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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張煥宗(Huan-Tsung Chang) | |
dc.contributor.author | Yu-Ting Su | en |
dc.contributor.author | 蘇瑜婷 | zh_TW |
dc.date.accessioned | 2021-06-15T03:53:08Z | - |
dc.date.available | 2011-07-06 | |
dc.date.copyright | 2010-07-06 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-07-05 | |
dc.identifier.citation | 第一章
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44699 | - |
dc.description.abstract | 本論文利用以DNA為模板所合成之銅銀奈米團簇 (DNA-Cu/Ag nanoclusters, DNA-Cu/Ag NCs) 配合巰基丙酸 (3-mercaptopropionic acid, MPA) 發展出一種簡單、免標定(label-free) 之銅離子螢光探針。其偵測機制是由於MPA與DNA-Cu/Ag NCs上之金屬離子作用導致團簇的構形瓦解,使螢光消光;此時在有額外銅離子存在下,MPA先和銅離子生成錯合物並進一步被氧化成雙硫形式 (disulfide),隨著銅離子濃度增加,使未作用的MPA濃度下降,導致DNA-Cu/Ag NCs螢光被消光的程度會下降,因此螢光強度會隨著銅離子濃度增加而增強。在最佳化的反應條件,其偵測極限 (limit of detection,LOD) 為3.5 nM,線性範圍5-200 nM (R2 = 0.988)。此方法對於銅離子具有極高的選擇性,為其他金屬離子的2300倍。將此方法應用於偵測土壤樣品中銅離子濃度,所測得濃度為2.60 (± 0.23) μM,與利用感應耦合電漿質譜分析儀 (Inductively coupled plasma mass spectrometry; ICP-MS) 分析結果一致,顯示此方法適合用於環境樣品的分析。 | zh_TW |
dc.description.abstract | This thesis focuses on devoloping a simple and homogeneous fluorescence assay—comprising 3-mercaptopropionic acid (MPA) with DNA-Cu/Ag nanoclusters (NCs) in aqueous solution—for the detection of Cu2+ ions. The sensing mechanism is based on the suppression of MPA induced fluorescence quenching of the DNA-Cu/Ag NCs by Cu2+. MPA-induced fluorescence quenching is due to changes in the DNA conformation as a result of the interactions between MPA and Cu/Ag clusters. The MPA-induced fluorescence quenching followed a typical characteristic of a Stern-Volmer plot and followed a static quenching mechanism. The presence of Cu2+ resulted in the oxidation of MPA to form disulfide, leading to suppression of the MPA-induced fluorescence quenching. The fluorescence of the DNA-Cu/Ag NCs in the presence of MPA increased upon increasing the concentration of Cu2+ over the range 5-200 nM. The DNA-Cu/Ag NC probe provided the limit of detection at a signal-to-noise of 3 of 2.7 nM for Cu2+ ions, with high selectivity (at least 2300-folds over tested metal ions). The practicality of this approach has been validated by the analyses of Montana soil and water samples (3 replicate measurements), showing the potential of the probe for detection of Cu2+ ions in environmental samples. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T03:53:08Z (GMT). No. of bitstreams: 1 ntu-99-R97223208-1.pdf: 863516 bytes, checksum: 05aefb01690ca356fda6e10b40833f5e (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 謝誌...................................................................................................................................I
中文摘要.........................................................................................................................III 英文摘要.........................................................................................................................IV 目錄..................................................................................................................................V 表目錄............................................................................................................................VII 圖目錄..........................................................................................................................VIII 第一章 序論.....................................................................................................................1 1.1 金屬奈米粒子....................................................................................................1 1.2 金屬奈米團簇與其電子結構............................................................................2 1.3 金屬原子簇的能階理論-The Jellium Model....................................................3 1.4 發光銀奈米團簇的製備方法............................................................................4 1.4.1 以聚合物穩定之銀奈米團簇.....................................................................5 1.4.2 以DNA分子穩定之銀奈米團簇..............................................................6 1.5 應用....................................................................................................................9 1.6 研究動機..........................................................................................................10 1.7 本章圖表..........................................................................................................11 1.8 參考文獻..........................................................................................................15 第二章 利用銅銀奈米團簇選擇性偵測銅離子...........................................................18 2.1 前言..................................................................................................................18 2.2 實驗材料與方法..............................................................................................19 2.2.1 實驗試藥...................................................................................................19 2.2.2 銅銀奈米團簇之製備...............................................................................20 2.2.3 硫醇分子對銅銀奈米團簇之消光作用...................................................21 2.2.4 螢光方法分析Cu2+...................................................................................21 2.2.5 分析土壤與湖水樣品中之Cu2+...............................................................21 2.3 實驗結果與討論..............................................................................................22 2.3.1 硫醇分子對銅銀奈米團簇之消光作用...................................................22 2.3.2 抑制硫醇分子對銅銀奈米團簇之消光作用...........................................24 2.3.3 圓二色光譜與X射線光電子光譜之測量...............................................25 2.3.4 Cu2+ 感測器的選擇性及靈敏度...............................................................26 2.3.5 利用Cu2+ 感測器偵測土壤以及湖水樣品..............................................27 2.4 結論..................................................................................................................28 2.5 本章圖表..........................................................................................................29 2.6 參考文獻..........................................................................................................43 表目錄 表1-1 奈米材料顆粒尺寸與表面原子數分率的關係..................................................11 表1-2 常見鹼金屬、鹼土金屬以及一些過渡金屬和DNA間的主要作用方式..........12 圖目錄 圖1-1 塊材金屬與金屬團簇的電子能階簡圖…........................................................13 圖1-2 鹼基結構式........................................................................................................14 圖2-1 DNA-Cu/Ag NCs搭配MPA分子偵測Cu2+示意圖.........................................29 圖2-2 DNA-Cu/Ag NCs之螢光光譜..........................................................................30 圖2-3 不同硫醇分子濃度下DNA-Cu/Ag NCs之Stern-Volmer plots…...................31 圖2-4 DNA-Cu/Ag NCs與硫醇分子反應後放光生命期偵測..................................32 圖2-5 DNA-Cu/Ag NCs於硫醇分子存在下,與不同濃度Cu2+反應後螢光增強幅度關係圖...........................................................................................................33 圖2-6 pH值對於DNA-Cu/Ag NCs螢光上升幅度的關係圖....................................34 圖2-7 DNA以及DNA-Cu/Ag NCs在不同條件下之圓二色光譜............................35 圖2-8 DNA-Cu/Ag NCs與不同濃度MPA反應後之圓二色光譜.............................36 圖2-9 DNA-Cu/Ag NCs與不同濃度Cu2+反應後之圓二色光譜..............................37 圖2-10 DNA-Cu/Ag NCs之Ag 3d軌域的電子束縛能圖譜.....................................38 圖2-11 DNA-Cu/Ag NCs偵測系統對Cu2+的選擇性................................................39 圖2-12 DNA-Cu/Ag NCs偵測系統對常見重金屬之容忍性....................................40 圖2-13 DNA-Cu/Ag NCs偵測Cu2+之螢光光譜........................................................41 圖2-14 DNA-Cu/Ag NCs偵測土壤樣品中Cu2+之螢光光譜....................................42 | |
dc.language.iso | zh-TW | |
dc.title | 利用銅銀奈米團簇偵測銅離子 | zh_TW |
dc.title | Detection of Copper Ions Using Copper/Silver Nanoclusters | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 劉春櫻,吳秀梅 | |
dc.subject.keyword | 銅銀奈米團簇,巰基丙酸,銅離子感測, | zh_TW |
dc.subject.keyword | copper/silver nanoclusters,3-mercaptopropionic acid,copper ions sensor, | en |
dc.relation.page | 45 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-07-05 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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