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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40942完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林文澧(Win-Li Lin) | |
| dc.contributor.author | Bo-Sian Lin | en |
| dc.contributor.author | 林伯憲 | zh_TW |
| dc.date.accessioned | 2021-06-14T17:07:57Z | - |
| dc.date.available | 2016-08-17 | |
| dc.date.copyright | 2011-08-17 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-11 | |
| dc.identifier.citation | [1] '中華民國行政院衛生署,' available in http://www.doh.gov.tw/cht2006/index_populace.aspx
[2] 'estrogen dominance,' available in http://www.estrogendominanceguide.com/breast-tenderness/anatomy-of-a-breast [3] Carolyn Jarvis, 'Physical Examination and Health Assessment 3/e,' Elserier (Singapore) Pte Ltd., 2003. [4] Chen B, Ning R, 'Cone-beam volume CT breast imaging: feasibility study. Medical Physics,'2002,29 (5):755-770. [5] Ruola Ning, 'Flat panel detector-based cone beam volume CT breast imaging: phantom and specimen study, ' Proceedings of SPIE-The International Society for Optical Engineering, 2002, 4682(5):24-26 [6] Karen K. Lindfors, John M. Boone et al, 'Dedicated Breast CT-Initial Clinical Experience1, ' Radiology: Volume 246: Number 3—March 2008 [7] John M. Boone, Alex L. C. Kwan et al, 'Computed tomography for imaging the breast,' J Mammary Gland Biol Neoplasia, 11: 103–111, 2006 [8] 'Aurora MRI imaging technology ,' available in http://www.auroramri.com/mri/ [9] Stefan O.R. Pfleiderer and Werner A. Kaiser, 'breast,' p221-229. [10] Gain Franco Barozio, E. Dieter Hager, 'Hyperthermia in Cancer Treatment: A Primer,' Springer Science+ Business Media, 2006. [11] Young-sun Kim, Hyunchul Rhim, Min Joo Choi, Hyo Keun Lim, and Dongil Choi, 'High-Intensity Focused Ultrasound Therapy: an Overview for Radiologists,' Korean J Radiol 2008; 9: 291-302. [12] Theodore J. Dubinsky, Carlos Cuevas, Manjiri K. Dighe, Orpheus Kolokythas, and Joo Ha Hwang, 'High-Intensity Focused Ultrasound: Current Potential and Oncologic Application,' AJR:190, January 2008; 190: 191-199. [13] C.-M. Ma, L. Chen, G. Freedman, and R. Bleicher, 'MR Guided Focused Ultrasound for High Risk and Recurrent Breast Cancer,' World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany IFMBE Proceedings, 2009, Volume 25/6, 140-143. [14] K.Hynynen, O. Pomery, D.N.Smith, P.E. Huber, N.J. McDannold, J. Kettenbach, J. Baum, S. Singer, and F.A. Jolesz, 'MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study,' Radiology, vol. 219, no. 1, 2001, pp. 176-185. [15] M. Malinen, T. Huttunen, K. Hynynen, and J.P. Kaipio, 'Simulation study for thermal dose optimization in ultrasound surgery of the breast,' Med Phys, vol. 31, no. 5, 2004, pp. 1296-1307. [16] D. Gianfelice, A. Khiat, M. Amara, A. Belblidia, and Y. Boulanger, 'MR imaging-guided focused US ablation of breast cancer: Histopathologic assessment of effectiveness-initial experience,' Radiology, vol. 227, pp. 849-855, 2003. [17] C.S. Ho, K.C. Ju, T.Y. Cheng, Y.Y. Chen, and W.L. Lin, 'Thermal therapy for breast tumors by using a cylindrical ultrasound phased array with multifocus pattern scanning: a preliminary numerical study,' Phys Med Biol, vol. 52, no. 15, 2007, pp. 4585-4599. [18] J.F. Bakker, M.M. Paulides, I.M. Obdeijn, G.C. van Rhoon, and K.W.A. van Dongen, 'An ultrasound cylindrical phased array for deep heating in the breast: theoretical design using heterogeneous models,' Phys Med Biol, vol.54, no 10, 2009, pp.3201-3215. [19] 周卓明, '壓電力學,' 全華科技圖書, 2003. [20] 馮若, '超聲手冊,' 南京大學出版社, 2001. [21] 'First-principles study of piezoelectricity in PZT ,' available in http://electronicstructure.wikidot.com/first-principles-study-of-piezoelectricity-in-pzt [22] Stewart Sherrit, Sean P. Leary, Benjamin P. Dolgin and Yoseph Bar-Cohen , 'Comparison of the Mason and KLM Equivalent Circuits for Piezoelectric Resonators in the Thickness Mode, ' Ultrasonics Symposium, 1999. Proceedings. 1999 ,IEEE [23] A. Buchacz, A. Wróbel, 'Piezoelectric layer modeling by equivalent circuit and graph method, ' Journal of Achievements in Materials and Manufacturing Engineering, Volume 20 Issues 1-2 January-February 2007. [24] 長谷川弘 著, 白中和 譯, '數位/類比高頻電路與實裝設計的關鍵技術,' 建興文化出版社, 2008. [25] ' KCF Technologies,' available in http://www.kcftech.com/products/piezoelectric.shtml [26] 蕭義正, '溫度感應型水膠應用於聚焦型超音波熱治療之研究,' 大同大學 機械工程研究所 碩士論文, 2007. [27] C.A. Cain ,and S. Umemura, 'Concentric-ring and sector-vortex phased-array applicators for ultrasound hyperthermia,' IEEE Transactions on Microwave Theory and Techniques, vol 34, no 5, 1986, pp.542-551. [28] 林江典, '環形相位陣列式超音波結合多聚焦型態於乳房腫瘤熱治療之研究,' 台灣大學 醫學工程研究所 碩士論文, 2009. [29] 高材, 林康平, 林峰輝, 陳家進等 主編, '生物醫學工程導論,' 滄海書局,2008. [30] H.H. Pennes, 'Analysis of Tissue and Arterial Blood Temperature in the Resting Human Forearm,' Journal of applied physiology, vol. 1, pp. 30, 1948. [31] S.A. Sapareto and W.C. Deway, 'Thermal dose determination in cancer therapy,' Int J Radiat Oncol Biol Phys, vol. 10, pp.787-800, Jun 1984. [32] Atam P. Dhawan, 'Medical Image Analysis,' A John Wiley & Sons, Inc., 2003. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40942 | - |
| dc.description.abstract | 由於高強度聚焦式超音波(HIFU)具有使能量集中的特性，能夠以極短時間在目標區域產生急遽的溫度上升，達到以高熱消滅細胞的效果；且超音波具有軟組織穿透能力，能以非侵入的方式進行治療，近年來已成為癌症治療的一種新方式。
本研究針對乳房腫瘤，開發環形相位聚焦式超音波換能器做為熱治療工具，換能器大小為直徑20公分、曲率半徑10公分、高2公分。本研究的環形換能器由16個獨立的壓電陶瓷組成，驅動頻率為1MHz，超音波能量藉由壓電陶瓷的壓電效應產生，並藉由實際測量壓電陶瓷的機電耦合係數和電聲轉換效率來確認換能器聲功率輸出的穩定性。 根據不同的臨床需求，可以利用調控輸出的聲波相位進行不同策略的熱治療。本研究藉由組織仿體和離體的里肌肉，針對腫瘤在乳房中心處進行不同相位模式的燒灼實驗，並搭配磁振造影系統觀察超音波聚焦區的溫度變化量和燒灼形態。由實驗結果可知，環形相位聚焦式換能器搭配不同相位的聚焦模式，產生足夠的加熱範圍，並確實有效使乳房中心位置的腫瘤產生足夠的溫度上升，使該處的組織變性而壞死，達到治療的目的。 | zh_TW |
| dc.description.abstract | High-intensity focused ultrasound (HIFU) has the characteristics of power concentration and can generate the steep temperature elevation at the target to kill the cells by hyperthermia. Because ultrasound has great ability of penetration to soft tissue and can apply non-invasive treatments, it becomes a new method for cancer therapies.
In this study, we develop a ring-shaped phase-array focused ultrasound transducer for the breast tumor treatment. The transducer size is 20cm in diameter, with a radius of curvature of 10cm and a height of 2cm. The transducer consists of 16 separated piezoelectric ceramics, and operate at the frequency of 1MHz. Piezoelectric ceramics generate the ultrasound power by the piezoelectric effect of materials. We measure the electro-mechanical coupling constant and the electro-acoustic transverse ratio to confirm the acoustic output power stability of the transducer. According to different clinical requirements, we set different phase of output acoustic wave to form different heating results for the different thermal treatment strategies. We assume the tumor is located at the center of the breast, and use the breast phantom and pork sample in vitro to do the ablation experiments of different heating models. Furthermore, the ablation experiment apparatus is collocated with the MRI system to observe the heating patterns and the temperature change in the focal region. Experiment results show that the ring-shaped phase-array focused ultrasound transducer using different heating models can generate sufficient heating range and make the effective temperature rise at the tumor in the center of breast, achieve the treatment purpose of tissue denature and necrosis. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-14T17:07:57Z (GMT). No. of bitstreams: 1 ntu-100-R98548043-1.pdf: 60923930 bytes, checksum: 4ca116df61d72835794f449924f821c8 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 誌謝..……………………………………………………………………Ⅰ
摘要..……………………………………………………………………Ⅱ Abstract..………………………………………………………………Ⅲ 目錄...………………………………………………………………….Ⅳ 圖目錄.......………………………………………………………….Ⅶ 表目錄.........……………………………………………………….Ⅹ 第一章 緒論………………………………………………………………1 1.1 乳癌...........……………………………………………………1 1.1.1 概述…..…………………………………………………...1 1.1.2 乳癌分期…………………………………………………...2 1.1.3 診斷和檢查………………………………………………...4 1.1.4 乳癌的治療………………………………………………...6 1.2 熱治療的發展…………….…………………………………………8 1.3 超音波熱治療…….…………………………………………………9 1.4 研究動機…………………………………………………………..11 第二章 壓電原理……………………………………………………….12 2.1 壓電效應……….………………………………………………...12 2.2 壓電材料特性參數…………………………………...………….13 2.3 壓電方程式…….………………………………………………...15 2.4 壓電材料振動模式……….………………………………..…….17 2.5 壓電材料種類………………….………………………………...18 2.6 壓電換能器等效電路模型……………………….………….…..21 2.6.1 梅森等效電路模型…………………………………………21 2.6.2 克里姆霍爾茲等效電路模型……………..………………22 第三章 換能器設計及製作……………………………….……………23 3.1 設計理念…………………………………………….…………...23 3.2 換能器製作…………………………………………….………...24 3.2.1 換能器外殼設計……………………………………….…..25 3.2.2 換能器封裝流程………………………………….………..26 3.3 阻抗匹配電路……………………………………………….…...28 3.3.1 最大功率轉換……………………………………………...30 3.3.2 耦合變壓器……………………………………….………..31 3.3.3 耦合變壓器繞製………………………………….………..34 第四章 環形換能器性能測試……………………………………….…37 4.1 壓電陶瓷特性測試………………………………………………..37 4.1.1 機電耦合係數 d33量測…………………………………….37 4.1.2 電聲轉換效率量測………………………………………...38 4.2 實驗材料與系統……………….………………………………...39 4.2.1 功率放大器……………………….………………………..39 4.2.2 組織仿體……………………………….…………………..40 4.3 環形換能器聚焦形態實驗……………………………………....41 4.3.1 聚焦模式選擇……………………………………………...41 4.3.2 實驗設計…………………………………………………….44 第五章 離體動物組織實驗………………………………………….…45 5.1 概述………………………………………………….…………...45 5.1.1 生物熱傳方程式……………………………………….…..46 5.1.2 熱劑量………………………………………………….…..47 5.1.3 核磁共振影像系統………………………………………...48 5.2 實驗設計…………………………………………………….…...49 第六章 結果與討論…………………………………………………….53 6.1 硬體製作及測試…………………………………………………..53 6.1.1 環形超音波換能器製作……………………………………53 6.1.2 阻抗匹配電路…………………….……………………...54 6.1.3 機電耦合係數d33量測……….………….……………….56 6.1.4 電聲轉換效率量測…………………………………………56 6.2聚焦形態測試實驗…………………………………………….……57 6.3 離體動物組織實驗………………………………..............67 第七章 結論與未來展望………….……………………………………80 參考文獻……………………………………………………………..…81 | |
| dc.language.iso | zh-TW | |
| dc.subject | 磁振溫度影像 | zh_TW |
| dc.subject | 環形相位陣列超音波換能器 | zh_TW |
| dc.subject | 乳房腫瘤 | zh_TW |
| dc.subject | 熱治療 | zh_TW |
| dc.subject | ring-shaped phase-array ultrasound transducer | en |
| dc.subject | MRI thermometry | en |
| dc.subject | hyperthermia | en |
| dc.subject | breast tumor | en |
| dc.title | 環形相位陣列聚焦式超音波結合磁振造影系統應用於乳房腫瘤治療的研究 | zh_TW |
| dc.title | Investigation of Ring-Shaped Phased-Array Focused Ultrasound with MRI System for Breast Tumor Treatment | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 陳景欣(Gin-Shin Chen) | |
| dc.contributor.oralexamcommittee | 陳永耀,顏家鈺 | |
| dc.subject.keyword | 環形相位陣列超音波換能器,乳房腫瘤,熱治療,磁振溫度影像, | zh_TW |
| dc.subject.keyword | ring-shaped phase-array ultrasound transducer,breast tumor,hyperthermia,MRI thermometry, | en |
| dc.relation.page | 83 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-08-12 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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