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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳秀男(Shiu-Nan Chen) | |
| dc.contributor.author | Wei-Cheng Lin | en |
| dc.contributor.author | 林微錚 | zh_TW |
| dc.date.accessioned | 2021-06-15T02:48:27Z | - |
| dc.date.available | 2016-08-22 | |
| dc.date.copyright | 2011-08-22 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-17 | |
| dc.identifier.citation | Anderson, G. P., Coyle, A. J., (1994). TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol Sci. 15, 324-32.
Amsen, D., Blander, J. M., Lee, G. R., Tanigaki, K., Honjo, T., Flavell, R. A., (2004). Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell. 117, 515-26. Abul K. Abbas, A. H. L., Shiv Pillai., (2007). Cellular and Molecular Immunology, 6th Edition Barnes, P. J., (1996). Pathophysiology of asthma. Br J Clin Pharmacol. 42, 3-10. Borchers, A. T., Stern, J. S., Hackman, R. M., Keen, C. L., and Gershwin, M. E., (1999). Mushrooms, tumors, and immunity. Proceedings of the Society for Experimental Biology and Medicine 221, 281-293. Barbisan LF, Miyamoto M, Scolastici C, Salvadori DMF, Ribeiro LR, Eira AF (2002). Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. J Ethnopharmacol 83, 25-32. Barbisan, L. F., Scolastici, C., Miyamoto, M., Salvadori, D. M., Ribeiro, L. R., da Eira, A. F., de Camargo, J. L., (2003). Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine. Genet Mol Res. 2, 295-308. Bauchau, V., Durham, S. R., (2004). Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J. 24, 758-64. Bouike, G., Nishitani, Y., Shiomi, H., Yoshida, M., Azuma, T., Hashimoto, T., Kanazawa, K., Mizuno, M., (2011). Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice. Evid Based Complement Alternat Med. Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., Stewart, T. A., (1993). Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 259, 1739-42. Derewenda, U., Li, J., Derewenda, Z., Dauter, Z., Mueller, G. A., Rule, G. S., Benjamin, D. C., (2002). The crystal structure of a major dust mite allergen Der p 2, and its biological implications. J Mol Biol. 318, 189-97. Elenkov, I. J., Chrousos, G. P., (1999). Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to Disease. Trends Endocrinol Metab. 10, 359-368. Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O'Shea, J. J., Koyasu, S., (2001). IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22, 556-60. Gould, H. J., Sutton, B. J., Beavil, A. J., Beavil, R. L., McCloskey, N., Coker, H. A., Fear, D., Smurthwaite, L., (2003). The biology of IGE and the basis of allergic disease. Annu Rev Immunol. 21, 579-628. Hansen, G., G. Berry, et al., (1999). Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest. 103 (2) , 175-183. Huntington, J. A., Stein, P. E., (2001). Structure and properties of ovalbumin. J Chromatogr B Biomed Sci Appl. 756, 189-98. Harada, T., Miura, N. N., Adachi, Y., Nakajima, M., Yadomae, T., Ohno, N., (2002). IFN-gamma induction by SCG, 1,3-beta-D-glucan from Sparassis crispa, in DBA/2 mice in vitro. J Interferon Cytokine Res. 22, 1227-39. Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR (2004). Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor rmonoclonal antibodies in murine tumor models. J Immunol. 173,797-806. Hetland, L. K. E. A. G., (2009). An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Clinical and Molecular Allergy. Ikekawa, T., Nakanishi, M., Uehara, N., Chihara, G., Fukuoka, F., (1968). Antitumor action of some Basidiomycetes, especially Phllinus linteus. Gann. 59, 155-7. Jesen, C. B., (1998). Food allergy. Br. Med. 1299-1302. Jung K, Ha Y, Ha S, Han DU, Kim D, Moon WK., (2004) Antiviral effect of Saccharomyces cerevisiae β-glucan to Swine Influenza virus by increased production of interferon-gand nitric oxide. J Vet Med B Infec Dis Vet Public Health 51,72-6. Klossek JM, G. C., Vervloet D, Deslandes B, Dufour X, Neukirch F., (2005). Epidemiology of Seasonal Spring-time Allergic Rhinitis in Adults in France. Lee, M. S., 2002. Cytokine synergism in apoptosis: its role in diabetes and cancer. J Biochem Mol Biol. 35, 54-60. Lindequist, U., Niedermeyer, T. H., Julich, W. D., (2005). The pharmacological potential of mushrooms. Evid Based Complement Alternat Med. 2, 285-99. Leung, M. Y. K., Liu, C., Koon, J. C. M., Fung, K. P., (2006). Polysaccharide biological response modifiers. Immunology Letters 105, 101-114. Lee, J., Lim, K. T., (2011). Inhibitory effect of phytoglycoprotein (24 kDa) on hepatocarcinogenesis in N-nitrosodiethylamine-treated ICR mice. J Pharm Pharmacol. 63, 840-8. Mizuno, T., Kinoshita, T., Zhuang, C., Ito, H., Mayuzumi, Y., (1995). Antitumor-active heteroglycans from niohshimeji mushroom, Tricholoma giganteum. Biosci Biotechnol Biochem. 59, 568-71. Mizuno, T., Yeohlui, P., Kinoshita, T., Zhuang, C., Ito, H., Mayuzumi, Y., (1996). Antitumor activity and chemical modification of polysaccharides from niohshimeji mushroom, Tricholma giganteum. Biosci Biotechnol Biochem. 60, 30-3. Mizuno, M., Morimoto, M., Minato, K., Tsuchida, H., (1998). Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem. 62, 434-7. Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM., (2000) M-1/M-2 macrophages and the Th1/Th2 paradigm. J. Immunol. 164,6166–6173, Mantyjarvi, R., Rautiainen, J., Virtanen, T., (2000). Lipocalins as allergens. Biochim Biophys Acta. 1482, 308-17. Miura, T., Miura, N. N., Ohno, N., Adachi, Y., Shimada, S., Yadomae, T., (2000). Failure in antitumor activity by overdose of an immunomodulating beta-glucan preparation, sonifilan. Biol Pharm Bull. 23, 249-53. Murata, Y., Shimamura, T., Tagami, T., Takatsuki, F., Hamuro, J., (2002). The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content. International Immunopharmacology. 2, 673-689. Moradali, M. F., Mostafavi, H., Ghods, S., Hedjaroude, G. A., (2007). Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). International Immunopharmacology 7, 701-724. Murphy, K. T., Paul., Walport, Mark (2008). Janeway’s Immunobiology. Mizuno, M., (2008). Immunomodulatory activities of beta-glucan in mushroom. Functional Food and Health. American Chemical Society,Washington, DC, P.399–P.407. Mizuno, M., (2010). In Vitro and In Vivo Immunomodulatory and Anti-allergic Effects of Agaricus blazei Murill. DIETARY COMPONENTS AND IMMUNE FUNCTION. Mursito, B., Jenie, U. A., Mubarika, S., Kardono, L. B., (2010). Isolation of beta- (1-3) glucan compound from the water extract of indonesian jamur tanduk (Termitomyces eurirrhizus Berk). Pak J Biol Sci. 13, 847-51. Nishikawa, H., Kitani, S., (2008). Tea catechins have dual effect on mast cell degranulation induced by compound 48/80. Int Immunopharmacol. 8, 1207-15. Ortolani, C., Vighi, G., (1995). Definition of adverse reactions to food. Allergy. 50, 8-13. Ooi VEC, Liu F., (1999) A review of pharmacyological activities of mushroom polysaccharides. Int J Med Mushroom 1, 195-206 Ohno, N., Furukawa, M., Miura, N. N., Adachi, Y., Motoi, M., Yadomae, T., (2001). Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull. 24, 820-8. Ormstad, H., Groeng, E. C., Duffort, O., Lovik, M., (2003). The effect of endotoxin on the production of IgE, IgG1 and IgG2a antibodies against the cat allergen Fel d 1 in mice. Toxicology. 188, 309-18. Romagnani, S., (1992). Human Th1 and Th2 Subsets - Regulation of Differentiation and Role in Protection and Immunopathology. International Archives of Allergy and Immunology. 98, 279-285. Roitt, I. M. B., Jonathan., Male, David K., (1997). Immunology, 5th. Steinmann, M. (1992). A parent's guide to allergies and asthma. Scharenberg, A. M., Kinet, J. P., (1994). Initial events in Fc epsilon RI signal transduction. J Allergy Clin Immunol. 94, 1142-6. Stephen Holgate, M. K. C., Lawrence M. Lichtenstein., (2001). Allergy 2nd. Suzuki, Y., Adachi, Y., Ohno, N., Yadomae, T., (2001). Th1/Th2-Balancing immunomodulating activity of gel-forming (1-->3)-beta-glucans from fungi. Biol Pharm Bull. 24, 811-9. Sampson, H.A. (2004). Update on food allergy. J Allergy Clin Immunol 113, 805-819; quiz 820. Smit, J. J., Folkerts, G., Nijkamp, F. P., (2004). Ramp-ing up allergies: Nramp1 (Slc11a1), macrophages and the hygiene hypothesis. Trends Immunol. 25, 342-7. Skapenko, A., Schulze-Koops, H., (2007). Analysis of Th1/Th2 T-cell subsets. Methods Mol Med. 136, 87-96. Shiv, A. K. A. A. H. L., (2009). Cellular and Molecular Immunology 6th Edition Sabin, B. R., C. A. Saltoun., (2011). Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol 127 (2): 342-350. Sullivan, R., Smith, J. E., Rowan, N. J., (2006). Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine. Perspect Biol Med. 49, 159-70. T.B Zhao., A. W., YZ Chen., ML Xiao., LK Duo., G Liu, YL Lau., J Karlberg, (2000). Prevalence of Children Asthma, Allergic Rhinitis and Eczema in Urumqi and Beijing. Takimoto, H., Wakita, D., Kawaguchi, K., Kumazawa, Y., (2004). Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull. 27, 404-6. Thomas J. Kindt, B. A. O., Richard A. Goldsby., (2004). Kuby Immunology 5th edition. Vetvicka, V., Yvin, J. C., (2004). Effects of marine beta-1,3 glucan on immune reactions. Int Immunopharmacol. 4, 721-30. Vetvicka V, Dvorak B, Vetvickova J, Richter J, Krizan J, Sima P, Yvin JC., (2006) Orally administered marine (1 -> 3)-β-D-glucan Phycarine stimulates both humoral and cellular immunity. Int J Biol Macromol 40, 291-298 Volman, J. J., Ramakers, J. D., Plat, J., (2008). Dietary modulation of immune function by beta-glucans. Physiology & Behavior 94, 276-284. Wuthrich, B. (1989). Epidemiology of the allergic diseases: are they really on the increase? Int Arch Allergy Appl Immunol. 90 Suppl 1: 3-10. Weiss, K. B., Gergen, P. J., Wagener, D. K., (1993). Breathing better or wheezing worse? The changing epidemiology of asthma morbidity and mortality. Annu Rev Public Health. 14, 491-513. Woolcock, A. J., Peat, J. K., (1997). Evidence for the increase in asthma worldwide. Ciba Found Symp. 206, 122-34. Wasser, S. P., (2002). Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 60, 258-74. Yamada, J., Hamuro, J., Hatanaka, H., Hamabata, K., Kinoshita, S., (2007). Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study. J Allergy Clin Immunol. 119, 1119-26. 水野卓、川合正允。1992。菇類的化學生化學，國立編譯館。台北，台灣。 行政院衛生署。2007。民國96年台灣地區主要死亡原因。http://www.doh.gov.tw/。 吳政翰。2004。β-葡聚多醣體對小白鼠吞噬細胞之吞噬作用和細胞素的影響。國立台灣大學動物學研究所碩士論文。 吳明立。2010。掃流式膜過濾分離原理。南台科技大學生物科技系。 吳家興，林瑞雄，謝貴雄，邱文達，陳麗美，邱淑緹，黃國晉，劉文良，邱宏毅，蕭慧娟，方淑慧，陳雄文，林嘉明，宋鴻章。1998。台灣北部國中學生氣 喘盛行率調查。中華公共衛生雜誌，17,214。 李夙雯。2007。Astragalus降低OVA誘發小鼠呼吸道發炎及支氣管過度反應。慈濟大學醫學生物技術研究所碩士論文。 林資博。2007。硫磺菌產物生物活性與輔助抗癌藥物抑制乳癌細胞之研究。南台 科技大學生物科技系碩士論文。 柯慧姍。2008。桂花萃取物對OVA致敏小鼠腦部氧化傷害的保護作用。中華醫事科技大學生物科技研究所碩士論文。 洪永瀚，林碧鳳。2004。以巨噬細胞株分泌發炎介質篩選抗發炎作用的模式評估。台灣營養學學會雜誌，129 (3), 159-167。 胡鄴方。2009。口服裂褶多醣體對免疫調節反應之影響。國立台灣大學漁業科學研究所碩士論文。 徐明麗。1997。薏仁抗過敏及抗腫瘤之研究。國立台灣大學食品科技研究所碩士論文。 徐欣億。2003。糙薏仁對特異性免疫反應及呼吸道發炎反應影響之研究。國立臺 灣大學食品科技研究所博士論文。 徐聿。2006。靈芝、樟芝、裂褶菌多醣體對大白鼠自然殺手細胞與細胞素的影響。國立台灣大學漁業科學研究所碩士論文。 高尚德。2002。保健食品-茯苓對細胞免疫之調節作用-塵螨致敏氣喘老鼠模式。行政院衛生署九十一年度科技研究發展計劃。 高紹軒。2005。大蒜與百慕達草花粉過敏原之鑑定與其免疫性質研究。國立臺灣大學醫學院生物化學暨分子生物學研究所博士論文。 張劭墉。2005。菇蕈多醣體對四氯化碳誘導大白鼠肝損傷之修復效果評估。國立臺灣大學動物學研究所碩士論文。 張琬晴。2005。茯苓粗多醣萃取物對Balb/c鼠的免疫調節及對轉殖CT26腫瘤之 作用。國立臺灣大學食品科技研究所博士論文。 張芷菱。2007。利用靈芝蛋白及多醣體進行免疫調節以減緩氣喘之呼吸道發炎反應。國立台灣大學醫學院口腔生物科學研究所碩士論文。 曹巧吟。2003。樟芝中免疫調節蛋白的純化與其生理活性之探討。國立臺灣大學園藝學研究所碩士論文。 陳志隆。2004。家塵蟎藉活化先天性免疫促進過敏性致敏和發炎。國立成功大學基礎醫學研究所博士論文。 陳秀男。2005。菇蕈葡聚多醣體的全方位健康策略。台灣生物多醣體協會。 陳逸璉。2008。樟芝多醣體對免疫細胞及OVA所誘發的氣喘動物模式其免疫調控之探討。台北醫學大學醫學科學研究所碩士論文。 陳俊旭。2009。過敏，原來可以根治。 黃舫。2005。遠離過敏體質的自然療法。 黃繼萱。2006。以動物模式評估液態靈芝產品對免疫功能的調節。國立台灣大學微生物與生化研究所碩士論文。 楊瑞泰。2009。中草藥多醣對黏膜免疫調節作用的研究。國立陽明大學生物藥學研究所碩士論文。 蔡肇基。2003。告別氣喘與過敏-蔡肇基的免疫治療。 劉怡霞。1998。佐劑對由塵璊在小鼠引發肺臟發炎反應之影響。國立成功大學微生物暨免疫學研究所碩士論文。 鄭啟清。2003。飲食與過敏及免疫相關疾病。財團法人國家衛生研究院。 謝貴雄。1995。小兒氣喘病之預防和處理。中華民國小兒科醫學會雜誌。 羅文音。2006。以卵蛋白致敏小鼠模式探討攝食山藥對過敏性氣喘的影響。國立台灣大學微生物與生化研究所碩士論文。 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44275 | - |
| dc.description.abstract | The aim of the experience is to understand mushroom polysaccharides can be prevented of allergy. The design of experiment continuous feeding different concentration of glucan for two weeks (0mg/200μl, 1mg/200μl, 2mg/200μl), and B6 mice were sensitized by OVA from twice to five times. Using different levels of sensitization to know the effect of polysaccharide feeding mice so we detected IFN-γ, IgG2a, IgE and IL-4 concentration in serum of the sensitization mice. Taking advantage of cytokines and immune globulin to study polysaccharides of the efficacy.
The results show that B6 mice sensitized several times, the group feeding mushroom polysaccharides of this experimental are eligible for a higher concentration of IFN-γ, and the group sensitized twice and four times by OVA, the experimental group and control group a comparison of significant differences (P <0.05). The IgG2a serum concentrations have similar results to IFN-γ, regardless of the sensitizion frequency,the group feeding glucan may be got higher IgG2a levels. The coparison of the polysaccharide treatment group and control group had a significant difference (P <0.05). The IgE concentrations in serum of feeding polysaccharides of B6 mice are lower than the control group, and the comparison of glucan treatmet and control had a significant difference (P <0.05) of the group sensitized twice to five times. The group fed 1mg/200μl of glucan had higher IL-4 concentrations in serum than any other treatment group or nontreayment froup, and there is significant difference (P <0.05). The result of IL-4 concentration in treatment group were lower than control group whether sensitization twice to five times, but no significant differences. The results show that mushroom polysaccharides can effectively enhance the IFN-γ and IgG2a concentration in the blood and reduce IgE levels, amount regardless of the number of allegens. Mushroom polysaccharides improved response to Th1cells, helps fight allergies, but the effects of IL-4 from mushroom polysaccharide is not obvious in this experiment. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T02:48:27Z (GMT). No. of bitstreams: 1 ntu-100-R97b45005-1.pdf: 2125383 bytes, checksum: a1734c826de0812937ff8680b4dcd154 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 第一章 前言……..........................................................................................................1
第二章 文獻整理 第一節 免疫與過敏……................. ................ ................................................ 3 第二節 過敏機制……............................ ................ ................ ................ ........8 第三節 過敏症狀……………………………………………………………..10 第四節 菇蕈簡介………………………………………………….………….13 第五節 菇蕈與過敏……………………………………………….………….14 第六節 常見實驗用致敏物質……………….……………………………….20 第七節 實驗動機…………………………………………………….……….22 第三章 材料與方法 第一節 實驗大綱…………………………………………………….……….23 第二節 實驗材料…………………………………………………….……….25 第三節 實驗方法…………………………………………………….……….26 第四章 結果………………………………………………………………..….........38 第五章 討論……………………………..……………………………………….....43 第六章 結論………………………………………………………………………...50 參考文獻………………………………………………………………….………....51 圖表…….....................................................................................................................63 | |
| dc.language.iso | zh-TW | |
| dc.subject | 過敏 | zh_TW |
| dc.subject | th2 | zh_TW |
| dc.subject | th1 | zh_TW |
| dc.subject | 卵蛋白 | zh_TW |
| dc.subject | 多醣體 | zh_TW |
| dc.subject | glucan | en |
| dc.subject | ovalbumin | en |
| dc.subject | OVA | en |
| dc.subject | allergy | en |
| dc.title | 菇蕈多醣體對卵蛋白致敏小鼠之影響 | zh_TW |
| dc.title | The Effects of β-glucan on OVA-sensitizes Mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 沈士新,劉秉忠,冉繁華 | |
| dc.subject.keyword | 過敏,多醣體,卵蛋白,th1,th2, | zh_TW |
| dc.subject.keyword | allergy,glucan,OVA,ovalbumin, | en |
| dc.relation.page | 84 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-08-17 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
| 顯示於系所單位： | 漁業科學研究所 | |
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