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標題: | 菸鹼酸皮膚貼片之紅腫反應在精神分裂症研究之應用:
比較目測法與紅外線攝相儀及其與血中脂肪酸濃度之關係 Application of Flush Response to Niacin Skin Patch in Schizophrenia Research: Comparing Visual Rating with Infrared Thermography and Their Relations to Fatty Acids Levels in Blood |
作者: | Ya-Hui Yu 游雅惠 |
指導教授: | 陳為堅(Wei J. Chen) |
關鍵字: | 精神分裂症,菸鹼酸皮膚貼片,紅腫分數,紅外線攝像儀,脂肪酸, Schizophrenia,Niacin skin test,Visual rating score,Infrared thermography,Temperature,Fatty acids, |
出版年 : | 2011 |
學位: | 碩士 |
摘要: | 目的:比較目測法與紅外線攝相儀於菸鹼酸皮膚貼片測驗的結果評估,並了解紅腫分數、溫度與血中脂肪酸濃度的關係。
方法:本研究利用兩組樣本,其一為試驗樣本(正常組:31位;精神分裂症:32位)進行菸鹼酸皮膚貼片測試,利用目測法與紅外線攝相儀評估40分鐘內的測驗反應。另一則為生化測驗樣本(正常組:15位;精神分裂症9位; 躁鬱症:7位)進行菸鹼酸皮膚貼片測試,同樣利用此兩種方式評估15分鐘內的反應結果,並利用氣相層析儀分析受試者之紅血球與血漿的脂肪酸組成。 結果:正常組與病人組於0.001M菸鹼酸皮膚貼片測驗的紅腫分數有顯著差異;在此三種濃度的菸鹼酸皮膚貼片測驗,溫度則均無顯著的組別差異。此外,由目測法得到的紅腫分數與紅外線攝像儀測得之溫度相關性弱。於生化測驗樣本,利用0.01M菸鹼酸皮膚貼片測驗之5分鐘的紅腫分數分為紅腫組與非紅腫組,非紅腫組之紅血球與血漿的n-6脂肪酸濃度傾向低於紅腫組,且EPA濃度顯著高於紅腫組。 結論:利用菸鹼酸皮膚貼片之紅腫反應分別精神分裂症病人與正常組,目測法得到的紅腫分數較紅外線攝像儀測得之溫度具有較佳之組別區分能力。本研究亦指出利用紅腫分數分組,可看到非紅腫組之紅血球與血漿的n-6脂肪酸濃度傾向低於紅腫組,且EPA濃度顯著高於紅腫組。將來可利用此簡易測驗評估方式,反應病人體內異常的生理現象。 Background: Attenuated niacin-induced flush response, a potential endophenotype for schizophrenia, has been postulated to involve a prostaglandin-related microvasodilation pathway where arachidonic acid or other fatty acids may play important roles. However, the correlations between the flush response and the implicated biochemical indexes remained incoherent, either because of different ways in giving niacin challenge test or in the evaluation of response. Alternatively measuring the raising temperature accompanying the niacin-induced flush might serve as an tool to assess the niacin-induced flush response. Objectives: This study aimed to: 1) evaluate the applicability of infrared thermography in measuring the niacin-induced flush response, and 2) examine the relations of the flush magnitude to fatty acids levels in blood. Methods: For the first aim, a pilot study of two groups of subjects were used to clarify the correlation between objectively measured temperature and visually rated flush score, whereas for the second aim another independent sample of psychiatric inpatients as well as healthy controls were used to explore the correlation between temperature, flush and fatty acids levels in red blood cells (RBCs) as well as in plasma. Three concentrations of niacin skin test with forty minute observation by visual rating method and infrared thermography method was performed in the sample of pilot study (31 patients with schizophrenia and 32 normal controls). On the other hand, niacin skin test with fifteen minute observation using both methods and blood fatty acids analysis were performed in the sample of biochemical study (9 patients with schizophrenia, 6 patients with bipolar disorder, and 15 normal controls). Fatty acids compositions of RBC and plasma were analyzed using gas chromatography. Results: Visual rating score method showed group difference in 0.001M while thermography method did not reveal group difference in all concentration and times. The correlations between these two methods were weak. Subjects of biochemical sample were re-grouped as non-flushers versus flushers on the basis of the flush score for 0.01M at 5 minute. The RBC and plasma levels of n-6 fatty acids in non-flushers tended to be lower than the corresponding ones of flushers and the RBC level of EPA was significantly higher in non-flushers than flushers. Conclusions: This study demonstrated that in measuring the niacin-induced flush response the visual rating method is better in discriminating schizophrenia patients from normal controls than the infrared thermography-based temperature rating. Furthermore, our results indicate that non-flushers tended to have lower levels of n-6 fatty acids but higher EPA levels than flushers. Future investigation is warranted to further explore the physiological abnormalities associated with the attenuated flush response in schizophrenia patients. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40831 |
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顯示於系所單位: | 流行病學與預防醫學研究所 |
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