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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林江珍 | |
| dc.contributor.author | Hui-Fen Lin | en |
| dc.contributor.author | 林蕙芬 | zh_TW |
| dc.date.accessioned | 2021-06-15T03:53:50Z | - |
| dc.date.available | 2015-07-12 | |
| dc.date.copyright | 2010-07-12 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-06-30 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44736 | - |
| dc.description.abstract | 在過去十年期間,抗菌材料發展受到很大的重視，其中以四級胺鹽被廣泛使用。本篇論文是利用本實驗室發明之高分子聚醚多胺 (polyamine)衍生物進行抗菌機制深討。首先分別利用poly(oxypropylene)-diamine 和triamine (POP-amine)與2,2-Bis[4-(glycidyloxy)phenyl]propane (DGEBA)進行偶合反應，製備出D400-terminating epoxy oligomers (DEO) and T403-terminating epoxy oligomers (TEO) 二種高分子聚醚多胺，高分子聚醚多胺擁有6個可酸化的胺基，利用鹽酸酸化不同比例1/6、3/6、6/6 (H+/amine equiv) 後，得到具有不同親疏水性的四級胺鹽。此論文中，我們利用表面張力儀得知親疏水性及界面活性劑的特性，並利用粒徑分析儀及穿透式電子顯微鏡觀察微胞的大小，發現酸化比例愈高時，微胞愈小。另外，對不同酸化比例的四級胺鹽進行抗菌測試，結果得知，當酸化比例愈高時，抗菌效果愈差。此外，利用掃描式電子顯微鏡去觀察四級胺鹽對大腸桿菌 (E. coli ) 及金黃色葡萄球菌 (S. aureus) 形態上的變化。綜合以上結果，可以推測抗菌機制與微胞大小有關，微胞大小則影響到接觸到細菌表面的局部濃度有關。此外，將我們合成的四級胺鹽與一般常用的抗菌劑比較，將具有調控親疏水性的功能及較好的抗菌效果。 | zh_TW |
| dc.description.abstract | Oligomeric amines were synthesized from the coupling reaction of poly(oxypropylene)-diamine and triamine (POP-amine) with 2,2-Bis[4-(glycidyloxy)phenyl]propane (DGEBA). Various equivalent amounts of acidification with hydrogen chloride at the acidified ratio of H+/amine equiv ratios rendered the oligomers with specific amphiphilic aggregations in water and antibacterial activity. The polyamine salts behave as a surfactant and exhibit the capability of surface tension until 47 mN/m at 0.01 wt %. Laser particle size analyzer and transmission electronic microscopy (TEM) results that polyamine salts at different acid ratios have the different micelle sizes, and further provide a large concentration on bacteria. The oligomers exhibited antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) at the minimum bactericidal concentration (MBC) of 1 μg/mL. Scanning electron microscope (SEM) revealed that polyamine salts confirmed morphological changes and the treated bacteria were damaged. Comparisons between poly(oxypropylene)- and poly(oxyethylene)-backbones for the oligomers had correlated the antibacterial properties that closely related to the different sizes of the micelle formation and the polyvalent ionic sites when interacting with bacteria. A comparison of the commercial product quaternary ammonium salts (QAS) ABLUMINE 1214, the polyamine salts displayed potent antibacterial activity. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T03:53:50Z (GMT). No. of bitstreams: 1 ntu-99-R97549002-1.pdf: 4108020 bytes, checksum: 7c736ab63a055fa1de21a05eb25eb571 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | Acknowledgements …………………………………………………………... Ι
中文摘要 Ⅱ Abstract Ⅲ Figure captions …………………………………………………………... Ⅶ Table captions …………………………………………………………... Ⅷ Chapter 1 Introduction…………………………... 1 Chapter 2 Literature Background………...…….………………….. 5 2-1 Application of antibacterial polymer...……….... 5 2-2 Mechanism of quaternary ammonium salts …... 6 2-3 Factors affecting the antibacterial activity……… 7 2-4 The difference in structure of cell walls between gram-positive and gram-negative bacteria……… 9 Chapter 3 Experimental………………………………………......... 11 3-1 Materials..……………………………………….. 11 3-2 Preparation of polyamines………………………. 12 3-3 Antibacterial activity tests…………….……........ 14 3-4 SEM of bacteria incubated with polyamine salts.. 15 3-5 Statistical analysis…………….…………............ 16 3-6 Characterization and Instruments……………….. 16 Chapter 4 Results and discussion…………………………………... 18 4-1 Dispersive and surfactant property of polyamine salts..………………………………...………....... 18 4-2 Emulsify micelle size of polyamines acidifies at different ratios……………................................... 21 4-3.1 Antibacterial activity of Polyamine Salts………. 24 4-3.2 Antibacterial activity of Jaffamine series and ABLUMINE 1214………………….................... 28 4-4 Scanning electron microscopy of bacteria incubated with polyamine salts………………… 31 4-5 Proposed antibacterial mechanism for polyamine salts…................................................................... 33 Chapter 6 Conclusion…………………………………………......... 36 Chapter 7 References...…………………………………………….. 37 | |
| dc.language.iso | en | |
| dc.subject | 局部濃度 | zh_TW |
| dc.subject | 四級胺鹽 | zh_TW |
| dc.subject | 界面活性劑 | zh_TW |
| dc.subject | 抗菌 | zh_TW |
| dc.subject | 微胞 | zh_TW |
| dc.subject | local concentration | en |
| dc.subject | surfactant | en |
| dc.subject | micelle | en |
| dc.subject | antibacterial | en |
| dc.subject | quaternary ammonium salts | en |
| dc.title | 高分子聚醚多胺衍生物之界面性質與抗菌機制探討 | zh_TW |
| dc.title | Amphiphilic Aggregation and Antibacterial Behaviors of Poly(oxyalkylene)-Polyamine-Salts | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 邱文英,謝國煌 | |
| dc.subject.keyword | 四級胺鹽,抗菌,微胞,界面活性劑,局部濃度, | zh_TW |
| dc.subject.keyword | quaternary ammonium salts,antibacterial,micelle,surfactant,local concentration, | en |
| dc.relation.page | 44 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-07-01 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 高分子科學與工程學研究所 | |
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