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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38017完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張正憲 | |
| dc.contributor.author | Kuan-Rong Huang | en |
| dc.contributor.author | 黃冠榮 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:56:47Z | - |
| dc.date.available | 2014-08-20 | |
| dc.date.copyright | 2011-08-20 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-09 | |
| dc.identifier.citation | Reference
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38017 | - |
| dc.description.abstract | 最近二十年，微混合器與生物感測器被廣泛的研究與發展。微混合器主要是運用力學機制來混合微流道內不同流體的一種裝置。而生物感測器則是因為具備了高靈敏度、微量檢測及即時偵測等優異特性，因此提供了即時且便利的生物檢測方式。
在微流道系統中，交流電動力往往被當作操控粒子在流體中運動以及擾動流場的一種機制，交流電動力主要包含了介電泳、交流電滲，以及電熱力等，而這些交流電動力，則會因為懸浮物的帶電量，電解溶液的導電度，以及交流電場電壓的不同等而有所區分。透過交流電場的施加，流場內的懸浮粒子將能被有效的操控，或者流場因電動力所產生的渦流，能被有效的攪拌。 本論文主要分成三個部分：微混合器，共振式微懸臂梁生物感測器以及生物感測器的免疫分析。在微混合器與生物感測器的免疫分析方面，由有限元素法的模擬方式，利用交流電熱力對其效能上的改善；在共振式微懸臂梁生物感測器方面，將透過理論與模擬來對其作一廣泛性的討論，包含其基本振動特性的研究，共振式微懸臂梁生物感測器的靈敏度討論與改良，以及不同型式的共振式生物感測器的比較等，而主要對象元件則包括，單一微懸臂梁生物感測器、微懸臂梁陣列，懸臂式微流道生物感測器，以及石英晶體微天平。 | zh_TW |
| dc.description.abstract | In the last two decades, micromixers and biosensors in the micro system are popularly investigated and developed. A micromixer is primarily employed for mixing fluids by means of externally or internally mechanical mechanisms. A biosensor is based on several advantages, such as highly sensitive, tiny mass load detection and capable of monitoring dynamic biomolecular interaction in real time, to be used as the apparatus for the biomolecule detection.
Then, the study of AC electrokinetics is correlated with the motion behavior of particles in fluids, and it is also widely applied on microfluidic devices in the recent decade. When microfluidic devices of the microfabricated electrode systems are subjected to AC electrical fields, the AC electrokinetics involving the dielectrophoresis, AC electroosmosis or AC electrothermal force will be generated according to charges of colloids, different properties of electrolytes or amplitude and frequency of external applied voltages. This thesis is divided into three major subjects: micromixers, resonant microcantilever-based biosensors, and immunoassay of the biosensor. In terms of AC electrokinetics: AC electrothermal force, micromixers and immunoassay of the biosensor will be concentrated on meliorating their working efficiency by employing finite element method. For resonant microcantilever-based biosensors, a comprehensive investigation will be theoretically and numerically executed, involving the study of fundamental vibrational properties, the sensitivity of resonant microcantilever-based biosensors, and a comparison of distinct resonant biosensors, etc. Target components comprise as follows: micorcantilever beam sensor (MCB), microcantilever beam array sensor, suspended microchannel resonator (SMR), quartz crystal micorbalance (QCM). | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:56:47Z (GMT). No. of bitstreams: 1 ntu-100-D94543005-1.pdf: 7347598 bytes, checksum: 8232b33a423d458757a3abe3bc4e8b49 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 誌謝 i
摘要 iii Abstract iv List of Figures viii List of Tables xvi Chapter 1 Introduction 1 1.1 Perliminary 1 1.2 Literature Reviews 3 1.3 Research Motivation & Dissertation Framework 11 Chapter 2 Mechanical investigations of a resonant microcantilver-based biosensor 16 2.1. Theory 16 2.1.1. An introduction for the governing equations of the fluid flow in microfluidic systems 16 2.1.2. Hydrodynamic loading induced by a microbeam vibrating in an incompressible viscous/ inviscid flow 19 2.1.3. Hydrodynamic loading induced by array of microbeams vibrating in an incompressible viscous/ inviscid flow 28 2.1.4. Squeezing film damping 32 2.1.5. A general dynamic theorem of beam structures immersed in an unbounded incompressible fluid 34 2.1.6. 1-D Beam Model of a suspended microchannel resonator 36 2.1.7. Resonant frequency of SMR under different boundary conditions 43 2.1.8. Resonant frequency of a cantilevered SMR with added mass 45 2.2. Results and Discussion 48 2.2.1. Dynamic response of a single microcantilever beam immersed in unbounded incompressible fluids 48 2.2.2. Dynamic response of an array of microcantilever beams immersed in unbounded incompressible fluids 52 2.2.3. Dynamic response of an array of microcantilever beams immersed in unbounded incompressible fluids with applications to the quality factor enhancement 73 2.2.4. Dynamic response of microcantilever beams in the fluid environment and application to atomic force microscopy with squeezing film damping 81 2.2.5. Comparison of 1-D beam model with 3-D FEM simulation 87 2.2.6. Resonant frequency shift due to net added mass 93 2.2.7. Added net mass-resonant frequency shift relation 98 2.2.8. Investigations between the SMR, the MCB, and the QCM 102 2.2.9. Investigations of a bridged SMR 108 Chapter 3 2D Simulation on binding efficiency enhancement of immunoassay for a biosensor with electrokinetic mechanisms: AC electrothermal and electroosmotic effect 113 3.1 Theory 114 3.1.1. AC Electrothermal force 114 3.1.2. AC electroosmotic mechanism 115 3.1.3. The electric field 117 3.1.4. The temperature field 118 3.1.5. The flow field 118 3.1.6. The concentration field 119 3.1.7. The reaction surface 119 3.1.8. Settings of boundary conditions 122 3.2 Results and Discussion 125 3.2.1. Stirring vortices, electrode length and AC operating frequencies for binding enhancement (ACET & ACEO) 125 3.2.2. The diffusion boundary layer (ACET&ACEO) 134 3.2.3. Effect of the conductivity of electrolyte and the height of microchannel (ACEO&ACET) 137 3.2.4. Effect of external devices (ACET) 142 3.2.5. The optimized position of the reaction surface and effect of temperature boundary conditions (ACET) 149 3.2.6. A connection between immunoassay for a biosensor and theory of the resonant MCB 153 Chapter 4 Simulations on the study of active micromixer with applying electrokinetic mechanisms: AC electrothermal effect 156 4.1 Theory 158 4.2 Results and Discussion 164 4.2.1. Mixing efficiency comparison among electrodes sizes, the gap between electrodes, and electrode arrangement patterns for the active micromixer 164 4.2.2. Comparisons between the active and conventional passive micromixer 168 4.2.3. Design of symmetric electrodes 172 4.2.4. Design of asymmetric electrodes 174 Chapter 5 Conclusions 183 Reference 191 Appendix 198 | |
| dc.language.iso | en | |
| dc.subject | 免疫分析 | zh_TW |
| dc.subject | 微混合器 | zh_TW |
| dc.subject | 微懸臂梁式生物感測器 | zh_TW |
| dc.subject | 微懸臂梁陣列 | zh_TW |
| dc.subject | 懸臂式微流道生物感測器 | zh_TW |
| dc.subject | 石英晶體微天平 | zh_TW |
| dc.subject | 交流電動力 | zh_TW |
| dc.subject | 介電泳 | zh_TW |
| dc.subject | 交流電滲 | zh_TW |
| dc.subject | 電熱力 | zh_TW |
| dc.subject | 有限元素法 | zh_TW |
| dc.subject | dielectrophoresis | en |
| dc.subject | AC electrokinetics | en |
| dc.subject | AC electroosmosis | en |
| dc.subject | finite element method | en |
| dc.subject | AC electrothermal force | en |
| dc.subject | micromixer | en |
| dc.subject | microcantilever-based biosensor | en |
| dc.subject | microcantilever beam array | en |
| dc.subject | suspended microchannel resonator | en |
| dc.subject | quartz crystal micorbalance | en |
| dc.subject | immunoassay | en |
| dc.title | 微混合器與共振式微懸臂梁生物感測器
的理論建立與數值模擬 | zh_TW |
| dc.title | Theoretical Investigations and Numerical Simulations for Micromixers and Resonant Microcantilever-Based Biosensors | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 金大仁,吳光鐘,黃美嬌,沈弘俊,趙聖德 | |
| dc.subject.keyword | 微混合器,微懸臂梁式生物感測器,微懸臂梁陣列,懸臂式微流道生物感測器,石英晶體微天平,免疫分析,交流電動力,介電泳,交流電滲,電熱力,有限元素法, | zh_TW |
| dc.subject.keyword | micromixer,microcantilever-based biosensor,microcantilever beam array,suspended microchannel resonator,quartz crystal micorbalance,immunoassay,AC electrokinetics,dielectrophoresis,AC electroosmosis,AC electrothermal force,finite element method, | en |
| dc.relation.page | 201 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-08-10 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
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