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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38048完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王兆麟(Jaw-Lin Wang) | |
| dc.contributor.author | Hsi-Yu Yu | en |
| dc.contributor.author | 虞希禹 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:58:41Z | - |
| dc.date.available | 2008-06-16 | |
| dc.date.copyright | 2008-06-16 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-05-20 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38048 | - |
| dc.description.abstract | 本研究以『希望依據每一位心衰竭病人個別的心臟狀況，量身訂製手術治療方案』，以心衰竭病患為研究的對象，以磁振造影術為研究工具，研究方法為程式分析心臟磁振造影術的影像資料，取得各項生物力學指標，應用心臟生物力學的知識加以分析。研究範圍包含下列主題：
(1) 心肌血液灌流的動力學分析：我們建立一個心肌血液灌流的動力學模型，包含五個參數（灌流速率、延遲時間、血管體積、間隙組織體積、通過微血管壁的交換速率）。代入磁振造影所得的心肌組織訊號強度變化，以求取各區心肌組織的灌流參數。進而分析組織的微循環動力學。 (2) 缺血性二尖瓣逆流之幾何學研究：我們完成以局部組織幾何學特色追蹤該區域的運動軌跡，進而分析左心室壁的運動狀態。套用於二尖瓣運動學的幾何模型（二尖瓣四角錐），分析因冠心症造成的缺血性二尖瓣逆流患者，其二尖瓣四角錐的幾何變異。 (3) 缺血性心肌病經心室整形手術治療後之收縮力分析：左心室整容術是以外科手術治療末期心衰竭的新希望。基本上是希望應用外科手術的方式以改變擴張的左心室的幾何外型，以改善心室的收縮效能。我們應用分析左心室壁運動的程式，分析接受左心室整容術術前以及術後局部心室收縮力的改變，以明瞭並確認該項手術成功的關鍵因素為何。 (4) 相關於左心室輸出阻力的主動脈彈性的探討：磁振造影術的phase-contrast造影技術是分析速度場的好方法。我們應用它來計算降行主動脈內血液的脈衝波速度，進而推論主動脈的張力。這是一個不必直接量測壓力而可以計算血管張力的好辦法。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:58:41Z (GMT). No. of bitstreams: 1 ntu-97-D91548003-1.pdf: 7127271 bytes, checksum: 60fb9e4739699f254245ed174ce4cf22 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 第一章 緒論 1
第一節：心衰竭的介紹 1 第二節 心臟的生物力學研究 1 第三節 心臟的磁振造影術 2 第四節 研究範疇 3 第二章 心肌血液灌流的動力學分析 7 第一節 心臟血流生理學 7 第二節 傳統心臟肌肉血液灌流量檢查 9 第三節 定量心臟肌肉的血液灌流動力學 11 第四節 以磁振造影術研究心肌血液灌流動力學於糖尿病患與正常人之差異 12 第五節 結果 21 第六節 討論 24 第三章 缺血性二尖瓣逆流的幾何分析 31 第一節 二尖瓣解剖生理學 31 第二節 缺血性二尖瓣逆流病理生理學 31 第三節 研究動機和目標 34 第四節 二尖瓣四角錐 35 第五節 MRI影像擷取以及二尖瓣四角錐周長測量 36 第六節 虛擬手術的研究 41 第七節 左心室的功能性隔間 45 第四章 缺血性心肌經心室整形手術治療後之收縮力分析 51 第一節 心室整形手術簡介 51 第二節 病患收集與研究方法 52 第三節 結果 56 第四節 討論與結論 57 第五章 主動脈彈性之討論 65 第一節 研究動機 65 第二節 脈衝波速度與管壁彈性張力 65 第三節 以相位偏差 (PHASE-CONTRAST) MRI測量主動脈PWV 67 第五節 波前的決定 72 第六節 以楊式彈性係數 (YOUNG’S MODULUS) 驗證PWV 75 第七節 實驗結果 77 第六章 討論與展望 83 | |
| dc.language.iso | zh-TW | |
| dc.subject | 磁振造影術 | zh_TW |
| dc.subject | 心臟病 | zh_TW |
| dc.subject | 心衰竭 | zh_TW |
| dc.subject | 生物力學 | zh_TW |
| dc.subject | 缺血性心肌病 | zh_TW |
| dc.subject | 二尖瓣逆流 | zh_TW |
| dc.subject | 二尖瓣四角錐 | zh_TW |
| dc.subject | 心室整容術 | zh_TW |
| dc.subject | 主動脈張力 | zh_TW |
| dc.subject | 脈衝波速度 | zh_TW |
| dc.subject | pulse wave velocity | en |
| dc.subject | ischemic heart disease | en |
| dc.subject | MRI | en |
| dc.subject | magnetic resonance imaging | en |
| dc.subject | biomechanics | en |
| dc.subject | Heart failure | en |
| dc.subject | Heart | en |
| dc.subject | coronary heart disease | en |
| dc.subject | CAD | en |
| dc.subject | mitral regurgitation | en |
| dc.subject | PWV | en |
| dc.subject | mitral tetrahedron | en |
| dc.subject | surgical ventricular restoration | en |
| dc.subject | SVR | en |
| dc.subject | aortic compliance | en |
| dc.title | 應用心臟磁振造影術於缺血性心臟病之生物力學研究 | zh_TW |
| dc.title | Bio-mechanical Study of Ischemic Heart Disease with Magnetic Resonance Imaging Technique | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 曾文毅(Wen-Yih I. Tseng),林芳郁(Fang-Yue Lin),陳益祥(Yih-Sang Chen),溫志湧(Chie-Yung Wen) | |
| dc.subject.keyword | 心臟病,心衰竭,生物力學,磁振造影術,缺血性心肌病,二尖瓣逆流,二尖瓣四角錐,心室整容術,主動脈張力,脈衝波速度, | zh_TW |
| dc.subject.keyword | Heart,Heart failure,biomechanics,magnetic resonance imaging,MRI,ischemic heart disease,coronary heart disease,CAD,mitral regurgitation,mitral tetrahedron,surgical ventricular restoration,SVR,aortic compliance,pulse wave velocity,PWV, | en |
| dc.relation.page | 84 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-05-21 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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