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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 董成淵 | |
| dc.contributor.author | Hsien-Chung Lee | en |
| dc.contributor.author | 李憲忠 | zh_TW |
| dc.date.accessioned | 2021-06-15T00:46:10Z | - |
| dc.date.available | 2010-09-02 | |
| dc.date.copyright | 2008-09-02 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-08-26 | |
| dc.identifier.citation | 1.Hsin-Yuan Tan et al. Multiphoton Fluorescence and Second Harmonic Generation Imaging of the Structural Alterations in Keratoconus Ex Vivo. IOVS. 2006;47:5251-5259.
2.Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297-319. 3.Sherwin T. Brookes NH. Morphological changes in keratoconus: pathology or pathogenesis. Clin Exp Ophthalmol. 2004;32:211-217. 4.Chi HH, Katzin HM, Teng CC. Histopathology of keratoconus. Am J Ophthalmol. 1956;42:847-860. 5.Tuft SJ, Moodaley, LC, Gregory WM, Davison CR, Buckley RJ. Prognostic factors for the progression of keratoconus. Ophthalmology. 1994;101:439-447. 6.Harrison RJ, Klouda PT, Easty DL, Manku M, Charles J, Stewart CM. Association between keratoconus and atopy. Br J Ophthalmol. 1989;73:816-822. 7.Lindsay RG, Bruce AS, Gutteridge IF. Keratoconus associated with continual eye rubbing due to punctual agenesis. Cornea. 2000;19:567-569. 8.Hartstein J. Keratoconus that developed in patients wearing corneal contact lenses. Arch Ophthalmol. 1968;80:345-346. 9.Matt Hasson. FDA backs launch of collagen cross-linking clinical trials. Ocular Surgery News U.S. Edition. Jan 25, 2008. 10.Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627. 11.Cosimo Mazzotta et al. Treatment of Progressive Keratoconus by Riboflavin-UVA-Induced Cross-Linking of Corneal Collagen. Cornea. 2007;26:390-397. 12.Eberhard Spoerl, Theo Seiler, et al. Safety of UVA-Riboflavin Cross-Linking of the Cornea. Cornea. 2007;26:385-389. 13.Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine cornea after riboflavin/ultraviolet-A-induced crosslinking. J Cataract Refract Surg. 2003;29:1780-1785. 14.Denk W, Strickler JH, Web WW. 2-Photon laser scanning fluorescence microscopy. Science. 1990;248:73-76. 15.So PTC, Dong CY, Masters BR, Berland KM. Two-photon excitation fluorescence microscopy. Annu Rev Biomed Eng. 2000;2:399-429. 16.Zoumi A, Yeh A, Tromberg BJ. Imaging cells and extracellular matrix in vivo by using second-harmonic generation and twophoton excited fluorescence. Proc Natl Acad Sci USA. 2002;99:11014-11019. 17.Zoumi A, Lu X, Kassab GS, Tromberg BJ. Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy. Biophys J. 2004;87:2778-2786. 18.Zipfel WR, Williams RM, Christie R, Nikitin AY, Hyman BT, WebbWW. Live tissue intrinsic emission microscopy using multiphotonexcited native fluorescence and second harmonic generation. Proc Natl Acad Sci USA. 2003;100:7075-7080. 19.Jester JV et al. The cellular basis of corneal transparency: evidence for corneal crystallins'. J Cell Sci. 1999;112:613-22. 20.Clare O’Donnell and James S Wolffsohn. Grading of corneal transparency. Contact Lens and Anterior Eye. 2004;27:161-170. 21.K M Meek et al. Transparency, swelling and scarring in the corneal stroma. Eye. 2003;17:927–936. 22.Suzanna Airiani MD et al. Evaluating Central Corneal Thickness Measurements With Noncontact Optical Low-Coherence Reflectometry and Contact Ultrasound Pachymetry. Am J Ophthal. 2006;142:164-165. 23.C. Ramakrishnan. In Memoriam: Professor G.N. Ramachandram (1922–2001). Protein Sci. 2001;10:1689-1691. 24.Kirkness CM et al. The success of Penetrating Keratoplasty for Keratoconus. Eye. 1990;4:673-688. 25.Troutman RC and Lawless MA. Penetrating Keratoplasty for Keratoconus. Cornea. 1987;6:298-305. 26.Fontana L, Parente G, Tassinari G. Clinical outcomes after deep anterior lamellar keratoplasty using the big-bubble technique in patients with keratoconus. Am J Ophthal. 2007;143;117-124. 27.Addition Technology, Inc. New Humanitarian Approval: INTACS Prescription Inserts for Keratoconus-H040002. FDA approved in July 26, 2004. 28.Siganos CS, Kymionis GD, Kartakis N, Theodorakis MA, Astyrakakis N, Pallikaris IG. Management of keratoconus with Intacs. Am J Ophthalmol. 2003;135:64-70. 29.Colin J, Cochener B, Savary G, Malet F. Correcting keratoconus with intracorneal rings. J Cataract Refract Surg. 2000 Aug;26:1117-1122. 30.Colin J, Velou S. Current surgical options for keratoconus. J Cataract Refract Surg. 2003;29:379-386. 31.Lombardi M and Abbondanza M. Asymmetric radial keratotomy for the correction of keratoconus. J Refract Surg. 1997;13:302-307. 32.Shi-Wei Chu. Quantitative Analysis of Backward Generation and Backscattering for Epi-collected Second Harmonic Generation in Biological Tissues. Journal of Medical and Biological Engineering. 2007;27:177-182. 33.Erich Götzinger et al. Imaging of Birefringent Properties of Keratoconus Corneas by Polarization-Sensitive Optical Coherence Tomography. IOVS. 2007;48:3551-3558. 34.G. OSTER, JUDITH S. BELLIN, and B. HOLMSTR6M. Photochemistry of Riboflavin. EXPERIENTIA. 1962;18:249-296. 35.Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg. 2003;29:1786-1790. 36.Spoerl, Eberhard, Wollensak, Gregor and Seiler Theo. Increased resistance of crosslinked cornea against enzymatic digestion. Current Eye Research. 2004;29:35-40. 37.M. Cristina Kenney and Donald J. Brown. The Cascade Hypothesis of Keratoconus. Contact Lens and Anterior Eye. 2003;26:139-146. 38.Matthews FJ et al. Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus. Exp Eye Res. 2007;84:1125-1134. 39.Alessandro Lambiase. Molecular basis for keratoconus: Lack of TrkA expression and its transcriptional repression by Sp3. PNAS. 2005;102:16795-16800. 40.Kanellopoulos and A John MD et al. Collagen Cross-Linking (CCL) With Sequential Topography-Guided PRK: A Temporizing Alternative for Keratoconus to Penetrating Keratoplasty. Cornea. 2007;26:891-895. 41.Chen-Kuan Chou et al. Polariation ellipticity compensation in polarization second-harmonic generation microscopy without specimen rotation. J. Biomed. Opt. 2008;13:014005-(1-7). 42.Wolf, E. Electromagnetic Diffraction in Optical Systems. I. An Integral Representation of the Image Field. Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences. 1959;253:349-357. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42091 | - |
| dc.description.abstract | The purpose of this study is to assess the possible application of second harmonic generation (SHG) microscopy for demonstrating the structural alterations of bovine cornea following riboflavin-UVA-induced cross-linking treatment, and to investigate its potential as being a clinical in vivo monitoring technique of cross-linking treatment. Riboflavin and UVA cross-linking treatment has been applied in the clinics for improving biomechanical strength in ecstatic corneal diseases including keratoconus and keratectasia following refractive surgery. Increasing the degree of cross-linking of stromal collagen may help to halt the progression of ecstatic changes of cornea. However, the efficacy and extension of current cross-linking protocol could not be quantified using current optical monitoring system. In this work, we attempted to use the non-invasive optical SHG imaging technique for demonstrating and quantifying the degree of cross-linking of stromal collagen in an experimental bovine corneal model. We found that significant curvy changes of parallel aligned corneal collagen fibers could be identified with SHG imaging. We proposed that SHG imaging can be an effective monitoring and quantifying system for evaluation of the efficacy of cross-linking treatment in the cornea. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T00:46:10Z (GMT). No. of bitstreams: 1 ntu-97-P94222001-1.pdf: 3747798 bytes, checksum: ddaaa8df3051762904dbce6b7aa8a833 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | Table of Contents
口試委員會審定書…………………………………………………i Acknowledgement………………………………………………ii 中文摘要……………………………………………………………iii Abstract………………………………………………………………iv List of Figures………………………………………………………vi List of Tables…………………………………………………………vii Chapter 1 Introduction……………………………………………1 1.1 Cornea and Collagen………………………………………3 1.2 Keratoconus and Treatments………………………………6 Chapter 2 Second Harmonic Generation (SHG) Microscopy………10 2.1 Second Harmonic Generation (SHG)……………………10 2.2 Related Concepts for BSHG, FSHG, and PSHG………15 Chapter 3 Riboflavin-UVA-induced Cross-linking Treatment……20 3.1 Riboflavin and Ultraviolet Irradiation……………………20 3.2 Performance and Safety…………………………………23 Chapter 4 Materials and Methods…………………………………27 4.1 Sample Preparation……………27 4.2 Riboflavin-UVA Cross-linking Procedures…………………………………………………31 4.3 SHG Imaging of Cornea Specimens……………………32 Chapter 5 Results and Discussion………………………33 Chapter 6 Conclusion……………………………………………40 References…………………………………………………………41 | |
| dc.language.iso | en | |
| dc.title | 以二倍頻顯微術觀測核黃素與紫外光誘導牛眼角膜膠原蛋白產生之交聯作用 | zh_TW |
| dc.title | Second Harmonic Generation Imaging of Riboflavin-UVA-Induced Cross-linking In Bovine Cornea | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張顏輝,石明豐,林頌然 | |
| dc.subject.keyword | 牛眼角膜,二倍頻,核黃素,紫外光,交聯, | zh_TW |
| dc.subject.keyword | bovine cornea,second harmonic generation,riboflavin,UVA,cross-linking, | en |
| dc.relation.page | 44 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-08-26 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 物理研究所 | zh_TW |
| 顯示於系所單位： | 物理學系 | |
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