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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 葉力森 | |
dc.contributor.author | Teng-Yu Tsai | en |
dc.contributor.author | 蔡騰猷 | zh_TW |
dc.date.accessioned | 2021-06-15T00:33:05Z | - |
dc.date.available | 2009-01-20 | |
dc.date.copyright | 2009-01-20 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2009-01-13 | |
dc.identifier.citation | Http://paindistraction.architecto.nl/onderzoek.php
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/41821 | - |
dc.description.abstract | 一、研究目的
本實驗的目的在研究lidocaine定速靜脈注射(constant rate infusion,CRI)、meloxicam與二者合併使用在進行子宮卵巢摘除手術(ovariohysterectomy,OHE)犬隻的止痛效果。 二、研究程序 對象為27隻預計於國立台灣大學生物資源暨農學院附設動物醫院外科進行子宮卵巢摘除手術的健康母犬。所有犬隻於手術前一天便先住進觀察室以減少環境的緊迫,並接受完整的理學檢查和血液學檢查。若犬隻具有潛在的全身性疾病或手術前有使用過任何的止痛藥物,皆不納入研究。 所有犬隻隨機分成三組:lidocaine(L)組,lidocaine以1 mg/kg靜脈注射後,接著以0.025 mg/kg/min的速率持續給予;meloxicam(M)組,0.2 mg/kg meloxicam靜脈注射後,乳酸林格氏液(Lacteated Ringer’s solution)以10 ml/kg/hr的速率給予;lidocaine + meloxicam(L + M)組,靜脈注射0.2 mg/kg meloxicam與1 mg/kg lidocaine後,以0.025 mg/kg/min的速率持續投予lidocaine。所有犬隻皆以propofol進行麻醉誘導,然後以isoflurane維持麻醉深度。 由三位不知動物已接受何種止痛藥物的評估員進行疼痛分數評估,評估的時間點為手術前、拔管的當下(t = 0),以及拔管後的第1、2、4、8、12小時;若動物的疼痛分數總分高於9分以上或單獨的評分項目為3分以上,則會給予挽救性止痛的fentanyl 3 μg/kg靜脈注射,同時此動物之後便不再納入研究資料中。另外,血清中cortisol和血糖濃度量測的進行與疼痛評估的時間點相同。最後全部的資料皆進行統計分析比較,評估三組止痛藥物的效果。 三、結果 本實驗中並無任何的動物需要挽救性的止痛藥物。三組術後的疼痛分數於統計上並無顯著的差異。 四、結論 實驗結果發現lidocaine定速靜脈注射與meloxicam在進行子宮卵巢摘除手術的犬隻具有相似的預防性止痛效果,而且實驗中並無任何動物出現明顯的副作用。 關鍵詞:犬、止痛、lidocaine、meloxicam、子宮卵巢摘除術 | zh_TW |
dc.description.abstract | Objective
To compare the systemic analgesic effects of intravenous lidocaine, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Study design Randomized, double blind, controlled clinical trial. Animals Twenty-seven dogs aged 16.4 ± 6.9 months and weighing 22.4 ± 17.6 kg. Methods Twenty-seven healthy dogs scheduled for ovariohysterectomy were randomly divided into 3 groups (n = 9): Meloxicam (M) group, which was given with 0.2 mg/kg intravenous (IV) meloxicam and consecutively with Lactated Ringer’s infusion at 10 ml/kg/hr; Lidocaine (L) group, which received a bolus of lidocaine (1 mg/kg IV) followed by a lidocaine infusion (0.025 mg/kg/min IV); and Lidocaine + Meloxicam (M + L) group, which was given with a combination of 0.2 mg/kg meloxicam and 1 mg/kg lidocaine intravenously and followed with a lidocaine infusion (0.025 mg/kg/min). Anesthesia was induced with propofol and maintained with isoflurane in oxygen. Serum cortisol and glucose concentrations were measured preoperatively and at 0, 1, 2, 4, 8, 12 hours after extubation (t = 0). Three different pain scores were assessed by three independent observers unaware of analgesic protocols used at t 0, 1, 2, 4, 8, and 12. Any dog with a total subjective pain score exceeding 9 (with the maximum possible of 24) or any sub-score above 3 in any one category received rescue analgesic (fentanyl 3 μg/kg IV) and was excluded from further data analysis. Results There was no significant differences in subjective pain scores, serum cortisol, and glucose concentrations within the three groups. No dogs received rescue analgesics in the study. Neither meloxicam, liodcaine infusion, nor of their combination caused any observable side effect. Conclusion and clinical relevance This study suggests that the intravenous lidocaine and meloxicam provide similar analgesic effect in healthy dogs undergoing ovariohysterectomy. No significant additive or synergic analgesic effect was observed in combination of the agents. Keywords dog, analgesia, lidocaine, meloxicam, ovariohysterectomy. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T00:33:05Z (GMT). No. of bitstreams: 1 ntu-97-R94629026-1.pdf: 1810806 bytes, checksum: 95b2426a9858b8d91a64198dba2bf978 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 口試委員會審定書 I
中文摘要 II 英文摘要 IIV 目錄 VI 圖次 IX 表次 X 第一章 序言 9 第二章 文獻探討 10 第一篇 疼痛的重要性 10 第一節 疼痛的定義 10 一、疼痛的定義 10 二、疼痛的形式 11 第二節 疼痛的生理機制 15 一、疼痛研究的歷史 15 二、疼痛的神經傳導 17 第三節 手術引起的疼痛 20 第四節 動物疼痛控制的重要性 22 一、動物疼痛控制不足的原因 23 二、動物疼痛控制的重要性 24 第五節 動物疼痛控制的方式 26 第二篇 動物疼痛的評估方式 31 第一節 疼痛的辨識 32 第二節 主觀的疼痛程度評估 35 一、口述分級評分法(Verbal Rating Scales,VRS)、分數評定量表(Numerical Rating Scales,NRS)和視覺類比量表(Visual Analog Scales,VAS)..36 二、複合式評量表(Ccomposite Scale,CS) 38 三、Modified Glasgow pain scale 41 第三節 血清cortisol與血糖濃度 43 第四節 機械性疼痛閥值測試(Mechanical nociceptive thresholds test) 45 第三篇 常用的手術止痛方式選擇 46 第一節 鴉片類止痛藥(Opioid analgesics) 49 一、作用機制 49 二、副作用 51 三、臨床應用 52 第二節 非固醇類消炎藥(Non-steroidal anti-inflammatory drugs,NSAIDs) 54 一、作用機制 54 二、副作用 56 三、臨床應用 57 第三節 Ketamine 59 一、作用機制 59 二、副作用 60 三、臨床應用 61 第四節 α-2致效劑(Alpha-2 agonists) 63 一、作用機制 63 二、副作用 64 三、臨床應用 65 第五節 其他止痛方式或藥物 67 一、局部麻醉與止痛(Local and regional anesthesia and analgesia) 67 二、硬膜外止痛(Epidural analgesia) 68 三、輔助性止痛方式與藥物 70 1. 緊迫的緩解(Stress relief) 70 2. 全身麻醉劑(General anesthetics) 71 3. 類固醇(Corticosteroids) 71 4. 三環抗憂鬱劑(Tricyclic antidepressants) 71 5. 抗痙攣劑(Anticonvulsants) 71 6. 非藥物性輔助止痛方式(Nonpharmacologic approaches) 72 第六節 預防性與混合式止痛(Pre-emptive and multimodal analgesia) 73 一、預防性止痛(Pre-emptive analgesia) 74 二、混合式止痛(Multi-modal analgesia) 75 第四篇 LIDOCAINE靜脈注射 77 第一節 作用機制 78 第二節 動物與人類的實驗模式 81 一、動物實驗模式 81 二、人類實驗模式 82 第三節 臨床應用 84 一、人醫方面 84 二、獸醫方面 85 第四節 副作用與潛在的優缺點 88 第五篇 參考文獻 90 第三章 比較靜脈注射LIDOCAINE與MELOXICAM及二者合併使用於子宮卵巢摘除手術犬隻的止痛效果 108 附錄 一、 Meloxicam組犬隻基本資料 ………………………………………138 附錄 二、 Lidocaine組犬隻基本資料………………………………………...138 附錄 三、 Meloxicam + Lidocaine組犬隻基本資料…………………………139 | |
dc.language.iso | zh-TW | |
dc.title | 比較靜脈注射lidocaine與meloxicam及二者合併使用於子宮卵巢摘除手術犬隻的止痛效果 | zh_TW |
dc.title | Comparison of analgesic effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林中天,張紹光 | |
dc.subject.keyword | 犬,止痛,lidocaine,meloxicam,子宮卵巢摘除術, | zh_TW |
dc.subject.keyword | dog,analgesia,lidocaine,meloxicam,ovariohysterectomy, | en |
dc.relation.page | 139 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-01-13 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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