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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 段維新 | |
| dc.contributor.author | Sheng-Wen Yu | en |
| dc.contributor.author | 余勝文 | zh_TW |
| dc.date.accessioned | 2021-06-15T01:16:36Z | - |
| dc.date.available | 2010-07-30 | |
| dc.date.copyright | 2009-07-30 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-28 | |
| dc.identifier.citation | [1] L. L. Hench, J. R. Jones (Ed.), Biomaterials, Artificial Organs and Tissue Engineering, CRC press, New York (2005)
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42571 | - |
| dc.description.abstract | 本實驗中以傳統粉末製程製作三種壓電陶瓷，分別為鈮酸鈉鉀、鈮酸鋰鈉鉀以及鈦酸鋇。鈮酸鈉鉀粉末經由保存方法的改良，發現有助於之後的燒結並可得到較佳的性質。而經由添加鋰進行改質，可以提高燒結密度、壓電性以及機械強度。另外最佳燒結溫度也隨著之降低，顯示添加鋰可固溶於鈮酸鈉鉀。富鈦的鈦酸鋇粉末燒結後可觀察到異常晶粒成長。壓電塊材經由浸泡在生理食鹽水達28天，可發現三種壓電材料皆顯現高穩定度。同時間可以觀察到非對稱的氯化鈉晶體沈積，亦即晶體皆沈積在塊材的正極面。細胞毒性則是採用老鼠纖維母細胞作為測試細胞，並且採用MTT毒性測試。結果發現使用粉末萃取液當做測試溶液，仍可得到相當高的細胞存活率。其中鈮酸鈉鉀為基材的壓電陶瓷，在模擬活體環境下有高度穩定度及低度細胞毒性，可評估在後續生醫上的應用具有潛力。 | zh_TW |
| dc.description.abstract | In the present study, three kinds of piezoelectric ceramics, including K0.5Na0.5NbO3 (KNN), Li0.06K0.47Na0.47NbO3 (LKNN) and BaTiO3, were prepared by using conventional powder processing. A dry environment for the storage of the KNN and LKNN powders is beneficial for densification. The modification of KNN by doping lithium can improve its density, piezoelectricity and mechanical strength. The optimal sintering temperature is also decreased, indicating that a solid solution of KNN and lithium is formed. The BaTiO3 powder used is a Ti-rich BaTiO3 powder. Relatively large grains are found in the sintered specimens. All three bulk ceramics show high stability after immersion in normal saline for up to 28 days, and anisotropic deposition of NaCl crystal was observed. The cytotoxicity is investigated by using the MTT assay, and L929 fibroblasts were used as the testing cells. The viabilities of cells after treatment of powder extract were all high for three groups. The KNN-based piezoelectric ceramics showed high stabilities and low toxicity in body-simulated environment. Therefore, it is a potential material for further biomedical applications. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T01:16:36Z (GMT). No. of bitstreams: 1 ntu-98-R96527002-1.pdf: 11061540 bytes, checksum: 689e8e64ed660f638404434293e692cf (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | Chapter 1: Introduction 1
Chapter 2: Literature Review 3 2-1 Piezoelectricity vs. ferroelectricity 3 2-1-1 Origin of piezoelectricity 3 2-1-2 Hysteresis loop 6 2-1-3 Classification of ferroelectric materials 8 2-2 Piezoelectric ceramic implants 13 2-2-1 Hard tissue replacements 13 2-2-2 Bio-ceramics for hard tissue engineering 15 2-3 Issues of piezoelectric implants and related works 20 2-4 K0.5Na0.5NbO3-based piezoelectric ceramics 28 Chapter 3: Experimental Procedure 34 3-1 Materials 34 3-2 Preparation of piezoelectric ceramic powders 34 3-3 Preparation of specimens 35 3-4 Characterizations of material properties 36 3-4-1 Phase identification 36 3-4-2 Density measurement 36 3-4-3 Microstructure observation 37 3-4-4 Measurement of piezoelectricity 37 3-5 Degradation test 37 3-5-1 Immersion of samples 37 3-5-2 pH value and weight loss 38 3-5-3 Observation of samples 39 3-6 Cytotoxicity test 41 3-6-1 Cell culture 41 3-6-2 Extract preparation 42 3-6-3 Determination of cytotoxicity – MTT assay 42 Chapter 4: Results 44 4-1 Phase identification 44 4-2 Density 46 4-3 Microstructure observation 49 4-4 Ferroelectricity 52 4-5 Degradation test 55 4-5-1 pH value and weight loss 55 4-5-2 Characteristics after immersion 58 4-5-2-1 Surface morphology 58 4-5-2-2 Bulk properties 66 4-6 Cytotoxicity test 68 Chapter 5: Discussion 72 5-1 Influence of processing on sintered properties 72 5-1-1 Powder preparation 73 5-1-2 Sintering behavior 78 5-1-2-1 Density 78 5-1-2-2 Piezoelectricity 80 5-2 Degradation test 86 5-2-1 weight loss and pH value 86 5-2-2 Stability of bulk properties 90 5-3 Cytotoxicity 92 Chapter 6: Conclusions 98 References 100 | |
| dc.language.iso | en | |
| dc.subject | 細胞毒性 | zh_TW |
| dc.subject | 壓電陶瓷 | zh_TW |
| dc.subject | 浸泡測試 | zh_TW |
| dc.subject | 鈮酸鈉鉀 | zh_TW |
| dc.subject | 鈦酸鋇 | zh_TW |
| dc.subject | 添加鋰改質 | zh_TW |
| dc.subject | BaTiO3 | en |
| dc.subject | piezoelectricity | en |
| dc.subject | cytotoxicity | en |
| dc.subject | immersion test | en |
| dc.subject | Li0.06K.047Na0.47NbO3 | en |
| dc.subject | K0.5Na0.5NbO3 | en |
| dc.title | 壓電陶瓷作為生醫植入物之可行性研究 | zh_TW |
| dc.title | Feasibility study on using piezoelectric ceramics as biomedical implants | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林峰輝,劉典謨,謝宗霖 | |
| dc.subject.keyword | 鈮酸鈉鉀,鈦酸鋇,添加鋰改質,浸泡測試,細胞毒性,壓電陶瓷, | zh_TW |
| dc.subject.keyword | K0.5Na0.5NbO3,BaTiO3,Li0.06K.047Na0.47NbO3,immersion test,cytotoxicity,piezoelectricity, | en |
| dc.relation.page | 109 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-07-28 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 材料科學與工程學系 | |
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