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???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
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dc.contributor.advisor | 廖中明 | |
dc.contributor.author | Min-Pei Ling | en |
dc.contributor.author | 凌明沛 | zh_TW |
dc.date.accessioned | 2021-06-13T16:37:35Z | - |
dc.date.available | 2007-07-07 | |
dc.date.copyright | 2005-07-07 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-06 | |
dc.identifier.citation | Abbas, R., Hayton, W.L., 1997. A physiologically based pharmacokinetic and pharmacodynamic model for paraoxon in rainbow trout. Toxicology and Applied Pharmacology 145, 192–201.
Andersen, M.E., 1995. Development of physiologically-based pharmacokinetic and physiologically-based pharmacodynamic models for applications in toxicology and risk assessment. Toxicology Letters 79, 35−44. ATSDR, 1993. Toxicological profile for arsenic. US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, Contract #205-88-0608. ATSDR, 2000. Toxicological Profile for Arsenic. Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Public Health Service, Washington, DC. ATSDR, 2003. 2003 CERCLA priority list of hazardous substances. Division of Toxicology, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia. Bourne, D.W.A., 1995. Mathematical modeling of pharmackinetic data. Lancaster, Penn: Technomic Publishing Company, Inc. Bridges, J., 2003. Human health and environmental risk assessment: the need for a more harmonised and integrated approach. Chemosphere 52, 1347−1351. Brown, K.G., Boyle, K.E., Chen, C.W., Gibb, H.J., 1989. A dose-response analysis of skin-cancer from inorganic arsenic in drinking-water. Risk Analysis 9, 519–528. Buchet, J.P., Lison, D., Ruggeri, M., Foa, V., Elia, G., 1996. Assessment of exposure to inorganic arsenic, a human carcinogen, due to the consumption of seafood. Archives of Toxicology 70, 773−778. Burmaster, D.E., Anderson, P.D., 1994. Principles of good practice for the use of Monte Carlo techniques in human health and ecological risk assessments. Risk Analysis 14, 477−481. Burmaster, D.E., Hull, D.A., 1997. Using lognormal distributions and lognormal probability plots in probabilistic risk assessment. Human and Ecological Risk Assessment 3, 235−255. Byrd, D.M., Cothern, C.R., 2000. Introduction to risk analysis: a systematic approach to science-based decision making, Rockville, MD: Government Institutes. Cammarota, V.A., 1980. Production and uses of zinc. In: Nriagu, J.O. (Ed.), Zinc in the environment. Volume I: Ecological cycling, Wiley, New York, USA, pp. 1−37. Caussy, D., 2003. Case studies of the impact of understanding bioavailability: arsenic. Ecotoxicology and Environmental Safety 56, 164–173. Cebrian, M.E., Albores, A., Aguilar, M., Blakely, E., 1983. Chronic arsenic poisoning in the north of Mexico. Human Toxicology 2, 121–133. Chatterjee, A., Das, D., Mandal, B.K., Chowdhury, T.R., Samanta, G., Chakraborti, D., 1995. Arsenic in ground water in six districts of West Bengal, India: the biggest arsenic calamity in the world. Part I. Arsenic species in drinking water and urine of the affected people. The Analyst 120, 643−650. Chen, B.C., 2004. Structure and mechanism of fish/shellfish involved transport and biouptake of metals in aquatic ecosystems. Unpublished PhD Dissertation. Taipei, Taiwan: National Taiwan University. 155pp. Chen, C.J., Chuang, Y.C., Lin, T.M., Wu, H.Y., 1985. Malignant neoplasms among residents of a blackfoot disease endemic area in Taiwan - high-arsenic artesian well water and cancers. Cancer Research 45, 5895–5899. Chen, C.J., Hsu, L.I., Wang, C.H., Shih, W.L., Hsu, Y.H., Tseng, M.P., Lin, Y.C., Chou, W.L., Chen, C.Y., Lee, C.Y., Wang, L.H., Cheng, Y.C., Chen, C.L., Chen, S.Y., Wang, Y.H., Hsueh, Y.M., Chiou, H.Y., Wu, M.M., 2005. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicology and Applied Pharmacology 206, 198–206. Chen, C.J., Hsueh, Y.M., Tseng, M.P., Lin, Y.C., Hsu, L.I., Chou, W.L., Chiou, H.Y., Wang, I.H., Chou, Y.L., Tseng, C.H., Liou, S.H., 2001. Individual susceptibility to arseniasis. In: Chappell, W.R., Abernathy, C.O., Calderon, R.L., (Eds.), Arsenic exposure and health effects IV. Elsevier, Oxford, UK, pp. 135–143. Chen, C.L., Hsu, L.I., Chiou, H.Y., Hsueh, Y.M., Chen, S.Y., Wu, M.M., Chen, C.J., 2004. Ingested arsenic, cigarette smoking, and lung cancer risk - A follow-up study in arseniasis-endemic areas in Taiwan. JAMA-Journal of the American Medical Association 292, 2984–2990. Chen, H.C., 1984. Studies on the aquaculture of small abalone, Haliotis diversicolor supertexta, in Taiwan. In: Liao, I.C., Hirano, R. (Eds.), Proceedings of ROC-Japan symposium on mariculture, Vol. 1. Tungkang Marine Laboratory, Pintung, Taiwan, pp. 143−159. Chen, H.C., 1989. Farming the small abalone, Haliotis diversicolor supertexta, in Taiwan. In: Hahn, K. O. (Ed.), Handbook of culture of abalone and other marine gastropods. CRC Press, FL., USA, pp. 265−283. Chen, J.C., Lee, W.C., 1999. Growth of Taiwan abalone Haliotis diversicolor supertexta fed on Gracilaria tenuistipitata and artificial diet in a multiple-tier basket system. Journal of Shellfish Research 18, 627−635. Chen, S.L., Dzeng, S.R., Yang, M.H., Chiu, K.H., Shieh, G..M., Wai, C.M., 1994. Arsenic species in groundwaters of the Blackfoot disease area, Taiwan. Environmental Science and Technology 28, 877−881. Chen, Y., Ahsan, H., 2004. Cancer burden from arsenic in drinking water in Bangladesh. American Journal of Public Health 94, 741−744. Chen, Y.C., Guo, Y.L.L., Su, H.J.J., Hsueh, Y.M., Smith, T.J., Lee, M.S., Chao, S.C., Lee, J.Y.Y., Christiani, D.C., 2003a. Arsenic methylation and skin cancer risk in southwestern Taiwan. Journal of Occupational and Environmental Medicine 45, 241−248. Chen, Y.C., Su, H.J.J., Guo, Y.L.L., Hsueh, Y.M., Smith, T.J., Ryan, L.M., Lee, M.S., Christiani, D.C., 2003b. Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes and Control 14, 303−310. Chiou, H.Y., Huang, W.I., Su, C.L., Chang, S.F., Hsu, Y.H., Chen, C.J., 1997. Dose−response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 28, 1717–1723. Chiou, H.Y., Chiou, S.T., Hsu, Y.H., Chou, Y.L., Tseng, C.H., Wei, M.L., Chen, C.J., 2001. Incidence of transitional cell carcinoma and arsenic in drinking water: A follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan. American Journal of Epidemiology 153, 411–418. Chun, Y.S., Choi, E., Kim, G.T., Lee, M.J., Lee, M.J., Lee, S.E., Kim, M.S., Park, J.W., 2000. Zinc induces the accumulation of hypoxia-inducible factor (HIF)-1 alpha, but inhibits the nuclear translocation of HIF-1 beta, causing HIF-1 inactivation. Biochemical and Biophysical Research Communications 268, 652−656. Clewell, H.J., 1995. The application of physiologically-based pharmacokinetic modeling in human health risk assessment of hazardous substances. Toxicology Letters 79, 207−217. Conory, P.T., Hunt, J.W., Anderson, B.S., 1996. Validation of a short-term toxicity test endpoint by comparison with longer-term effects on larval red abalone Haliotis rufescens. Environmental Toxicology and Chemistry 15, 1245−1250. Crane, M., Whitehouse, P., Comber, S., Watts, C., Giddings, J., Moore, D.R.J., Grist, E., 2003. Evaluation of probabilistic risk assessment of pesticides in the UK: chlorpyrifos use on top fruit. PEST Management Science 59, 512−526. Crawford-Brown, D.J., 1999. Risk-based environment decisions: culture and methods. Kluwer Academic, Boston, USA. Croteau, M.N., Hare, L., Tessier, A., 1998. Refining and testing a trace metal biomonitor (Chaoborus) in highly acidic lakes. Environmental Science and Technology 32, 1348−1353. Daume, S., 2003. Early life history of abalone (Haliotis rubra, Haliotis laevigata): settlement, survival and early growth. Final report for FRDC project 1998/306, Fisheries research contract report No. 3, Department of Fisheries, Western Australia, 110 pp. Department of Health, 2002. Health and National Health Insurance Annual Statistics Information Service. Department of Health, Ministry of Interior, Executive Yuan, Taipei, ROC (in Chinese). Department of Statistics, 2004. Yearly Statistics of Population. Department of Statistics, Ministry of Interior, Executive Yuan, Taipei, ROC (in Chinese). Donohue, J.M., Abernathy, C.O., 1999. Exposure to inorganic arsenic from fish and shellfish. In: Chappell, W.R., Abernathy, C.O., Calderon, R.L., (Eds.), Arsenic exposure and health effects. Elsevier, Oxford, UK, pp. 89–98. Edelmann, K.G., Burmaster, D.E., 1997. Are all distribution of risk with the same 95th percentile equally acceptable? Human and Ecological Risk Assessment 3, 223–234. Eisler, R., 1980. Accumulation of zinc by marine biota. In: Nriagu, J. O. (Ed.), Zinc in the Environment. Part II: health effects. John Wiley & Sons, Inc., New York, USA, pp. 259–351. Finley, B., Paustenbach, D., 1994. The benefits of probabilistic exposure assessment: three case studies involving contaminated air, water, and soil. Risk Analysis 14, 53−73. Fisheries Agency, 2004. Fisheries Statistical Yearbook, Taiwan. Fisheries Agency, Council of Agriculture, Executive Yuan, Taipei, ROC (in Chinese). Francesconi, K.A., Kuehnelt, D., 2004. Determination of arsenic species: A critical review of methods and applications, 2000–2003. Analyst 129, 373–395. Gentry, P.R., Covington, T.R., Mann, S., Shipp, A.M., Yager, J.W., Clewell, H.J., 2004. Physiologically based pharmacokinetic modeling of arsenic in the mouse. Journal of Toxicology and Environmental Health-Part A 67, 43–71. Giesy, J.P., Bowling, J.W., Kania, H.J., 1980. Cadmium and zinc accumulation and elimination by freshwater crayfish. Archives of Environmental Contamination and Toxicology 9, 683–697. Ginsberg, G., Hattis, D., Sonawane, B., 2004. Incorporating pharmacokinetic differences between children and adults in assessing children’s risks to environmental toxicants. Toxicology and Applied Pharmacology 198, 164–183. Hahn, K.O., 1989. Biotic and abiotic factors affecting the culture of abalone. In: Hahn, K. O. (Ed.), Handbook of culture of abalone and other marine gastropods. CRC Press, FL., USA, pp. 113−283. Helton, J.C., Shiver, A.W., 1996. A Monte Carlo procedure for the construction of complementary cumulative distribution functions for comparison with the EPA release limits for radioactive waste disposal. Risk Analysis 16, 43−55. Hsueh, Y.M., Ko, Y.F., Huang, Y.K., Chen, H.W., Chiou, H.Y., Huang, Y.L., Yang, M.H., Chen, C.J., 2003. Determinants of inorganic arsenic methylation capability among residents of the Lanyang Plain, Taiwan: arsenic and selenium exposure and alcohol consumption. Toxicology Letters 137, 49–63. Huang, S.L., Weng, Y.M., Huang, C.H., 2004. Lipid peroxidation in sarcoplasmic reticulum and muscle of tilapia is inhibited by dietary vitamin E supplementation. Journal of food biochemistry 28, 101–111. Huang, Y.K., Lin, K.H., Chen, H.W., Chang, C.C., Liu, C.W., Yang, M.H., Hsueh, Y.M., 2003. Arsenic species contents at aquaculture farm and in farmed mouthbreeder (Oreochromis mossambicus) in blackfood disease hyperendemic areas. Food and chemical toxicology 41, 1491–1500. Huebert, D.B., Shay, J.M., 1992. Zinc toxicity and its interaction with cadmium in the submerged aquatic macrophyte Lemna trisulca L. Environmental Toxicology and Chemistry 11, 715–720. Hughes, M.F., Kenyon, E.M., Edwards, B.C., Mitchell, C.T., Del Razo, L.M., Thomas, D.J., 2003. Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate. Toxicology and Applied Pharmacology 191, 202−210. IARC, 1980. Monographs on the evaluation of the carcinogenic risk of chemicals to man: Some metals and metallic compounds, Vol. 23. International Agency for Research on Cancer, Lyon, pp. 39–141. IARC, 1987. Monographs on the evaluation of the carcinogenic risk to humans: Arsenic and arsenic compounds (Group 1), Supplement 7. International Agency for Research on Cancer, Lyon, pp. 100–103. Kelly, E.J., Campbell, K., 2000. Separating variability and uncertainty in environmental risk assessment - Making choices. Human and Ecological Risk Assessment 6, 1−13. Knauer, K., Behra, R., Sigg, L., 1997. Effects of free Cu2+ and Zn2+ ions on growth and metal accumulation in freshwater algae. Environmental Toxicology and Chemistry 16, 220−229. Koch, I., Reimer, K.J., Beach, A., Cullen, W.R., Gosden, A., Lai, V.W.M., 2001. Arsenic speciation in fresh-water fish and bivalves. In: Chappell, W.R., Abernathy, C.O., Calderon, R.L., (Eds), Arsenic exposure and health effects IV. Elsevier, Oxford, UK, pp. 115–123. Kohn, M.C., 1995. Achieving credibility in risk assessment models. Toxicology Letters 79, 107−114. Lalonde, R.L., 1992. Pharmacodynamics. In: Evans, W.E., Schentag, J.J., Jusko, W.J., (Eds.), Applied pharmacokinetics. New York: Lip-pincott Williams and Wilkins, pp. 4-1−4-33. Larsen, E.H., Quetel, C.R., Munoz, R., FialaMedioni, A., Donard, O.F.X., 1997. Arsenic speciation in shrimp and mussel from the Mid-Atlantic hydrothermal vents. Marine Chemistry 57, 341–346. Lawrence, G.S., Gobas, F.A.P.C., 1997. A pharmacokinetic analysis of interspecies extrapolation in dioxin risk assessment. Chemosphere 35, 427–452. Lee, C.L., Chen, H.Y., Chuang, M.Y., 1996. Use of oyster, Crassostrea gigas, and ambient water to assess metal pollution status of the Charting coastal area, Taiwan, after the 1986 green oyster incident. Chemosphere 33, 2505−2532. Leggett, R.W., Williams, L.R., Melo, D.R., Lipsztein, J.L., 2003. A physiologically based biokinetic model for cesium in the human body. Science of the Total Environment 317, 235–255. Liao, C.M., Chen, B.C., Lin, M.C., Chen, J.W., 2000. An optimal trace zinc biomonitor (Haliotis diversicolor supertexta) control system design in aquacultural ecosystems. Applied Mathematical Modelling 24, 27–43. Liao, C.M., Lin, M.C., 2001. Toxicokinetics and acute toxicity of waterborne zine in abalone (Haliotis diversicolor supertexta Lischke). Bulletin of Environmental Contamination and Toxicology 66, 597−602. Liao, C.M., Chen, B.C., Lin, M.C., Chiu, H.M., Chou, Y.H., 2002a. Coupling toxicokinetics and pharmacodynamics for predicting survival of abalone (Haliotis diversicolor supertexta) exposed to waterborne zinc. Environmental Toxicology 17, 478−486. Liao, C.M., Lin, M.C., Chen, J.S., Chen, J.W., 2002b. Linking biokinetics and consumer-resource dynamics of zinc accumulation in pond abalone Haliotis diversicolor supertexta. Water Research 36, 5102−5112. Liao, C.M., Chen, B.C., Singh, S., Lin, M.C., Liu, C.W., Han, B.C., 2003a. Acute toxicity and bioaccumulation of arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. Environmental Toxicology 18, 252–259. Liao, C.M., Ling, M.P., Chen, J.S., 2003b. Appraising zinc bioaccumulation in abalone Haliotis diversicolor supertexta and alga Gracilaria tenuistipitata var. liui by probabilistic analysis. Aquaculture 217, 285–299. Liao, C.M., Tsai, J.W., Ling, M.P., Liang, H.M., Chou, Y.H., Yang, P.T., 2004. Organ-specific toxicokinetics and dose-response of arsenic in tilapia Oreochromis mossambicus. Archives of Environmental Contamination and Toxicology 47, 502–510. Liao, C.M., Liang, H.M., Chen, B.C., Singh, S., Tsai, J.W., Chou, Y.H., Lin, W.T., 2005. Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. Environmental Pollution 135, 221–233. Lien, G.J., McKim, J.M., Hoffman, A.D., Jenson, C.T., 2001. A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush). Aquatic Toxicology 51, 335–350. Lin, C.J., Wu, M.H., Hsueh, Y.M., Sun, S.S.M., Cheng, A.L., 2005. Tissue distribution of arsenic species in rabbits after single and multiple parenteral administration of arsenic trioxide: tissue accumulation and the reversibility after washout are tissue-selective. Cancer Chemotherapy and Pharmacology 55, 170−178. Lin, J.K., Chiang, H.C., 2002. Arsenic concentration in drinking well water in Lanyang area and its preliminary health risk assessment. NSC/90/2218/E/238/003. National Science Council, Taipei, ROC. Lin, M.C., Liao, C.M., 1999. 65Zn(II) accumulation in the soft tissue and shell of abalone Haliotis diversicolor supertexta via the alga Gracilaria tenuistipitata var. liui and the ambient water. Aquaculture 178, 89−101. Lin, M.C., Liao, C.M., Liu, C.W., Singh, S., 2001. Bioaccumulation of arsenic in aquacultural large-scale mullet Liza macrolepis from blackfoot disease area in Taiwan. Bulletin of Environmental Contamination and Toxicology 67, 91–97. Lin, M.C., Cheng, H.H., Lin, H.Y., Chen, Y.C., Chen, Y.P., Chang-Chien, G.P., Chou, Y.H., Liao, C.M., Dai, C.F., Han, B.C., Liu, C.W., 2004. Arsenic accumulation and acute toxicity in aquacultural juvenile milkfish (Chanos chanos) from blackfoot disease area in Taiwan. Bulletin of Environmental Contamination and Toxicology 72, 248–254. Linkov, I., von Stackelberg, K.E., Burmistrov, D., Bridges, T.S., 2001. Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments. Science of the Total Environment 274, 255–269. Livingstone, D.R., 1991. Towards a specific index of impact by organic pollution for marine-invertebrates. Comparative Biochemistry and Physiology C-Pharmacology Toxicology and Endocrinology 100, 151−155. Lung, S.C.C., Chen, C.F., Hu, S.C., Bau, Y.P., 2003. Exposure of Taiwan residents to polychlorinated biphenyl congeners from farmed, ocean-caught, and imported fish. Environmental Science and Technology 37, 4579–4585. Maher, W., Goessler, W., Kirby, J., Raber, G.., 1999. Arsenic concentrations and speciation in the tissues and blood of sea mullet (Mugil cephalus) from Lake Macquarie NSW, Australia. Marine Chemistry 68, 169–182. Mance, G., 1987. Pollution threat of heavy metals in aquatic environments. In: Mellanby, K. (Ed.), Pollution monitoring Series. Elseiver Applied Science, London, UK. Mandal, B.K., Suzuki, K.L., 2002. Arsenic round world: a review. Talanta 58, 201−235. Mann, S., Droz, P.O., Vahter, M., 1996. A physiologically based pharmacokinetic model for arsenic exposure. II. Validation and application in humans. Toxicology and Applied Pharmacology 140, 471–486. Martin, M., Coughtrey, P.J., 1993. Biological monitoring of heavy metal pollution: land and air, Applied Science, London. Mckone, T.E., 1994. Uncertainty and variability in human exposures to soil contaminants through home-grown food: a Monte Carlo assessment. Risk Analysis 14, 449−463. Meacher, D.M., Menzel, D.B., Dillencourt, M.D., Bic, L.F., Schoof, R.A., Yost, L.J., Eickhoff, J.C., Farr, C.H., 2002. Estimation of multimedia inorganic arsenic intake in the US population. Human and Ecological Risk Assessment 8, 1697–1721. Melnick, R.L., Kohn, M.C., Dunnick, J.K., Leininger, J.R., 1998. Regenerative hyperplasia is not required for liver tumor induction in female B6C3F(1) mice exposed to trihalomethanes. Toxicology and Applied Pharmacology 148, 137–147. Morton, W., Starr, G., Phol, D., 1976. Skin cancer and water arsenic in Lane Contry, Oregon. Cancer 37, 2523−2532. Moore, D.R.J., Sample, B.E., Suter, G.W., Parkhurst, B.R., Teed, R.S., 1999. A probabilistic risk assessment of the effects of methylmercury and PCBS on mink and kingfishers along East Fork Poplar Creek, Oak Ridge, Tennessee, USA. Environmental Toxicology and Chemistry 18, 2941−2953. Nichols, J.W., Hensen, K.M., Tietge, J.E., Johnson, R.D., 1998. Physiologically based toxicokinetic model for maternal transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin in brook trout (Salvelinus fontinalis). Environmental Toxicology and Chemistry 17, 2422–2434. Nordstrom, D.K., 2002. Public health - Worldwide occurrences of arsenic in ground water. Science 296, 2143−2145. NRC, 1987. Pharmacokinetics in risk assessment: drinking water and health. National Research Council, Natl. Acad. Press, Washington, DC. NRC, 2001. Arsenic in Drinking Water. National Research Council, National Academy Press, Washington, DC. Paustenbach, D.J., 2002. Human and ecological risk assessment: theory and practice. John Wiley & Sons, New York, USA. Rainbow, P.S., 1995. Biomonitoring of heavy metal availability in the marine environment. Marine Pollution Bulletin 31, 183−192. Renwick, A.G., 2004. Risk characterisation of chemicals in food. Toxicology Letters 149, 163–176. Rice, D.C., 2004. The US EPA reference dose for methylmercury: sources of uncertainty. Environmental Research 95, 406–413. Richardson, C.A., 2001. Oceanography and marine biology. Oceanography and Marine Biology 39, 103−164. ROC EPA, 2004. Groundwater Monitoring Data. Soil and Groundwater Remediation Web. http://wq.epa.gov.tw/WQ/Public2/ImageGW.asp. Schoof, R.A., Eickhoff, J., Yost, L.J., Crecelius, E.A., Cragin, D.W., Meacher, D.M., Menzel, D.B., 1999a. Dietary exposure to inorganic arsenic. In: Chappell, W.R., Abernathy, C.O., Calderon, R.L., (Eds.), Arsenic exposure and health effects. Elsevier, Oxford, UK, pp. 81–88. Schoof, R.A., Yost, L.J., Eickhoff, J., Crecelius, E.A., Cragin, D.W., Meacher, D.M., Menzel, D.B., 1999b. A market basket survey of inorganic arsenic in food. Food and Chemical Toxicology 37, 839–846. Shargel, L., Wu-Pong, S., Yu, A.B.C., 2005. Applied Biopharmaceutics and Pharmacokinetics, fifth edition. McGraw-Hill, New York, pp. 575−611. Simkiss, K., Taylor, M., Mason, A.Z., 1982. Metal detoxification and bioaccumulation in mollusks. Marine Biology Letters 3, 187−201. Singhagraiwan, T., Doi, M., 1993. Seed production and culture of a tropical abalone, Haliotis asinina Linne. The Eastern Marine Fisheries Development Center. Thailand, 31pp. Smith, A.H., Hopenhaynrich, C., Bates, M.N., Goeden, H.M., Hertzpicciotto, I., Duggan, H.M., Wood, R., Kosnett, M.J., Smith, M.T., 1992. Cancer risks from arsenic in drinking-water. Environmental Health Perspectives 97, 259−267. Smith, A.H., Sciortino, S., Goeden, H., Wright, C.C., 1996. Consideration of background exposures in the management of hazardous waste sites: a new approach risk assessment. Risk Analysis 16, 619−625. Smith, R.L., 1994. Use of Monte Carlo simulation for human exposure assessment at a superfund site. Risk Analysis 12, 433−439. Taylor, D., Maddock, B.G., Mance, G., 1985. The acute toxicity of nine ‘‘grey list’’ metals (arsenic, boron, chromium, copper, lead, nickel, tin, vanadium, and zinc) to two marine fish species: Dab (Limanda limanda) and grey mullet (Chelon labrosus). Aquatic Toxicology 7, 135–144. Tchounwou, P.B., Centeno, J.A., Patlolla, A.K., 2004. Arsenic toxicity, mutagenesis, and carcinogenesis a health risk assessment and management approach. Molecular and Cellular Biochemistry 255, 47–55. Thornton, I., Farago, M., 1999. The geochemistry of arsenic. In: Chappell, W.R., Abemathy, C.O., Calderon, R.L., (Eds), Arsenic Exposure and human health Effects. Elsevier, Oxford, UK, pp. 1−16. Thomann, R.V., Shkreli, F., Harrison, S., 1997. A pharmacokinetic model of cadmium in rainbow trout. Environmental Toxicology and Chemistry 16, 2268–2274. Timmermans, K.R., Spijkerman, E., Tonkes, M., Govers, H., 1992. Cadmium and zinc uptake by two species of aquatic invertebrate predators from dietary and aqueous sources. Canadian Journal of Fisheries and Aquatic Sciences 49, 655–662. Tokur, B., Polat, A., Beklevik, G., Ozkutuk, S., 2004. Changes in the quality of fishburger produced from Tilapia (Oreochromis niloticus) during frozen storage (-18 degrees C). European Food Research and Technology 218, 420–423. Tressou, J., Crepet, A., Bertail, P., Feinberg, M.H., Leblanc, J.C., 2004. Probabilistic exposure assessment to food chemicals based on extreme value theory. Application to heavy metals from fish and sea products. Food and Chemical Toxicology 42, 1349−1358. Tsai, J.W., Chou, Y.H., Chen, B.C., Liang, H.M., Liao, C.M., 2004. Growth toxicity bioassays of abalone Haliotis diversicolor supertexta exposed to waterborne zinc. Bulletin of Environmental Contamination and Toxicology 72, 70−77. Tsai, S.Y., Chou, H.Y., The, H.W., Chen, C.M., Chen, C.J., 2003. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 24, 747–753. Tseng, C.H., Chong, C.K., Chen, C.J., Tai, T.Y., 1996. Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan. Atherosclerosis 120, 125−133. Tseng, W.P., Chu, H.M., How, S.W., Fong, J.M., Lin, C.S., Yeh, S., 1968. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. Journal of the National Cancer Institute 40, 453−463. US EPA, 1988. Special report on ingested inorganic arsenic. Skin cancer; Nutritional essentiality. EPA/625/3-87/-13, US Environmental Protection Agency, Washington, DC. US EPA, 1989. Risk assessment guidance for superfund, human health evaluation manual. EPA/540/1/89/0002, US Environmental Protection Agency, Office of Emergency and Remedial Response, Washington, DC. US EPA, 1998. Guidelines for ecological risk assessment. EPA/630/R/95/002F, US Environmental Protection Agency, Washington, DC. US EPA, 2000a. Technical progress report of the implementation plan for probabilistic ecological assessments: aquatic systems. Meeting scheduled for April 6-7, US Environmental Protection Agency, Washington, DC. US EPA, 2000b. Guidelines for Assessing Chemical Contaminant Data for Use in Fish Advisories. II. Risk Assessment and Fish Consumption Limits. EPA/823/B/00/008, US Environmental Protection Agency, Washington, DC. US EPA, 2002a. Child-Specific Exposure Factors Handbook (Interim Report). EPA/600/P/00/002B, US Environmental Protection Agency, Washington, DC. US EPA, 2002b. National recommended water quality criteria. EPA/822/R/02/047, US Environmental Protection Agency, Washington, DC. US FDA, 1993. Guidance document for arsenic in shellfish. US Food and Drug Administration, Washington, DC, pp. 25–27. Voit, E.O., Schubauer-Berigan, M.K., 1998. Canonical modeling as a unifying framework for ecological and human risk assessment. In: Newman, M.C., Strojan, C.L., (Eds.), Risk assessment: logic and measurement. Ann Arbor Press, Chelsea, MI, USA, pp. 101−139. Walsh, A.R., O’Halloran. J., 1998. Accumulation of chromium by a population of mussels (Mytilus edulis (L.)) exposed to leather tannery effluent. Environmental Toxicology and Chemistry 17, 1429−1438. Wang, W.X., Ke, C.H., 2002. Dominance of dietary intake of cadmium and zinc by two marine predatory gastropods. Aquatic Toxicology 56, 153−165. Warila, J., Batterman, S., Passino-Reader, D.R., 2001. A probabilistic model for silver bioaccumulation in aquatic systems and assessment of human health risks. Environmental Toxicology and Chemistry 20, 432−441. Widianarko, B., Kuntoro, F.X.S., Van Gestel, C.A.M., Van Straalen, N.M., 2001. Toxicokinetics and toxicity of zinc under time-varying exposure in the guppy (Poecilia reticulata). Environmental Toxicology and Chemistry 20, 763−768. Wu, M.M., Kuo, T.L., Hwang, Y.H., Chen, C.J., 1989. Dose−response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. American Journal of Epidemiology 130, 1123−1132. Yang, C.Y., Chang, C.C., Tsai, S.S., Chuang, H.Y., Ho, C.K., Wu, T.N., 2003. Arsenic in drinking water and adverse pregnancy outcome in an arseniasis-endemic area in northeastern Taiwan. Environmental Research 91, 29–34. Yu, D., 1998. Uncertainties in a pharmacokinetic modeling for inorganic arsenic. Journal of Toxicology and Environmental Health-Part A 33, 1369–1390. Yu, D., 1999a. A physiologically based pharmacokinetic model of inorganic arsenic. Regulatory toxicology and pharmacology 29, 128–141. Yu, D., 1999b. A physiologically modeling of inorganic arsenic: a short-term oral exposure model for humans. Chemosphere 39, 2737–2747. Yu, W.H., Harvey, C.M., Harvey, C.F., 2003. Arsenic in groundwater in Bangladesh: A geostatistical and epidemiological framework for evaluating health effects and potential remedies. Water Resources Research 39, 1146, doi:10.1029/2002WR001327. Zar, J.H., (4th Ed.), 1999. Biostatistical Analysis. Prentice-Hall, Inc. New Jersey, USA. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38566 | - |
dc.description.abstract | 本研究計畫之目的在於發展一新穎之生物為基礎機率風險評估整合架構,以研析九孔暴露於含鋅水域、吳郭魚暴露於含砷水域以及人食用受砷污染養殖海鮮及飲用地下水之健康風險。此機率模式包含結合生物動力與資源-消耗者動態模式之一階雙區塊生物累積模式,描述九孔暴露於含鋅水域之動態行為。並採用生理為基礎之藥理動力及動態(PBPK/PD)模式,除用以描述吳郭魚暴露於含砷水域之暴露分析外,亦用於人體健康風險評估上。研究中探討養殖九孔受鋅和吳郭魚受砷污染下之各標的組織濃度曲線,並藉由重新建立以生物為基礎之劑量與反應關係,來預測九孔成長抑制/死亡風險及吳郭魚之死亡風險,並推估人攝取受砷污染之養殖海鮮及地下水之非致癌/致癌風險。本研究以機率風險評估架構來描述特定年齡族群居民於烏腳病盛行區(食用養殖吳郭魚、虱目魚及豆仔魚)與蘭陽平原(飲用地下水和食用養殖海鮮(如:香魚及草蝦))之無機砷暴露風險。本研究亦以造成人體潛在致癌風險為基礎,推估人可攝取無機砷之飲食忠告。
在九孔暴露於含鋅水域之風險分析結果顯示,位於臺灣北中南的頭城、口湖及安平三地養殖池水中之含鋅量,對九孔造成存活影響之風險機率較低。此外,預測抑制九孔成長之危害商數(growth hazard quotient),第90百分位潛在風險值分別為頭城:1.94、口湖:0.47及安平:0.51。推估九孔死亡之預期風險分別為頭城:0.46、口湖:0.36及安平:0.29。本研究結果指出,台灣口湖與安平兩地之養殖九孔暴露於含鋅水域並無顯著之風險;而相較之下,頭城養殖池則有較高之抑制九孔成長風險,應提出警訊。靈敏度分析結果指出,水域中鋅濃度為影響藻類及九孔體內鋅濃度之最主要因子,其變異貢獻範圍為82.85–91.87%。 由吳郭魚暴露於含砷水域之風險分析結果指出,以風險值為0.1為例,10%以上機率因吳郭魚各標的器官受到砷污染後,約有10-9到10-6%吳郭魚會受到死亡之影響。吳郭魚各標的器官如魚肉、鰓及肝之預期死亡超越風險分別為0.3、0.1及0.3,顯示烏腳病盛行區暴露於含砷水域之吳郭魚存活率約有70–90%,其受到死亡危害之風險較不顯著。 此外,本研究探討烏腳病盛行區及蘭陽平原當地孩童(4–12歲,暴露時間:8年)、青少年(13–20歲,暴露時間:16年)與成年人(21–65歲,暴露時間:61年)攝食養殖海鮮及飲用地下水之健康風險。研究分析指出攝取來自慢性砷中毒盛行區受到砷污染之養殖海鮮及地下水,可能會增加威脅當地所有居民得到皮膚病變及成年人得到皮膚癌之盛行率,並增加成年人因受砷所誘導肺癌及膀胱癌而導致死亡之潛在發生率。由研究結果發現蘭陽平原當地居民得到皮膚病變與皮膚癌之病症,及誘導成肺癌及膀胱癌所導致死亡之風險皆較烏腳病盛行區當地居民高。 本研究並以最保守風險分析為基礎之飲食忠告,求得當地居民最大可接受之風險值。在致癌風險考量下,建議烏腳病盛行區之當地青少年(13–20歲,暴露時間:16年)每月最大允許養殖海鮮攝食量(中位值)為不超過15–28餐(或每日25–46公克),當地成年人(21–65歲,暴露時間:61年)每月攝食量則建議需少於一餐(或每日0.19–0.30公克)。在蘭陽平原一帶,本研究建議當地青少年(13–20歲,暴露時間:16年)每月攝食量為不超過4–7餐(或每日6–11公克),當地成年人(21–65歲,暴露時間:61年)每月攝食量則需少於一餐(或每日0.08–0.12公克)。 | zh_TW |
dc.description.abstract | The purpose of this dissertation is to develop a novel biologically-based probabilistic risk assessment (PRA) integrated framework for abalone Haliotis diversicolor supertexta exposed to waterborne zinc (Zn), arsenic (As) exposure estimates for tilapia Orechromis mossambicus, and age-specific human health risks through consumption of As-contaminated farmed seafood and groundwater. The probabilistic models implemented include linking a first-order two-compartment bioaccumulation model, with biokinetic and consumer−resource dynamic models for abalone exposed to waterborne Zn and employing a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model not only for describing As exposure in tilapia, but also assessing human health risks. Target organ metal (Zn or As) concentration profiles in aquatic organisms (abalone or tilapia) and human follow a reconstructed dose−response relationship to predict growth and mortality risks of abalone, mortality risk of tilapia, and morbidity and fatality risks for human. This study carries out PRA framework to characterize age-specific exposure risks to ingested inorganic As in BFD-endemic area (through farmed tilapia, milkfish, and large-scale mullet) and in Lanyang Plain (through drinking groundwater and farmed seafood such as smelt and grass shrimp). This study also determines the consumption advice for inorganic As based on the estimates of potential carcinogenic risks. Risk analysis indicates that abalone reared near Toucheng, Kouhu, and Anping, respectively, in north, central, and south Taiwan region show a relative low likelihood that survival is being affected by waterborne Zn. The predicted 90th percentiles of growth HQ (GHQ) for potential growth risk were estimated as 1.94 (Toucheng), 0.47 (Kouhu), and 0.51 (Anping). Expected risks of mortality for abalone were estimated as 0.46 (Toucheng), 0.36 (Kouhu), and 0.29 (Anping). These findings indicate that waterborne Zn exposure poses no significant risk to farmed abalone in Kouhu and Anping, yet a relative high growth risk in Toucheng is alarming. Sensitivity analysis indicated that the key parameter in estimating Zn in algae and abalone is water Zn content that contribution to variance ranged from 82.85 − 91.87%. Risk analysis demonstrates that the probabilities that 10% or more of the tilapia muscle, gill, and liver (risk=0.1) affected ranged from 10-9 to 10-6%, whereas the expected exceedence risk of mortality for tilapia muscle, gill, and liver were calculated to be 0.3, 0.1, and 0.3, respectively, indicating less significant adverse effect for tilapia major organs exposed to waterborne As from selected tilapia farms in the BFD-endemic area. This study performs the health risk for children (4 − 12 yrs, exposure duration: 8 yrs), adolescents (13 − 20 yrs, exposure duration: 16 yrs), and adults (21 − 65 yrs, exposure duration: 61 yrs) consumption of farmed seafood and groundwater by residents in BFD-endemic area and in Lanyang Plain. Risk analysis indicates that consumption of As-contaminated farmed seafood and groundwater from arseniasis-endemic areas may increase threat to prevalence ratios of arsenicosis for all residents and skin cancer for adults, whereas increase potential incidence rates from As-induced lung and bladder cancer for adults. Here this study shows a higher morbidity for arsenicosis and skin cancer and fatality for lung and bladder cancers for residents living in Lanyang Plain. The analysis of the most restrictive risk-based consumption advice, which reflects the highest risks, suggest that the median farmed seafood consumption rate of carcinogenic effects for adolescents (13 − 20 yrs, exposure duration: 16 yrs) is no more than 15 − 28 meals mon-1 (or 25 − 46 g d-1), whereas less than one meal mon-1 (or 0.19 − 0.30 g d-1) for adults (21 − 65 yrs, exposure duration: 61 yrs) in BFD-endemic area. In Lanyang Plain, we suggest that the median consumption rate for adolescents (13 − 20 yrs, exposure duration: 16 yrs) is no more than 4 − 7 meals mon-1 (or 6 − 11 g d-1), whereas less than one meal mon-1 (or 0.08 − 0.12 g d-1) for adults (21 − 65 yrs, exposure duration: 61 yrs). | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T16:37:35Z (GMT). No. of bitstreams: 1 ntu-94-F90622042-1.pdf: 2179830 bytes, checksum: b43da568d15794e9c2e7328346818ffe (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | ABSTRACT I
ABSTRACT (CHINESE) IV TABLE OF CONTENTS VI LIST OF TABLES IX LIST OF FIGURES XI NOMENCLATURE XIV CHAPTER 1 INTRODUCTION 1 CHAPTER 2 BACKGROUND AND RESEARCH OBJECTIVES 3 2.1 Background 3 2.2 Research Objectives 7 CHAPTER 3 LITERATURE REVIEW 8 3.1 Interactions Between Target Species and Target Metals 8 3.1.1 Abalone-Zinc 8 3.1.2 Tilapia⎯Arsenic 15 3.1.3 Human-Arsenic 19 3.1.3.1 Arsenic Levels in Farmed Seafood from BFD-Endemic Area 23 3.1.3.2 Arsenic Levels in Farmed Seafood and Groundwater at Lanyang Plain 24 3.2 Risk Analysis 26 3.2.1 Risk Assessment Challenge 26 3.2.2 Evaluations of Probabilistic Risk Assessment 28 3.2.3 Ecological Risk Assessment Process 30 3.2.4 Applications of PBPK Modeling 32 3.2.5 PD-Based 3-Parameter Hill Modeling 34 CHAPTER 4 MATERIALS AND METHODS 37 4.1 Problem Formulation 37 4.1.1 Zinc in Abalone and Algae 38 4.1.2 Arsenic in Tilapia 394.1.3 Arsenic in Human 40 4.2 Exposure Analysis 41 4.2.1 Consumer−Resource Dynamic Model for Abalone-Zinc System 41 4.2.2 Physiologically Based Pharmacookinetic Model for Tilapia-Arsenic and Human-Arsenic Systems 45 4.3 Effect Analysis 53 4.3.1 Pharmacodynamic Model for Mortality in Abalone-Zinc, Tilapia-Arsenic Systems 53 4.3.2 Pharmacodynamic Model for Morbidity and Fatality in Human-Arsenic System 55 4.4 Risk Characterization 60 4.4.1 Growth Effect for Abalone-Zinc System 60 4.4.2 Mortality Effect for Abalone-Zinc and Tilapia-Arsenic Systems 61 4.4.3 Morbidity and Fatality Effects for Human-Arsenic System 64 4.4.4 Consumption Advice of Arsenic for Human 65 4.5 Uncertainty Analysis 66 4.5.1 Uncertainty/Sensitivity Analysis 66 4.5.2 Model Parameterization 68 4.5.2.1 Abalone⎯Zinc 68 4.5.2.2 Tilapia⎯Arsenic 71 4.5.2.3 Human⎯Arsenic 75 CHAPTER 5 RESULTS AND DISCUSSION 81 5.1 Abalone⎯Zinc 81 5.1.1 Exposure Analysis 81 5.1.2 Concentration−Response Analysis 86 5.1.3 Growth Risk 88 5.1.4 Mortality Risk 90 5.1.5 Sensitivity Analysis 94 5.2 Tilapia⎯Arsenic 97 5.2.1 Exposure Analysis 97 5.2.2 Organ-Specific Concentration−Response Analysis 103 5.2.3 Mortality Risk 106 5.2.4 Sensitivity Analysis 109 5.3 Human⎯Arsenic 111 5.3.1 Exposure Analysis 111 5.3.2 Age-Specific Concentration−Response Analysis 113 5.3.3 Morbidity and Fatality Risk 121 5.3.4 Risk-Based consumption Advice 129 5.3.5 Sensitivity Analysis 1325.4 Implications 134 CHAPTER 6 CONCLUSIONS 137 CHAPTER 7 SUGGESTIONS FOR FUTURE RESEARCH 140 BIBLIOGRAPHY 142 CURRICULUM VITAE 161 | |
dc.language.iso | en | |
dc.title | 以生物為基礎之整合架構研析水域生態系金屬生物累積及人體健康風險 | zh_TW |
dc.title | A Biologically-Based Integrated Framework to Assess Metals Bioaccumulation in Aquatic Ecosystems and Human Health Risks | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 劉振宇,江漢全,傅承德,李美慧,陳瑞昇 | |
dc.subject.keyword | 九孔,吳郭魚,年齡別,鋅,砷,機率,生理為基礎之藥理動力及藥理動態,模式為基礎之風險評估,飲食忠告, | zh_TW |
dc.subject.keyword | Abalone,Tilapia,Age-specific,Zinc,Arsenic,Probabilistic,PBPK/PD,Model-based risk assessment,Consumption advice, | en |
dc.relation.page | 161 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-06 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 生物環境系統工程學研究所 | zh_TW |
Appears in Collections: | 生物環境系統工程學系 |
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