以樹脂複合材研發牙本質黏合劑之研究

Abstract

隨著美容牙科的盛行，樹脂複合材料的快速發展，對牙體復形的要求也從不間斷，因此在牙科材料上不斷改良、推陳出新，只為求得更完美的修復。本研究團隊相繼研究開發針對在根管治療後維持牙體上所使用之材料，從中心根柱到外圍與牙齒黏著所用之黏著劑（cement）皆有不錯的效果；而先前在與牙齒之黏著系統研究中，團隊研發之樹脂黏著劑（resin cement）所搭配使用的黏合劑為市售產品OptiBond Solo Plus，因此在本實驗中使用團隊研發之樹脂黏合劑，並以先前團隊中發展之樹脂基質為基本的樹脂成分，研究在此黏著系統下之黏合劑所需因子，以提供研發增強與牙本質黏著強度之黏合劑。 實驗中利用Bis-GMA（Bisphenol-A-glycidyl dimethacrylate）與TEGDMA（triethylene glycol dimethacrylate）為黏合劑的樹脂單體，分別加入不同的單體或溶劑，探討對牙本質之黏著能力的影響；本實驗利用接觸角的量測去觀察黏合劑對酸蝕過的牙本質之潤濕能力，實驗發現，所加入的單體與溶劑皆可以提升黏合劑對牙本質的潤濕能力；另外，利用微拉伸測試法以及推離鍵結測試法來量測樹脂黏著劑搭配黏合劑的使用對牙本質的黏著強度，分別探討不同成分對黏著效果的影響，並藉由掃描式電子顯微鏡觀察測試後之牙齒破壞面的微結構；結果發現，在我們所發展的黏合系統，對酸蝕過的牙本質已具有不錯的潤濕能力，能進入牙小管以及牙本質的空隙，但與牙本質的黏著力，仍有待進一步改善。

Development of resin composites advances very fast because of the demand of esthetic dentistry. For better dental restoration, various kinds of new materials have been developed. Our research group studies new materials for endodontic therapy. We have developed new post and resin cement having high binding strength to the root canal dentin. However, the high binding strength relies on using the commercial product OptiBond Solo Plus as the bonding agent. The aim of this study is to explore the role of bonding agent in enhancing the binding strength to dentin, as a first step to develop new bonding agents suitable for the post and resin cement that we developed. Bis-GMA (bisphenol-A-glycidyl dimethacrylate) and TEGDMA (triethylene glycol dimethacrylate) were used as the resin monomers of the bonding agents. Various of monomers and solvents were added in the resin monomers to enhance their binding strength to dentin. The wetting ability of the bonding agents on the etched dentin surface was evaluated by using the contact angle measurement. The results showed that all the additives elevated the wetting ability. Also, the micro-tensile bond test and the push-out bond test were used to evaluate the adhesion strength between dentin and the bonding agents, together with examining the microstructure of dentin surface, to study the influence of the additives on binding strength to dentin. The results indicated that bonding agents we developed had good wetting ability on dentin surface, but further enhancement of their binding strength is still needed.