. J Am Vet Med Assoc 1990;196:1288-1290. 2. Biller DS, DiBartola SP, Eaton KA, Pflueger S, Wellman ML, Radin MJ. Inheritance of polycystic kidney disease in Persian cats. J Hered 1996;87:1-5. 3. Barrs VR, Gunew M, Foster SF, Beatty JA, Malik R. Prevalence of autosomal dominant polycystic kidney disease in Persian cats and related-breeds in Sydney and Brisbane. Aust Vet J 2001;79:257-259. 4. Beck C, Lavelle RB. Feline polycystic kidney disease in Persian and other cats: a prospective study using ultrasonography. Aust Vet J 2001;79:181-184. 5. Cannon MJ, MacKay AD, Barr FJ, Rudorf H, Bradley KJ, Gruffydd-Jones TJ. Prevalence of polycystic kidney disease in Persian cats in the United Kingdom. Vet Rec 2001;149:409-411. 6. Barthez PY, Rivier P, Begon D. Prevalence of polycystic kidney disease in Persian and Persian related cats in France. J Feline Med Surg 2003;5:345-347. 7. Bonazzi M, Volta A, Gnudi G, Bottarelli E, Gazzola M, Bertoni G. Prevalence of the polycystic kidney disease and renal and urinary bladder ultrasonographic abnormalities in Persian and Exotic Shorthair cats in Italy. J Feline Med Surg 2007;9:387-391. 8. Domanjko-Petric A, Cernec D, Cotman M. Polycystic kidney disease: a review and occurrence in Slovenia with comparison between ultrasound and genetic testing. J Feline Med Surg 2008;10:115-119. 9. Lyons LA, Biller DS, Erdman CA, et al. Feline polycystic kidney disease mutation identified in PKD1. J Am Soc Nephrol 2004;15:2548-2555. 10. Nicolau C, Torra R, Badenas C, et al. Autosomal dominant polycystic kidney disease types 1 and 2: assessment of US sensitivity for diagnosis. Radiology 1999;213:273-276. 11. Young AE, Biller DS, Herrgesell EJ, Roberts HR, Lyons LA. Feline polycystic kidney disease is linked to the PKD1 region. Mamm Genome 2005;16:59-65. 12. Bonazzi M, Volta A, Gnudi G, et al. Comparison between ultrasound and genetic testing for the early diagnosis of polycystic kidney disease in Persian and Exotic Shorthair cats. J Feline Med Surg 2009;11:430-434. 13. Eaton KA, Biller DS, DiBartola SP, Radin MJ, Wellman ML. Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats. Vet Pathol 1997;34:117-126. 14. Helps C, Tasker S, Harley R. Correlation of the feline PKD1 genetic mutation with cases of PKD diagnosed by pathological examination. Exp Mol Pathol 2007;83:264-268. 15. Grantham JJ, Nair V, Winklhofer F. Cystic Diseases of the Kidney. In: Brenner BM, ed. Brenner and Rector's the kidney. 6 ed. Philadelphia :: Saunders, 2000:1699-1730. Chapter 3 1. Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med 1993;329:332-342. 2. Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007;369:1287-1301. 3. Barrett BJ, Foley R, Morgan J, Hefferton D, Parfrey P. Differences in hormonal and renal vascular responses between normotensive patients with autosomal dominant polycystic kidney disease and unaffected family members. Kidney Int 1994;46:1118-1123. 4. Chapman AB. Autosomal dominant polycystic kidney disease: time for a change? J Am Soc Nephrol 2007;18:1399-1407. 5. Gabow PA, Chapman AB, Johnson AM, et al. Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney Int 1990;38:1177-1180. 6. Schrier RW. Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol 2009;20:1888-1893. 7. Loghman-Adham M, Soto CE, Inagami T, Cassis L. The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol 2004;287:F775-788. 8. Brown S, Atkins C, Bagley R, et al. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med 2007;21:542-558. 9. Miller R, Lehmkuhl L, Smeak D, DiBartola S, Radin J. Effect of enalapril on blood pressure, renal function, and the renin-angiotensin-aldosterone system in cats with autosomal dominant polycystic kidney disease. Am J Vet Res 1999;60:1516-1525. 10. Pedersen KM, Pedersen HD, Haggstrom J, Koch J, Ersboll AK. Increased mean arterial pressure and aldosterone-to-renin ratio in Persian cats with polycystic kidney disease. J Vet Intern Med 2003;17:21-27. 11. Brown SA, Henik RA. Diagnosis and treatment of systemic hypertension. Vet Clin North Am Small Anim Pract 1998;28:1481-1494, ix. 12. Cowgill LD, James KM, Levy JK, et al. Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure. J Am Vet Med Assoc 1998;212:521-528. 13. Littman MP. Spontaneous systemic hypertension in 24 cats. J Vet Intern Med 1994;8:79-86. 14. Stiles J, Polzin DJ, Bistner SI. The prevalence of retinopathy in cats with systemic hypertension and chronic renal failure or hyperthyroidism. J Am Anim Hosp Assoc 1994;30:564-572. 15. Kobayashi DL, Peterson ME, Graves TK, Lesser M, Nichols CE. Hypertension in cats with chronic renal failure or hyperthyroidism. J Vet Intern Med 1990;4:58-62. 16. Bartges JW, Willis AM, Polzin DJ. Hypertension and renal disease. Vet Clin North Am Small Anim Pract 1996;26:1331-1345. 17. Bodey AR, Michell AR. Epidemiological study of blood pressure in domestic dogs. J Small Anim Pract 1996;37:116-125. 18. Syme HM, Barber PJ, Markwell PJ, Elliott J. Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc 2002;220:1799-1804. 19. Safar M. Ageing and its effects on the cardiovascular system. Drugs 1990;39 Suppl 1:1-8. 20. McEniery CM, Wilkinson IB, Avolio AP. Age, hypertension and arterial function. Clin Exp Pharmacol Physiol 2007;34:665-671. 21. Mooney CT. Hyperthyroidism. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterimary Internal Medicine. 6 ed. St. Louis, Missouri: Elsevier Saunders, 2005:1544-1559. 22. Polzin DJ, Osborne CA, Ross S. Chronic kidney disease. In: Ettinger SJ, Feldman B, eds. Textbook of Veterinary Internal Medicine. St. Louis, Missouri: Elsevier Saunders, 2005:1756-1785. Chapter 4 1. Barrs VR, Gunew M, Foster SF, Beatty JA, Malik R. Prevalence of autosomal dominant polycystic kidney disease in Persian cats and related-breeds in Sydney and Brisbane. Aust Vet J 2001;79:257-259. 2. Beck C, Lavelle RB. Feline polycystic kidney disease in Persian and other cats: a prospective study using ultrasonography. Aust Vet J 2001;79:181-184. 3. Cannon MJ, MacKay AD, Barr FJ, Rudorf H, Bradley KJ, Gruffydd-Jones TJ. Prevalence of polycystic kidney disease in Persian cats in the United Kingdom. Vet Rec 2001;149:409-411. 4. Barthez PY, Rivier P, Begon D. Prevalence of polycystic kidney disease in Persian and Persian related cats in France. J Feline Med Surg 2003;5:345-347. 5. Bonazzi M, Volta A, Gnudi G, Bottarelli E, Gazzola M, Bertoni G. Prevalence of the polycystic kidney disease and renal and urinary bladder ultrasonographic abnormalities in Persian and Exotic Shorthair cats in Italy. J Feline Med Surg 2007;9:387-391. 6. Domanjko-Petric A, Cernec D, Cotman M. Polycystic kidney disease: a review and occurrence in Slovenia with comparison between ultrasound and genetic testing. J Feline Med Surg 2008;10:115-119. 7. Duprez DA. Systolic hypertension in the elderly: addressing an unmet need. Am J Med 2008;121:179-184 e173. 8. Bodey AR, Sansom J. Epidemiological study of blood pressure in domestic cats. J Small Anim Pract 1998;39:567-573. 9. McEniery CM, Wilkinson IB, Avolio AP. Age, hypertension and arterial function. Clin Exp Pharmacol Physiol 2007;34:665-671. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/45182 | - |
dc.description.abstract | 多囊性腎病在人類是常見的遺傳性疾病之一,多數為體顯性遺傳。患者在腎臟會出現為數不等的囊狀空泡,並隨年齡增大,進而壓迫正常腎臟組織而影響腎功能,最終造成腎臟衰竭。在貓也可發現此種體顯性遺傳的多囊性腎病,主要好發於波斯及波斯混種的貓隻,偶爾可也在其他貓種發現。貓的多囊性腎病與人類的多囊性腎病不論在形態學或發生學上都非常相似,也有類似的臨床表現,並在疾病末期造成腎臟衰竭。多囊性腎病的診斷主要依據為腎臟超音波檢查,而近年來在致病基因的研究中亦發現一個位於PKD1基因位置的突變,因此也可利用分子生物學的方式針對PKD1基因異常做檢測。此論文包含兩個部份的研究,第一個研究為評估多囊性腎病在台灣貓隻的盛行率,並比較不同診斷方式的結果;第二個研究為評估血壓與貓隻是否罹患多囊性腎病及其血清肌酐酸濃度間之關聯。第一個研究結果顯示在波斯貓族群中,多囊性腎病之盛行率為23.3%,相較其他研究報告為低;而在整體貓族群中,多囊性腎病之盛行率為12.0%。而比較超音波檢查與異常PKD1基因的結果,顯示在波斯貓中此二種檢查具有高度的一致性(κ=0.84),但在其他貓種則為極低程度的一致性(κ=0)。此結果表示異常基因之檢查僅適用於波斯及其相關貓種,但整體而言,腎臟超音波仍為較適合的診斷工具。第二個研究結果顯示,雖然高血壓在人類為多囊性腎病常見的併發症,但貓的多囊性腎病與血壓之間並無關聯。在本研究中,會顯著影響血壓的因子只有年齡 (P=0.01),而較年老的貓通常具有較高的血壓。 | zh_TW |
dc.description.abstract | Polycystic kidney disease (PKD) is one of the most common inherited diseases in human, which is mostly autosomal dominant inherited and characterized by numbers of cysts occurred in renal parenchyma and results in end stage renal disease. In cats, the autosomal dominant PKD (ADPKD) is common in Persian cats and its out-crossed breeds, and could also be found in others breeds occasionally. Feline ADPKD shares many morphologic and pathogenetic features with ADPKD in human patients, and often results in renal failure at the end of disease. Diagnosis of PKD has primarily relied on renal ultrasonography, and a newly developed molecular method has been used to detect the mutated gene, PKD1 .This thesis includes two studies, the prevalence of polycystic kidney disease in cats in Taipei city and comparison of ultrasonographic findings and PCR result, and evaluation of systolic blood pressure and serum creatinine concentration in cats with and without polycystic kidney disease. Results of the first study revealed the prevalence of 23.3% in PKD in Persian and Persian related breeds and 12.0% in overall cats. The agreement between ultrasonography and PCR results was almost perfect (κ=0.84) in Persian and Persian related cats but slight in other breeds (κ=0), indicating PCR might only available in Persians, and ultrasonography might be a preferable method for diagnosis of PKD. Results of the second study revealed no significant correlation between PKD and systolic blood pressure or hypertension, although hypertension is a common complication in human patients with PKD. Furthermore, age (P=0.01) was the only factor affecting blood pressure in this study, and older cats tended to have higher blood pressure. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T04:07:49Z (GMT). No. of bitstreams: 1 ntu-99-R96643011-1.pdf: 507302 bytes, checksum: aa6eb1f7613fe9d99cbf9f71b03f63a3 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 口試委員審定書 (i)
致謝 (ii) Abstract (iii) 中文摘要 (iv) Table of contents (v) List of Figures (vi) List of Tables (vii) Chapter 1. General introduction (1) Chapter 2. Prevalence of polycystic kidney disease in cats in Taiwan and comparison of ultrasonographic findings and PCR result (11) Chapter 3. Evaluation of systolic blood pressure and serum creatinine concentration in cats with and without polycystic kidney disease (32) Chapter 4. Summarizing discussion and conclusions (50) | |
dc.language.iso | en | |
dc.title | 貓多囊性腎病之臨床研究 | zh_TW |
dc.title | Clinical Evaluation of Feline Polycystic Kidney Disease | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳應寧,季昭華 | |
dc.subject.keyword | 貓,多囊性腎病,盛行率,超音波,聚合酶,鏈鎖反應,血壓, | zh_TW |
dc.subject.keyword | Feline,polycystic kidney disease,ultrasonography,PCR,blood pressure, | en |
dc.relation.page | 52 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-02-05 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
顯示於系所單位: | 臨床動物醫學研究所 |
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