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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 馬一中(Yee-Chung Ma) | |
| dc.contributor.author | Yung-Kang Chen | en |
| dc.contributor.author | 陳泳鋼 | zh_TW |
| dc.date.accessioned | 2021-06-15T03:58:14Z | - |
| dc.date.available | 2013-09-09 | |
| dc.date.copyright | 2010-09-09 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-05-22 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44916 | - |
| dc.description.abstract | 空氣品質惡化可能會導致眼睛和呼吸系統的刺激、過敏、發炎反應、心血管疾病，和氧化壓力產生，此現象在易感受族群更為明顯。台北地區氣喘發生率顯示氣喘學童有逐年攀升的趨勢。本研究探討空氣汙染與氣喘學童的呼出氣體（Exhaled breath）中揮發性有機物質（VOCs）及肺功能（Lung function）相關性，以及空氣中微粒所產生的延遲效應（Lag effect）。
本研究將受試者分為有無罹患氣喘的學童，配合環保署超級測站的空氣品質監測資料，進行五個月的評估實驗，以比較兩組學童的生理指標變化情形。指標的檢測方法中，呼出氣體VOCs以熱脫附儀與氣相層析質譜儀進行分析，以呼出氣體中戊烷作為氧化性壓力的代表；肺功能以全自動肺功能檢測儀測量。由於實驗會重複量測受試者的各項生理指標，因此使用廣義線性估計方程式（Generalized Estimating Equations, GEEs）進行檢定，分析環境污染物質對呼出氣體及肺功能指標的影響。 結果指出，氣喘學童（Pentane=0.106, AG）氧化性壓力比非氣喘學童（Pentane=0.095, AG）高。而氣喘學童的肺功能指標平均值皆低於非氣喘學童。氧化壓力也會受性別、身體質量指數、感冒與否與空氣污染物，包括：SO2、CO、NO、NO2、PM2.5的影響。肺功能則會受到身高、體重、身體質量指數、住家是否鄰近大馬路、灰塵量多寡、有無服用維他命與SO2、CO、O3、NO、NO2、PM2.5等空氣污染物的影響。PM2.5的延遲效應可表現氧化性壓力的Lag10、Lag14、Lag30。PM10的延遲效應在氧化性壓力Lag5、Lag7、Lag10、Lag14、Lag30及肺功能指標的FVC、FEV1中有顯著關係。 在易感受族群的氣喘學童中氧化性壓力有高於非氣喘學童的趨勢。空氣污染物的急性與慢性傷害會表現在學童的氧化性壓力與肺功能指標上。懸浮微粒所產生的延遲效應，在氧化性壓力與肺功能指標中可以看到顯著關係存在。研究發現，氧化性壓力的敏感度高且可反映出長期暴露造成的傷害；另外，從肺功能指標可觀察到PM10的延遲效應。 | zh_TW |
| dc.description.abstract | Expose to air pollution has been associated with eye and respiratory system irritation, allergic and inflamed effects and cardiovascular disease. These symptoms were observable in susceptible groups. In Taipei metropolis, the asthma incidence rate rise yearly in schoolchildren. Therefore, the objective of this study was to investigate exhaled breath VOCs and lung function relevance of the air pollution in asthmatic children. Besides, the lag effect of exposure to particulate matter would also be studied.
The study divided participants into asthmatic and non-asthmatic schoolchildren. Take the exhaled breath and lung function cooperate with the air quality monitor data of EPA Supersite. The thermal desorption GC/MS was used to analyze the exhaled breath and conducted pentane as an indicator of oxidative stress; moreover, the lung function was measured by spirometer. Generalized Estimating Equations (GEEs) was used to examine the repeated measurement of the exhaled breath and lung function affected by air pollution. As the result, the higher oxidative stress and the lower average lung function in asthmatic children (Pentane=0.106 and 0.095, AG) was observed gender, body mass index (BMI), flu, and air pollutant (SO2, CO, NO, NO2, PM2.5) had significant influence in oxidative stress. Lung function were affected by height, weight, BMI, road, dust, vitamins, and air pollutant (SO2, CO, O3, NO, NO2, PM2.5). Lag effect of PM2.5 exhibit the oxidative stress in Lag10, Lag14, Lag30. The lung function (FVC, FEV1) and Lag5, Lag7, Lag10, Lag14, Lag30 in oxidative stress showed the lag effect of PM10. Asthmatic children which are susceptible had higher oxidative stress. The effects of air pollution display in oxidative stress and lung function of schoolchildren. The lag effects in oxidative stress and lung function of particulate matter were significant. This study indicated that oxidative stress is a sensitive factor and can reflect the long-term injury of exposure. In addition, the lag effect of PM10 was observed by lung function. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T03:58:14Z (GMT). No. of bitstreams: 1 ntu-99-R96844016-1.pdf: 1110115 bytes, checksum: 3910b294ba901921dcb5896a873426c4 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 摘要 I
Abstract III 目錄 V 圖目錄 IX 表目錄 XI 附錄 XIII 第一章、緒論 1 1.1 研究背景 1 1.2 研究目的 2 第二章、文獻探討 3 2.1 空氣污染造成的傷害 3 2.1.1 空氣污染的影響 3 2.1.2 氣狀污染物的影響 4 2.1.3 粒狀污染物的影響 5 2.2 空氣污染與氣喘的關係 6 2.3 氧化性壓力 7 2.4 呼出氣體中Pentane的應用 8 2.5呼出氣體之研究 10 2.5.1 呼出氣體之特性 10 2.5.2呼氣分析研究種類 11 2.6 肺功能測試 11 2.6.1 氣喘與肺功能的關係 12 2.6.2 肺功能的影響因子 12 2.7 微粒的延遲效應（Lag Effect） 13 第三章、材料與方法 15 3.1 實驗設計 15 3.2 實驗對象 15 3.3 採樣方法 16 3.4 實驗器材與設備 17 3.4.1 設備及材料 17 3.4.2 試劑 19 3.5 儀器操作條件 20 3.5.1 熱脫附裝置 20 3.5.2低溫濃縮捕集裝置 21 3.5.3氣相層析儀 21 3.5.4 質譜儀 21 3.5.5全自動肺功能檢測儀 22 3.6 呼出氣體樣本前處理 22 3.6.1 採樣管之填充 22 3.6.2 採樣管脫附（Conditioning） 22 3.6.3 樣本保存 23 3.6.4採樣管流量校正 24 3.6.5 採樣袋淨化 24 3.7 呼出氣體分析步驟 24 3.7.1 熱脫附裝置調整 24 3.7.2氣相層析儀 25 3.7.3 呼出氣體樣本分析 25 3.8 肺功能指標 26 3.9 QA/QC 26 3.9.1 儀器的空白分析 26 3.9.2 重複樣品分析 27 3.9.3 破出試驗 28 3.10 呼出氣體的定性、定量分析 28 3.10.1定性分析 28 3.10.2定量分析 28 3.11 空氣微粒的延遲效應 29 3.12 統計分析 30 第四章、結果 31 4.1 人口學基本資料 31 4.2 空氣污染背景調查 31 4.3 呼出氣體定性分析 32 4.4氣喘與非氣喘學童呼出氣體中VOCs比較 32 4.5學童肺功能之比較 33 4.5.1 氣喘與非氣喘族群間 33 4.5.2 男性與女性族群間 34 4.6 影響呼出氣體與肺功能的因子探討 34 4.6.1 人口學的資料探討 34 4.6.2 空氣污染資料的相關性 37 4.6.3 PM2.5的延遲效應 38 4.6.4 PM10的延遲效應 38 4.7 氧化性壓力與空氣污染的相關性 39 第五章、討論 41 5.1呼出氣體中VOCs的比較 41 5.2肺功能的比較 41 5.3 影響呼出氣體的變項 42 5.4 影響肺功能的變項 43 5.5 延遲效應 45 5.6 外生性氣體和氧化性壓力的相關性 46 5.7 研究限制 47 5.8 結論 48 參考文獻 49 | |
| dc.language.iso | zh-TW | |
| dc.title | 空氣污染與學童呼出氣體及肺功能之相關性探討 | zh_TW |
| dc.title | Effects of Air Pollution on School Children in Exhaled Breath and Lung Function | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭育良(Yue-Liang Guo),毛義方(I-Fang Mao) | |
| dc.subject.keyword | 呼出氣體,氧化性壓力,肺功能,延遲效應,戊烷, | zh_TW |
| dc.subject.keyword | Exhaled breath,Oxidative stress,Lung function,Lag effect,Pentane, | en |
| dc.relation.page | 94 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-05-23 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境衛生研究所 | zh_TW |
| 顯示於系所單位： | 環境衛生研究所 | |
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