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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林俊彬(Chun-Pin Lin) | |
dc.contributor.author | Yen-Jung Chen | en |
dc.contributor.author | 陳妍蓉 | zh_TW |
dc.date.accessioned | 2021-06-15T03:51:03Z | - |
dc.date.available | 2016-08-26 | |
dc.date.copyright | 2011-08-26 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-23 | |
dc.identifier.citation | Abdulkader A, Duguid R, Saunders EM (1996) The antibacterial activity of endodontic sealers to anaerobic bacteria. International Endodontic Journal 29: 280–83.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44553 | - |
dc.description.abstract | 在根管治療完成徹底清創之後,根管封填劑配合馬來膠錐體的使用,使根管系統達到滴水不漏的密封。理想的根管封填劑須要有良好的生物相容性並且希望能有抗菌效果。我研究團隊所研發出的胺酯壓克力樹酯封填劑,有良好操作性質並且與聚胺脂錐體材料及牙本質之間的黏著有優於傳統根管封填劑的表現。為了更進一步了解聚胺酯根管封填劑臨床使用的安全性。本研究目的為探討新型胺酯壓克力樹酯封填劑細胞毒性表現及抗菌性質。結果顯示,在細胞毒性測試PC合成的胺酯壓克力樹酯封填劑和市售材料Apexit相較於PBA合成的胺酯壓克力樹酯封填劑及市售材料 EndoREZ、AHplus 及 Tubliseal 有較低的細胞毒性。而在抗菌性質測試中,市售材料AHplus有較高的抗菌效果,胺酯壓克力樹脂封填劑相較於市售材料的抗菌效果低。因此,細胞毒性與抗菌性質是有相關性的,材料抗菌的同時對細胞也會造成影響。而PC合成胺酯壓克力樹酯封填劑具有高轉換率及良好的生物相容性,故極具潛力可以應用於未來的臨床根管治療。 | zh_TW |
dc.description.abstract | For sealing off of the root canal system after completely cleaning and shaping, the standard root canal filling is a combination of sealers with gutta-percha cone. The ideal root canal sealer needs good biocompatibility and antibacterial effect. Our research team has developed dual-cured urethane-acrylate (UA) sealer. Theses materials have good handling characteristics and bonding strength. For further research about the safety of urethane-acrylate sealer. The purposes of this study were to investigate the cytotoxicity and antibacterial effect of UA sealer.
The results showed the PC-based UA sealer and Apexit have lower cytotoxicity than PBA-based UA sealer and commercial products such as Endorez, AHplus and Tubliseal. In antibacterial effect test, AHplus has higher antibacterial effect and UA sealers have lower antibacterial effect than other commercial products. We conclude that the cytotoxicity and antibacterial effect have correlations, and the higher bactericide effect may also kill the normal cell. PC-based UA sealer with higher conversion rate and good biocompatibility has high potential for clinical use. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T03:51:03Z (GMT). No. of bitstreams: 1 ntu-100-R97422019-1.pdf: 1984182 bytes, checksum: 567ba2125bf5d426eadd3ab4e12c5097 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 謝誌 i
中文摘要 ii Abstract iii 簡寫表 iv 目 錄 v 圖 次 viii 表 次 x 第一章 前言 1 第二章 文獻回顧 4 2.1 理想的根管封填 5 2.2 根管封填錐體材料 (Cone Materials) 5 2.3 根管封填劑材料 (Sealer Materials) 6 2.3.1 傳統根管封填劑材料的發展 7 2.4 高分子根管封填劑 8 2.4.1 ResilonTM/EpiphanyTM 根管封填系統 9 2.4.2 EndoREZTM 根管封填系統 12 2.5 聚胺酯材料作為高分子根管封填系統的潛力 13 2.5.1 熱塑型聚胺酯 (TPU) 13 2.5.2 本研究團隊初步試驗結果 14 2.6 樹酯類根管封填劑細胞毒性之測試 15 2.6.1 MTT assay 15 2.6.2 LDH assay 15 2.7 樹酯類根管封填劑之抗菌性質 15 2.7.1 瓊脂凝膠擴散法 16 2.7.2 直接接觸法 17 第三章 動機與目的 19 第四章 材料與方法 21 4.1 體外細胞毒性測試 (Cytotoxicity test in vitro study) 21 4.1.1 3T3 細胞培養 (3T3 cell culture) 21 4.1.2 封填劑材料之樣本與萃取液備製 21 4.1.3 MTT assay 22 4.1.4 LDH assay 23 4.1.5 統計分析 24 4.2 抗菌測試 24 4.2.1 測試菌種和生長條件 24 4.2.2 瓊脂凝膠擴散法 25 4.2.3 直接接觸法 25 4.2.4 統計分析 26 第五章 結果 27 5.1 根管封填劑細胞毒性測試結果 27 5.1.1 MTT assay 27 5.1.2 LDH assay 27 5.2 根管封填劑抗菌性質結果 29 5.2.2 瓊脂凝膠擴散法測試結果 29 5.2.3 直接接觸法測試結果 29 第六章 討論 30 6.1 根管封填劑體外細胞毒性測試之探討 31 6.1.1 市售封填劑細胞毒性之討論 31 6.1.2 胺酯壓克力樹酯封填劑細胞毒性之討論: 32 6.2 根管封填劑抗菌性質之探討 33 6.2.1 市售封填劑抗菌性質之討論 33 第七章 結論 35 第八章 未來研究目標 36 參考文獻 37 | |
dc.language.iso | zh-TW | |
dc.title | 新型胺酯壓克力樹酯封填劑:細胞毒性及抗菌性質 | zh_TW |
dc.title | Novel Urethane-acrylate Root Canal Sealer:Cytotoxicity and Antibacterial Effect | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林峰輝(Feng-Huei Lin),鄧麗珍(Lee-Jene Teng) | |
dc.subject.keyword | 根管封填劑,胺酯壓克力樹酯,細胞毒性,抗菌性質, | zh_TW |
dc.subject.keyword | root canal sealer,thermoplatic polyurethane,cytotoxicity,antibacterial effect, | en |
dc.relation.page | 72 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-23 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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