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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 黃耀輝 | |
dc.contributor.author | Chun-Hung Liu | en |
dc.contributor.author | 劉俊宏 | zh_TW |
dc.date.accessioned | 2021-06-15T02:41:52Z | - |
dc.date.available | 2014-09-16 | |
dc.date.copyright | 2009-09-16 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-08-11 | |
dc.identifier.citation | Åkesson, A., Bjellerup, P., Lundh, T., Lidfeldt, J., Nerbrand, C., Samsioe, G., et al., 2006. Cadmium-induced effects on bone in a population-based study of women. Environmental Health Perspectives. 114, 830-4.
Al-Saleh, I., Shinwari, N., Nester, M., Mashhour, A., Moncari, L., El Din Mohamed, G., et al., 2008. Longitudinal study of prenatal and postnatal lead exposure and early cognitive development in Al-Kharj, Saudi Arabia: a preliminary results of cord blood lead levels. Journal of Tropical Pediatrics. 54, 300-7. Alfvén, T., Elinder, C., Carlsson, M., Grubb, A., Hellström, L., Persson, B., et al., 2000. Low-level cadmium exposure and osteoporosis. Journal of Bone and Mineral Research. 15, 1579-1586. Alimonti, A., Petrucci, F., Laurenti, F., Papoff, P., Caroli, S., 2000. Reference values for selected trace elements in serum of term newborns from the urban area of Rome. Clinica Chimica Acta. 292, 163-73. Ataniyazova, O. A., Baumann, R. A., Liem, A. K., Mukhopadhyay, U. A., Vogelaar, E. F., Boersma, E. R., 2001. Levels of certain metals, organochlorine pesticides and dioxins in cord blood, maternal blood, human milk and some commonly used nutrients in the surroundings of the Aral Sea (Karakalpakstan, Republic of Uzbekistan). Acta Paediatr. 90, 801-8. ATSDR,2007. Agency for Toxic Substances and Disease Registry, Toxicological Profile for Arsenic. Accessed on June, 2009 at http://www.atsdr.cdc.gov/toxprofiles/tp2.html. ATSDR, 2008. Agency for Toxic Substances and Disease Registry, Toxicological Profile for Cadmium. Accessed on June, 2009 at http://www.atsdr.cdc.gov/toxprofiles/tp5.html. ATSDR, 2007. Agency for Toxic Substances and Disease Registry, Toxicological Profile for Lead. Accessed on June, 2009 at http://www.atsdr.cdc.gov/toxprofiles/tp13.html. ATSDR, 2008. Agency for Toxic Substances and Disease Registry, Toxicological Profile for Manganese. Accessed on June, 2009 at http://www.atsdr.cdc.gov/toxprofiles/tp151.html. ATSDR, 1999. Agency for Toxic Substances and Disease Registry, Toxicological Profile for Mercury. Accessed on June, 2009 at http://www.atsdr.cdc.gov/toxprofiles/tp46.html. Baig, S., Hasnain, N. U., Ud-din, Q., 2003. Studies on Zn, Cu, Mg, Ca and phosphorus in maternal and cord blood. Journal of the Pakistan Medical Association. 53, 417-22. Baranowska, I., 1995. Lead and cadmium in human placentas and maternal and neonatal blood (in a heavily polluted area) measured by graphite furnace atomic absorption spectrometry. Occupational and environmental medicine. 52, 229-32. Bazzi, A., Nriagu, J. O., Linder, A. M., 2008. Determination of toxic and essential elements in children's blood with inductively coupled plasma-mass spectrometry. Journal of environmental monitoring. 10, 1226-32. Bellinger, D. C., 2008a. Lead neurotoxicity and socioeconomic status: conceptual and analytical issues. NeuroToxicology. 29, 828-32. Bellinger, D. C., 2008b. Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr. 20, 172-7. Berkowitz, Z., Price-Green, P., Bove, F. J., Kaye, W. E., 2006. Lead exposure and birth outcomes in five communities in Shoshone County, Idaho. International Journal of Hygiene and Environmental Health. 209, 123-132. Bhatnagar, S., Natchu, U. C., 2004. Zinc in child health and disease. Indian J Pediatr. 71, 991-5. Bjerregaard, P., Hansen, J. C., 2000. Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland. Science of the Total Environment. 245, 195-202. Butler Walker, J., Houseman, J., Seddon, L., McMullen, E., Tofflemire, K., Mills, C., et al., 2006. Maternal and umbilical cord blood levels of mercury, lead, cadmium, and essential trace elements in Arctic Canada. Environmental Research. 100, 295-318. Canfield, R. L., Henderson, C. R., Jr., Cory-Slechta, D. A., Cox, C., Jusko, T. A., Lanphear, B. P., 2003. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. The New England journal of medicine. 348, 1517-26. Castro-González, M. I., Mèndez-Armenta, M., 2008. Heavy metals: Implications associated to fish consumption. Environmental Toxicology and Pharmacology. 26, 263-271. CDC, 2005. Third National Report on Human Exposure to Environmental Chemicals. Centers for Disease Control and Prevention, Atlanta. Accessed on June, 2009 at http://www.cdc.gov/exposurereport/ Chan, S., Gerson, B., Subramaniam, S., 1998. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clinics in laboratory medicine. 18, 673-85. Concha, G., Vogler, G., Lezcano, D., Nermell, B., Vahter, M., 1998. Exposure to inorganic arsenic metabolites during early human development. Toxicological sciences. 44, 185-90. Conti, M.E., 2008. Biological monitoring: Theory & Applications. WIT Press, Boston. Davidson, P. W., Myers, G. J., Weiss, B., 2004. Mercury exposure and child development outcomes. Pediatrics. 113, 1023-9. Davidson, P. W., Strain, J. J., Myers, G. J., Thurston, S. W., Bonham, M. P., Shamlaye, C. F., et al., 2008. Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy. NeuroToxicology. 29, 767-775. Davis, J., 1998. Methylcyclopentadienyl manganese tricarbonyl: health risk uncertainties and research directions. Environmental Health Perspectives. 106, 191-201. Dennis, C. A., Fehr, F., 1975. The relationship between mercury levels in maternal and cord blood. Science of the Total Environment. 3, 275-7. Devereux, G., McNeill, G., Newman, G., Turner, S., Craig, L., Martindale, S., et al., 2007. Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates. Clinical and experimental allergy. 37, 1000-8. Dewailly, E., Suhas, E., Mou, Y., Dallaire, R., Chateau-Degat, L., Chansin, R., 2008. High fish consumption in French Polynesia and prenatal exposure to metals and nutrients. Asia Pacific journal of clinical nutrition. 17, 461-70. Diez, S., Delgado, S., Aguilera, I., Astray, J., Perez-Gomez, B., Torrent, M., et al., 2009. Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country. Archives of environmental contamination and toxicology. 56, 615-22. Erikson, K. M., Thompson, K., Aschner, J., Aschner, M., 2007. Manganese neurotoxicity: a focus on the neonate. Pharmacology & therapeutics. 113, 369-77. Fok, T. F., Lam, H. S., Ng, P. C., Yip, A. S., Sin, N. C., Chan, I. H., et al., 2007. Fetal methylmercury exposure as measured by cord blood mercury concentrations in a mother-infant cohort in Hong Kong. Environment International. 33, 84-92. Frisbie, S. H., Ortega, R., Maynard, D. M., Sarkar, B., 2002. The concentrations of arsenic and other toxic elements in Bangladesh's drinking water. Environmental Health Perspectives. 110, 1147-53. Gao, Y., Yan, C. H., Tian, Y., Wang, Y., Xie, H. F., Zhou, X., et al., 2007. Prenatal exposure to mercury and neurobehavioral development of neonates in Zhoushan City, China. Environmental Research. 105, 390-9. Godschalk, R., Hogervorst, J., Albering, H., Mercelina-Roumans, P., van Schooten, F. J., de Haan, J., et al., 2005. Interaction between cadmium and aromatic DNA adducts in hprt mutagenesis during foetal development. Mutagenesis. 20, 181-5. Goldhaber, S. B., 2003. Trace element risk assessment: essentiality vs. toxicity. Regulatory toxicology and pharmacology. 38, 232-42. Gonzalez-Reyes, R., Gutierrez-Alvarez, A., Moreno, C., 2007. Manganese and epilepsy: A systematic review of the literature. Brain research reviews. 53, 332-336. Hafeman, D., Factor-Litvak, P., Cheng, Z., van Geen, A., Ahsan, H., 2007. Association between manganese exposure through drinking water and infant mortality in Bangladesh. Environmental Health Perspectives. 115, 1107-12. Hall, M., Gamble, M., Slavkovich, V., Liu, X., Levy, D., Cheng, Z., et al., 2007. Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Environmental Health Perspectives. 115, 1503-9. Heitland, P., Köter, H. D., 2006. Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS. Journal of Trace Elements in Medicine and Biology. 20, 253-262. Hsu, C. S., Liu, P. L., Chien, L. C., Chou, S. Y., Han, B. C., 2007. Mercury concentration and fish consumption in Taiwanese pregnant women. BJOG: An International Journal of Obstetrics & Gynaecology. 114, 81-5. Hu, H., Tellez-Rojo, M. M., Bellinger, D., Smith, D., Ettinger, A. S., Lamadrid-Figueroa, H., et al., 2006. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environmental Health Perspectives. 114, 1730-5. Hwang, Y. H., Ko, Y., Chiang, C. D., Hsu, S. P., Lee, Y. H., Yu, C. H., et al., 2004. Transition of cord blood lead level, 1985-2002, in the Taipei area and its determinants after the cease of leaded gasoline use. Environmental Research. 96, 274-282. Hwang, Y. H., Wang, J. D., 1990. Temporal fluctuation of the lead level in the cord blood of neonates in Taipei. Archives of environmental health. 45, 42-5. Iijima, K., Otake, T., Yoshinaga, J., Ikegami, M., Suzuki, E., Naruse, H., et al., 2007. Cadmium, lead, and selenium in cord blood and thyroid hormone status of newborns. Biological Trace Element Research. 119, 10-8. Jarup, L., 2003. Hazards of heavy metal contamination. Br Med Bull. 68, 167-82. Jarup, L., Berglund, M., Elinder, C. G., Nordberg, G., Vahter, M., 1998. Health effects of cadmium exposure-a review of the literature and a risk estimate. Scandinavian journal of work, environment & health. 24 Suppl 1, 1-51. Jedrychowski, W., Jankowski, J., Flak, E., Skarupa, A., Mroz, E., Sochacka-Tatara, E., et al., 2006. Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Annals of Epidemiology. 16, 439-47. Jedrychowski, W., Perera, F., Jankowski, J., Rauh, V., Flak, E., Caldwell, K. L., et al., 2007a. Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life: Krakow epidemiologic study. Environment International. 33, 1057-1062. Jedrychowski, W., Perera, F., Jankowski, J., Rauh, V., Flak, E., Caldwell, K. L., et al., 2008. Prenatal low-level lead exposure and developmental delay of infants at age 6 months (Krakow inner city study). International Journal of Hygiene and Environmental Health. 211, 345-351. Jedrychowski, W., Perera, F., Rauh, V., Flak, E., Mroz, E., Pac, A., et al., 2007b. Fish intake during pregnancy and mercury level in cord and maternal blood at delivery: an environmental study in Poland. International Journal of Occupational Medicine & Environmental Health. 20, 31-7. Jedrychowski, W., Perera, F. P., Jankowski, J., Mrozek-Budzyn, D., Mroz, E., Flak, E., et al., 2009. Very low prenatal exposure to lead and mental development of children in infancy and early childhood: Krakow prospective cohort study. Neuroepidemiology. 32, 270-8. Jelliffe-Pawlowski, L. L., Miles, S. Q., Courtney, J. G., Materna, B., Charlton, V., 2006. Effect of magnitude and timing of maternal pregnancy blood lead (Pb) levels on birth outcomes. Journal of perinatology. 26, 154-62. Jusko, T. A., Henderson, C. R., Lanphear, B. P., Cory-Slechta, D. A., Parsons, P. J., Canfield, R. L., 2008. Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age. Environmental Health Perspectives. 116, 243-8. Kosanovic, M., Jokanovic, M., Jevremovic, M., Dobric, S., Bokonjic, D., 2002. Maternal and fetal cadmium and selenium status in normotensive and hypertensive pregnancy. Biological Trace Element Research. 89, 97-103. Krachler, M., Rossipal, E., Micetic-Turk, D., 1999. Trace element transfer from the mother to the newborn--investigations on triplets of colostrum, maternal and umbilical cord sera. European Journal of Clinical Nutrition. 53, 486-94. Lanphear, B. P., 2007. The conquest of lead poisoning: a Pyrrhic victory. Environmental Health Perspectives. 115, A484-5. Levesque, B., Duchesne, J. F., Gariepy, C., Rhainds, M., Dumas, P., Scheuhammer, A. M., et al., 2003. Monitoring of umbilical cord blood lead levels and sources assessment among the Inuit. Occupational & Environmental Medicine. 60, 693-5. Levin, R., Brown, M. J., Kashtock, M. E., Jacobs, D. E., Whelan, E. A., Rodman, J., et al., 2008. Lead exposures in U.S. Children, 2008: implications for prevention.[erratum appears in Environ Health Perspect. 2008 Oct;116(10):1291]. Environmental Health Perspectives. 116, 1285-93. Lorenzo Alonso, M. J., Bermejo Barrera, A., Cocho de Juan, J. A., Fraga Bermudez, J. M., Bermejo Barrera, P., Lorenzo Alonso, M. J., et al., 2005. Selenium levels in related biological samples: human placenta, maternal and umbilical cord blood, hair and nails. Journal of Trace Elements in Medicine & Biology. 19, 49-54. Mahaffey, K. R., Clickner, R. P., Jeffries, R. A., 2009. Adult women's blood mercury concentrations vary regionally in the United States: association with patterns of fish consumption (NHANES 1999-2004). Environmental Health Perspectives. 117, 47-53. Mahaffey, K. R., Corneliussen, P. E., Jelinek, C. F., Fiorino, J. A., 1975. Heavy metal exposure from foods. Environmental Health Perspectives. 12, 63-9. Makri, A., Goveia, M., Balbus, J., Parkin, R., 2004. Children's susceptibility to chemicals: a review by developmental stage. Journal of toxicology and environmental health. Part B, Critical reviews. 7, 417-35. Mandal, B. K., Suzuki, K. T., 2002. Arsenic round the world: a review. Talanta. 58, 201-35. McKelvey, W., Gwynn, R. C., Jeffery, N., Kass, D., Thorpe, L. E., Garg, R. K., et al., 2007. A biomonitoring study of lead, cadmium, and mercury in the blood of New York city adults. Environmental Health Perspectives. 115, 1435-41. Mokhtar, G., Hossny, E., el-Awady, M., Zekry, M., 2002. In utero exposure to cadmium pollution in Cairo and Giza governorates of Egypt. East Mediterr Health J. 8, 254-60. Muntner, P., Menke, A., DeSalvo, K. B., Rabito, F. A., Batuman, V., 2005. Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys. Archives of internal medicine. 165, 2155-61. Odland, J. O., Nieboer, E., Romanova, N., Thomassen, Y., Lund, E., 1999. Blood lead and cadmium and birth weight among sub-arctic and arctic populations of Norway and Russia. Acta obstetricia et gynecologica Scandinavica. 78, 852-60. Oken, E., Bellinger, D. C., 2008. Fish consumption, methylmercury and child neurodevelopment. Current opinion in pediatrics. 20, 178-83. Ong, C. N., Chia, S. E., Foo, S. C., Ong, H. Y., Tsakok, M., Liouw, P., 1993. Concentrations of heavy metals in maternal and umbilical cord blood. BioMetals. 6, 61-6. Ong, C. N., Phoon, W. O., Law, H. Y., Tye, C. Y., Lim, H. H., 1985. Concentrations of lead in maternal blood, cord blood, and breast milk. Archives of Disease in Childhood. 60, 756-9. Osman, K., Akesson, A., Berglund, M., Bremme, K., Schutz, A., Ask, K., et al., 2000. Toxic and essential elements in placentas of Swedish women. Clinical biochemistry. 33, 131-8. Palkovicova, L., Ursinyova, M., Masanova, V., Yu, Z., Hertz-Picciotto, I., 2008. Maternal amalgam dental fillings as the source of mercury exposure in developing fetus and newborn. Journal of exposure science & environmental epidemiology. 18, 326-31. Pathak, P., Kapil, U., 2004. Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian journal of pediatrics. 71, 1003-5. Ramon, R., Murcia, M., Ballester, F., Rebagliato, M., Lacasana, M., Vioque, J., et al., 2008. Prenatal exposure to mercury in a prospective mother-infant cohort study in a Mediterranean area, Valencia, Spain. Science of the Total Environment. 392, 69-78. Ratnaike, R. N., 2003. Acute and chronic arsenic toxicity. Postgraduate medical journal. 79, 391-6. Rodrigues, J. L., Batista, B. L., Fillion, M., Passos, C. J. S., Mergler, D., Barbosa Jr, F., 2009. Trace element levels in whole blood of riparian villagers of the Brazilian Amazon. Science of the Total Environment. 407, 4168-4173. Rodrigues, J. L., Batista, B. L., Nunes, J. A., Passos, C. J. S., Barbosa Jr, F., 2008. Evaluation of the use of human hair for biomonitoring the deficiency of essential and exposure to toxic elements. Science of the Total Environment. 405, 370-376. Rodriguez, V. M., Jimenez-Capdeville, M. E., Giordano, M., 2003. The effects of arsenic exposure on the nervous system. Toxicology letters. 145, 1-18. Rogan, W. J., Ware, J. H., 2003. Exposure to lead in children--how low is low enough? The New England journal of medicine. 348, 1515-6. Rollin, H. B., Rudge, C. V., Thomassen, Y., Mathee, A., Odland, J. O., 2009. Levels of toxic and essential metals in maternal and umbilical cord blood from selected areas of South Africa--results of a pilot study. Journal of environmental monitoring. 11, 618-27. Rosado, J. L., Ronquillo, D., Kordas, K., Rojas, O., Alatorre, J., Lopez, P., et al., 2007. Arsenic exposure and cognitive performance in Mexican schoolchildren. Environmental Health Perspectives. 115, 1371-5. S.M. Awadallah, K.H. Abu-Elteen, A.Z. Elkarmi, S.H. Qaraein, N.M. Salem, M.S. Mubarak, 2004. Maternal and cord blood serum levels of zinc, copper, and iron in healthy pregnant Jordanian women. The Journal of Trace Elements in Experimental Medicine. 17, 1-8. Sakamoto, M., Kaneoka, T., Murata, K., Nakai, K., Satoh, H., Akagi, H., et al., 2007. Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population. Environmental Research. 103, 106-11. Satarug, S., Moore, M., 2004. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environmental Health Perspectives. 1099-1103. Sato, R. L., Li, G. G., Shaha, S., Sato, R. L., Li, G. G., Shaha, S., 2006. Antepartum seafood consumption and mercury levels in newborn cord blood. American Journal of Obstetrics & Gynecology. 194, 1683-8. Schoeters, G., Den Hond, E., Zuurbier, M., Naginiene, R., van den Hazel, P., Stilianakis, N., et al., 2006. Cadmium and children: exposure and health effects. Acta paediatrica (Oslo, Norway : 1992). Supplement. 95, 50-4. Schulpis, K. H., Karakonstantakis, T., Gavrili, S., Chronopoulou, G., Karikas, G. A., Vlachos, G., et al., 2004. Maternal--neonatal serum selenium and copper levels in Greeks and Albanians. European Journal of Clinical Nutrition. 58, 1314-8. Semczuk, M., Semczuk-Sikora, A., 2001. New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy. Medical science monitor. 7, 332-40. Shaheen, S. O., Newson, R. B., Henderson, A. J., Emmett, P. M., Sherriff, A., Cooke, M., et al., 2004. Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. European Respiratory Journal. 24, 292-7. Sirot, V., Guérin, T., Volatier, J. L., Leblanc, J. C., 2009. Dietary exposure and biomarkers of arsenic in consumers of fish and shellfish from France. Science of the Total Environment. 407, 1875-1885. Smargiassi, A., Takser, L., Masse, A., Sergerie, M., Mergler, D., St-Amour, G., et al., 2002. A comparative study of manganese and lead levels in human umbilical cords and maternal blood from two urban centers exposed to different gasoline additives. Science of the Total Environment. 290, 157-64. Soong, Y. K., Tseng, R., Liu, C., Lin, P. W., 1991. Lead, cadmium, arsenic, and mercury levels in maternal and fetal cord blood. Journal of the Formosan Medical Association. 90, 59-65. Soria, M. L., Sanz, P., Martinez, D., Lopez-Artiguez, M., Garrido, R., Grilo, A., et al., 1992. Total mercury and methylmercury in hair, maternal and umbilical blood, and placenta from women in the Seville area. Bulletin of environmental contamination and toxicology. 48, 494-501. Srivastava, S., Mehrotra, P. K., Srivastava, S. P., Siddiqui, M. K., Siddiqui, M. K. J., 2002. Some essential elements in maternal and cord blood in relation to birth weight and gestational age of the baby. Biological Trace Element Research. 86, 97-105. Srivastava, S., Mehrotra, P. K., Srivastava, S. P., Tandon, I., Siddiqui, M. K., 2001. Blood lead and zinc in pregnant women and their offspring in intrauterine growth retardation cases. Journal of Analytical Toxicology. 25, 461-5. Surkan, P. J., Zhang, A., Trachtenberg, F., Daniel, D. B., McKinlay, S., Bellinger, D. C., 2007. Neuropsychological function in children with blood lead levels <10μg/dL. NeuroToxicology. 28, 1170-1177. Survey, B. G., 2001. Arsenic Contamination of Ground Water in Bangladesh British Geological Survey Technical Report, WC/00/19, Vol 1 (Kinniburgh DG, Smedley PL, eds). Keyworth, UK:British Geological Survey. Takser, L., Lafond, J., Bouchard, M., St-Amour, G., Mergler, D., Takser, L., et al., 2004. Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population. Environmental Research. 95, 119-25. Takser, L., Mergler, D., Hellier, G., Sahuquillo, J., Huel, G., 2003. Manganese, monoamine metabolite levels at birth, and child psychomotor development. NeuroToxicology. 24, 667-74. Tellez-Rojo, M. M., Bellinger, D. C., Arroyo-Quiroz, C., Lamadrid-Figueroa, H., Mercado-Garcia, A., Schnaas-Arrieta, L., et al., 2006. Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics. 118, e323-30. Tofail, F., Vahter, M., Hamadani, J. D., Nermell, B., Huda, S. N., Yunus, M., et al., 2009. Effect of arsenic exposure during pregnancy on infant development at 7 months in rural Matlab, Bangladesh. Environmental Health Perspectives. 117, 288-93. Truska, P., Rosival, L., Balazova, G., Hinst, J., Rippel, A., Palusova, O., et al., 1989. Blood and placental concentrations of cadmium, lead, and mercury in mothers and their newborns. Journal of hygiene, epidemiology, microbiology, and immunology. 33, 141-7. Tsai, S.-Y., Chou, H.-Y., The, H.-W., Chen, C.-M., Chen, C.-J., 2003. The Effects of Chronic Arsenic Exposure from Drinking Water on the Neurobehavioral Development in Adolescence. NeuroToxicology. 24, 747-753. Tsuchiya, H., Mitani, K., Kodama, K., Nakata, T., 1984. Placental transfer of heavy metals in normal pregnant Japanese women. Archives of environmental health. 39, 11-7. Unuvar, E., Ahmadov, H., Kiziler, A. R., Aydemir, B., Toprak, S., Ulker, V., et al., 2007. Mercury levels in cord blood and meconium of healthy newborns and venous blood of their mothers: clinical, prospective cohort study. Science of the Total Environment. 374, 60-70. USGS, 2009. Mineral commodity summaries, U.S. Geological Survey. Accessed on June, 2009 at http://minerals.usgs.gov/minerals/pubs/mcs/ Vahter, M., Akesson, A., Liden, C., Ceccatelli, S., Berglund, M., 2007. Gender differences in the disposition and toxicity of metals. Environmental Research. 104, 85-95. Vahter, M., Berglund, M., Akesson, A., Liden, C., 2002. Metals and women's health. Environmental Research. 88, 145-55. Vigeh, M., Yokoyama, K., Ramezanzadeh, F., Dahaghin, M., Fakhriazad, E., Seyedaghamiri, Z., et al., 2008. Blood manganese concentrations and intrauterine growth restriction. Reproductive Toxicology. 25, 219-223. Vigeh, M., Yokoyama, K., Ramezanzadeh, F., Dahaghin, M., Sakai, T., Morita, Y., et al., 2006. Lead and other trace metals in preeclampsia: a case-control study in Tehran, Iran. Environmental Research. 100, 268-75. Von Ehrenstein, O. S., Poddar, S., Yuan, Y., Mazumder, D. G., Eskenazi, B., Basu, A., et al., 2007. Children's intellectual function in relation to arsenic exposure. Epidemiology. 18, 44-51. Wang, C., Huang, L., Zhou, X., Xu, G., Shi, Q., Wang, C., et al., 2004. Blood lead levels of both mothers and their newborn infants in the middle part of China. International Journal of Hygiene & Environmental Health. 207, 431-6. Wasserman, G., Liu, X., Parvez, F., Ahsan, H., Levy, D., Factor-Litvak, P., et al., 2006. Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Environmental Health Perspectives. 124-129. Wilhelm, M., Ewers, U., Schulz, C., 2004. Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine. International Journal of Hygiene and Environmental Health. 207, 69-73. Wilhelm, M., Schulz, C., Schwenk, M., 2006. Revised and new reference values for arsenic, cadmium, lead, and mercury in blood or urine of children: basis for validation of human biomonitoring data in environmental medicine. International Journal of Hygiene & Environmental Health. 209, 301-5. Wood, R. J., 2009. Manganese and birth outcome. Nutrition reviews. 67, 416-20. Wright, R. O., Amarasiriwardena, C., Woolf, A. D., Jim, R., Bellinger, D. C., 2006. Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site. NeuroToxicology. 27, 210-216. Xue, F., Holzman, C., Rahbar, M. H., Trosko, K., Fischer, L., 2007. Maternal fish consumption, mercury levels, and risk of preterm delivery. Environmental Health Perspectives. 115, 42-7. Yamauchi, H., Takahashi, K., Mashiko, M., Saitoh, J., Yamamura, Y., 1992. Intake of different chemical species of dietary arsenic by the Japanese, and their blood and urinary arsenic levels. Applied Organometallic Chemistry. 6. Zhang, Y., Zhao, Y., Wang, J., Zhu, H., Liu, Q., Fan, Y., et al., 2004. Effects of zinc, copper, and selenium on placental cadmium transport. Biological Trace Element Research. 102, 39-49. Ziaee, H., Daniel, J., Datta, A. K., Blunt, S., McMinn, D. J., 2007. Transplacental transfer of cobalt and chromium in patients with metal-on-metal hip arthroplasty: a controlled study. The Journal of bone and joint surgery. British volume. 89, 301-5. 吳惠琤,2005。一、出生體重與懷孕週數常模二、重金屬對胎兒成長與神經發育的影響。[碩士論文]臺灣大學職業醫學與工業衛生研究所。 林屏沂,2004。暴露二手菸孕婦血液、臍血及胎盤中鉛、鎘之相關性研究。[碩士論文]中國醫藥大學環境醫學研究所。 陳志強,2002。汽油油品及引擎排放廢氣中金屬元素之特徵。[碩士論文]成功大學環境工程學系碩博士班。 洪盈鈴,2007。以微波消化法和灰化法分析中藥材內所含鉛、銅、鎘之重金屬。[碩士論文]中原大學化學研究所。 張超群,莊惟傑,2008。由台灣高科技產業需求,探討金屬材料發展策略。經濟部技術處發行,臺北市。 連森興,2001。中藥成藥中金屬濃度與人體暴露評估---以苗栗地區為例。[碩士論文]台北醫學院公共衛生學研究所。 黃國維,蔡幸甫,2002。輕金屬在新世代產品的應用與商機。臺北電腦商業同業工會經銷,臺北市。 劉佩玲,2004。胎盤與臍帶血汞濃度之相關研究。[碩士論文]台北醫學院公共衛生學研究所。 內政部統計處,2005。統計統計通報95年第2週(94年新生嬰兒生母狀況分析。Accessed on June, 2009 at http://sowf.moi.gov.tw/stat/week/list.htm。 衛生署疾病管制局,2008。新生兒愛滋篩檢計畫。Accessed on June, 2009 at http://www.cdc.gov.tw/public/Attachment/972216573571.doc。 衛生署國民健康局,2005。出生通報統計資料。Accessed on June, 2009 at http://www.bhp.doh.gov.tw/BHPnet/Portal/Them.aspx?No=200712250046。 環境保護署資源回收基管會,2009。廢物品及容器稽核認證回收量統計表。Accessed on June, 2009 at http://recycle.epa.gov.tw/epa/menu/index.asp?sNo=12。 環境保護署環境檢驗所,2004。環境檢驗方法偵測極限測定指引。Accessed on June, 2009 at http://www.niea.gov.tw/analysis/information/PA107環境檢驗方法偵測極限測定指引931004.doc。 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44143 | - |
dc.description.abstract | 金屬元素遍佈於環境中,有些是天然環境中已存在的,但有些是人為所產生的。人類透過各種日常活動暴露到這些環境金屬元素,尤其懷孕婦女與其胎兒更是易感受族群。藉由血液金屬多元素分析作為生物監測之工具,可以較具體地瞭解人體內金屬元素暴露的情形。因此本研究的目的設定為:
1.藉由分析臍帶血中18種金屬元素濃度,建立台灣臍帶血中金屬濃度之常模值,作為環境汙染暴露監測的基礎背景參考資料。 2.探討臍帶血中18種金屬元素濃度分布之相關影響因子。 本研究收樣期間為2004年4月到2005年7月,共收集1526對產婦及其新生兒為研究對象,所有受邀產婦會被告知相關問卷與樣本收集流程,並請其簽署參與計劃同意書。問卷資料在產婦分娩後進行收集,而臍帶血樣本則在分娩時,由護士進行採樣,並儲存於-80℃冰箱保存。總共收集1407個臍帶血樣本,以感應偶合電漿質譜儀進行18種金屬元素的分析,包括鈹(Be)、鉻(Cr)、錳(Mn)、鈷(Co)、鎳(Ni)、銅(Cu)、鋅(Zn)、砷(As)、硒(Se)、鉬(Mo)、鎘(Cd)、銻(Sb)、鉑(Pt)、汞(Hg)、鉈(Tl)、鉛(Pb)、釷(Th)、鈾(U)等共18種元素。 臍帶血金屬濃度分布其特性顯示,臍帶血中濃度最高金屬元素為鋅(Zn),平均濃度值為2452 ± 1018 μg/L。其次為銅(Cu)、硒(Se),其平均濃度值分別為534 ± 105 μg/L、204 ± 47 μg/L。再其次為錳(Mn)、汞(Hg)、鉛(Pb)等,平均濃度分別為48.9 ± 15.7、10.8 ± 6.5、13.9 ± 6.0 μg/L。 過去二十年來,台灣臍帶血中鉛濃度從1987年74.8 μg/L下降至本研究2005年測得的14.5 μg/L。而臍帶血中汞濃度也從1988年28.8 μg/L下降至本研究2005年測得的11.6 μg/L。 在ANOVA統計分析結果顯示,除了鎳元素,其他17種臍帶血中金屬元素濃度在產婦居住地理區域分組間有顯著差異(p<0.0001)。臍帶血中汞濃度,隨著產婦教育程度與家庭年收入的提高,濃度有升高的現象,而臍帶血中鉛濃度則是呈相反趨勢(p<0.05)。同時,汞濃度在產婦年齡分組間有顯著差異(p<0.05)。 在逐步複迴歸分析結果顯示,產婦懷孕期間是否吸煙會影響臍帶血中鎘濃度 (β=0.201, p<0.001)。影響臍帶血中鉛濃度的因素則包括產婦年齡(β=0.159, p<0.05)、產婦教育程度(β=-1.050, p<0.001)。臍帶血中汞濃度則受產婦年齡(β=0.193, p<0.001)、產婦教育程度(β=0.996, p<0.001)、食用海水魚量(β=0.260, p<0.01)、食用淡水魚量(β=-0.273, p<0.15)等因素的影響。 藉由本研究得知台灣新生兒的臍帶血中金屬元素暴露常模值,提供後續其他研究作為參考。而台灣臍帶血中鉛、汞濃度已有下降的現象,目前臍帶血中鉛、汞濃度約為10 μg/L等級。如此低濃度暴露是否會帶來相關的新生兒健康危害,仍需持續關切。 臍帶血中金屬元素濃度監測,可作為新生兒受環境中金屬暴露的指標。因此建立國人相關血中金屬多元素監測是必要的,藉長期血液中金屬濃度的變化趨勢與空間分布關係來瞭解人類受環境金屬污染暴露情形。 | zh_TW |
dc.description.abstract | Trace metals are widely distributed in our environment (air, water and soil). People usually expose to trace metals by daily activities.Pregnant women and their neonates are particularly susceptible to them. Biomonitoring of metal elements in blood has become an important tool to characterize the distributions of trace metals in human body.
The aim of this study was set to understand the distributions of trace metals in umbilical cord blood in Taiwan and establish the corresponding norm values for further environmental pollution monitoring, and to explore the potential determinants for the metal concentrations in umbilical cord blood. In total, 1526 pairs of delivering women and their neonates were recruited from April 2004 to July 2005. All participants were informed about the content of this research and the statements of consents have been signed before they participated in the study. Questionnaire information was collected from delivering women after delivery. In total, 1407 Cord blood samples were collected at delivery by nurses and stored in EDTA tubes under -80℃ frozen condition until laboratory analysis with inductively coupled plasma mass spectrometry for 18 trace elements, including As, Be, Cd, Cr, Co, Cu, Ga, Hg, Mn, Mo, Ni, Pb, Pt, Sb, Se, Tl, Th, Zn, U. The highest concentration of metal in cord blood was found for zinc with mean of 2452 ± 1018 μg/L, followed by copper and selenium with means of 534 ± 105 μg/L and 204 ± 47 μg/L, respectively, and by manganese, mercury, lead with means of 48.9 ± 15.7、10.8 ± 6.5、13.9 ± 6.0 μg/L, respectively. Over the past two decades, cord blood lead level in Taiwan declined from 74.8 μg/L in 1987 to 14.5 μg/L in 2005. The mercury level in umbilical cord blood also decreased from 28.8 μg/L in 1988 to 11.6 μg/L in 2005. Results of ANOVA indicated there was significant difference among geographical zones for all study metal levels in cord blood expect for Ni (p<0.0001). The concentration of Hg in umbilical cord blood was positively associated with maternal education and family income levels, while that of Pb was negatively (p<0.05). Meanwhile, there was significant difference in cord blood Hg level among age groups of delivering women. In conclusion, the norms of metal levels in cord blood in Taiwan were established, and could be used as references in further. Cord blood lead and mercury levels in Taiwan presented a decreasing trend in th past years. The current cord blood lead and mercury levels is about 10 μg/L. It’s still of concern whether such low level exposure to lead and mercury would lead to potential adverse health effects of neonates. In the future, a longitudinal monitoring for cord blood metals shall be established to monitor the longitudinal and spatial trend of blood metal level to characterize the human exposure to environmental metal pollutants. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T02:41:52Z (GMT). No. of bitstreams: 1 ntu-98-R95841006-1.pdf: 944570 bytes, checksum: 1f125fc173bcaf2af33553829af40c1f (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 摘要.................................................................................................................................. I
Abstract.......................................................................................................................... III 第一章 研究背景............................................................................................................ 1 第二章 研究目的............................................................................................................ 2 第三章 文獻回顧............................................................................................................ 3 1.1 砷........................................................................................................................ 3 1.2 鎘........................................................................................................................ 4 1.3 汞........................................................................................................................ 5 1.4 錳........................................................................................................................ 6 1.5 鉛........................................................................................................................ 6 1.6 其它必需元素................................................................................................... 7 1.7 稀有元素使用情形........................................................................................... 8 1.8 分析技術........................................................................................................... 9 1.9 生物監測(Biological Monitoring) ............................................................... 9 1.10 低濃度分布情形............................................................................................. 9 1.11 胎兒易感受族群........................................................................................... 10 1.12 各國臍帶血中金屬濃度的研究情形........................................................... 10 第四章 材料與方法...................................................................................................... 12 4.1 研究族群......................................................................................................... 12 4.2 問卷資料收集................................................................................................. 12 4.3 臍帶血樣本收集............................................................................................. 13 4.4 臍帶血樣本處理與分析................................................................................. 13 4.4.1 臍帶血樣本處理.................................................................................. 13 4.4.2 檢量線樣本配製.................................................................................. 13 4.4.3 血液樣本分析...................................................................................... 14 4.5 實驗分析之品質管制..................................................................................... 14 4.6 統計分析......................................................................................................... 15 第五章 結果.................................................................................................................. 16 第六章 討論.................................................................................................................. 24 第七章 結論與建議...................................................................................................... 35 第八章 參考文獻.......................................................................................................... 36 | |
dc.language.iso | zh-TW | |
dc.title | 台灣臍帶血中微量元素與重金屬濃度分布情形 | zh_TW |
dc.title | Concentration Distributions of Trace Elements and Heavy Metals in Umbilical Cord Blood in Taiwan | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 郭育良,吳聰能,張順欽 | |
dc.subject.keyword | 臍帶血,金屬,微量元素,常模,感應偶合電漿質譜儀,鉛,汞, | zh_TW |
dc.subject.keyword | Cord blood,metal,trace element,norm,ICP-MS,lead,mercury, | en |
dc.relation.page | 75 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-08-11 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
顯示於系所單位: | 職業醫學與工業衛生研究所 |
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