請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/43699
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林璧鳳 | |
dc.contributor.author | Chen-Yen Yang | en |
dc.contributor.author | 楊政諺 | zh_TW |
dc.date.accessioned | 2021-06-15T02:26:18Z | - |
dc.date.available | 2011-08-21 | |
dc.date.copyright | 2009-08-21 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-08-18 | |
dc.identifier.citation | 吳繼恆、林進忠、林金源、林璧鳳 (2007) 膳食油脂的種類與量對卵蛋白致敏BALB/c小鼠過敏免疫反應的影響 臺灣營養學會雜誌 32(3): 83-93
吳繼恆 (2008) 具影響干擾素γ分泌的食材對OVA致敏BALB/c小鼠免疫反應的影響 國立臺灣大學微生物與生化學研究所 碩士論文 李坤珀 (2009) 研究B-1淋巴球在免疫調節功能的機轉 國立臺灣大學醫學院免疫學研究所 碩士論文 李佩芸 (2005) 口服Dp2重組蛋白質對致敏小鼠過敏免疫調節之影響 國立臺灣大學微生物與生化學研究所 碩士論文 洪永瀚 (2007) 苜蓿芽乙酸乙酯萃取物對發炎反應與自體免疫鼠病程的影響 國立臺灣大學微生物與生化學研究所 博士論文 許銘志 (2007) 塵蟎蛋白質致敏小鼠短期攝取塵蟎蛋白產生口服耐受性的機制探討 國立臺灣大學微生物與生化學研究所 碩士論文 陳妙齡 (2006) 松杉靈芝對過敏免疫反應之調節研究 國立臺灣大學微生物與生化學研究所 博士論文 陳妙齡 (2007) 篩選調節過敏反應食材之細胞培養及小鼠評估方法 臺灣農業化學與食品科學 45(6): 316-26 陳盈竹 (2003) 葉酸營養狀況對自體免疫小鼠組織L-isoaspartate含量和免疫反應的影響 國立臺灣大學微生物與生化學研究所 碩士論文 謝佳倩 (2004) 炸油與維生素E對卵蛋白致敏BALB/c鼠過敏免疫反應之影響 國立臺灣大學微生物與生化學研究所 博士論文 謝貴雄 (1995) 小兒氣喘病之預防和處理。中華民國兒科醫學會雜誌 36:S9-20 羅文音 (2006) 以卵蛋白致敏小鼠模式探討攝食山藥對過敏性氣喘的影響 國立臺灣大學微生物與生化學研究所 碩士論文 Adolfsson, O., Huber, B., & Meydani, S. (2001). Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. The Journal of Immunology , 167 (7), 3809-17. Adorini, L., & Penna, G. (2008). Control of autoimmune diseases by the vitamin D endocrine system. Nature Clinical Practice Rheumatology , 4 (8), 404-12. Agrawal, S., Tripathi, P., & Naik, S. (2008). Roles and mechanism of natural killer cells in clinical and experimental transplanation. Expert Review of Clinical Immunology , 4 (1), 79-91. Alugupalli, K., Leong, J., Woodland, R., Muramatsu, M., Honjo, T., & Gerstein, R. (2004). B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity , 21 (3), 379-90. Annacker, O., Coombes, J., Malmstrom, V., Uhlig, H., Bourne, T., Johansson-Lindbom, B., et al. (2005). Essential role for CD103 in the T cell-mediated regulation of experimental colitis. The Journal of Experimental Medicine , 202 (8), 1051-61. Asturias, J., Ibarrola, I., Arilla, M., Vidal, C., Ferrer, A., Gamboa, P., et al. (2009). Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen-specific immunotherapy. Clinical Experimental Allergy , 39 (7), 1088-98. Aukrust, P., Muller, F., Ueland, T., Svardal, A., Berge, R., & Froland, S. (2000). Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. European Journal of Clinical Investigation , 30 (3), 252-9. Barrat, F., Cua, D., Boonstra, A., Richards, D., Crain, C., Savelkoul, H., et al. (2002). In Vitro Generation of Interleukin 10-producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)- and Th2-inducing Cytokines. The Journal of Experimental Medicine , 195 (5), 603. Baum, M., Shor-Posner, G., Lu, Y., Rosner, B., Sauberlich, H., Fletcher, M., et al. (1995). Micronutrients and HIV-1 disease progression. AIDS (London, England) , 9 (9), 1051-6. Bennett, C., Bennett, C., Christie, J., Christie, J., Ramsdell, F., Ramsdell, F., et al. (2001). The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genetics , 27 (1), 20. Benson, M., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. (2007). All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. The Journal of Experimental Medicine , 204 (8), 1765-74. Berrington, A., Green, J., & Newton, R. (2000). Vitamin D deficiency and tuberculosis. Lancet , 356 (9223), 74; author reply 74-5. Boonstra, A., Barrat, F., Crain, C., Heath, V., Savelkoul, H., & O'garra, A. (2001). 1{alpha},25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4+ T Cells to Enhance the Development of Th2 Cells. The Journal of Immunology , 167 (9), 4974. Cain, G., Elderfield, A., Green, R., Smillie, F., Chapman, M., Custovic, A., et al. (1998). The effect of dry heat on mite, cat, and dog allergens. Allergy , 53 (12), 1213-5. Cantorna, M. (2006). Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease. Progress in Biophysics and Molecular Biology , 92 (1), 60-64. Cantorna, M., Hayes, C., & Deluca, H. (1998). 1,25-Dihydroxycholecalciferol Inhibits the Progression of Arthritis in Murine Models of Human Arthritis. The Journal of Nutrition , 128 (1), 68. Cantorna, M., Hayes, C., & Deluca, H. (1996). 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America , 93 (15), 7861-4. Carvalho, C., & Vaz, N. (1996). Indirect effects are independent of the way of tolerance induction. Scandinavian Journal of Immunology , 43 (6), 613-8. Chang, Y., & Hsieh, K. (1989). The study of house dust mites in Taiwan. Annals of Allergy , 62 (2), 101-6. Chen, S., Sims, G., Chen, X., Gu, Y., Chen, S., & Lipsky, P. (2007). Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. The Journal of Immunology , 179 (3), 1634-47. Chen, Y., Inobe, J., Kuchroo, V., Baron, J., Janeway, C., & Weiner, H. (1996). Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proceedings of the National Academy of Sciences of the United States of America , 93 (1), 388-91. Chen, Y., Inobe, J., Marks, R., Gonnella, P., Kuchroo, V., & Weiner, H. (1995). Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature , 376 (6536), 177-80. Chirdo, F., Millington, O., Beacock-Sharp, H., & Mowat, A. (2005). Immunomodulatory dendritic cells in intestinal lamina propria. European The Journal of Immunology , 35 (6), 1831-40. Coombes, J., Robinson, N., Maloy, K., Uhlig, H., & Powrie, F. (2005). Regulatory T cells and intestinal homeostasis. Immunological Reviews , 204, 184-94. Coombes, J., Siddiqui, K., Arancibia-Carcamo, C., Hall, J., Sun, C., Belkaid, Y., et al. (2007). A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med , 204 (8), 1757-64. Correale, J., Ysrraelit, M., & Gaitan, M. (2009). Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain : A Journal of Neurology , 132 (Pt 5), 1146-60. Courtemanche, C., Elson-Schwab, I., Mashiyama, S., Kerry, N., & Ames, B. (2004). Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. The Journal of Immunology , 173 (5), 3186-92. Derewenda, U., Li, J., Derewenda, Z., Dauter, Z., Mueller, G., Rule, G., et al. (2002). The crystal structure of a major dust mite allergen Der p 2, and its biological implications. The Journal of Molecular Biology , 318 (1), 189-97. Dhur, A., Galan, P., & Hercberg, S. (1991). Folate status and the immune system. Progress in Food & Nutrition Science , 15 (1-2), 43-60. Dietrich, T., Nunn, M., Dawson-Hughes, B., & Bischoff-Ferrari, H. (2005). Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. The American Journal of Clinical Nutrition , 82 (3), 575-80. Erickson, L., Foy, T., & Waldschmidt, T. (2001). Murine B1 B cells require IL-5 for optimal T cell-dependent activation. The Journal of Immunology , 166 (3), 1531-9. Gorman, S., Kuritzky, L., Judge, M., Dixon, K., McGlade, J., Mason, R., et al. (2007). Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. The Journal of Immunology , 179 (9), 6273-83. Grant, W., & Holick, M. (2005). Benefits and requirements of vitamin D for optimal health: a review. Alternative Medicine Review : A Journal of Clinical Therapeutic , 10 (2), 94-111. Gregori, S., Giarratana, N., Smiroldo, S., Uskokovic, M., & Adorini, L. (2002). A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes , 51 (5), 1367-74. Hales, B., Hazell, L., Smith, W., & Thomas, W. (2002). Genetic variation of Der p 2 allergens: effects on T cell responses and immunoglobulin E binding. Clinical & Experimental Allergy , 32 (10), 1461-7. Hales, B., Shen, H., & Thomas, W. (2000). Cytokine responses to Der p 1 and Der p 7: house dust mite allergens with different IgE-binding activities. Clinical & Experimental Allergy , 30 (7), 934-43. Han, S., Wu, D., Ha, W., Beharka, A., Smith, D., Bender, B., et al. (2000). Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus. Immunology , 100 (4), 487-93. Heymann, P., Chapman, M., Aalberse, R., Fox, J., & Platts-Mills, T. (1989). Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). The Journal of Allergy and Clinical Immunology , 83 (6), 1055-67. Hoffjan, S., & Ober, C. (2002). Present status on the genetic studies of asthma. Current Opinion in Immunology , 14 (6), 709-17. Inada, S., Yoshino, S., Haque, M., Ogata, Y., & Kohashi, O. (1997). Clonal anergy is a potent mechanism of oral tolerance in the suppression of acute antigen-induced arthritis in rats by oral administration of the inducing antigen. Cellular Immunology , 175 (1), 67-75. Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004). Retinoic Acid Imprints Gut-Homing Specificity on T Cells. Immunity , 21 (4), 527-538. Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004). Retinoic Acid Imprints Gut-Homing Specificity on T Cells. Immunity , 21 (4), 527-538. Izeradjene, K., Revillard, J.-P., & Genestier, L. (2001). Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells. International Immunology , 13 (1), 85. Jirapongsananuruk, O. (2000). Additive immunosuppressive effects of 1,25-dihydroxyvitamin D3 and corticosteroids on TH1, but not TH2, responses. The Journal of Allergy and Clinical Immunology , 106 (5), 981-985. Johansson-Lindbom, B., Svensson, M., Pabst, O., Palmqvist, C., Marquez, G., Forster, R., et al. (2005). Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. The Journal of Experimental Medicine , 202 (8), 1063-73. Johansson-Lindbom, B., Svensson, M., Wurbel, M.-A., Malissen, B., Marquez, G., & Agace, W. (2003). Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. The Journal of Experimental Medicine , 198 (6), 963-9. Kam, K., & Hsieh, K. (1994). Comparison of three in vitro assays for serum IgE with skin testing in asthmatic children. Annals of Allergy , 73 (4), 329-36. Kang, S., Lim, H., Andrisani, O., Broxmeyer, H., & Kim, C. (2007). Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells. The Journal of Immunology , 179 (6), 3724-33. Kim, C. (2006). Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system. Experimental Hematology , 34 (8), 1033-1040. Kim, H., Hwang, S., Kim, B., Jung, K., & Chung, D. (2006). NKT cells play critical roles in the induction of oral tolerance by inducing regulatory T cells producing IL-10 and transforming growth factor beta, and by clonally deleting antigen-specific T cells. Immunology , 118 (1), 101-11. Kim, Y.-I., Hayek, M., Mason, J., & Meydani, S. (2002). Severe Folate Deficiency Impairs Natural Killer Cell-Mediated Cytotoxicity in Rats . The Journal of Nutrition , 132 (6), 1361. Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M., & von Boehmer, H. (2005). Inducing and expanding regulatory T cell populations by foreign antigen. Nature Immunology , 6 (12), 1219-27. Kuo, I., Yi, F., Cheong, N., Shek, L., Chew, F., Lee, B., et al. (1999). Sensitization to Blomia tropicalis and dermatophagoides pteronyssinus-a comparative study between Singapore and Taiwan. Asian Pacific Journal of Allergy and Immunology , 17 (3), 179-88. Lee, J., Kang, S., & Kim, C. (2007). FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues. The Journal of Immunology , 178 (1), 301. Leech, M., Benson, R., De Vries, A., Fitch, P., & Howie, S. (2007). Resolution of Der p1-induced allergic airway inflammation is dependent on CD4+CD25+Foxp3+ regulatory cells. The Journal of Immunology , 179 (10), 7050-8. Lemon, B., & Freedman, L. (1996). Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo. Molecular and Cellular Biology , 16 (3), 1006-16. Li, G., Liu, Z., Liao, B., & Zhong, N. (2009). Induction of Th1-type immune response by chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen Der p 2 for oral vaccination in mice. Cellular & Molecular Immunology , 6 (1), 45-50. Mantyjarvi, R., Rautiainen, J., & Virtanen, T. (2000). Lipocalins as allergens. Biochimica et Biophysica Acta , 1482 (1-2), 308-17. Martineau, A., Wilkinson, R., Wilkinson, K., Newton, S., Kampmann, B., Hall, B., et al. (2007). A single dose of vitamin D enhances immunity to mycobacteria. American Journal of Respiratory and Critical Care Medicine , 176 (2), 208-13. Matheu, V., Back, O., Mondoc, E., & Issazadeh-Navikas, S. (2003). Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. The Journal of Allergy and Clinical Immunology , 112 (3), 585-92. Mora, J., & von Andrian, U. (2004). Retinoic acid: an educational 'vitamin elixir' for gut-seeking T cells. Immunity , 21 (4), 458-60. Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., et al. (2007). Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science , 317 (5835), 256-60. Nakamura, K., Kitani, A., & Strober, W. (2001). Cell Contact-dependent Immunosuppression by CD4+CD25+ Regulatory T Cells Is Mediated by Cell Surface-bound Transforming Growth Factor {beta}. The Journal of Experimental Medicine , 194 (5), 629. Naureckiene, S., Sleat, D., Lackland, H., Fensom, A., Vanier, M., Wattiaux, R., et al. (2000). Identification of HE1 as the second gene of Niemann-Pick C disease. Science , 290 (5500), 2298-301. Niess, J., & Reinecker, H.-C. (2005). Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract. Current Opinion in Gastroenterology , 21 (6), 687-91. Notas, G., Kisseleva, T., & Brenner, D. (2009). NK and NKT cells in liver injury and fibrosis. Clinical immunology , 130 (1), 16-26. O'Hehir, R., Verhoef, A., Panagiotopoulou, E., Keswani, S., Hayball, J., Thomas, W., et al. (1993). Analysis of human T cell responses to the group II allergen of Dermatophagoides species: localization of major antigenic sites. The Journal of Allergy and Clinical Immunology , 92 (1 Pt 1), 105-13. Pasatiempo, A., Kinoshita, M., Taylor, C., & Ross, A. (1990). Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens. The FASEB Journal , 4 (8), 2518. Pavli, P., Woodhams, C., Doe, W., & Hume, D. (1990). Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria. Immunology , 70 (1), 40-7. Penna, G., Amuchastegui, S., Giarratana, N., Daniel, K., Vulcano, M., Sozzani, S., et al. (2007). 1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells. The Journal of Immunology , 178 (1), 145. Robinson, D. (2009, Jun 17). Regulatory T cells and asthma. Clinical & Experimental Allergy . Schuster, G., Kenyon, N., & Stephensen, C. (2008). Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. The Journal of Immunology , 180 (3), 1834-42. Shams, N., Reddy, C., Watanabe, K., Elgebaly, S., Hanninen, L., & Kenyon, K. (1994). Increased interleukin-1 activity in the injured vitamin A-deficient cornea. Cornea , 13 (2), 156-66. Staeva-Vieira, T., & Freedman, L. (2002). 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. The Journal of Immunology , 168 (3), 1181-9. Stagg, A., Kamm, M., & Knight, S. (2002). Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. European Journal of Immunology , 32 (5), 1445-54. Stephensen, C., Rasooly, R., Jiang, X., Ceddia, M., Weaver, C., Chandraratna, R., et al. (2002). Vitamin A Enhances in Vitro Th2 Development Via Retinoid X Receptor Pathway. The Journal of Immunology , 168 (9), 4495. Sun, C., Hall, J., Blank, R., Bouladoux, N., Oukka, M., Mora, J., et al. (2007). Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. The Journal of Experimental Medicine , 204 (8), 1775-85. Svensson, M., Marsal, J., Ericsson, A., Carramolino, L., Broden, T., Marquez, G., et al. (2002). CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. The Journal of Clinical Investigation , 110 (8), 1113-21. Szalai, K., Fuhrmann, J., Pavkov, T., Scheidl, M., Wallmann, J., Bramswig, K., et al. (2008). Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2. Molecular Immunology , 45 (5), 1308-17. Szondy, Z., Reichert, U., & Fesus, L. (1998). Retinoic acids regulate apoptosis of T lymphocytes through an interplay between RAR and RXR receptors. Cell Death and Differentiation , 5 (1), 4-10. Tadokoro, C., Shakhar, G., Shen, S., Ding, Y., Lino, A., Maraver, A., et al. (2006). Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. The Journal of Experimental Medicine , 203 (3), 505. Taher, Y., van Esch, B., Hofman, G., Henricks, P., & van Oosterhout, A. (2008). 1alpha,25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta. The Journal of Immunology , 180 (8), 5211-21. Tan, P., Sagoo, P., Chan, C., Yates, J., Campbell, J., Beutelspacher, S., et al. (2005). Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. The Journal of Immunology , 174 (12), 7633-44. Thomas, W., Smith, W.-A., Hales, B., Mills, K., & O'Brien, R. (2002). Characterization and immunobiology of house dust mite allergens. International Archives of Allergy and Immunology , 129 (1), 1-18. Tokuyama, Y. (1996). Retinoids as Ig Isotype-Switch Modulators The Role of Retinoids in Directing Isotype Switching to IgA and IgG1 (IgE) in Association with IL-4 and IL-5. Cellular Immunology , 170 (2), 230-234. Trombone, A., Tobias, K., Ferriani, V., Schuurman, J., Aalberse, R., Smith, A., et al. (2002). Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis. Clinical & Experimental Allergy , 32 (9), 1323-8. Tsai, J., Shen, H., & Chua, K. (2000). Purification of group 2 Dermatophagoides pteronyssinus allergen and prevalence of its specific IgE in asthmatics. International Archives of Allergy and Immunology , 121 (3), 205-10. van Etten, E., & Mathieu, C. (2005). Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. The Journal of Steroid Biochemistry and Molecular Biology , 97 (1-2), 93-101. Vignali, D., Collison, L., & Workman, C. (2008). How regulatory T cells work. Nature Reviews Immunology , 8 (7), 523-32. von Boehmer, H. (2007). Oral tolerance: is it all retinoic acid? The Journal of Experimental Medicine , 204 (8), 1737-9. Walker, L. (2007). Regulatory T cells: Folate receptor 4: a new handle on regulation and memory? Immunoloy and Cell Biology . Wan, Y., & Flavell, R. (2005). Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proceedings of the National Academy of Sciences of the United States of America , 102 (14), 5126-31. West, K. (2002). Extent of vitamin A deficiency among preschool children and women of reproductive age. The Journal of Nutrition , 132 (9 Suppl), 2857S-2866S. Wu, D., Mura, C., Beharka, A., Han, S., Paulson, K., Hwang, D., et al. (1998). Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. The American Journal of Physiology , 275 (3 Pt 1), C661-8. Yamaguchi, T., Hirota, K., Nagahama, K., Ohkawa, K., Takahashi, T., Nomura, T., et al. (2007). Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity , 27 (1), 145-59. Yu, S., & Cantorna, M. (2008). The vitamin D receptor is required for iNKT cell development. Proceedings of the National Academy of Sciences of the United States of America , 105 (13), 5207-12. Zhang, X., Izikson, L., Liu, L., & Weiner, H. (2001). Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration. The Journal of Immunology , 167 (8), 4245. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/43699 | - |
dc.description.abstract | 已知維生素A視網酸、維生素D 1,25-dihydroxyvitamin D3、維生素E α-toco- pherol與葉酸會參與免疫調控影響免疫反應。本研究分別分離出正常鼠、塵蟎蛋白(Dp2)致敏鼠及口服Dp2致敏鼠的初代脾臟、腸繫膜淋巴結(MLN)和腸道皮耶氏體(PP)細胞,以體外培養模式,比較四種維生素在不同生理情況影響T細胞的效應,並以口服Dp2致敏鼠初代脾臟細胞培養,探討這些維生素對調節型T細胞(Treg)的影響,進一步探究維生素是否能提升口服致敏原所誘發之Treg的表現。最後,以飲食缺乏維生素D之動物模式,探討維生素D對免疫系統的影響。本研究Dp2致敏鼠,利用腹腔注射Dp2致敏原兩次的方式,確實可以成功提高小鼠血清中總IgE抗體的含量,顯示小鼠在兩次腹腔注射之後,已產生過敏免疫反應。口服Dp2致敏鼠除了腹腔注射Dp2之外,並同時連續7天餵食致敏原Dp2。結果顯示,脾臟細胞Treg在Dp2特異性刺激下,Control組與口服組Foxp3+ Treg的百分比均有顯著提升,口服組Treg表現顯著較Control組高,顯示口服Dp2鼠初代細胞在特異性抗原刺激下可以明顯誘發Treg表現。在三項實驗小鼠初代細胞培養模式中,視網酸、1,25-dihydroxyvitamin D3與α-tocopherol皆有減弱IFN-γ或IL-2、增強IL-5細胞激素的作用。1,25-Dihydroxyvitamin D3與α-tocopherol可以促進正常小鼠脾臟細胞分泌IFN-γ。在兩項致敏小鼠脾臟細胞中,視網酸與1,25-dihydroxyvitamin D3均降低抑制性細胞激素IL-10和TGF-β1。葉酸對正常及致敏小鼠脾臟Th1細胞激素沒有影響,但在口服Dp2小鼠細胞顯著增加IFN-γ與IL-2,且明顯提升IL-10和TGF-β1表現。在口服Dp2小鼠腸道淋巴結中,視網酸顯著降低MLN細胞中口服Dp2所誘發之Treg百分比,1,25-dihydroxyvitamin D3則顯著抑制PP細胞Foxp3的表現,只有葉酸明顯增加MLN細胞Treg比例。因此葉酸具有促使口服Dp2鼠Th2傾向之脾臟細胞轉向Th1的作用,也能提高口服致敏原所誘發之Treg的表現,並增加抑制性細胞激素的分泌。本研究餵食親代母鼠缺乏維生素D飼料6週,再使之與公鼠交配產生缺乏維生素D子代小鼠(VDD)。結果顯示,VDD組血清中維生素D營養指標25-hydroxyvitamin D3與肝臟重量均顯著較Control組低。以流式細胞儀分析肝臟、脾臟及腸繫膜淋巴結中各種免疫細胞的組成,發現缺乏維生素D可以顯著改變肝臟中多項免疫細胞的比例,無論6週齡或12週齡VDD組均以肝臟免疫細胞變化最明顯,其中以自然殺手T細胞(Natural Killer T cell, NKT)與B1細胞亞群受維生素D缺乏的影響最顯著。因此,維生素D對於肝臟免疫系統發展成熟的過程扮演不可或缺的角色。 | zh_TW |
dc.description.abstract | Vitamin A (retinoic acid), D (1,25-dihydroxyvitamin D3), E (α-tocopherol) and folic acid has been associated with immuno-modulation for a long time. Most of these vitamins involved in the development of Foxp3+ regulatory T cell (Treg). However, it remains unclear whether vitamins are capable of converting already activated and polarized T cells to Tregs and, thereby, to interfere with unwanted, ongoing immune responses. In order to identify the immuno-regulatroy effects of these vitamins on polarized T cells and Tregs, we examined the effects of these vitamins on cytokine production and Treg expression using in vitro primary spleen, mesenteric lymph node (MLN) and Peyer’s patch (PP) cell culture from normal, Der p 2 (Dp2)-sensitized as well as Dp2-sensitized and oral administered BALB/c mice. Treatment with retinoic acid, 1,25-dihydroxyvitamin D3 and α-tocopherol in primary cell culture strongly decreased IFN-γ or IL-2, but enhanced IL-5. Both 1,25-dihydroxyvitamin D3 and α-tocopherol could increase the IFN-γ production in primary splenocyte culture from normal mice. Besides, retinoic acid and 1,25-dihydroxyvitamin D3 strongly inhibited IL-10 and TGF-β1 secretion in splenocyte culture from Dp2-sensitized as well as Dp2-sensitized and oral administered mice. Folic acid had no effects on Th1 cytokine production from normal and Dp2-sensitized mice; however, we found that in primary splenocyte culture from Dp2-sensitized and oral administered mice, folic acid effectively increased IFN-γ and IL-2 production. The inhibitory cytokines, IL-10 and TGF-β1, were also highly produced by splenocytes after in vitro treatment with folic acid. Unlike retinoic acid, folic acid efficiently promote the in vitro generation of Foxp3+ Treg in MLN cell culture from Dp2-sensitized and oral administered mice. These data show that folic acid has the potential of switching Th2-bias T cell response toward Th1 and enhancing the expression of Tregs induced by Dp2 feeding. Furthermore, we investigated the in vivo effects of vitamin D deficiency on phenotypic frequency of immune cells and cytokine secretion in liver, spleen and mesenteric lymph node from vitamin D deficient C57BL/6 mice. We demonstrated that the distribution of immune cells from control mice will be dramatically altered, no matter at age 6-week or 12-week, in vitamin D deficient mice, especially Natural Killer T cell and B1 cell subsets in liver. These data suggest that vitamin D may play an important and necessary role in the normal development of liver immune system. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T02:26:18Z (GMT). No. of bitstreams: 1 ntu-98-R95b47307-1.pdf: 5038060 bytes, checksum: f926bc09f935e1eb101b627b66b674dd (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 中文摘要 I
英文摘要 III 目錄 V 圖目錄 IX 表目錄 X 第一章 序論 第一節 文獻回顧 1 一、營養素與免疫反應 1 (一)維生素A 1 (二)維生素D 2 (三)維生素E 4 (四)葉酸 5 二、調節型T細胞與口服耐受性 6 (一)調節型T細胞的功能與來源 6 (二)口服耐受性與腸道免疫系統 7 (三)腸道免疫系統與調節型T細胞 8 三、塵蟎過敏原 9 (一)家塵蟎與過敏性氣喘 9 (二)Dp2與口服耐受性 11 第二節 研究動機與大綱 13 一、研究動機 13 二、研究大綱 14 第二章 材料與方法 第一節 Dp2之生產與純化 15 一、來源 15 二、菌種準備 15 三、發酵流程 16 四、蛋白質純化 18 五、蛋白質定量 18 六、蛋白質電泳 19 第二節 實驗分析 23 一、血清收集 23 二、初代細胞之收集與培養 23 (一)脾臟細胞 23 (二)腸繫膜淋巴結細胞 24 (三)腸道皮耶氏體細胞 24 (四)肝臟淋巴細胞 25 三、脾臟細胞存活率 27 四、脾臟細胞增生 27 五、細胞激素 28 (一)酵素連結免疫分析法(ELISA) 28 (二)BDTM Cytometric Bead Array (CBA) 32 六、血清總IgE抗體 32 七、血清25-Hydroxy Vitamin D3 34 八、免疫細胞表型分析 34 九、統計分析 36 第三節 實驗流程 37 一、正常小鼠細胞模式 37 (一)動物飼養 37 二、Dp2致敏小鼠細胞模式 37 (一)動物飼養 37 (二)致敏方式 38 三、口服Dp2致敏小鼠細胞模式 39 (一)動物飼養 39 (二)致敏與管餵 39 四、缺乏維生素D子代鼠動物模式 41 (一)動物飼養 41 (二)脾臟細胞之收集與培養 42 第三章 結果與討論 第一節 Dp2純化與致敏小鼠細胞模式 43 一、Dp2純化分析 43 二、Dp2致敏對血清總IgE含量的影響 43 三、口服Dp2對調節型T細胞表現的影響 44 第二節 視網酸對小鼠初代免疫細胞的影響 45 一、脾臟細胞存活率 45 二、脾臟細胞增生能力 45 三、細胞激素分泌 45 (一)脾臟細胞 45 (二)腸繫膜淋巴結細胞 46 四、調節型T細胞之表現 47 第三節 1,25-Dihydroxyvitamin D3對小鼠初代免疫細胞的影響 48 一、脾臟細胞存活率 48 二、脾臟細胞增生能力 48 三、細胞激素分泌 48 (一)脾臟細胞 48 (二)腸繫膜淋巴結細胞 49 四、調節型T細胞之表現 50 第四節 α-Tocopherol對小鼠初代免疫細胞的影響 51 一、脾臟細胞存活率 51 二、脾臟細胞增生能力 51 三、細胞激素分泌 51 (一)脾臟細胞 51 (二)腸繫膜淋巴結細胞 52 四、調節型T細胞之表現 52 第五節 葉酸對小鼠初代免疫細胞的影響 53 一、脾臟細胞存活率 53 二、脾臟細胞增生能力 53 三、細胞激素分泌 53 (一)脾臟細胞 53 (二)腸繫膜淋巴結細胞 54 四、調節型T細胞之表現 55 第六節 缺乏維生素D對小鼠子代免疫反應的影響 56 一、生長情形與器官重量 56 二、血清25-Hydroxy Vitamin D3 56 三、免疫細胞表型分析 56 (一)肝臟免疫細胞 56 (二)脾臟細胞 57 (三)腸繫膜淋巴結細胞 57 四、脾臟細胞激素分泌 58 第四章 結論 第一節 綜合討論 88 一、維生素與小鼠初代細胞Th1/Th2細胞激素平衡之關係 88 二、維生素與口服Dp2致敏小鼠調節型T細胞表現之關係 90 三、缺乏維生素D對小鼠子代肝臟及脾臟免疫細胞的影響 93 第二節 結論 95 參考文獻 97 | |
dc.language.iso | zh-TW | |
dc.title | 維生素對小鼠初代免疫細胞及子代免疫反應的影響 | zh_TW |
dc.title | In vitro and In vivo Study on The Immuno-regulatory Effects of Vitamins on Mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 江伯倫,黃青真,李昆達,吳文勉 | |
dc.subject.keyword | 視網酸,1,25-dihydroxyvitamin D3,α-tocopherol,葉酸,塵蟎,蛋白Dp2,口服耐受性,Foxp3+調節型T細胞, | zh_TW |
dc.subject.keyword | retinoic acid,1,25-dihydroxyvitamin D3,α-tocopherol,folic acid,Der p 2,oral tolerance,Foxp3+ regulatory T cell, | en |
dc.relation.page | 106 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-08-18 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-98-1.pdf 目前未授權公開取用 | 4.92 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。