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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 黃慧璧(Hui-Pi Huang) | |
dc.contributor.author | Shih-Wan Wang | en |
dc.contributor.author | 汪士琬 | zh_TW |
dc.date.accessioned | 2021-06-15T02:47:16Z | - |
dc.date.available | 2010-08-19 | |
dc.date.copyright | 2009-08-19 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-08-07 | |
dc.identifier.citation | Chapter 1
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A rapid test for B-type natriuretic peptide correlates with falling wedge pressures in patients treated for decompensated heart failure: a pilot study. J Card Fail 2001;7:21-29. 5. Anand IS, Fisher LD, Chiang YT, et al. Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT). Circulation 2003;107:1278-1283. 6. Wijeysundera HC, Hansen MS, Stanton E, et al. Neurohormones and oxidative stress in nonischemic cardiomyopathy: relationship to survival and the effect of treatment with amlodipine. Am Heart J 2003;146:291-297. 7. Iwanaga Y, Nishi I, Furuichi S, et al. B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure. J Am Coll Cardiol 2006;47:742-748. 8. Boswood A, Dukes-McEwan J, Loureiro J, James RA, Martin M, Stafford-Johnson M, Smith P, Little C, Attree S. The diagnostic accuracy of different natriuretic peptides in the investigation of canine cardiac disease. J Small Anim Pract. 2008;49:26-32. 9. Oyama MA, Fox PR, Rush JE, Rozanski EA, Lesser M. Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. J Am Vet Med Assoc. 2008 15;232:1496-503. 10. Tarnow I, Olsen LH, Kvart C, Hoglund K, Moesgaard SG, Kamstrup TS, Pedersen HD, Häggström J. Predictive value of natriuretic peptides in dogs with mitral valve disease.Vet J. 2009;180:195-201. 11. Hori Y, Tsubaki M, Katou A, Ono Y, Yonezawa T, Li X, Higuchi SI. Evaluation of NT-pro BNP and CT-ANP as markers of concentric hypertrophy in dogs with a model of compensated aortic stenosis.J Vet Intern Med. 2008;22:1118-23. 12. Takeda S, Yamashita A, Maeda K, et al. Structure of the core domain of human cardiac troponin in the Ca (2+)-saturated form. Nature 2003;424:35-41. 13. Dhoot GK, Gell PG, Perry SV. The localization of the different forms of troponin I in skeletal and cardiac muscle cells. Exp Cell Res 1978;117:357-370. 14. Dhoot GK, Perry SV. Distribution of polymorphic forms of troponin components and tropomyosin in skeletal muscle. Nature 1979;278:714-718. 15. MacDonald KA, Kittleson MD, Munro C, Kass P. Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure. J Vet Intern Med 2003;17:172-177. 16. Maack T. The broad homeostatic role of natriuretic peptides. Arq Bras Endocrinol Metabol 2006;50:198-207. 17. Oyama MA, Sisson DD, Solter PF. Prospective screening for occult cardiomyopathy in dogs by measurement of plasma atrial natriuretic peptide, B-type natriuretic peptide, and cardiac troponin-I concentrations. Am J Vet Res 2007;68:42-47. 18. Fine DM, Declue AE, Reinero CR. Evaluation of circulating amino terminal-pro-B-type natriuretic peptide concentration in dogs with respiratory distress attributable to congestive heart failure or primary pulmonary disease. J Am Vet Med Assoc 2008;232:1674-1679. 19. Mukoyama M, Nakao K, Hosoda K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest 1991;87:1402-1412. 20. Tan LB, Jalil JE, Pick R, Janicki JS, Weber KT. Cardiac myocyte necrosis induced by angiotensin II. Circ Res 1991;69:1185-1195. 21. Leung DY, Boyd A, Ng AA, Chi C, Thomas L. Echocardiographic evaluation of left atrial size and function: current understanding, pathophysiologic correlates, and prognostic implications. Am Heart J. 2008 ;156:1056-64 22. Buchanan JW, Bucheler J. Vertebral scale system to measure canine heart size in radiographs. J Am Vet Med Assoc.1995;206: 194–199. 23. Spratt DP, Mellanby RJ, Drury N, Archer J. Cardiac troponin I: evaluation I of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract. 2005 ;46:139-45. Chapter 3 1. Schober KE. Biochemical makers of cardiovascular disease. In: Ettinger SJ, Feldman EC. Textbook of veterinary internal medicine. 6th ed. Philadelphia: WB Saunders, 2005:940-947. 2. Ware WA. Management of heart failure. In: Nelson RW, Couto CG. Small animal internal medicine. 4th ed. St. Louis: Mosby Inc, 2009:53-62. 3. Takeda S, Yamashita A, Maeda K, Maeda Y. Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form. Nature 2003;424:35-41. 4. Dhoot GK, Gell PG, Perry SV. The localization of the different forms of troponin I in skeletal and cardiac muscle cells. Exp Cell Res 1978;117:357-370. 5. Dhoot GK, Perry SV. Distribution of polymorphic forms of troponin components and tropomyosin in skeletal muscle. Nature 1979;278:714-718. 6. Santalo Bel M, Guindo Soldevila J, Ordonez Llanos J. Biological markers of myocardial necrosis. Rev Esp Cardiol 2003;56:703-720. 7. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J 2007;28:2525-2538. 8. Packer M. Current role of beta-adrenergic blockers in the management of chronic heart failure. Am J Med. 2001;110:81S-94S 9. Dalla-Volta S. Safety and efficacy study of delapril versus enalapril in patients with congestive heart failure. Am J Cardiol. 1995;75:44F-49F. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44252 | - |
dc.description.abstract | 心臟生物指標(biomaker)主要可以分為兩大類,分別是結構性蛋白及功能性蛋白。其中最常被應用的結構性蛋白為心臟肌鈣蛋白I (cardiac troponin I),負責測定各種造成心肌受損的疾病,是一種高敏感性及專一性的心臟生物指標。功能性蛋白N-terminal-pro B-type natriuretic peptide (NT-proBNP)是一種荷爾蒙,當細胞外液體過多造成心臟負擔時,心室壁會分泌此蛋白排出過多水分,維持體內正常循環。此論文包含兩個部份,第一部分研究心臟肌鈣蛋白I及NT-proBNP在健康及心臟瓣膜疾病之心衰竭患犬的血清濃度,第二部分研究治療前後心臟瓣膜疾病之心衰竭患犬心臟肌鈣蛋白I的濃度差異。研究結果指出心衰竭患犬血清的心臟肌鈣蛋白I及NT-proBNP濃度都明顯比健康犬高(分別為P=0.02, P<0.001),而且發現當心衰竭愈嚴重,血清中的心臟肌鈣蛋白I及NT-proBNP濃度愈高(分別為P=0.02, P<0.0001)。血清中心臟肌鈣蛋白I濃度,在治療後雖然明顯下降,但在統計結果並沒有顯著差異性存在(P=0.09)。根據此次的研究結果顯示測量血清中心臟肌鈣蛋白I及NT-proBNP濃度可以做為篩選是否罹患心臟疾病,並預測心衰竭嚴重程度。 | zh_TW |
dc.description.abstract | Biomarkers have been extensively used in human and veterinary medicine, and divided into two groups: the leakage markers and functional makers. Cardiac troponin I (cTnI), a structure protein of cardiomyocyte, is a sensitive, specific, is a leakage marker for cardiac injury. N-terminal-pro B-type natriuretic peptide (NT-proBNP), a hormone exerts a variety of effects of maintaining circulatory homeostasis in states of increased extracellular volume, is a functional maker. The thesis includes two sections: first part, association NT-proBNP and cTnI of clinically healthy dogs and dogs with heart failure (HF); second part, changes of cTnI concentrations before and after treatment for HF. The result of this study illustrated that concentrations of NT-proBNP and cTnI in the dogs with HF were higher than those in the control dogs (P<0.001, P=0.02, respectively), and these two cardiac makers were positively associated with severity of HF (P<0.0001, P=0.02, respectively). Serum cTnI concentrations decreased after treatment, but not reach significant different (P=0.09). Based on these findings, both cardia markers were able to identify presence of cardiac disease, and determine severity of HF in dogs. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T02:47:16Z (GMT). No. of bitstreams: 1 ntu-98-R95629030-1.pdf: 455625 bytes, checksum: 3646f7174a85b173c8805eec883c8d39 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 口試委員會審定書 i
Acknowledgment ii Abstract iii 中文摘要 iv Table of contents v List of Tables vi List of Figures vii Chapter 1 General Introduction 1 Reference 4 Chapter 2 Serum concentration of NT-proBNP and cardiac troponin I in determination of severity of canine heart failure caused by chronic degenerative mitral valvular disease 8 Reference 15 Chapter 3 Changes of serum cardiac troponin I concentrations before and after treatment for congestive heart failure caused by chronic degenerative mitral valvular disease in dogs 22 Reference 28 Chapter 4 General discussion and conclusion 37 | |
dc.language.iso | zh-TW | |
dc.title | 血清心臟肌鈣蛋白濃度與慢性心臟瓣膜疾病患犬之關係 | zh_TW |
dc.title | The Serum Concentration of Cardiac Troponin I in Association of Dogs with Chronic Degenerative Valvular Diseases | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 季昭華,張本恆 | |
dc.subject.keyword | 心臟肌鈣蛋白I,心臟瓣膜疾病,心衰竭, | zh_TW |
dc.subject.keyword | Cardiac Troponin I,Chronic Degenerative Valvular Diseases,heart failure, | en |
dc.relation.page | 38 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-08-07 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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