結合超音波影像導引與溫度回授之超音波熱手術系統開發

Abstract

本研究開發了搭配超音波影像與熱電偶溫度量測之聚焦式超音波熱手術系統，利用油壓缸與電腦控制伺服馬達將聚焦超音波換能器移動至目標區並由防水光學尺量測實際移動距離。熱手術系統將自動定位系統、聚焦超音波換能器、電功率放大器、超音波影像系統、熱電偶溫度量測系統整合至圖形化使用者介面。而熱手術治療流程包含利用由診斷用超因波波束與聚焦超音波波束所形成的聲干擾作為聚焦超音波焦點的影像導引，並將兩根熱電偶透過超音波影像導入蛋白仿體與豬肉組織體，用來量測溫度治療區溫度來監控受測體治療過程。而為了達到多點治療的目的，聚焦超音波換能器利用聲干擾焦點定位法導引移動至其他欲治療區並使用相同電功率和時間作治療。初步的蛋白仿體與豬肉組織實驗結果證明此熱手術系統能有效地完成所規劃的治療策略。

In this study, we developed a focused ultrasound (FUS) thermal therapy system with B-mode ultrasound image guidance and thermocouple temperature measurement feedback. Hydraulic position devices and computer-controlled servo motors were used to move the FUS transducer to the desired location with the measurement of actual movement by linear scale. The entire system integrated automatic position devices, FUS transducer, power amplifier, ultrasound image system, and thermocouple temperature measurement system into a graphical user interface. For the treatment procedure, thermocouples were implanted into a targeted treatment region in a tissue-mimicking phantom or pork tissue under ultrasound image guidance and then the acoustic interference pattern formed by image ultrasound beam and high-power FUS beam was employed as image guidance, to move the FUS transducer to the desired treatment region The measurement of temperature was used to monitor the status of sonication duration. For a multiple lesion formation, the FUS transducer was moved under the acoustic interference guidance to a new location and then it sonicated with the same power level and duration. The preliminary phantom and pork tissue experimental results demonstrated that the system could achieve the desired treatment plan effectively.