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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉振軒(Chen-Hsuan Liu) | |
| dc.contributor.author | Chia-Da Hsu | en |
| dc.contributor.author | 許家達 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:44:55Z | - |
| dc.date.available | 2008-07-09 | |
| dc.date.copyright | 2008-07-09 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-02 | |
| dc.identifier.citation | Adams, P. C. and Barton, J. C. (2007). Haemochromatosis. Lancet, 370, 1855-1860.
Aisen, P. (2004). Transferrin receptor 1. Int J Biochem Cell Biol, 36, 2137-2143. Andrews, N. C. (2000). Iron homeostasis: insights from genetics and animal models. Nat Rev Genet, 1, 208-217. Barton, J. C., Edwards, C. Q., Bertoli, L. F., Shroyer, T. W. and Hudson, S. L. (1995). Iron overload in African Americans. Am J Med, 99, 616-623. Beutler, E., West, C., Speir, J. A., Wilson, I. A. and Worley, M. (2001). The HFE gene of browsing and grazing rhinoceroses: A possible site of adaptation to a low-iron diet. Blood Cells Molecules and Diseases, 27, 342-350. Bullen, J. J. and Griffiths, E. (1999). Iron and Infection: Molecular, Physiological and Clinical Aspects., John Wiley & Sons, Chichester, UK, pp. 1-26. Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D. and Harford, J. B. (1988). Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science, 240, 924-928. Cork, S. C. (2000). Iron storage diseases in birds. Avian Pathology, 29, 7-12. Crissey, S. D., Ward, A. M., Block, S. E. and Maslanka, M. T. (2000). Hepatic iron accumulation over time in European starlings (Sturnus vulgaris) fed two levels of iron. Journal of Zoo and Wildlife Medicine, 31, 491-496. Donovan, A. and Andrews, N. C. (2004). The molecular regulation of iron metabolism. Hematol J, 5, 373-380. Drews, A. V., Redrobe, S. P. and Patterson-Kane, J. C. (2004). Successful reduction of hepatocellular hemosiderin content by dietary modification in toco toucans (Ramphastos toco) with iron-storage disease. Journal of Avian Medicine and Surgery, 18, 101-105. Farina, L. L., Heard, D. J., LeBlanc, D. M., Hall, J. O., Stevens, G., Wellehan, J. F. X. and Detrisac, C. J. (2005). Iron storage disease in captive Egyptian fruit bats (Rousettus aegyptiacus): Relationship of blood iron parameters to hepatic iron concentrations and hepatic histopathology. Journal of Zoo and Wildlife Medicine, 36, 212-221. Fleming, R. E. and Britton, R. S. (2006). Iron Imports. VI. HFE and regulation of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol, 290, G590-594. Fleming, R. E. and Sly, W. S. (2002). Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol, 64, 663-680. Frazer, D. M. and Anderson, G. J. (2005). Iron imports. I. Intestinal iron absorption and its regulation. Am J Physiol Gastrointest Liver Physiol, 289, G631-635. Ganz, T. and Nemeth, E. (2006). Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol, 290, G199-203. Graham, R. M., Chua, A. C., Herbison, C. E., Olynyk, J. K. and Trinder, D. (2007). Liver iron transport. World J Gastroenterol, 13, 4725-4736. Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F. and Koeffler, H. P. (1999). Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem, 274, 20826-20832. Kononen, J., Bubendorf, L., Kallioniemi, A., Barlund, M., Schraml, P., Leighton, S., Torhorst, J., Mihatsch, M. J., Sauter, G. and Kallioniemi, O. P. (1998). Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med, 4, 844-847. Latunde-Dada, G. O., Van der Westhuizen, J., Vulpe, C. D., Anderson, G. J., Simpson, R. J. and McKie, A. T. (2002). Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism. Blood Cells Mol Dis, 29, 356-360. Lowenstine, L. J. and Petrak, M. L. (1980). Iron pigment in the livers of birds. The comparative pathology of zoo animals. Ma, Y., Yeh, M., Yeh, K. Y. and Glass, J. (2006). Iron Imports. V. Transport of iron through the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol, 290, G417-422. Mackenzie, B. and Garrick, M. D. (2005). Iron Imports. II. Iron uptake at the apical membrane in the intestine. Am J Physiol Gastrointest Liver Physiol, 289, G981-986. Mete, A., Dorrestein, G. M., Marx, J. J. M., Lemmens, A. G. and Beynen, A. C. (2001). A comparative study of iron retention in mynahs, doves and rats. Avian Pathology, 30, 479-486. Mete, A., Hendriks, H. G., Klaren, P. H., Dorrestein, G. M., van Dijk, J. E. and Marx, J. J. (2003). Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis. Avian Pathol, 32, 625-632. Mete, A., Jalving, R., van Oost, B. A., van Dijk, J. E. and Marx, J. J. (2005). Intestinal over-expression of iron transporters induces iron overload in birds in captivity. Blood Cells Mol Dis, 34, 151-156. Norrdin, R. W., Hoopes, K. J. and O'Toole, D. (2004). Skeletal changes in hemochromatosis of Salers cattle. Vet Pathol, 41, 612-623. Olsen, G. P., Russell, K. E., Dierenfeld, E., Falcon, M. D. and Phalen, D. N. (2006). Impact of supplements on iron absorption from diets containing high and low iron concentrations in the European starling (Sturnus vulgaris). Journal of Avian Medicine and Surgery, 20, 67-73. Packeisen, J., Korsching, E., Herbst, H., Boecker, W. and Buerger, H. (2003). Demystified...tissue microarray technology. Mol Pathol, 56, 198-204. Pearson, E. G., Hedstrom, O. R. and Poppenga, R. H. (1994). Hepatic cirrhosis and hemochromatosis in 3 horses. Journal of the American Veterinary Medical Association, 204, 1053-1056. Ratledge, C. and Dover, L. G. (2000). Iron metabolism in pathogenic bacteria. Annu Rev Microbiol, 54, 881-941. Roels, S., Ducatelle, R. and Cornelissen, H. (1996). Quantitative image analysis as an alternative to chemical analysis for follow-up of liver biopsies from a toucan with hemochromatosis - A technique with potential value for the follow-up of hemochromatosis in humans. Analytical and Quantitative Cytology and Histology, 18, 221-224. Rolfs, A., Bonkovsky, H. L., Kohlroser, J. G., McNeal, K., Sharma, A., Berger, U. V. and Hediger, M. A. (2002). Intestinal expression of genes involved in iron absorption in humans. Am J Physiol Gastrointest Liver Physiol, 282, G598-607. Schoemaker, N. J., Lumeij, J. T., Dorrestein, G. M. and Beynen, A. C. (1999). Diet-related problems in pet birds. Tijdschrift Voor Diergeneeskunde, 124, 39-43. Sharp, P. and Srai, S. K. (2007). Molecular mechanisms involved in intestinal iron absorption. World J Gastroenterol, 13, 4716-4724. Sheppard, C. and Dierenfeld, E. (2002). Iron storage disease in birds: Speculation on etiology and implications for captive husbandry. Journal of Avian Medicine and Surgery, 16, 192-197. Siah, C. W., Ombiga, J., Adams, L. A., Trinder, D. and Olynyk, J. K. (2006). Normal iron metabolism and the pathophysiology of iron overload disorders. Clin Biochem Rev, 27, 5-16. Simovich, M. J., Conrad, M. E., Umbreit, J. N., Moore, E. G., Hainsworth, L. N. and Smith, H. K. (2002). Cellular location of proteins related to iron absorption and transport. Am J Hematol, 69, 164-170. Takikita, M., Chung, J. Y. and Hewitt, S. M. (2007). Tissue microarrays enabling high-throughput molecular pathology. Curr Opin Biotechnol, 18, 318-325. Trinder, D., Olynyk, J. K., Sly, W. S. and Morgan, E. H. (2002). Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc Natl Acad Sci U S A, 99, 5622-5626. Tufft, L. S., Nockels, C. F. and Fettman, M. J. (1988). Effects of Escherichia-coli on iron, copper, and zinc-metabolism in chicks. Avian Diseases, 32, 779-786. Ward, R. J., Legssyer, R., Henry, C. and Crichton, R. R. (2000). Does the haemosiderin iron core determine its potential for chelation and the development of iron-induced tissue damage? Journal of Inorganic Biochemistry, 79, 311-317. Wessling-Resnick, M. (2006). Iron Imports. III. Transfer of iron from the mucosa into circulation. American Journal of Physiology-Gastrointestinal and Liver Physiology, 290, G1-G6. West, G. D., Garner, M. M. and Talcott, P. A. (2001). Hemochromatosis in several species of lories with high dietary iron. Journal of Avian Medicine and Surgery, 15, 297-301. Wilson, R. B. (1994). Hepatic hemosiderosis and Klebsiella bacteremia in a green aracari (Pteroglossus viridis). Avian Dis, 38, 679-681. Wish, J. B. (2006). Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol, 1 Suppl 1, S4-8. Witzleben, C. L. and Buck, B. E. (1971). Iron overload hepatotoxicity: a postulated pathogenesis. Clin Toxicol, 4, 579-583. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37809 | - |
| dc.description.abstract | 血色素沉著症 (Hemochromatosis) 是一種鐵代謝的異常導致鐵在人類和動物造成鐵過度的蓄積的常見疾病，又稱為鐵蓄積症 (Iron storage disease) 。在過去的三十年之間有越來越多的文獻指出；在圈養的鳥類有這一類疾病發生。所報告的鳥類的品種多以果實及昆蟲為主食，包括天堂鳥 (Paradiseadae) 、巨嘴鳥 (Ramphastidae) 、掠鳥 (Sturnidae) 及八哥 (Mynas) 等。在診斷上最常使用的是鐵染色 (Berlin blue) 以確認鐵在細胞內的堆積，這些受到損傷的細胞可能會因此而死亡且被纖維組織所取代。本研究中共收集186隻圈飼禽類解剖病例，其中有59隻 (31.7%) 以Berlin blue鐵染色確認罹患血色素沉著症，其中包括11個目，最常蓄積的組織以肝臟為主，依其嚴重程度分為三個等級 (Grade 1-3) ，嚴重者伴隨肝細胞壞死、肝索凌亂、肝細胞變性、膽管增生、Kupffer cell內有色素沉著、肝細胞內含有鐵質顆粒以及炎症反應的產生。此外，亦在心臟、腎臟及脾臟等器官出現。另外，針對於59例分析其飲食習慣、性別、年齡以及感染情況，分析結果顯示是否有患病與是否會感染間有著顯著之差異存在，證實患有血色素沉著症與感染之間有著交互關係存在。 | zh_TW |
| dc.description.abstract | Hemochromatosis is a common disorder of iron metabolism resulting in iron overload and affecting human and animals, particularly avian species. Genetic and dietary factors are considered as predisposing factors to cause hemochromatosis in these affected birds. Hemochromatosis has been diagnosed in 59 (31.7%) from 186 avian necropsies in this study and the affected species included 11 avian orders, and the most affected species is weaver bird. The organs most commonly affected are the liver. Histochemistry of iron stain (Berlin blue) is routinely used to confirm iron storage in the target tissues. Twenty-one out of 59 cases are hemochromatosis combined with infectious disease and 38 cases are hemochromatosis only. The statistic results show significant difference between the infections and hemochromatosis. In another test, no significant difference is analyzed among hemochromatosis with feeding behavior, age, and sex. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:44:55Z (GMT). No. of bitstreams: 1 ntu-97-R95629011-1.pdf: 1865386 bytes, checksum: b39fe15c8f49502e8cee0afd53b260b0 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 目錄
目錄 I 圖次 III 表次 IV 中文摘要 V 英文摘要 VI 第一章 前言 1 第二章 文獻探討 3 第一節 鐵的代謝 3 2.1.1 鐵的作用 3 2.1.2 鐵的吸收 4 2.1.3 腸道黏膜細胞吸收 5 2.1.4 Basolateral membrane 6 2.1.5 血漿到各臟器 7 2.1.6 肝細胞 7 第二節 鐵與感染 9 第三節 血色素沉著症 10 2.3.1 人類血色素沉著症 10 2.3.2 禽類血色素沉著症 11 第四節 組織微陣列晶片 12 第三章 材料與方法 14 第一節 實驗設計與流程 14 第二節 材料來源 15 第三節 型態病理學檢查 15 3.3.1 肉眼病理學檢查 15 3.3.2 組織病理學檢查 15 3.3.3 組織化學染色 18 3.3.4 組織微陣列晶片 20 第四節 病理變化統計 20 第五節 陽性程度計算 21 第六節 邏輯式回歸統計 21 第四章 結果 23 第一節 禽類血色素沉著症 23 4.1.1 臨床資料 23 4.1.2 肉眼病理學 23 4.1.3 組織病理學 24 4.1.4 合併疾病分析 25 第五章 討論 33 第一節 禽類血色素沉著症臨床資料分析 33 第二節 血色素沉著症組織病理型態學之探討 33 第三節 血色素沉著症與感染等變因統計分析 35 第四節 結論 36 第六章 參考文獻 39 | |
| dc.language.iso | zh-TW | |
| dc.subject | 血色素沉著症 | zh_TW |
| dc.subject | 鐵蓄積 | zh_TW |
| dc.subject | 禽類 | zh_TW |
| dc.subject | Avian | en |
| dc.subject | Iron storage | en |
| dc.subject | Hemochromatosis | en |
| dc.title | 禽類血色素沉著症之致病機制與感染關係之探討 | zh_TW |
| dc.title | Studies on Pathogenesis of Avian Hemochromatosis and Relationship with Infections | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李進成,林中天,張清棟 | |
| dc.subject.keyword | 禽類,血色素沉著症,鐵蓄積, | zh_TW |
| dc.subject.keyword | Avian,Hemochromatosis,Iron storage, | en |
| dc.relation.page | 43 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-07-02 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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