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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳俊宏(Jiun-Hong Chen) | |
dc.contributor.author | Hsin-Cheuh Chen | en |
dc.contributor.author | 陳欣玨 | zh_TW |
dc.date.accessioned | 2021-06-15T01:45:46Z | - |
dc.date.available | 2009-07-27 | |
dc.date.copyright | 2009-07-27 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-07-09 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/43261 | - |
dc.description.abstract | 漢丁頓舞蹈症是一種遺傳性的神經退化性疾病,主要的特徵是由REST/NRSF所調控的基因轉錄受到抑制,導致紋狀體的神經細胞大量死亡。REST/NRSF是一個抑制型轉錄因子,會與啟動子上一段含有23個鹼基對的保守序列RE1/NRSE結合,藉此在胚胎幹細胞、未分化的神經先驅幹細胞及非神經細胞中,抑制與許多神經有關的基因表現。REST/NRSF會招募許多輔助抑制物,包括C端結合蛋白CtBP1, 而形成一個新奇複合物,藉此執行抑制的功能。我們實驗室先前從GCH-1的顯性負面調控機制中,鑑定了一個新奇基因Bec1。Bec1的C端有一個保守的YTH區域,此保守區域曾被證明具有與RNA結合及ATP水解酶的能力。在我們的研究中,我們發現Bec1會藉由與CtBP1結合,來誘導某些含有RE1/NRSE序列的基因表現,例如:SCG10、BDNF。同時,Bec1的YTH區域對於Bec1及CtBP1兩者間結合是很重要的。另外,我們實驗室之前的實驗結果顯示Bec1在R6/2老鼠中,其表現量會降低,而我們的實驗結果也發現突變的Huntingtin會減少細胞中可溶解的Bec1蛋白質。Bec1蛋白質表現量的降低可能也是造成在漢丁頓舞蹈症中含有RE1/NRSE序列的基因表現受到抑制的原因之一。 | zh_TW |
dc.description.abstract | Huntington’s disease is an inherited neurodegenerative disease characterized by the repression of REST/NRSF target gene transcription, leading to large amounts of neuron death in the striatum. REST/NRSF is a silencing transcription factor binding to a consensus 23bp DNA sequence in promoter, RE1/NRSE, to restrict neural gene expression in embryo stem cells, undifferentiated neuronal progenitor and non-neuronal cells. REST/NRSF recruits a lot of corepressor, including a C-terminal binding protein, CtBP1, and forms a novel corepressor complex, to exert repression activity. Our lab previously identified a novel gene, Bec1, from the GCH-1 dominant negative cell models. The C-terminal of Bec1, a conserved YTH domain, has been recorded having RNA-binding and ATPase ability. In our study, we discovered that Bec1 can induce some RE1/NRSE-containing gene expression, such as SCG10 and BDNF, through interaction with CtBP1. Meanwhile, the YTH domain of Bec1 is important for Bec1 and CtBP1 interaction. Furthermore, our lab previously shows that Bec1 is reduced in R6/2 mice and our data also are found that mutant Htt reduces soluble Bec1 in cells. The reduction of Bec1 might be a reason for RE1/NRSE gene repression in HD. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T01:45:46Z (GMT). No. of bitstreams: 1 ntu-98-R96b41023-1.pdf: 5559709 bytes, checksum: f8b634e085218465ca4d1f84b31d6dcd (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | Contents
口試委員審定書 i 誌謝 ii 中文摘要 iii English Abstract iv Abbrevation v Chapter1 Introduction 1 1.1 The role of REST/NRSF during neuronal development 1 1.2 The corepressor CtBP 5 1.3 The novel gene Bec1 and its known function 6 1.4 Huntington’s disease 9 Chapter2 Materials and Methods 14 2.1 Plasmid constructions 14 2.1.1 Luciferase Reporter gene constructs 14 2.1.2. siRNA constructs for REST/NRSF gene suppression 15 2.1.3. Dominant-negative NRSF 16 2.1.4. CtBP expression constructs 16 2.1.5. Full-length, deleted and mutant form of Bec1 expression constructs 16 2.1.6. PolyQ constructs 17 2.2 STHdHQ7 and STHdHQ109 cell 18 2.3 Cell culture and transient transfection 18 2.4 R6/2 mice 19 2.5 Luciferase assay 19 2.6 RT-PCR 19 2.7 Immunofluorescence staining 20 2.8 Chromatin immunoprecipitation (ChIP 21 2.9 GST and His tagged protein induction 22 2.10 GST-pull down assay 22 2.11 Western blotting 23 2.12 Separation of protein soluble fractions and precipitates 24 Chapter 3 Results 25 3.1 RE1/NRSE is a silencer of SCG10 promoter and represses SCG10 expression by REST/NRSF repressive complex mediation 25 3.1.1 The RE1/NRSE regulates SCG10 expression in REST/NRSF+ cell in vitro 25 3.1.2 Silencing of REST/NRSF by a siRNA strategy results in an increase of SCG10 transcription in REST/NRSF+ cell in vitro and in vivo 26 3.1.3 Overexpression of dominant-negative NRSF (dn NRSF) reverses REST/ NRSF-mediated SCG10 suppression in vitro 27 3.1.4 SCG10 is silenced through histone modification not by DNA methylation 27 3.2 Bec1 promotes RE1/NRSE-containing gene expression 28 3.2.1 Bec1 induces SCG10 expression in vitro 28 3.2.2 Repression of neuronal gene expression is disrupted by Bec1 in vivo 29 3.3 Bec1 increases some neural-specific genes expression by impairing the REST/NRSF repression system 30 3.4 Interaction of Bec1 and CtBP1 is a possible mechanism for RE1/NRSE-containing gene derepression 31 3.4.1 Subcellular localization of Bec1 in HeLa cell 31 3.4.2 Subcellular localization of CtBP1 in HeLa cel 31 3.4.3 Interaction of Bec1 and CtBP1 32 3.4.4 Bec1 interacts with CtBP1 by C-terminal domain 32 3.4.5 Bec1 and CtBP1 interact directly in vitro, and YTH domain of Bec1 is significant in this event 33 3.5 The protein level of Bec1 is reduced in STHdHQ7and STHQ109cells during neural differentiation 34 3.6 81Q-Htt facilitates aggregate formation of Bec1 35 Chapter 4 Discussion 36 4.1 Bec1 is a novel gene involved in neural differentiation 36 4.2 Bec1 induces neuronal gene expression by derepressing REST/NRSF repressive complex 37 4.3 Bec1-CtBP1 interaction is a possible mechanism for REST/NRSF repressive complex disruption 38 4.4 YTH domain of Bec1 is significant for CtBP1 binding and RE1/NRSE-containing gene induction 39 4.5 Bec1 is aggregated by mutant Htt and lost its function in R6/2 mice 40 4.6. Bec1 is aggregated by mutant Htt and lost its function in R6/2 mice 41 Chapter 5 Reference 43 Chapter 6 Figures and Tables 55 Figure 1. Repression of SCG10 expression by REST/NRSF 55 Figure 2. Induction of SCG10 Expression by dnNRSF or siNRSF in vitro 56 Figure 3. Induction of SCG10 by Bec1 in vivo 57 Figure 4. Induction of SCG10 by Bec1 and d200 in vitro 58 Figure 5. Induction of SCG10 by Bec1 in vivo 59 Figure 6. Induction of SCG10 expression by interfering REST /NRSF repressive complex in vivo 60 Figure 7. Immunofluorescence staining of co-localization of Bec1 and CtBP1 61 Figure 8. Interaction of Bec1 and CtBP1 by GST-pull down assay analysis 62 Figure 9. Direct interaction of Bec1 and CtBP1 63 Figure 10. Direct interaction of Bec1 and CtBP1 64 Figure 11. Reduction of proteins level of Bec1 in STHdHQ7 and STHdHQ109 cells during neural differentiation 65 Figure 12. Promotion of Bec1 aggregation by 81Q-Htt 66 Table 1. Plasmid constructs used in our study 67 Table 2. Primers used in RT-PCR 68 Chapter 7 Appendix 69 Appendix 1. NRSE/RE1 sequences in neural-specific gene 69 Appendix 2. Model of NRSE/RE1 dependent NRSF/REST repressive complex 70 Appendix 3. Reduction of Bec1 in R6/2 mice 71 Appendix 4. Amino acid sequence and possible functional domain of Bec1 72 Appendix 5. Involvement of Bec1 in cholinergic neuron differentiation 73 Appendix 6.The corepressors role of CtBP in REST/NRSF repressive complex 74 | |
dc.language.iso | en | |
dc.title | Bec1/CtBP1複合體在神經分化及漢丁頓舞蹈症對含有RE1/NRSE 基因表現的調控 | zh_TW |
dc.title | The Role of Bec1/CtBP1 complex in Regulation of RE1/NRSE-Containing Gene Expression in Neuronal Gene Differentiation and Huntington’s disease | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 李玉梅(Yu-May Lee) | |
dc.contributor.oralexamcommittee | 張?仁(Ching-Jin Chang),陳儀莊(Yi-juang Chern),杜邦憲(Pang-Hsien Tu) | |
dc.subject.keyword | 漢丁頓舞蹈症,RE1/NRSE,REST/NRSF,Bec1,CtBP1,YTH區域, | zh_TW |
dc.subject.keyword | RE1/NRSE,REST/NRSF,CtBP1,YTH domain, | en |
dc.relation.page | 74 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-07-09 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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