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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 江伯倫 | |
| dc.contributor.author | Kun-Po Li | en |
| dc.contributor.author | 李坤珀 | zh_TW |
| dc.date.accessioned | 2021-06-15T01:15:09Z | - |
| dc.date.available | 2009-09-15 | |
| dc.date.copyright | 2009-09-15 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-28 | |
| dc.identifier.citation | Allman, D., and Pillai, S. (2008). Peripheral B cell subsets. Current Opinion in Immunology 20, 149-157.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42510 | - |
| dc.description.abstract | B-1 cells are a class of atypical B lymphocytes distinguished from conventional B-2 cells. It has been reported that the B-1 cells may play some roles in innate immunity, autoimmune diseases, and leukemia. Since B-1 cells are one of the most important sources of IL-10, we hypothesize that the B-1 cells may suppress the T cells activity and induce the generation of Tr1 cells. The mouse peritoneal cavity cells were analyzed and the B-1 cells were purified for following experiments. These B-1 cells could spontaneously secreted IL-10 and up-regulated the IL-10 production after LPS stimulation. The B-1 cells would inhibit proliferation of T cells through soluble factors. However, the B-1 cells could not efficiently induce the generation of IL-10-producing Treg cells in our system. In the contrast, the B-2 cell-induced Treg cells, “TofB2” cells, showed suppressive ability, and they presented Foxp3-CD25+CD62L+ phenotype and expressed high level of IL-10 and IL-4. In conclusion, the B-1 cells inhibited proliferation of T cells through soluble factors, and the B-2 cells join the immune modulation through inducing Treg cells generation. In different mechanisms, both B cell populations play regulatory roles in immune response. The studies may provide potent clinical application in treatments for autoimmune diseases. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T01:15:09Z (GMT). No. of bitstreams: 1 ntu-98-R96449005-1.pdf: 5224644 bytes, checksum: 26acfbfbcb8caf453151b76364739090 (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 1. 摘要…………………………………………………………………………………i
2. Abstract……………………………………………………………………………ii 3. Contents…………………………………………………………………………iii 4. Contents of Figures………………………………………………………...…….iv 5. Introduction…………………………………..……………………………………1 6. Experimental Aims………………………………..………………………………9 7. Materials………………………………………………………………………….10 8. Methods…………………………………………………………………………..15 9. Results……………………………………………………………………………22 10. Discussion………………………………………………………………………...30 11. Figures……………………………………………………………………………39 12. References………………………………………………………………………63 | |
| dc.language.iso | en | |
| dc.subject | 介白素-１０ | zh_TW |
| dc.subject | Ｂ-１淋巴球 | zh_TW |
| dc.subject | Ｂ-２淋巴球 | zh_TW |
| dc.subject | 調節性Ｔ細胞 | zh_TW |
| dc.subject | Regulatory T cells (Treg) | en |
| dc.subject | B-1 Lymphocytes | en |
| dc.subject | IL-10 | en |
| dc.subject | B-2 Lymphocytes | en |
| dc.title | 研究B-1淋巴球在免疫調節功能的機轉 | zh_TW |
| dc.title | The Roles of B-1 Cells in Immune Modulation | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 沈家瑞,繆希椿 | |
| dc.subject.keyword | Ｂ-１淋巴球,Ｂ-２淋巴球,調節性Ｔ細胞,介白素-１０, | zh_TW |
| dc.subject.keyword | B-1 Lymphocytes,B-2 Lymphocytes,Regulatory T cells (Treg),IL-10, | en |
| dc.relation.page | 68 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-07-28 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 免疫學研究所 | zh_TW |
| Appears in Collections: | 免疫學研究所 | |
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| File | Size | Format | |
|---|---|---|---|
| ntu-98-1.pdf Restricted Access | 5.1 MB | Adobe PDF |
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