請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42208
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 姚宗珍 | |
dc.contributor.author | Hui-Yi Chen | en |
dc.contributor.author | 陳慧怡 | zh_TW |
dc.date.accessioned | 2021-06-15T00:52:53Z | - |
dc.date.available | 2013-10-05 | |
dc.date.copyright | 2011-10-05 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-14 | |
dc.identifier.citation | Andersen TL, del Carmen Ovejero M, Kirkegaard T, Lenhard T, Foged NT, Delaisse JM. 2004. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone 35(5): 1107-1119.
Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L. 1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656): 175-179. Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T. 1999. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med 190(12): 1741-1754. Atkins GJ, Kostakis P, Welldon KJ, Vincent C, Findlay DM, Zannettino AC. 2005. Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium. J Cell Physiol 203(3): 573-582. Banes AJ, Gilbert J, Taylor D, Monbureau O. 1985. A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro. J Cell Sci 75: 35-42. Bharti AC, Takada Y, Shishodia S, Aggarwal BB. 2004. Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism. J Biol Chem 279(7): 6065-6076. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA. 1993. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4(2): 197-250. Breckon JJW, Papaioannou S, Kon LWM, Tumber A, Hembry RM, Murphy G, Reynolds JJ, Meikle MC. 1999. Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro. Journal of Bone and Mineral Research 14(11): 1880-1890. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. 2003. Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 253(1-2): 269-285. Chambers TJ, Darby JA, Fuller K. 1985. Mammalian collagenase predisposes bone surfaces to osteoclastic resorption. Cell Tissue Res 241(3): 671-675. Chambers TJ, Magnus CJ. 1982. Calcitonin alters behaviour of isolated osteoclasts. J Pathol 136(1): 27-39. Cho NH, Hong KP, Hong SH, Kang S, Chung KY, Cho SH. 2004. MMP expression profiling in recurred stage IB lung cancer. Oncogene 23(3): 845-851. Crawford HC, Matrisian LM. 1996. Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells. Enzyme Protein 49(1-3): 20-37. Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. 1998. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem 273(32): 20551-20555. de Vernejoul MC. 1996. Dynamics of bone remodelling: biochemical and pathophysiological basis. Eur J Clin Chem Clin Biochem 34(9): 729-734. Debari K, Sasaki T, Udagawa N, Rifkin BR. 1995. An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions. Calcif Tissue Int 56(6): 566-570. Delaisse JM, Engsig MT, Everts V, del Carmen Ovejero M, Ferreras M, Lund L, Vu TH, Werb Z, Winding B, Lochter A et al. 2000. Proteinases in bone resorption: obvious and less obvious roles. Clin Chim Acta 291(2): 223-234. Domon S, Shimokawa H, Matsumoto Y, Yamaguchi S, Soma K. 1999. In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement. Arch Oral Biol 44(11): 907-915. Dreier R, Wallace S, Fuchs S, Bruckner P, Grassel S. 2001. Paracrine interactions of chondrocytes and macrophages in cartilage degradation: articular chondrocytes provide factors that activate macrophage-derived pro-gelatinase B (pro-MMP-9). J Cell Sci 114(Pt 21): 3813-3822. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89(5): 747-754. Elliot KJ, Millward-Sadler SJ, Wright MO, Robb JE, Wallace WH, Salter DM. 2004. Effects of methotrexate on human bone cell responses to mechanical stimulation. Rheumatology (Oxford) 43(10): 1226-1231. Everts V, Delaisse JM, Korper W, Jansen DC, Tigchelaar-Gutter W, Saftig P, Beertsen W. 2002. The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation. J Bone Miner Res 17(1): 77-90. Fazzalari NL. 2008. Bone remodeling: A review of the bone microenvironment perspective for fragility fracture (osteoporosis) of the hip. Semin Cell Dev Biol 19(5): 467-472. Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U. 1997. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11(24): 3482-3496. Freije JM, Balbin M, Pendas AM, Sanchez LM, Puente XS, Lopez-Otin C. 2003. Matrix metalloproteinases and tumor progression. Adv Exp Med Biol 532: 91-107. Frost HM. 1986. Intermediary organization of the skeleton. CRC Press, Boca Raton, Fla. Frost HM. 1997. Obesity, and bone strength and 'mass': a tutorial based on insights from a new paradigm. Bone 21(3): 211-214. Galazka G, Windsor LJ, Birkedal-Hansen H, Engler JA. 1996. APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide. Biochemistry 35(34): 11221-11227. Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF. 1994. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266(5184): 443-448. Gross J, Lapiere CM. 1962. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci U S A 48: 1014-1022. Halleen JM, Raisanen S, Salo JJ, Reddy SV, Roodman GD, Hentunen TA, Lehenkari PP, Kaija H, Vihko P, Vaananen HK. 1999. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem 274(33): 22907-22910. Harrison RK, Chang B, Niedzwiecki L, Stein RL. 1992. Mechanistic studies on the human matrix metalloproteinase stromelysin. Biochemistry 31(44): 10757-10762. Helfrich MH, Nesbitt SA, Lakkakorpi PT, Barnes MJ, Bodary SC, Shankar G, Mason WT, Mendrick DL, Vaananen HK, Horton MA. 1996. Beta 1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. Bone 19(4): 317-328. Hert J, Fiala P, Petrtyl M. 1994. Osteon orientation of the diaphysis of the long bones in man. Bone 15(3): 269-277. Hillam RA, Skerry TM. 1995. Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo. J Bone Miner Res 10(5): 683-689. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. 1997. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem 272(35): 22053-22058. Horton MA, Rimmer EF, Lewis D, Pringle JA, Fuller K, Chambers TJ. 1984. Cell surface characterization of the human osteoclast: phenotypic relationship to other bone marrow-derived cell types. J Pathol 144(4): 281-294. Hsieh YF, Turner CH. 2001. Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 16(5): 918-924. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I et al. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A 96(7): 3540-3545. Inui T, Ishibashi O, Inaoka T, Origane Y, Kumegawa M, Kokubo T, Yamamura T. 1997. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption. J Biol Chem 272(13): 8109-8112. John A, Tuszynski G. 2001. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res 7(1): 14-23. Kadow-Romacker A, Hoffmann JE, Duda G, Wildemann B, Schmidmaier G. 2009. Effect of mechanical stimulation on osteoblast- and osteoclast-like cells in vitro. Cells Tissues Organs 190(2): 61-68. Kelly T, Borset M, Abe E, Gaddy-Kurten D, Sanderson RD. 2000. Matrix metalloproteinases in multiple myeloma. Leuk Lymphoma 37(3-4): 273-281. Klein-Nulend J, Veldhuijzen JP, van Strien ME, de Jong M, Burger EH. 1990. Inhibition of osteoclastic bone resorption by mechanical stimulation in vitro. Arthritis Rheum 33(1): 66-72. Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N et al. 2000. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 191(2): 275-286. Kurata K, Uemura T, Nemoto A, Tateishi T, Murakami T, Higaki H, Miura H, Iwamoto Y. 2001. Mechanical strain effect on bone-resorbing activity and messenger RNA expressions of marker enzymes in isolated osteoclast culture. J Bone Miner Res 16(4): 722-730. Lagasse E, Weissman IL. 1997. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 89(7): 1021-1031. Lazenby RA. 1990a. Continuing periosteal apposition. I: Documentation, hypotheses, and interpretation. Am J Phys Anthropol 82(4): 451-472. Lazenby RA. 1990b. Continuing periosteal apposition. II: The significance of peak bone mass, strain equilibrium, and age-related activity differentials for mechanical compensation in human tubular bones. Am J Phys Anthropol 82(4): 473-484. Lin PM, Chen CT, Torzilli PA. 2004. Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage. Osteoarthritis Cartilage 12(6): 485-496. Liskova M, Hert J. 1971. Reaction of bone to mechanical stimuli. 2. Periosteal and endosteal reaction of tibial diaphysis in rabbit to intermittent loading. Folia Morphol (Praha) 19(3): 301-317. Liu W, Wang S, Wei S, Sun L, Feng X. 2005. Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4. J Biol Chem 280(52): 43064-43072. Macdonald BR, Takahashi N, Mcmanus LM, Holahan J, Mundy GR, Roodman GD. 1987. Formation of Multinucleated Cells That Respond to Osteotropic Hormones in Long-Term Human-Bone Marrow Cultures. Endocrinology 120(6): 2326-2333. MacQuarrie RA, Fang Chen Y, Coles C, Anderson GI. 2004. Wear-particle-induced osteoclast osteolysis: the role of particulates and mechanical strain. J Biomed Mater Res B Appl Biomater 69(1): 104-112. Makihira S, Kawahara Y, Yuge L, Mine Y, Nikawa H. 2008. Impact of the microgravity environment in a 3-dimensional clinostat on osteoblast- and osteoclast-like cells. Cell Biol Int 32(9): 1176-1181. Malemud CJ. 2006. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci 11: 1696-1701. Martin DK, Bootcov MR, Campbell TJ, French PW, Breit SN. 1995. Human macrophages contain a stretch-sensitive potassium channel that is activated by adherence and cytokines. J Membr Biol 147(3): 305-315. Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H et al. 2004. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem 279(25): 26475-26480. Matsuzaki K, Udagawa N, Takahashi N, Yamaguchi K, Yasuda H, Shima N, Morinaga T, Toyama Y, Yabe Y, Higashio K et al. 1998. Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem Biophys Res Commun 246(1): 199-204. Minkin C. 1982. Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif Tissue Int 34(3): 285-290. Mitsui N, Suzuki N, Koyama Y, Yanagisawa M, Otsuka K, Shimizu N, Maeno M. 2006. Effect of compressive force on the expression of MMPs, PAs, and their inhibitors in osteoblastic Saos-2 cells. Life Sci 79(6): 575-583. Murphy G, Cockett MI, Ward RV, Docherty AJ. 1991. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP). Biochem J 277 ( Pt 1): 277-279. Nagase H, Enghild JJ, Suzuki K, Salvesen G. 1990. Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate. Biochemistry 29(24): 5783-5789. Naka T, Boltze C, Kuester D, Schulz TO, Samii A, Herold C, Ostertag H, Roessner A. 2004. Expression of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, cathepsin B, and urokinase plasminogen activator in non-skull base chordoma. Am J Clin Pathol 122(6): 926-930. Okada Y, Gonoji Y, Naka K, Tomita K, Nakanishi I, Iwata K, Yamashita K, Hayakawa T. 1992. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. J Biol Chem 267(30): 21712-21719. Opdenakker G, Van den Steen PE, Van Damme J. 2001. Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol 22(10): 571-579. Owen JL, Torroella-Kouri M, Iragavarapu-Charyulu V. 2008. Molecular events involved in the increased expression of matrix metalloproteinase-9 by T lymphocytes of mammary tumor-bearing mice. Int J Mol Med 21(1): 125-134. Ozawa H, Imamura K, Abe E, Takahashi N, Hiraide T, Shibasaki Y, Fukuhara T, Suda T. 1990. Effect of a continuously applied compressive pressure on mouse osteoblast-like cells (MC3T3-E1) in vitro. J Cell Physiol 142(1): 177-185. P Oc, Wongkajornsilp A, Rhys-Evans PH, Eccles SA. 2004. Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells. Int J Cancer 111(2): 174-183. Page-McCaw A, Ewald… A. 2007. Matrix metalloproteinases and the regulation of tissue remodelling. Nature Reviews Molecular Cell …. Parfitt AM. 1979. Quantum concept of bone remodeling and turnover: implications for the pathogenesis of osteoporosis. Calcif Tissue Int 28(1): 1-5. Parfitt AM. 1994. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55(3): 273-286. Parfitt AM. 2000. The mechanism of coupling: a role for the vasculature. Bone 26(4): 319-323. Parks WC, Wilson CL, Lopez-Boado YS. 2004. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 4(8): 617-629. Partington GA, Fuller K, Chambers TJ, Pondel M. 2004. Mitf-PU.1 interactions with the tartrate-resistant acid phosphatase gene promoter during osteoclast differentiation. Bone 34(2): 237-245. Patwari P, Fay J, Cook MN, Badger AM, Kerin AJ, Lark MW, Grodzinsky AJ. 2001. In vitro models for investigation of the effects of acute mechanical injury on cartilage. Clin Orthop Relat Res(391 Suppl): S61-71. Pavalko FM, Chen NX, Turner CH, Burr DB, Atkinson S, Hsieh YF, Qiu J, Duncan RL. 1998. Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions. Am J Physiol 275(6 Pt 1): C1591-1601. Pavlovic S, Du B, Sakamoto K, Khan KMF, Natarajan C, Breyer RM, Dannenberg AJ, Falcone DJ. 2006. Targeting prostaglandin E-2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages. Journal of Biological Chemistry 281(6): 3321-3328. Pioletti DP, Muller J, Rakotomanana LR, Corbeil J, Wild E. 2003. Effect of micromechanical stimulations on osteoblasts: development of a device simulating the mechanical situation at the bone-implant interface. J Biomech 36(1): 131-135. Rahnert J, Fan X, Case N, Murphy TC, Grassi F, Sen B, Rubin J. 2008. The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells. Bone 43(1): 48-54. Raisz LG. 1999. Physiology and pathophysiology of bone remodeling. Clin Chem 45(8 Pt 2): 1353-1358. Redlich M, Reichenberg E, Harari D, Zaks B, Shoshan S, Palmon A. 2001. The effect of mechanical force on mRNA levels of collagenase, collagen type I, and tissue inhibitors of metalloproteinases in gingivae of dogs. J Dent Res 80(12): 2080-2084. Reponen P, Sahlberg C, Munaut C, Thesleff I, Tryggvason K. 1994. High expression of 92-kDa type IV collagenase (gelatinase) in the osteoclast lineage during mouse development. Ann N Y Acad Sci 732: 472-475. Robling AG, Castillo AB, Turner CH. 2006. Biomechanical and molecular regulation of bone remodeling. Annu Rev Biomed Eng 8: 455-498. Rodan GA, Martin TJ. 1981. Role of osteoblasts in hormonal control of bone resorption--a hypothesis. Calcif Tissue Int 33(4): 349-351. Roodman GD, Ibbotson KJ, Macdonald BR, Kuehl TJ, Mundy GR. 1985. 1,25-Dihydroxyvitamin-D3 Causes Formation of Multinucleated Cells with Several Osteoclast Characteristics in Cultures of Primate Marrow. Proceedings of the National Academy of Sciences of the United States of America 82(23): 8213-8217. Rubin C, Judex S, Hadjiargyrou M. 2002. Skeletal adaptation to mechanical stimuli in the absence of formation or resorption of bone. J Musculoskelet Neuronal Interact 2(3): 264-267. Rubin J, Biskobing D, Fan X, Rubin C, McLeod K, Taylor WR. 1997. Pressure regulates osteoclast formation and MCSF expression in marrow culture. J Cell Physiol 170(1): 81-87. Rubin J, Fan X, Biskobing DM, Taylor WR, Rubin CT. 1999. Osteoclastogenesis is repressed by mechanical strain in an in vitro model. J Orthop Res 17(5): 639-645. Sanuki R, Shionome C, Kuwabara A, Mitsui N, Koyama Y, Suzuki N, Zhang F, Shimizu N, Maeno M. 2010. Compressive force induces osteoclast differentiation via prostaglandin E(2) production in MC3T3-E1 cells. Connect Tissue Res 51(2): 150-158. Sasaki K, Takagi M, Konttinen YT, Sasaki A, Tamaki Y, Ogino T, Santavirta S, Salo J. 2007. Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. J Biomed Mater Res B Appl Biomater 80(2): 491-498. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89(2): 309-319. Smola-Hess S, Schnitzler R, Hadaschik D, Smola H, Mauch C, Krieg T, Pfister H. 2001. CD40L induces matrix-metalloproteinase-9 but not tissue inhibitor of metalloproteinases-1 in cervical carcinoma cells: imbalance between NF-kappaB and STAT3 activation. Exp Cell Res 267(2): 205-215. Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS. 2002. Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J Bone Miner Res 17(9): 1613-1620. Steenport M, Khan K, Du B, Barnhard S, Dannenberg A, Falcone D. 2009. Matrix Metalloproteinase (MMP)-1 and MMP-3 Induce Macrophage MMP-9: Evidence for the Role of TNF-{alpha} and Cyclooxygenase-2. The Journal of Immunology 183(12): 8119. Stricklin GP, Jeffrey JJ, Roswit WT, Eisen AZ. 1983. Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin. Biochemistry 22(1): 61-68. Suda T, Tanaka S, Takahashi N. 1993. Macrophage Colon-Stimulating Factor (M-Csf) Is Essential for Differentiation Rather Than Proliferation of Osteoclast Progenitors. Osteoporosis International 3: S111-S113. Suzuki K, Enghild JJ, Morodomi T, Salvesen G, Nagase H. 1990. Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry 29(44): 10261-10270. Taira H, Fujikawa Y, Kudo O, Itonaga I, Torisu T. 2003. Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. Calcif Tissue Int 73(1): 78-85. Takahashi N, Akatsu T, Sasaki T, Nicholson GC, Moseley JM, Martin TJ, Suda T. 1988a. Induction of calcitonin receptors by 1 alpha, 25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells. Endocrinology 123(3): 1504-1510. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T. 1988b. Osteoblastic cells are involved in osteoclast formation. Endocrinology 123(5): 2600-2602. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T. 1988c. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122(4): 1373-1382. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J et al. 2002. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3(6): 889-901. Tanaka SM, Li J, Duncan RL, Yokota H, Burr DB, Turner CH. 2003. Effects of broad frequency vibration on cultured osteoblasts. J Biomech 36(1): 73-80. Tasevski V, Sorbetti JM, Chiu SS, Shrive NG, Hart DA. 2005. Influence of mechanical and biological signals on gene expression in human MG-63 cells: evidence for a complex interplay between hydrostatic compression and vitamin D3 or TGF-beta1 on MMP-1 and MMP-3 mRNA levels. Biochem Cell Biol 83(1): 96-107. Tjaderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T. 1998. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 77(8): 1622-1629. Tondravi MM, McKercher SR, Anderson K, Erdmann JM, Quiroz M, Maki R, Teitelbaum SL. 1997. Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature 386(6620): 81-84. Turner CH, Forwood MR, Otter MW. 1994. Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J 8(11): 875-878. Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T. 1989. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125(4): 1805-1813. Vaananen HK, Laitala-Leinonen T. 2008. Osteoclast lineage and function. Arch Biochem Biophys 473(2): 132-138. van Bezooijen RL, ten Dijke P, Papapoulos SE, Lowik CW. 2005. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev 16(3): 319-327. Vincent C, Kogawa M, Findlay DM, Atkins GJ. 2009. The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditions. J Bone Miner Metab 27(1): 114-119. Wang ZQ, Ovitt C, Grigoriadis AE, Mohle-Steinlein U, Ruther U, Wagner EF. 1992. Bone and haematopoietic defects in mice lacking c-fos. Nature 360(6406): 741-745. Wetterwald A, Hoffstetter W, Cecchini MG, Lanske B, Wagner C, Fleisch H, Atkinson M. 1996. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone 18(2): 125-132. Wong BR, Josien R, Lee SY, Sauter B, Li HL, Steinman RM, Choi Y. 1997. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 186(12): 2075-2080. Yang JH, Sakamoto H, Xu EC, Lee RT. 2000. Biomechanical regulation of human monocyte/macrophage molecular function. Am J Pathol 156(5): 1797-1804. Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N, Sato Y, Goto M, Yamaguchi K, Kuriyama M et al. 1998. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 139(3): 1329-1337. Yoshida H, Hayashi SI, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa SI. 1990. The Murine Mutation Osteopetrosis Is in the Coding Region of the Macrophage Colony Stimulating Factor Gene. Nature 345(6274): 442-444. Zhang YH, Heulsmann A, Tondravi MM, Mukherjee A, Abu-Amer Y. 2001. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem 276(1): 563-568. Zou W, Hakim I, Tschoep K, Endres S, Bar-Shavit Z. 2001. Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism. J Cell Biochem 83(1): 70-83. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42208 | - |
dc.description.abstract | 在矯正治療的過程中,是藉由矯正裝置來對牙齒進行施力,而牙周組織,包含牙周韌帶,齒槽骨等,扮演著接受力量刺激的角色,並且產生一連串的代謝反應而使得牙齒移動。過去已知骨母細胞接受力學刺激後會調控蝕骨細胞的分化以進行骨質重塑活動,其中基質金屬蛋白酶-3(MMP-3可能扮演重要角色。同時,蝕骨細胞本身亦可能是直接接受力學刺激的細胞,而力量刺激可能會影響蝕骨細胞的分化。本研究以小鼠RAW 264.7細胞為對象,培養8~132小時,觀察MMP-3及RANKL對於蝕骨細胞分化的影響。 以即時定量聚合酶鏈鎖反應(Real-time PCR)分析,結果在同時加入RANKL及MMP-3的細胞其TRAP及MMP-9基因表現量會較僅加入RANKL為多,並且在染色的結果上會有較多TRAP染色的細胞,同時也會有較多鈣化物質吸收之能力。這證明MMP-3與RANKL對於蝕骨細胞的分化調控具有加成作用。另外並將RAW264.7細胞培養於3D膠原蛋白凝集體中,施予細胞1%週期性壓力刺激 24小時,並給予有無RANKL刺激。而蝕骨細胞在直接接受週期性壓力後,會有形態上的改變,但是其TRAP表現上並無顯著差異。證明蝕骨細胞亦會受到力學刺激調控,但並非使其成熟分化。 | zh_TW |
dc.description.abstract | Orthodontic tooth movement is based on the force delivered by the appliance and transducing to the surrounding tissue such as periodontal ligament , and alveolar bone to recieve the mechanical stimulation. The serial metabolic effect after force stimulation that known as bone remodeling involves both osteoblast and osteoclast. Osteoblast can regulate osteoclast function after force stimulation, and MMP-3 is proposed to be one of the key factors. Besides, osteoclast might be stimulated by mechanical force directly. We used mouse monocyte cell line RAW 264.7 cell, cultured with RANKL and MMP-3 to evaluate the indirect mechanical stimulation on osteoclast. In order to verify how the mechanical compression may affect osteoclast directly, 1% cyclic compression force for 24 hours with or without RANKL was applied to RAW 264.7 cells grown in a 3D collagen gel to mimic the physiologic environment. The result of real-time PCR showed that MMP-9 and TRAP genes were up regulated significantly after 84 hours cultured with combination of RANKL and MMP-3 then with RANKL only. TRAP stain and pit assay indicated more mature osteoclast function in the combination group. Therefore, we suggest a synergic effect of MMP-3 and RANKL in regulating osteoclast differentiation. Force stimulation also cause morphological change of osteoclast without significant change of TRAP expression, which suggest osteoclastmay have mechanical receptor itself, but not this direct influence the differentiation process. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T00:52:53Z (GMT). No. of bitstreams: 1 ntu-100-R97422011-1.pdf: 17219724 bytes, checksum: 667c845609b76b6e0e5c812d0df7e091 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 致謝 .... I
中文摘要 . II Abstract .. III 第 1 章 引言 .. 1 1.1 骨質重塑現象 .... 1 1.2 主導骨重塑的因子 (蝕骨及成骨細胞間的互動) . 2 1.3 蝕骨細胞 (培養方式 文獻回顧) ... 4 1.4 影響骨重塑的因子 . 6 1.5 基質金屬蛋白酶(MMPs)與骨吸收機制 7 1.5.1 基質金屬蛋白酶 (matrix metalloproteinases ,MMP) ... 7 1.5.2 基質金屬蛋白酶(Matrix Metalloproteinases, MMPs)之調控機制 ... 8 1.5.3 基質金屬蛋白酶(MMPs)與骨質重塑機制之關聯性 .... 9 1.6 機械力量刺激對於MMP 基因表現的影響 .. 11 第 2 章 實驗目的 12 第 3 章 實驗材料與方法 .. 14 3.1 細胞培養 ... 14 3.2 細胞培養方式: .... 14 3.3 蝕骨細胞分化 .. 14 3.4 基質金屬蛋白酶-3 對於蝕骨細胞的影響 14 3.5 MMP-3 的活化 .. 15 3.6 蝕骨細胞定性分析 ... 15 3.6.1 Alarma blue . 15 3.6.2 Acting ring ... 15 3.6.3 TRAP stain .. 16 3.6.4 Pit Assay 16 3.7 週期性壓力刺激實驗 17 3.7.1 製備3D 細胞膠原凝集體 ... 17 V 3.7.2 週期性壓力刺激 17 3.8 RNA 萃取及定量 .... 18 3.9 反轉錄聚合酶反應 (Reverse Transcription PCR) 19 3.10 即時定量聚合酶連鎖反應 (Real-time PCR) 19 第 4 章 實驗結果 21 4.1 蝕骨細胞的培養及分化現象 .... 21 4.2 MMP-3 直接對於蝕骨細胞分化之影響 ... 22 4.2.1 TRAP 染色結果(定性分析) 22 4.2.2 即時定量聚合酶連鎖反應 (Real-time PCR) 23 4.2.3 孔洞分析 (Pit Assay) 23 4.3 週期性壓力對於蝕骨細胞分化之影響 ... 24 4.3.1 H&E 染色結果(定性分析) ... 24 4.3.2 TRAP 染色結果(定性分析) . 24 第 5 章 討論 25 5.1 關於實驗設計 .. 25 5.1.1 蝕骨細胞的培養及分化現象 ... 25 5.1.2 MMP-3 直接對於蝕骨細胞分化之影響 .. 27 5.1.3 週期性壓力對於蝕骨細胞分化之影響 .. 29 5.2 實驗結果討論 .. 29 5.2.1 MMP-3 直接對於蝕骨細胞分化之影響 .. 29 5.2.2 週期性壓力對於蝕骨細胞分化之影響 .. 31 第 6 章 結論 33 6.1 蝕骨細胞的培養 .... 33 6.2 MMP-3 對於老鼠單核球細胞株分化的影響: ... 33 6.3 週期性壓力對於蝕骨細胞分化的影響: 33 第 7 章 未來研究方向 .. 34 第 8 章 參考文獻 62 | |
dc.language.iso | zh-TW | |
dc.title | 週期性壓力刺激以及其引發之細胞外基質金屬蛋白-3對蝕骨細胞的影響 | zh_TW |
dc.title | The Effect of Cyclic Compression Force Stimulation and Extra-cellular Matrix Metalloproteinase-3 MMP-3 to Osteoclast in vitro | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳羿貞,張博鈞 | |
dc.subject.keyword | 基質金屬蛋白酶,機械力量刺激,RAW 264.7, | zh_TW |
dc.subject.keyword | matrix metalloproteinase,mechanical stress,RAW 264.7 osteoclast, | en |
dc.relation.page | 65 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-15 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-100-1.pdf 目前未授權公開取用 | 16.82 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。