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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 黃偉邦(Wei-Pang Huang) | |
dc.contributor.author | Yi-Shin Tsai | en |
dc.contributor.author | 蔡怡馨 | zh_TW |
dc.date.accessioned | 2021-06-14T17:09:27Z | - |
dc.date.available | 2010-07-30 | |
dc.date.copyright | 2008-07-30 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-26 | |
dc.identifier.citation | 參考文獻
Abeliovich, H., C. Zhang, et al. (2003). 'Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy.' Mol Biol Cell 14(2): 477-90. Amar, N., G. Lustig, et al. (2006). 'Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.' EMBO Rep 7(6): 635-42. Azevedo, J. E. and W. Schliebs (2006). 'Pex14p, more than just a docking protein.' Biochim Biophys Acta 1763(12): 1574-84. Barth, H., K. Meiling-Wesse, et al. (2001). 'Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p.' FEBS Lett 508(1): 23-8. Bellu, A. R., M. Komori, et al. (2001). 'Peroxisome biogenesis and selective degradation converge at Pex14p.' J Biol Chem 276(48): 44570-4. Bordallo, J., R. Cueva, et al. (1995). 'Transcriptional regulation of the yeast vacuolar aminopeptidase yscI encoding gene (APE1) by carbon sources.' FEBS Lett 364(1): 13-6. Braun, R. J. and H. Zischka (2008). 'Mechanisms of Cdc48/VCP-mediated cell death - from yeast apoptosis to human disease.' Biochim Biophys Acta. Braun, R. J., H. Zischka, et al. (2006). 'Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast.' J Biol Chem 281(35): 25757-67. Burda, P., S. M. Padilla, et al. (2002). 'Retromer function in endosome-to-Golgiretrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.' J Cell Sci 115(Pt 20): 3889-900. Cao, Y. and D. J. Klionsky (2007). 'Atg26 is not involved in autophagy-related pathways in Saccharomyces cerevisiae.' Autophagy 3(1): 17-20. Chang, C. Y. and W. P. Huang (2007). 'Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy.' Mol Biol Cell 18(3): 919-29. Cheong, H., U. Nair, et al. (2008). 'The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae.' Mol Biol Cell 19(2): 668-81. Cheong, H., T. Yorimitsu, et al. (2005). 'Atg17 regulates the magnitude of the autophagic response.' Mol Biol Cell 16(7): 3438-53. Conibear, E., J. N. Cleck, et al. (2003). 'Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p.' Mol Biol Cell 14(4): 1610-23. Cox, R., S. H. Chen, et al. (2007). 'Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex.' BMC Evol Biol 7: 12. Cuervo, A. M. (2004). 'Autophagy: many paths to the same end.' Mol Cell Biochem 263(1-2): 55-72.Diderich, J. A., M. Schepper, et al. (1999). 'Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae.' J Biol Chem 274(22): 15350-9. Diderich, J. A., M. Schepper, et al. (1999). 'Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae.' J Biol Chem 274(22): 15350-9. Fujioka, Y., N. N. Noda, et al. (2008). 'In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy.' J Biol Chem 283(4): 1921-8. Fujita, N., T. Itoh, et al. (2008). 'The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy.' Mol Biol Cell 19(5): 2092-2100. Funakoshi, T., A. Matsuura, et al. (1997). 'Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae.' Gene 192(2): 207-13. Granell, S. and G. Baldini (2008). 'Inclusion bodies and autophagosomes: are ER-derived protective organelles different than classical autophagosomes?' Autophagy 4(3): 375-7. Greatrix, B. W. and H. J. van Vuuren (2006). 'Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress.' Curr Genet 49(4): 205-17. Haas, A. K. and F. A. Barr (2007). 'COP sets TRAPP for vesicles.' Dev Cell 12(3): 326-7. Hanada, T., N. N. Noda, et al. (2007). 'The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.' J Biol Chem 282(52): 37298-302. Hanada, T. and Y. Ohsumi (2005). 'Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy.' Autophagy 1(2): 110-8. Harrison-Lowe, N. J. and L. J. Olsen (2008). 'Autophagy Protein 6 (ATG6) is Required for Pollen Germination in Arabidopsis thaliana.' Autophagy 4(4). Hayashi, M., K. Nito, et al. (2000). 'AtPex14p maintains peroxisomal functions by determining protein targeting to three kinds of plant peroxisomes.' Embo J 19(21): 5701-10. He, C. and D. J. Klionsky (2007). 'Atg9 trafficking in autophagy-related pathways.' Autophagy 3(3): 271-4. He, C., H. Song, et al. (2006). 'Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast.' J Cell Biol 175(6): 925-35. Hutchins, M. U., M. Veenhuis, et al. (1999). 'Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway.' J Cell Sci 112 ( Pt 22): 4079-87. Ichimura, Y., T. Kirisako, et al. (2000). 'A ubiquitin-like system mediates protein lipidation.' Nature 408(6811): 488-92. Inoue, Y., T. Suzuki, et al. (2006). 'AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells.' Plant Cell Physiol 47(12): 1641-52. Ishihara, N., M. Hamasaki, et al. (2001). 'Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion.' Mol Biol Cell 12(11): 3690-702. James, P., J. Halladay, et al. (1996). 'Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.' Genetics 144(4): 1425-36. Johnston, M. and J. H. Kim (2005). 'Glucose as a hormone: receptor-mediated glucose sensing in the yeast Saccharomyces cerevisiae.' Biochem Soc Trans 33(Pt 1): 247-52. Juhasz, G. and T. P. Neufeld (2008). 'Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis.' Autophagy 4(3): 357-8. Kabeya, Y., Y. Kamada, et al. (2005). 'Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy.' Mol Biol Cell 16(5): 2544-53. Kabeya, Y., T. Kawamata, et al. (2007). 'Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.' Biochem Biophys Res Commun 356(2): 405-10. Kamada, Y., T. Funakoshi, et al. (2000). 'Tor-mediated induction of autophagy via an Apg1 protein kinase complex.' J Cell Biol 150(6): 1507-13. Kametaka, S., T. Okano, et al. (1998). 'Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.' J Biol Chem 273(35): 22284-91. Kawamata, T., Y. Kamada, et al. (2005). 'Characterization of a novel autophagy-specific gene, ATG29.' Biochem Biophys Res Commun 338(4): 1884-9. Ketelaar, T., C. Voss, et al. (2004). 'Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins.' FEBS Lett 567(2-3): 302-6. Kihara, A., T. Noda, et al. (2001). 'Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.' J Cell Biol 152(3): 519-30. Kim, J., V. M. Dalton, et al. (1999). 'Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways.' Mol Biol Cell 10(5): 1337-51. Kim, J., W. P. Huang, et al. (2001). 'Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex.' J Cell Biol 152(1): 51-64. Kim, J. H. and M. Johnston (2006). 'Two glucose-sensing pathways converge on Rgt1 to regulate expression of glucose transporter genes in Saccharomyces cerevisiae.' J Biol Chem 281(36): 26144-9. Kim, J. H. and M. Johnston (2006). 'Two glucose-sensing pathways converge on Rgt1 to regulate expression of glucose transporter genes in Saccharomyces cerevisiae.' J Biol Chem 281(36): 26144-9. Kimura, S., T. Noda, et al. (2007). 'Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3.' Autophagy 3(5): 452-60. Kirisako, T., M. Baba, et al. (1999). 'Formation process of autophagosome is traced with Apg8/Aut7p in yeast.' J Cell Biol 147(2): 435-46. Klionsky, D. J. (2005). 'The molecular machinery of autophagy: unanswered questions.' J Cell Sci 118(Pt 1): 7-18. Klionsky, D. J., R. Cueva, et al. (1992). 'Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.' J Cell Biol 119(2): 287-99. Klockow, C., F. Stahl, et al. (2008). 'In vivo regulation of glucose transporter genes at glucose concentrations between 0 and 500mg/L in a wild type of Saccharomyces cerevisiae.' J Biotechnol 135(2): 161-7. Komatsu, M., Q. J. Wang, et al. (2007). 'Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration.' Proc Natl Acad Sci U S A 104(36): 14489-94. Komori, M., S. W. Rasmussen, et al. (1997). 'The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis.' Embo J 16(1): 44-53. Kouroku, Y., E. Fujita, et al. (2007). 'ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.' Cell Death Differ 14(2): 230-9. Kruse, K. B., J. L. Brodsky, et al. (2006). 'Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.' Mol Biol Cell 17(1): 203-12. Kundu, M. and C. B. Thompson (2005). 'Macroautophagy versus mitochondrial autophagy: a question of fate?' Cell Death Differ 12 Suppl 2: 1484-9. Leao-Helder, A. N., A. M. Krikken, et al. (2004). 'Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha.' FEBS Lett 577(3): 491-5. Lee, S. B., S. Kim, et al. (2007). 'ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase.' EMBO Rep 8(4): 360-5. Lee, Y. J. and R. B. Wickner (1992). 'AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases.' Yeast 8(9): 787-90. Lemasters, J. J. (2007). 'Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism.' J Gastroenterol Hepatol 22 Suppl 1: S31-7. Levine, B. and D. J. Klionsky (2004). 'Development by self-digestion: molecular mechanisms and biological functions of autophagy.' Dev Cell 6(4): 463-77. Liewluck, T., Y. K. Hayashi, et al. (2007). 'Unfolded protein response and aggresome formation in hereditary reducing-body myopathy.' Muscle Nerve 35(3): 322-6. Liu, Y., M. Schiff, et al. (2005). 'Autophagy regulates programmed cell death during the plant innate immune response.' Cell 121(4): 567-77. Longtine, M. S., A. McKenzie, 3rd, et al. (1998). 'Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae.' Yeast 14(10): 953-61. Lopez-Huertas, E., J. Oh, et al. (1999). 'Antibodies against pex14p block ATP-independent binding of matrix proteins to peroxisomes in vitro.' FEBS Lett 459(2): 227-9. Luo, S. and D. C. Rubinsztein (2007). 'Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy.' Cell Death Differ 14(7): 1247-50. Ma, J., R. Jin, et al. (2007). 'Overexpression of autophagy-related genes inhibits yeast filamentous growth.' Autophagy 3(6): 604-9. Mari, M. and F. Reggiori (2007). 'Atg9 trafficking in the yeast Saccharomyces cerevisiae.' Autophagy 3(2): 145-8. Matsushita, M., N. N. Suzuki, et al. (2007). 'Structure of Atg5.Atg16, a complex essential for autophagy.' J Biol Chem 282(9): 6763-72. Mayer, A., W. Wickner, et al. (1996). 'Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles.' Cell 85(1): 83-94. Mazon, M. J., P. Eraso, et al. (2007). 'Efficient degradation of misfolded mutant Pma1 by endoplasmic reticulum-associated degradation requires Atg19 and the Cvt/autophagy pathway.' Mol Microbiol 63(4): 1069-77. Meiling-Wesse, K., H. Barth, et al. (2004). 'Atg21 is required for effective recruitment of Atg8 to the preautophagosomal structure during the Cvt pathway.' J Biol Chem 279(36): 37741-50. Meiling-Wesse, K., U. D. Epple, et al. (2005). 'Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.' J Biol Chem 280(39): 33669-78. Mizushima, N., T. Noda, et al. (1999). 'Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.' Embo J 18(14): 3888-96. Mizushima, N., T. Noda, et al. (1998). 'A protein conjugation system essential for autophagy.' Nature 395(6700): 395-8. Mizushima, N., T. Yoshimori, et al. (2002). 'Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.' FEBS Lett 532(3): 450-4. Monastyrska, I., T. Shintani, et al. (2006). 'Atg11 directs autophagosome cargoes to the PAS along actin cables.' Autophagy 2(2): 119-21. Monastyrska, I., M. van der Heide, et al. (2005). 'Atg8 is essential for macropexophagy in Hansenula polymorpha.' Traffic 6(1): 66-74. Nakatogawa, H., T. Hanada, et al. (2006). '[Characterization of yeast Atg proteins].' Tanpakushitsu Kakusan Koso 51(10 Suppl): 1457-63. Nakatogawa, H., Y. Ichimura, et al. (2007). 'Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.' Cell 130(1): 165-78. Nakatsukasa, K., G. Huyer, et al. (2008). 'Dissecting the ER-associated degradation of a misfolded polytopic membrane protein.' Cell 132(1): 101-12. Nazarko, T. Y., J. Huang, et al. (2005). 'Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae.' Autophagy 1(1): 37-45. Nazarko, T. Y., A. S. Polupanov, et al. (2007). 'The requirement of sterol glucoside for pexophagy in yeast is dependent on the species and nature of peroxisome inducers.' Mol Biol Cell 18(1): 106-18. Nazarko, V. Y., K. O. Futej, et al. (2008). 'Differences in glucose sensing and signaling for pexophagy between the baker's yeast Saccharomyces cerevisiae and the methylotrophic yeast Pichia pastoris.' Autophagy 4(3): 381-4. Nazarko, V. Y., K. O. Futej, et al. (2008). 'Differences in glucose sensing and signaling for pexophagy between the baker's yeast Saccharomyces cerevisiae and the methylotrophic yeast Pichia pastoris.' Autophagy 4(3): 381-4. Nemoto, T., I. Tanida, et al. (2003). 'The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.' J Biol Chem 278(41): 39517-26. Neuber, O., E. Jarosch, et al. (2005). 'Ubx2 links the Cdc48 complex to ER-associated protein degradation.' Nat Cell Biol 7(10): 993-8. Noda, N. N., Y. Fujioka, et al. (2008). 'Crystallization of the Atg12-Atg5 conjugate bound to Atg16 by the free-interface diffusion method.' J Synchrotron Radiat 15(Pt 3): 266-8. Oku, M., T. Nishimura, et al. (2006). 'Role of Vac8 in formation of the vacuolar sequestering membrane during micropexophagy.' Autophagy 2(4): 272-9. Onodera, J. and Y. Ohsumi (2005). 'Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation.' J Biol Chem 280(36): 31582-6. Ozcan, S. and M. Johnston (1995). 'Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose.' Mol Cell Biol 15(3): 1564-72. Ozcan, S., T. Leong, et al. (1996). 'Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription.' Mol Cell Biol 16(11): 6419-26. Palomino, A., P. Herrero, et al. (2005). 'Rgt1, a glucose sensing transcription factor, is required for transcriptional repression of the HXK2 gene in Saccharomyces cerevisiae.' Biochem J 388(Pt 2): 697-703. Pankiv, S., T. H. Clausen, et al. (2007). 'p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.' J Biol Chem 282(33): 24131-45. Pasula, S., D. Jouandot, 2nd, et al. (2007). 'Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.' FEBS Lett 581(17): 3230-4. Pasula, S., D. Jouandot, 2nd, et al. (2007). 'Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.' FEBS Lett 581(17): 3230-4. Patel, S. and S. P. Dinesh-Kumar (2008). 'Arabidopsis ATG6 is required to limit the pathogen-associated cell death response.' Autophagy 4(1): 20-7. Pattingre, S., L. Espert, et al. (2008). 'Regulation of macroautophagy by mTOR and Beclin 1 complexes.' Biochimie 90(2): 313-23. Phillips, A. R., A. Suttangkakul, et al. (2008). 'The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana.' Genetics 178(3): 1339-53. Polager, S., M. Ofir, et al. (2008). 'E2F1 regulates autophagy and the transcription of autophagy genes.' Oncogene. Polish, J. A., J. H. Kim, et al. (2005). 'How the Rgt1 transcription factor of Saccharomyces cerevisiae is regulated by glucose.' Genetics 169(2): 583-94. Reggiori, F., T. Shintani, et al. (2005). 'Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts.' Autophagy 1(2): 101-9. Reggiori, F., K. A. Tucker, et al. (2004). 'The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.' Dev Cell 6(1): 79-90. Reggiori, F., C. W. Wang, et al. (2003). 'Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion.' J Biol Chem 278(7): 5009-20. Sacher, M., J. Barrowman, et al. (2001). 'TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.' Mol Cell 7(2): 433-42. Schindler, C. and A. Spang (2007). 'Interaction of SNAREs with ArfGAPs precedes recruitment of Sec18p/NSF.' Mol Biol Cell 18(8): 2852-63. Scott, S. V., D. C. Nice, 3rd, et al. (2000). 'Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting.' J Biol Chem 275(33): 25840-9. Shintani, T. and D. J. Klionsky (2004). 'Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway.' J Biol Chem 279(29): 29889-94. Shintani, T., K. Suzuki, et al. (2001). 'Apg2p functions in autophagosome formation on the perivacuolar structure.' J Biol Chem 276(32): 30452-60. Siniossoglou, S. and H. R. Pelham (2002). 'Vps51p links the VFT complex to the SNARE Tlg1p.' J Biol Chem 277(50): 48318-24. Stephan, J. S. and P. K. Herman (2006). 'The regulation of autophagy in eukaryotic cells: do all roads pass through Atg1?' Autophagy 2(2): 146-8. Stromhaug, P. E., F. Reggiori, et al. (2004). 'Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.' Mol Biol Cell 15(8): 3553-66. Suzuki, K., T. Kirisako, et al. (2001). 'The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.' Embo J 20(21): 5971-81. Suzuki, K., Y. Kubota, et al. (2007). 'Hierarchy of Atg proteins in pre-autophagosomal structure organization.' Genes Cells 12(2): 209-18. Tang, F., Y. Peng, et al. (2006). 'Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes.' Traffic 7(10): 1368-77. Tanida, I., N. Mizushima, et al. (1999). 'Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy.' Mol Biol Cell 10(5): 1367-79. Tanida, I., T. Nishitani, et al. (2002). 'Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing.' Biochem Biophys Res Commun 296(5): 1164-70. Tanida, I., Y. S. Sou, et al. (2006). 'Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.' Febs J 273(11): 2553-62. Tanida, I., E. Tanida-Miyake, et al. (2002). 'Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.' J Biol Chem 277(16): 13739-44. Tucker, K. A., F. Reggiori, et al. (2003). 'Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy.' J Biol Chem 278(48): 48445-52. Ullman, E., Y. Fan, et al. (2008). 'Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress.' Cell Death Differ 15(2): 422-5. Valis, K., T. Masek, et al. (2006). 'Immunity to killer toxin K1 is connected with the Golgi-to-vacuole protein degradation pathway.' Folia Microbiol (Praha) 51(3): 196-202. Veit, M., R. Laage, et al. (2001). 'Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion.' Embo J 20(12): 3145-55. Wang, C. W., J. Kim, et al. (2001). 'Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways.' J Biol Chem 276(32): 30442-51. Wang, Y. X., N. L. Catlett, et al. (1998). 'Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.' J Cell Biol 140(5): 1063-74. Wu, B. X., A. G. Darden, et al. (2006). 'The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina.' Mol Vis 12: 1292-302. Xenarios, I., E. Fernandez, et al. (2001). 'DIP: The Database of Interacting Proteins: 2001 update.' Nucleic Acids Res 29(1): 239-41. Xiong, Y., A. L. Contento, et al. (2005). 'AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana.' Plant J 42(4): 535-46. Yamada, Y., N. N. Suzuki, et al. (2007). 'The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation.' J Biol Chem 282(11): 8036-43. Yamazaki-Sato, H., I. Tanida, et al. (2003). 'The carboxyl terminal 17 amino acids within Apg7 are essential for Apg8 lipidation, but not for Apg12 conjugation.' FEBS Lett 551(1-3): 71-7. Yang, Z., J. Huang, et al. (2006). 'Atg22 recycles amino acids to link the degradative and recycling functions of autophagy.' Mol Biol Cell 17(12): 5094-104. Yen, W. L. and D. J. Klionsky (2007). 'Atg27 is a second transmembrane cycling protein.' Autophagy 3(3): 254-6. Yen, W. L. and D. J. Klionsky (2007). 'Atg27 is a second transmembrane cycling protein.' Autophagy 3(3): 254-6. Yen, W. L., J. E. Legakis, et al. (2007). 'Atg27 is required for autophagy-dependent cycling of Atg9.' Mol Biol Cell 18(2): 581-93. Yorimitsu, T. and D. J. Klionsky (2005). 'Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.' Mol Biol Cell 16(4): 1593-605. Yorimitsu, T. and D. J. Klionsky (2005). 'Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.' Mol Biol Cell 16(4): 1593-605. Yorimitsu, T. and D. J. Klionsky (2005). 'Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.' Mol Biol Cell 16(4): 1593-605. Yorimitsu, T. and D. J. Klionsky (2005). 'Autophagy: molecular machinery for self-eating.' Cell Death Differ 12 Suppl 2: 1542-52. Yoshimoto, K., H. Hanaoka, et al. (2004). 'Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy.' Plant Cell 16(11): 2967-83. Yoshimura, K., M. Shibata, et al. (2006). 'Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues.' Autophagy 2(3): 200-8. Yuan, W., P. E. Stromhaug, et al. (1999). 'Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein.' Mol Biol Cell 10(5): 1353-66. Zhao, Z., L. B. Thackray, et al. (2007). 'Coronavirus replication does not require the autophagy gene ATG5.' Autophagy 3(6): 581-5. Zutphen, T., M. Veenhuis, et al. (2008). 'Pex14 is the sole component of the peroxisomal translocon that is required for pexophagy.' Autophagy 4(1): 63-6. Johnston, M., and Kim, J.H. (2005). “Glucose as a hormone: receptor-mediated glucose sensing in the yeast Saccharomyces cerevisiae. “ Biochemical Society transactions 33, 247-252. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40970 | - |
dc.description.abstract | 細胞自噬(autophagy)途徑為真核生物特有的膜運輸(membrane trafficking)機制,它對於單一細胞的存活扮演重要的角色。在養分缺乏的環境下,細胞自噬可以扮演維持生命的功能,這個機制是透過一個雙層膜的自噬體(autophgosome),包裹一些細胞質中的物質和胞器,透過與溶小體或液泡(lysosome/vacuole)癒合而完成消化分解作用,以提供細胞能量來源並維持細胞生存。
本篇論文的第一部份,透過酵母菌雙雜交實驗分析,建立細胞自噬蛋白交互辨識圖譜,並與已知的細胞自噬蛋白質間的交互作用資訊分析,深入探討細胞自噬的分子調控機制。 本篇論文的第二部份,則是透過酵母菌雙雜交實驗,尋找酵母菌的cDNA庫中可與細胞自噬蛋白Atg9作用的分子;由此實驗中所發現Atg9交互作用的17個蛋白中,選擇Trs23深入探討其與細胞自噬間的關係。Trs23與Trs85為TRAPP複合體的成員,其中Trs85已被證實參與調控細胞自噬及細胞質至液泡傳遞途徑(cytoplasm to vacuole targeting, Cvt pathway),因此我進一步分析Trs23是否與細胞自噬或Cvt途徑的調控有關。另外,Trs85如何調控細胞自噬以及細胞質至液泡傳遞途徑至今仍不清楚,因此我也嚐試測試Trs85與Atg9分子直接交互作用的可能性。 | zh_TW |
dc.description.abstract | Autophagy is a membrane-trafficking mechanism conserved in all eukaryotic cells, which plays an important role for survival of unicellular organisms in nutrient starvation conditions. During the starvation conditions, a double membrane-bound vesicle, named an autophagosome, mediates the degradation of cytosolic components in the lysosome/vacuole to provide energy sources.
For the first part of this study, I used the dual reporter yeast two-hybrid system to establish the Atg protein interaction map. Comparing to already published Atg protein interactions, this Atg protein interaction map may bring us insights for future analysis of the autophagy molrculer mechainsm. For the second part of this study, I used Atg9 as a bait protein to screen for it’s interaction partners. Among those 17 proteins identified by the yeast two-hybrid analysis as Atg9 interaction proteins, Trs23 is particularly interesting and was chosen for further study. Like Trs85, Trs23 is a subunit of the TRAPP complex, which regulates membrane trafficking between the ER and the Gogi complex. Trs85 has already been reported to be required for the autophagy and Cvt pathway. Therefore, I was interested to test if Trs23 was required for the autophagy and Cvt pathway or not. In addition, the detailed molecular mechanism underlying how Trs85 regulates autophagy and the Cvt pathway is still unknown. I have examined if Trs85 like Trs23 also interact with Atg9 to facilitate autophagic transport. | en |
dc.description.provenance | Made available in DSpace on 2021-06-14T17:09:27Z (GMT). No. of bitstreams: 1 ntu-97-R95b41012-1.pdf: 2565693 bytes, checksum: 59f41b50bc588b53ccf4f3159e3876f8 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 目錄
誌謝……………………………………………………………………02 中文摘要………………………………………………………………03 英文摘要………………………………………………………………04 前言……………………………………………………………………06 材料與方法……………………………………………………………13 結果……………………………………………………………………19 討論……………………………………………………………………25 參考文獻………………………………………………………………30 表………………………………………………………………………51 圖………………………………………………………………………63 附錄……………………………………………………………………75 | |
dc.language.iso | zh-TW | |
dc.title | 建立細胞自噬蛋白交互辨識圖譜與分析運輸蛋白Trs23和Trs85在細胞自噬上扮演之角色 | zh_TW |
dc.title | Construction of the Atg Protein Interaction Map and Study of the Roles of Trs23 and Trs85 in Autophagy pathway | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李心予(Hsin-Yu Lee),陳俊宏(Jiun-Hong Chen) | |
dc.subject.keyword | 細胞自噬,自噬體,TRAPP蛋白質複合,酵母菌雙雜交系統,交互作用圖表, | zh_TW |
dc.subject.keyword | autophagy,Trs85,TRAPP,autophagosme,yeast two hybrid, | en |
dc.relation.page | 44 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2008-07-29 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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