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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 何國川 | |
| dc.contributor.author | Po-Yen Chen | en |
| dc.contributor.author | 陳柏延 | zh_TW |
| dc.date.accessioned | 2021-06-15T04:01:38Z | - |
| dc.date.available | 2013-03-10 | |
| dc.date.copyright | 2010-03-10 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-02-22 | |
| dc.identifier.citation | Malhotra, B. D., Chaubey, A., and Singh, S. P. 'Prospects of conducting polymers in biosensors,' Analytica Chimica Acta 578 (2006): 59-74.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/45022 | - |
| dc.description.abstract | 本論文主要探討化學修飾電極及分子模版修飾電極在電化學生物感測器之應用。所研究的電化學生物感測器是利用媒子(mediators)以及分子模版(MIPs)對電極進行修飾。在研究的初期，首先使用一個新型的導電高分子-poly(PD-BCD)製備分子模版電極，並將此電極應用在尿酸(uric acid)的感測上，研究結果發現：改變高分子含量達到0.6 wt%時電極具有最佳的模版效率(3.73)，此時分子模版以及非分子模版的靈敏度分別為24.72以及 6.63 μA/mM cm2。此感測器的偵測下限可達到0.3 | zh_TW |
| dc.description.abstract | This dissertation deals with chemically modified electrodes and molecularly imprinted polymer (MIP) electrodes for electrochemical biosensors. The electrochemical biosensors were based on modifying mediators and MIP. Initially, a novel amine-imide type conducting polymer, denoted as poly(PD-BCD), was molecularly imprinted with uric acid (UA). The results revealed that the imprinting efficiency (IE) was highly associated with the polymer content. It was found that the optimum polymer content at 0.6 wt% gives the highest imprinting efficiency of 3.73. The sensitivities of the MIP and the non-MIP (NMIP) electrodes made with 0.6 wt% of polymer were calculated to be 24.72 and 6.63 μA/ mM cm2, respectively. The limit of detection (LOD) for the MIP electrode was found to be 0.3 μM. This MIP electrode was used as a biosensor for the detection of UA in the presence of ascorbic acid (AA) in a sample containing these species in the same concentrations as those in a human serum. Only 7% increase in current was noticed when sensing the mixed sample, as compared to the UA sample alone. In further research, a non-conducting polymer, poly-methacrylic acid (PMAA) was polymerized on the surface of multi-walled carbon nanotubes (MWCNTs) for sensing UA. The adsorption isotherms suggest that a good IE of 4.41 for UA. The adsorption isotherms were correlated successfully by the Freundlich model. Amperometric detection also revealed similar aspect, as compared to the adsorption data, and showed high selectivity toward AA, with an IE value of 2.05. For the extension of non-conducting polymers, a novel MIP electrode was fabricated by using a mediator as the reactive center and a MIP layer as the recognition part. Because of this new system, reactive mediators were investigated subsequently.
It was found that quercetin (Q), an ideal mediator, possesses catalytic effect to the neurotransmitter which was named dopamine (DA). Glassy carbon (GC) electrode was modified using MWCNTs, quercetin and Nafion® in this sequence. A possible reaction mechanism between Q and DA was proposed. The amperometric detection potential was fixed at 0.45 V (vs. Ag/AgCl sat’d KCl) as determined by the linear sweep voltammetry (LSV). The GC/MWCNTs/Q/Nafion® electrode shows a current density of about 900 µA cm-2 for DA, comparing to that of 80 µA cm-2 for the GC electrode. The 11-fold sensitivity enhancement for the modified GC electrode in sensing DA is attributed to the composite modification of the electrode. The composite electrode does eliminate the interference against AA. Calibration curves of batch and flow systems were obtained by amperometry for the detection of DA. Moreover, another mediator, flavin adenine dinucleotide (FAD), which plays a role of reducing agent for hydrogen peroxide (H2O2), was found. FAD was immobilized on a poly(3,4-ethylenedioxy-thiophene) (PEDOT) conducting polymer-modified GC electrode and was proposed to detect H2O2. The amperometric detection potential was fixed at -0.40 V (vs. Ag/AgCl sat’d KCl) as determined by the LSV. The sensitivity and the LOD for the GC/PEDOT-FAD electrode were 92.3 mA/M cm2 and 143 | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T04:01:38Z (GMT). No. of bitstreams: 1 ntu-99-D94524009-1.pdf: 3768006 bytes, checksum: 273da7b4b89a80b6f22cc03ccbb05350 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | Table of contents
Abstract VII Chinese abstract IX List of Tables XI List of Figures XII Chapter 1 Introduction 1 1.1 Brief introduction to chemical modified electrodes (CMEs) 1 1.1.1 Adsorption type CMEs 3 1.1.2 Non-adsorption type CMEs 5 1.1.2 Quantum dots CMEs 6 1.2 Brief introduction to molecularly imprinting polymers 9 1.2.1 Preparation of MIPs 10 1.2.2 Application of MIPs 16 1.3 Scope of this dissertation 27 Chapter 2 Experimental 32 2.1 Experimental method for MIPs modified electrode (Chapter 3) 32 2.1.1 Chemicals and apparatus 32 2.1.2 Preparation of MIP and NMIP electrodes 33 2.1.3 Electrochemical measurements 33 2.1.4 Morphological characterization 35 2.2 Experimental method for the preparation of MWCNTs Coated with a Layer of Imprinted PMAA (Chapter 4) 36 2.2.1 Reagents and Apparatus 36 2.2.2 Preparation of MIP-MWCNTs/PMAA particles 36 2.2.3 Rebinding test of the MIP and NMIP particles 39 2.2.4 Electrochemical experiments 39 2.3 Experimental method for the GC/MWCNTs/Q/Nafion® electrode (Chapter 5) 41 2.3.1 Reagents and Apparatus 41 2.3.2 Fabrication of the modified electrode 41 2.3.3 Electrochemical measurements 42 2.3.4 Real serum preparation and HPLC analysis 43 2.4 Experimental methods for the GC/PEDOT-FAD electrode (Chapter 6) 44 2.4.1 Reagents and Apparatus 44 2.4.2 Fabrication of the GC/PEDOT-FAD electrode 44 2.4.3 Electrochemical measurement 45 2.5 Experimental method for the MIP SAM/mediator system (Chapter 7) 47 2.5.1 Reagents and Apparatus 47 2.5.2 Fabrication of the MIP Au/TGA/Q electrode 48 2.5.3 FTIR, SECM and electrochemical measurements 50 2.6 Experimental method for the MIP SAM/mediator system with different AM/TGA molar ratio (Chapter 8) 53 2.6.1 Reagents and Apparatus 53 2.6.2 Preparation of MIP Au/TGA/Q electrode with different TGA density 54 Chapter 3 A Novel Molecularly Imprinted Polymer Thin Film as Biosensor for Uric Acid 56 3.1 Brief introduction 56 3.2 Experimental results and discussion 60 3.2.1 Performance evaluation of the MIP sensor 60 3.2.2 Optimization of the polymer content for the MIP electrode 64 3.2.3 Selectivity of the MIP electrode for UA in the presence of AA 69 Chapter 4 Detection of Uric Acid by Using MWCNTs Coated with a Layer of Imprinted PMAA 73 4.1 Brief introduction 73 4.2 Experimental results and discussion 74 4.2.1 SEM of the MIP-MWCNTs/PMAA particles 74 4.2.2 Adsorption characterization of the MIP-MWCNTTs/PMAA and the NMIP-MWCNTTs/PMAA particles 75 4.2.3 Electrochemical tests 79 Chapter 5 Enhancing Dopamine Detection Using a Glassy Carbon Electrode Modified with MWCNTs, Quercetin, and Nafion® 86 5.1 Brief introduction 86 5.2 Experimental results and discussion 88 5.2.1 CVs of the GC electrode without and with a coating of Q, Nafion®, and MWCNTs 88 5.2.2 CV of the GC electrode with the composite coating 92 5.2.3 CV of the GC electrode with the composite coating 93 5.2.4 Linear sweep voltammograms of the modified electrode 95 5.2.5 Calibration curves of batch and flow analyses 97 5.2.6 Interference due to AA 100 5.2.7 Real serum sample measurement 101 Chapter 6 An Amperometric Hydrogen Peroxide Biosensor based on a GC/PEDOT-FAD Electrode 103 6.1 Brief introduction 103 6.2 Experimental results and discussion 105 6.2.1 Electro-polymerization of the GC/PEDOT-FAD electrode 105 6.2.2 H2O2 induced FAD oxidation 109 6.2.3 Determination of sensing potential 109 6.2.4 The sensitivity of the GC/PEDOT/FAD electrode 111 6.2.5 Selectivity of the GC/PEDOT/FAD modified electrode 112 Chapter 7 Fabrication of a Molecularly Imprinted Polymer Sensor by Self-Assembling Monolayer/Mediator System 116 7.1 Brief introduction 116 7.2 Experimental results and discussion 117 7.2.1 Characterization of the MIP modified electrode 117 7.2.2 Electrocatalysis effect between Q and DA 121 7.2.3 Amperometric detection based on MIP and NMIP electrodes 122 7.2.4 Interference study 124 Chapter 8 Molecularly Imprinted SAM/Mediator Gold Electrode for High Selective Dopamine Sensor 130 8.1 Brief introduction 130 8.2 Experimental results and discussion 130 8.2.1 Surface morphology of the MIP electrode 130 8.2.2 Determination of the sensing potential 131 8.2.3 Structural recognition ability 133 Chapter 9 Conclusions and Suggestions 138 9.1 A novel molecularly imprinted polymer thin film as biosensor for uric acid 138 9.2 Detection of Uric Acid Based on Multi-Walled Carbon Nanotubes Polymerized with a Layer of Molecularly Imprinted PMAA 139 9.3 Enhancing Dopamine Detection Using a Glassy Carbon Electrode Modified with MWCNTs, Quercetin, and Nafion® 139 9.4 An amperometric hydrogen peroxide biosensor based on a GC/PEDOT-FAD electrode 140 9.5 Fabrication of a molecularly imprinted polymer sensor by self-assembling monolayer/mediator system 141 9.6 Molecularly Imprinted SAM/Mediator Gold Electrode for High Selective Dopamine Sensor 142 9.7 Suggestions and future developments 142 Chapter 10 References 144 Appendix A Method for Preparation of Zinc Oxide Nanorods Substrate 186 Appendix B Linear regression of Langmuir and Freundlich equation 192 Appendix C Curriculum Vitae 196 | |
| dc.language.iso | en | |
| dc.subject | 感測器 | zh_TW |
| dc.subject | 化學修飾電極 | zh_TW |
| dc.subject | 媒子 | zh_TW |
| dc.subject | 分子模版 | zh_TW |
| dc.subject | 自我組裝 | zh_TW |
| dc.subject | Molecularly imprinted polymer | en |
| dc.subject | Chemically modified electrode | en |
| dc.subject | Sensor | en |
| dc.subject | Self-assembly monolayer | en |
| dc.subject | Mediator | en |
| dc.title | 化學修飾電極及分子模版修飾電極在電化學式生物感測器之應用 | zh_TW |
| dc.title | Chemically Modified Electrodes and Molecularly Imprinted Polymer Electrodes for Electrochemical Biosensors | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 周澤川,許梅娟,楊明長,邱文英,戴子安 | |
| dc.subject.keyword | 化學修飾電極,媒子,分子模版,自我組裝,感測器, | zh_TW |
| dc.subject.keyword | Chemically modified electrode,Mediator,Molecularly imprinted polymer,Self-assembly monolayer,Sensor, | en |
| dc.relation.page | 204 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-02-22 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
| Appears in Collections: | 化學工程學系 | |
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