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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張尊國 | |
| dc.contributor.author | Shu-De Lin | en |
| dc.contributor.author | 林恕德 | zh_TW |
| dc.date.accessioned | 2021-06-15T01:19:00Z | - |
| dc.date.available | 2009-07-29 | |
| dc.date.copyright | 2009-07-29 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-27 | |
| dc.identifier.citation | 1. 王一雄 (1997)。土壤環境污染與農藥，明文書局，臺北，16，229-260。
2. 方瀅絜 (2007)。健康傳播宣傳效果研究-以社區檳榔防制宣導為例。世新大學傳播管理學研究所碩士論文。 3. 朱健銘 (2000)。土地利用空間型態之研究。國立臺灣大學地理學研究所碩士論文。 4. 李靜芬，何佩珊，郭瑩璱，楊奕馨 (2008)。臺灣地區行業與職業別檳榔嚼食率及吸菸盛行率比較。臺灣口腔醫學衛生科學雜誌，24，182-204。 5. 邱皓政 (2002)。量化硏究與統計分析 : SPSS中文視窗版資料分析範例解析。五南出版社，臺北市。 6. 何勝惟 (2002)。應用多變量統計於土壤重金屬污染與土地利用之分析。國立臺灣大學生物環境系統工程學研究所碩士論文。 7. 林主恩 (2002)。全民健保的實施對醫療資源分佈影響之空間統計分析。國立臺灣大學經濟研究所碩士論文。 8. 周國屏、謝純瑩 (2002)。應用空間自相關分析於人口老化時空變遷之研究，人口學刊，25，91-119。 9. 胡立諄、賴進貴 (2006)。臺灣女性癌症的空間分析。臺灣地理資訊學刊，4，39-55。 10. 胡立諄 (2007)。臺灣癌症的空間分析。國立臺灣大學地理環境資源學研究所碩士班論文。 11. 陳怡君 (2005)。臺東池上地區蛇紋岩土壤中鉻和鎳之生物地質化學特徵。屏東科技大學環境工程與科學系所碩士論文。 12. 張尊國，黃國珍，徐貴新 (1997)。土壤重金屬污染特性探討-因子分析。中國農業工程學報，43(2)，11-19。 13. 黃聖峰 (2004）。臺灣各縣市經濟指標空間自相關分析─兼論工資收斂性假說。 世新大學經濟學系研究所碩士論文。 14. 彭漣漪 (1997)。生病的環境生病的人。摘自天下雜誌編，環境臺灣，173-180。 15. 鄒克萬 (2000)。區域人口分布之時空分析。臺灣土地科學學報，1，33-50。 16. 楊奕馨，陳鴻榮，曾筑瑄、謝天渝 (2002)。臺灣地區各縣市良嚼食率調查報告。臺灣口腔醫學衛生科學雜誌，18，1-16。 17. 趙怡惠 (2003)。臺灣地區山地鄉與非山地鄉嬰幼兒死亡率的差異研究。國立臺灣大學經濟學研究所碩士論文。 18. 鄭淑娟 （2002），一階格點空間模型之方向相關係數檢定，國立清華大學統計學研究所碩士論文。 19. 鄭克聲，張尊國，張丕宇 (2002)。農地土壤重金屬調查與場址列管計畫，111公頃，行政院環保署，EPA-90-GA13-03-90A285，中鼎工程股份有限公司。 20. 劉滄棽，郭鴻裕，朱戩良，連深 (2007)。臺灣東部蛇紋岩母質化育土壤地區重金屬特性之初探。臺灣農業研究，56，65-78。 21. 鍾建安 (2007)。以克利金法建構臺灣地區生活型態及健康行為。國立彰化師範大學統計資訊研究所碩士論文。 22. 顏月珠 (1992)。 無母數統計方法(再版)，三民書局，臺北市。 23. 謝純瑩，周國屏 (2002) 應用空間自相關分析於人口老化時空變遷之研究。人口學刊，25，91-119。 24. Akaike H. (1974). A new look at the statistical model identification. IEEE. Transactions on Automatic Control, AC-19, 716-723. 25. Akaike H. (1981). Likelihood of a Model and Information Criteria. Journal of Econometrics 16, 3-14 26. Alloway, B. J. (1995). Heavy metal in soils, 2nd ed., Blackie Academic and Professional, Glasgow, UK. 27. American Institute for Cancer Research (AICR) (1999). Stopping Cancer BeforeIit Starts , New York: Golden Books. 癌症止步(馬雨沛譯)。臺北：原水出版社。 28. Anselin L. (1988) Spatial Econometrics: Methods and Models., Kluwer Academic: Boston Mass. 29. Anselin, L. (1995). Local Indicators of Spatial Association –LISA. Geographical Analysis 27, 94-115. 30. Anselin, L. (1996). The Moran scatter plot as an ESDA tool to assess local instability in spatial association. In Fischer, M., Scholten, J. and Unwin, D.(eds.) Spatial Analytical Perspectives on GIS. London: Taylor & Francis, 111-125. 31. Anselin L. (2003). An Introduction to Spatial Autocorrelation Analysis with GeoDa, Spatial Analysis Laboratory Department of Agricultural and Consumer Economics University of Illinois, Urbana-Champaign Urbana, IL 61801. 32. Anselin L. (2003). GeoDaTM 0.9 User’s Guide, Spatial Analysis Laboratory Department of Agricultural and Consumer Economics University of Illinois, Urbana-Champaign Urbana, IL 61801. 33. Albanese S., De Luca M. L., De Vivo B., Lima A., Grezzi G. (2008). Relationships Between Heavy Metal Distribution and Cancer Mortality Rates in the Campania Region, Italy. Environmental Geochemistry - Site Characterization, Data Analysis and Case Histories, Chp 16, 387-400. 34. Augustin J., Zejda R. (1991). Cancer incidence and geochemical factors in the environment. The Science of the Total Environment 106, 155-163. 35. Baller R. D., Messner S. F., Anselin L., Deane G. (2002). The Interchangeability of Homicide Data Sources: A Spatial Analytical Perspective. Homicide Studies 6, 211-227. 36. Block, C. R., Block, C. R., (1995). Space, Place and Crime: Hot Spot Areas and Hot Places of Liquor-Related Crime, In Crime Places in Crime Theory. edited by John E. Eck and David Weisburd. Newark, NJ: Rutgers Crime Prevention Studies Series, Criminal Justice Press. 37. Chen C. H. (1990). Igneous rocks in Taiwan. Central Geological Survey, Ministry of Economic Affairs, Teipei, 137. 38. Cliff A. D., Ord J. K. (1969). The problem of spatial autocorrelation. In Scott A. J., ed., Studies in regional science. London: Pion, 25-55. 39. Cliff A. D., Ord J. K. (1973). Spatial autocorrelation. London: Pion. 40. Cressie N.（1991). Statistics for spatial data. New York: Wiley. 41. Choi S.Y., Kahyo H. (1991). Effect of cigarette smoking and alcohol consumption in the aetiology of cancer of the oral cavity, pharynx and larynx. International Journal of Epidemiology 20, 878-885. 42. Dally H., Hartwig A. (1997). Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells. Carcinogenesis 18, 1021-1026. 43. Demirel R., Erdogan S., Sozen M. (2009). Determination of High Risk Regions of Human Brucellosis in Turkey Using Exploratory Spatial Analysis. Turkiye Klinikleri Journal of Medical Sciences 29, 25-35. 44. Dever G. E. A. (1975). An Epidemiological Model for Health Policy Analysis. Social Indicators Research 2, 453-466. 45. Doreian P. (1980). Linear Models with Spatially Distributed Data: Spatial Disturbances or Spatial Effects. Sociological Methods and Research 9, 29-60. 46. Doreian P. (1982). Maximum Likelihood Methods for Linear Models: Spatial Effect and Spatial Disturbance Terms. Sociological Methods and Research 10, 243-269. 47. Eker P., Sanner T. (1983). Assay for initiators and promoters of carcinogenesis based on attachment-independent survival of cells in aggregates. Cancer Res 43, 320-323. 48. Ferlay J, Bray F, Pisani P, et al. Globocan (2000). Cancer Incidence, Mortality and Prevalence Worldwide. Version 1.0. Lyon, France: IARC Press, 2001. 49. Franceschi S., Levi F., Vecchia C. L., Conti E., Maso L. D., Barzan L., Talamni R. (1999). Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer. International journal of cancer 83, 1-4. 50. Gallo J. L., Ertur C. (2003). Exploratory spatial data analysis of the distribution of regional per capita GDP in Europe, 1980–1995. Papers in Regional Science 82, 175-201. 51. Glick, B. (1979). The spatial autocorrelation of cancer mortality. Social science & medicine 13, 123-130. 52. Grant R. and Grant C. (Eds.) (1987). Grant and Hackh's Chemical Dictionary, New York: McGraw-Hill. 53. Huillier L. L., Edighoffe S. (1996). Extractability of nickel and its concentration in cultivated plants in Ni rich ultramafic soils of New Caledonia. Plant and Soil 186, 255-264. 54. IARC (1980). Arsenic and arsenic compounds. IARC Monograph on Evaluation of Carcinogenic Risk to Humans 23, 39–141. 55. IARC (2004). Betel-quid and areca-nut chewing and some arecanut related nitrosamines. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 85. 56. IARC (1987). Cadmium and cadmium compounds. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 58, 139–142. 57. IARC (1990). Chromium, Nickel and Welding. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 49, 1–677. 58. IARC (2006). Inorganic and Organic Lead Compounds. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 87. 59. IARC (1982). Lead and Lead Compounds. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 23, 325. 60. IARC (2004). Tobacco Smoke and Involuntary Smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 83. 61. Kasprzak K. S. (1995). Possible role of oxidative damage in metal-induced carcinogenesis. Cancer invest 13, 411-430. 62. Keller A. Z. and Terris M. (1965). The association of alcohol and tobacco with cancer of the mouth and pharynx. American Journal of Public Health and the Nation's Health 55, 1578-1585. 63. Ko Y. C. , Huang Y. L., Lee C. H., Chen M. J., Lin L. M., Tsai C. C. (1995). Betel quid chewing, cigarette smoking and alcohol consumption reiated to oral cancer in Taiwan. Journal of Oral Pathology & Medicine 24, 450-463. 64. Lam N. S. (1986) .Geographical patterns of cancer mortality in China. Social Science and Medicine 23, 241-247. 65. Lea T., Griffith D. (2001). Opposites don’t attract in spatial autocorrelation, GEOWOLD 14, 42-44. 66. Lee Y. W., Klein C. B., Kargacin B. (1995). Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation：a new model for epigenetic carcinogens. Molecular and Cellular Biology 15, 2547-2557. 67. Lim U. (2003). A Spatial Analysis of Regional Income Convergence, University of Texas Planning Forum 9, 60-78. 68. Lu C. T., Yeh Y. Y., Ho C. S., Ko Y. C., Tsai C. C., Hsieh C. C. (1996). A case-control study of oral cancer in Changhua County, Taiwan. Journal of Oral Pathology & Medicine 25, 245-248. 69. McGrath S. P. (1995). Chromium and nickel. In Heavy Metals in Soils, 2nd edn, ed Alloway BJ, Blackie Academic & Professional, London. 70. Moran, P. A. P. (1950). Notes on Continuous Stochastic Phenomena, Biometrika 37, 17–23. 71. Moscone F., Knapp M. (2005). Exploring the Spatial Pattern of Mental Health Expenditure. The Journal of Mental Health Policy and Economics 8, 205-217. 72. Muir K., Rattanamongkolgula S., Smallman M., Thomasc M., Downera S., Jenkinson C. (2004). Breast cancer incidence and its possible spatial association with pesticide application in two counties of England. Public Health 118, 513–520. 73. Negri E, Vecchia C. L., Franceschi S., Tavani A. (1993). Attributable risk for oral cancer in northern Italy. Cancer Epidemiology Biomarkers & Prevention 2, 189-193. 74. Neuberger J. S., Mulhall M., Pomatto M. C., Sheverbush J., Hassanein R. S. (1990). Health problems in Galena, Kansas: A Heavy metal mining superfund site. The Science of the Total Environment 94, 261-272. 75. Pouliou T., Elliott S. J. (2009). An exploratory spatial analysis of overweight and obesity in Canada. Preventive Medicine 48, 362-367. 76. Pulido M. D., Parrish A. R. (2003). Metal-induced apoptosis: mechanisms. Mutation Research 533, 227–241. 77. Rheeder J. P., Marasas W. F., Farina M. P., Thompson G. R., Nelson P. E.. (1994). Soil fertility factors in relation to oesophageal cancer risk areas in Transkei, southern Africa. European Journal of Cancer Prevention 3, 49-56. 78. Schwarz G. (1978). Estimating the dimension of a model. Annals of Statistics 6, 461-464. 79. Senesi G. S., Baldassarre G., Senesi N., Radina B. (1999). Trace element inputs into soils by anthropogenic activities and implications for human health. Chemosphere 39, 343-377. 80. Su C. C., Chung J. A., Hsu Y. Y., Huang S. J., Lian I. B. (2008). Age at diagnosis and prognosis of oral cancer in relation to the patient’s residential area: Experience from a medical center in Taiwan. Oral Oncology 44, 1032-1038. 81. Tim Nawrot, Michelle Plusquin, Janneke Hogervorst, Harry A Roels, Hilde Celis, Thijs L., Vangronsveld J., Hecke E. V., Staessen J. A. (2006). Environmental exposure to cadmium and risk of cancer: a prospective population-based study. The Lancet Oncology 7,119-126. 82. Türkdoğan M. K. , Kilicel F., Kara K. , Tuncer I., Uygan I. (2002). Heavy metals in soil, vegetables and fruits in the endemic upper gastrointestinal cancer region of Turkey. Environmental Toxicology and Pharmacology 13, 175-179. 83. Tobler, W. (1970). A computer movie simulating urban growth in the Detroit region, Economic Geography 46, 234–240. 84. Younas M., Afzal F. S., Khan I. M., Ali K. (1998). Assessment of Cd, Ni, Cu, and Pb pollution in Lahore, Pakistan. Environment International 24, 761-766. 85. Zeng D. D., Yan P., Li S. (2008). Spatial Regression-Based Environmental Analysis in Infectious Disease Informatics. BioSecure, 175-181. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42659 | - |
| dc.description.abstract | 口腔癌為臺灣地區急遽成長的癌症之ㄧ，男性成長率達17.89 %為近幾年來成長最快的癌症。本研究目的希望藉由統計分析方法初步找出導致口腔癌之可能環境影響因子，進一步提供未來臨床醫學及流行病學領域上相關研究方向之參考。以鄉鎮為單元，考慮環境因子土壤重金屬砷、鎘、鉻、銅、汞、鎳、鉛、鋅，以及生活習慣因子嚼食檳榔、抽菸為導致口腔癌之危險因子。結合Spearman等級相關和空間自相關Moran’s I檢定，挑選出與口腔癌呈現相關且具有空間特性之變數。最後比較不考慮空間特性的傳統迴歸模式與納入空間特性的空間誤差模式兩者結果之差異。許多研究已證實嚼食檳榔及抽菸之習慣因子皆會導致口腔癌，但在考慮空間特性之情況下，兩項致癌危險因子與口腔癌發生之間關係並不顯著，主要是由於兩致癌危險因子並無存在空間相關性，造成在此一研究模式下無法突顯出此兩項致癌危險因子的特性。而在環境因子中，唯獨土壤重金屬鎳與口腔癌的發生呈現顯著相關。推斷彰化地區為口腔癌高發區之原因，可能是因為在類似的嚼食檳榔及抽菸盛行率之下的鄉鎮單元，彰化地區當地土壤重金屬鎳濃度含量偏高所造成。導致彰化地區土壤鎳濃度較高的主因為早期急速工業化，工廠農地混雜且管理不當。因此推論工業化造成工廠集中、工廠管理不健全為促使居住於此環境污染下居民罹患口腔癌之風險增高。 | zh_TW |
| dc.description.abstract | The incidence rate of oral cancer in Taiwan is one of the rapidly growing cancers. For male, the increasing rate of oral cancer incidence is 17.89% between 2001 and 2005, and it is the fastest growing cancer. The purpose of this study was to find out the probably environmental factors of oral cancer by preliminary statistical methods step by step. These results can provide for areas of clinical medicine and epidemiology as a direction in the future. We took the soil heavy metal contents which include As, Cd, Cr, Cu, Hg, Ni, Pb, Zn and the lifestyle factors which include betel quid chewing (BQC) and cigarette smoking (CS) as risk factors for oral cancer. Spearman rank correlation in combination with spatial autocorrelation analysis was used to determine variables which positively correlate with oral cancer and have spatial characteristics. Finally, we compared the differences between these results of ordinary least regression and spatial regression error model. Many studies have been confirmed that BQC and CS habits will lead to oral cancer, but these results of this study revealed that the two lifestyle factors and oral cancer incidence are not significant when taking account of spatial characteristics. These showed that the spatial statistical method or the statistical unit of data types were unable to highlight the characteristics of these two lifestyle factors. For the environmental factors, nickel is the only one heavy metal which significantly correlates to oral cancer. Changhua county is with the most serious nickel contamination, so we infer that is why Changhua with higher incidence of oral cancer than the other towns with similar BQC or CS rates. Residents living in contaminated areas who suffer from a higher risk of oral cancer. And this study reveals that there is the most significant correlation between the soil heavy metal nickel and oral cancer incidence. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T01:19:00Z (GMT). No. of bitstreams: 1 ntu-98-R96622007-1.pdf: 2650906 bytes, checksum: af6d31fafaed7b8eb45590fc8589c699 (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 目錄
口試委員會審定書 I 誌謝 II 中文摘要 III 英文摘要 IV 表目錄 VIII 圖目錄 X 第一章 緒 論 1 1-1 前言 1 1-2 研究動機 2 1-2-1 口腔癌發生率的快速成長 2 1-2-2 土壤重金屬因子 6 1-3 研究目的 8 1-4 論文架構 10 第二章 文獻回顧 12 2-1 環境重金屬因子 12 2-2 臺灣地區農地土壤污染現地調查概況 13 2-3 生活習慣因子 20 2-4 空間統計分析 22 2-4-1探索式空間資料分析(Exploratory Spatial Data Analysis, ESDA) 24 2-4-2 空間自相關 25 2-4-3空間權重矩陣(Spatial Weights Matrix) 27 2-4-4 傳統迴歸模式與空間迴歸模式 31 第三章 材料與方法 34 3-1 材料 34 3-1-1 研究區域 34 3-1-2 臺灣地區鄉鎮單元平均重金屬濃度 34 3-1-3 口腔癌年齡標準化發生率資料 34 3-1-4 人類健康行為相關因子 35 3-2 研究方法 36 3-2-1 鄉鎮單元土地重金屬資料換算 36 3-2-2年齡標準化發生率(Age-Standardized Incidence Ratio, ASIR) 37 3-2-3人類健康行為相關因子 38 3-3 Spearman等級相關 40 3-4 空間自相關分析 41 3-4-1 全域型空間自相關檢定 41 3-4-2 區域型空間自相關檢定 43 3-5 空間迴歸分析 45 3-5-1 空間滯延模式(Spatial Lag Model, SLM) 46 3-5-2 空間誤差模式(Spatial Error Model, SEM) 47 3-5-3 迴歸模式檢定參數 48 第四章 結果與討論 50 4-1 敘述統計(Descriptive Statistics) 50 4-1-1 背景資料 50 4-1-2資料分佈型態 60 4-1-3 發生率與各因子趨勢比較 67 4-2 Spearman 等級相關分析 72 4-3 傳統迴歸分析 76 4-4 空間自相關 78 4-4-1全域自相關檢定分析(Global Spatial Autocorrelation) 78 4-4-2 不同門檻距離下的Moran’s I值變化 79 4-4-3 不同門檻距離下的空間自相關顯著水準檢定值Z(I)值變化 82 4-4-4 不同門檻距離下的傳統迴歸誤差項 84 4-4-5 區域空間自相關檢定分析(Local Spatial Autocorrelation) 87 4-5 空間迴歸模式 101 4-5-1 迴歸模式選定 101 4-5-2 迴歸模式之建立 103 4-5-3 空間迴歸模式與傳統迴歸模式比較 108 第五章 結論與建議 110 5-1 結論 110 5-2 研究限制與建議 111 第六章 參考文獻 112 | |
| dc.language.iso | zh-TW | |
| dc.title | 土壤重金屬含量與口腔癌發生率之空間相關性探討 | zh_TW |
| dc.title | The Investigation of Spatial Correlation between Soil Heavy Metals Content and the Incidence of Oral Cancer | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 鄭克聲,張文亮,林裕彬,余化龍 | |
| dc.subject.keyword | 重金屬,口腔癌,空間自相關,空間迴歸模式, | zh_TW |
| dc.subject.keyword | Heavy metals,Oral cancer,Spatial Autocorrelation,Spatial Regression Model, | en |
| dc.relation.page | 119 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-07-27 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物環境系統工程學研究所 | zh_TW |
| 顯示於系所單位： | 生物環境系統工程學系 | |
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