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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 朱瑞民 | |
dc.contributor.author | Chun-Pei Chang | en |
dc.contributor.author | 張君珮 | zh_TW |
dc.date.accessioned | 2021-06-13T15:33:45Z | - |
dc.date.available | 2016-08-17 | |
dc.date.copyright | 2011-08-17 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-10 | |
dc.identifier.citation | Trinchieri, G. 1989. Biology of natural killer cells. Adv Immunol 47:187-376.
2. Cooper, M. A., T. A. Fehniger, and M. A. Caligiuri. 2001. The biology of human natural killer-cell subsets. Trends Immunol 22:633-640. 3. Caligiuri, M. A. 2008. Human natural killer cells. Blood 112:461-469. 4. Herberman, R. B., M. E. Nunn, and D. H. Lavrin. 1975. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer 16:216-229. 5. Herberman, R. B., M. E. Nunn, H. T. Holden, and D. H. Lavrin. 1975. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer 16:230-239. 6. Degli-Esposti, M. A., and M. J. Smyth. 2005. Close encounters of different kinds: dendritic cells and NK cells take centre stage. Nat Rev Immunol 5:112-124. 7. Strowig, T., F. Brilot, and C. Munz. 2008. Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 180:7785-7791. 8. Lanier, L. L. 1998. NK cell receptors. Annu Rev Immunol 16:359-393. 9. Hayakawa, Y., and M. J. Smyth. 2006. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol 176:1517-1524. 10. Janeway, C. A., Jr., and R. Medzhitov. 2002. Innate immune recognition. Annu Rev Immunol 20:197-216. 11. Bassing, C. H., W. Swat, and F. W. Alt. 2002. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109 Suppl:S45-55. 12. Farag, S. S., and M. A. Caligiuri. 2006. Human natural killer cell development and biology. Blood Rev 20:123-137. 13. Vivier, E., D. H. Raulet, A. Moretta, M. A. Caligiuri, L. Zitvogel, L. L. Lanier, W. M. Yokoyama, and S. Ugolini. 2011. Innate or adaptive immunity? The example of natural killer cells. Science 331:44-49. 14. Karre, K. 2008. Natural killer cell recognition of missing self. Nat Immunol 9:477-480. 15. Ljunggren, H. G., and K. Karre. 1990. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 11:237-244. 16. Fernandez, N. C., A. Lozier, C. Flament, P. Ricciardi-Castagnoli, D. Bellet, M. Suter, M. Perricaudet, T. Tursz, E. Maraskovsky, and L. Zitvogel. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5:405-411. 17. Yu, Y., M. Hagihara, K. Ando, B. Gansuvd, H. Matsuzawa, T. Tsuchiya, Y. Ueda, H. Inoue, T. Hotta, and S. Kato. 2001. Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. J Immunol 166:1590-1600. 18. Gerosa, F., B. Baldani-Guerra, C. Nisii, V. Marchesini, G. Carra, and G. Trinchieri. 2002. Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 195:327-333. 19. Granucci, F., I. Zanoni, N. Pavelka, S. L. Van Dommelen, C. E. Andoniou, F. Belardelli, M. A. Degli Esposti, and P. Ricciardi-Castagnoli. 2004. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med 200:287-295. 20. Andrews, D. M., A. A. Scalzo, W. M. Yokoyama, M. J. Smyth, and M. A. Degli-Esposti. 2003. Functional interactions between dendritic cells and NK cells during viral infection. Nat Immunol 4:175-181. 21. Ferlazzo, G., B. Morandi, A. D'Agostino, R. Meazza, G. Melioli, A. Moretta, and L. Moretta. 2003. The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells. Eur J Immunol 33:306-313. 22. Brillard, E., J. R. Pallandre, D. Chalmers, B. Ryffel, A. Radlovic, E. Seilles, P. S. Rohrlich, X. Pivot, P. Tiberghien, P. Saas, and C. Borg. 2007. Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes. Exp Hematol 35:416-425. 23. Nocentini, G., S. Ronchetti, S. Cuzzocrea, and C. Riccardi. 2007. GITR/GITRL: more than an effector T cell co-stimulatory system. Eur J Immunol 37:1165-1169. 24. Jinushi, M., T. Takehara, T. Tatsumi, S. Yamaguchi, R. Sakamori, N. Hiramatsu, T. Kanto, K. Ohkawa, and N. Hayashi. 2007. Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Immunology 120:73-82. 25. Gao, N., T. Dang, and D. Yuan. 2001. IFN-gamma-dependent and -independent initiation of switch recombination by NK cells. J Immunol 167:2011-2018. 26. Della Chiesa, M., M. Vitale, S. Carlomagno, G. Ferlazzo, L. Moretta, and A. Moretta. 2003. The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Eur J Immunol 33:1657-1666. 27. Iijima, N., Y. Yanagawa, J. M. Clingan, and K. Onoe. 2005. CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells. Int Immunol 17:1201-1212. 28. Jang, M. H., N. Sougawa, T. Tanaka, T. Hirata, T. Hiroi, K. Tohya, Z. Guo, E. Umemoto, Y. Ebisuno, B. G. Yang, J. Y. Seoh, M. Lipp, H. Kiyono, and M. Miyasaka. 2006. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 176:803-810. 29. Ohl, L., M. Mohaupt, N. Czeloth, G. Hintzen, Z. Kiafard, J. Zwirner, T. Blankenstein, G. Henning, and R. Forster. 2004. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279-288. 30. Rivas-Caicedo, A., G. Soldevila, T. I. Fortoul, A. Castell-Rodriguez, L. Flores-Romo, and E. A. Garcia-Zepeda. 2009. Jak3 is involved in dendritic cell maturation and CCR7-dependent migration. PLoS One 4:e7066. 31. Yanagihara, S., E. Komura, J. Nagafune, H. Watarai, and Y. Yamaguchi. 1998. EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol 161:3096-3102. 32. Lu, L., H. J. Kim, M. B. Werneck, and H. Cantor. 2008. Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A 105:19420-19425. 33. Lu, L., K. Ikizawa, D. Hu, M. B. Werneck, K. W. Wucherpfennig, and H. Cantor. 2007. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26:593-604. 34. Lunemann, A., J. D. Lunemann, S. Roberts, B. Messmer, R. Barreira da Silva, C. S. Raine, and C. Munz. 2008. Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. J Immunol 181:6170-6177. 35. Moretta, A., C. Bottino, M. Vitale, D. Pende, R. Biassoni, M. C. Mingari, and L. Moretta. 1996. Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 14:619-648. 36. Long, E. O. 1999. Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17:875-904. 37. Moretta, A., R. Biassoni, C. Bottino, D. Pende, M. Vitale, A. Poggi, M. C. Mingari, and L. Moretta. 1997. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 155:105-117. 38. Lanier, L. L., B. Corliss, and J. H. Phillips. 1997. Arousal and inhibition of human NK cells. Immunol Rev 155:145-154. 39. Moretta, A., C. Bottino, M. Vitale, D. Pende, C. Cantoni, M. C. Mingari, R. Biassoni, and L. Moretta. 2001. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 19:197-223. 40. Moretta, A., R. Biassoni, C. Bottino, M. C. Mingari, and L. Moretta. 2000. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis. Immunol Today 21:228-234. 41. Bottino, C., R. Biassoni, R. Millo, L. Moretta, and A. Moretta. 2000. The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering. Hum Immunol 61:1-6. 42. Sivori, S., M. Vitale, L. Morelli, L. Sanseverino, R. Augugliaro, C. Bottino, L. Moretta, and A. Moretta. 1997. p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med 186:1129-1136. 43. Pessino, A., S. Sivori, C. Bottino, A. Malaspina, L. Morelli, L. Moretta, R. Biassoni, and A. Moretta. 1998. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med 188:953-960. 44. Pende, D., S. Parolini, A. Pessino, S. Sivori, R. Augugliaro, L. Morelli, E. Marcenaro, L. Accame, A. Malaspina, R. Biassoni, C. Bottino, L. Moretta, and A. Moretta. 1999. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med 190:1505-1516. 45. Cantoni, C., C. Bottino, M. Vitale, A. Pessino, R. Augugliaro, A. Malaspina, S. Parolini, L. Moretta, A. Moretta, and R. Biassoni. 1999. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J Exp Med 189:787-796. 46. Orloff, D. G., C. S. Ra, S. J. Frank, R. D. Klausner, and J. P. Kinet. 1990. Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature 347:189-191. 47. Lanier, L. L., B. C. Corliss, J. Wu, C. Leong, and J. H. Phillips. 1998. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391:703-707. 48. Lanier, L. L., B. Corliss, J. Wu, and J. H. Phillips. 1998. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity 8:693-701. 49. Wu, J., Y. Song, A. B. Bakker, S. Bauer, T. Spies, L. L. Lanier, and J. H. Phillips. 1999. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285:730-732. 50. Bauer, S., V. Groh, J. Wu, A. Steinle, J. H. Phillips, L. L. Lanier, and T. Spies. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285:727-729. 51. Chang, C., J. Dietrich, A. G. Harpur, J. A. Lindquist, A. Haude, Y. W. Loke, A. King, M. Colonna, J. Trowsdale, and M. J. Wilson. 1999. Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J Immunol 163:4651-4654. 52. Wu, J., H. Cherwinski, T. Spies, J. H. Phillips, and L. L. Lanier. 2000. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J Exp Med 192:1059-1068. 53. Vilches, C., and P. Parham. 2002. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol 20:217-251. 54. Purdy, A. K., and K. S. Campbell. 2009. Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol Ther 8:2211-2220. 55. Bashirova, A. A., M. P. Martin, D. W. McVicar, and M. Carrington. 2006. The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu Rev Genomics Hum Genet 7:277-300. 56. Moretta, A., G. Tambussi, C. Bottino, G. Tripodi, A. Merli, E. Ciccone, G. Pantaleo, and L. Moretta. 1990. A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function. J Exp Med 171:695-714. 57. Al Omar, S., D. Middleton, E. Marshall, D. Porter, G. Xinarianos, O. Raji, J. K. Field, and S. E. Christmas. 2010. Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors. Hum Immunol 71:976-981. 58. Parham, P. 2005. MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5:201-214. 59. van Bergen, J., C. A. Stewart, P. J. van den Elsen, and J. Trowsdale. 2005. Structural and functional differences between the promoters of independently expressed killer cell Ig-like receptors. Eur J Immunol 35:2191-2199. 60. Nelson, G. W., M. P. Martin, D. Gladman, J. Wade, J. Trowsdale, and M. Carrington. 2004. Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis. J Immunol 173:4273-4276. 61. Marsh, S. G., P. Parham, B. Dupont, D. E. Geraghty, J. Trowsdale, D. Middleton, C. Vilches, M. Carrington, C. Witt, L. A. Guethlein, H. Shilling, C. A. Garcia, K. C. Hsu, and H. Wain. 2003. Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Immunogenetics 55:220-226. 62. MacFarlane, A. W. t., and K. S. Campbell. 2006. Signal transduction in natural killer cells. Curr Top Microbiol Immunol 298:23-57. 63. Goodridge, J. P., C. S. Witt, F. T. Christiansen, and H. S. Warren. 2003. KIR2DL4 (CD158d) genotype influences expression and function in NK cells. J Immunol 171:1768-1774. 64. Kikuchi-Maki, A., T. L. Catina, and K. S. Campbell. 2005. Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. J Immunol 174:3859-3863. 65. Rajagopalan, S., J. Fu, and E. O. Long. 2001. Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol 167:1877-1881. 66. Mason, L. H., P. Gosselin, S. K. Anderson, W. E. Fogler, J. R. Ortaldo, and D. W. McVicar. 1997. Differential tyrosine phosphorylation of inhibitory versus activating Ly-49 receptor proteins and their recruitment of SHP-1 phosphatase. J Immunol 159:4187-4196. 1. Trinchieri, G. 1989. Biology of natural killer cells. Adv Immunol 47:187-376. 2. Cooper, M. A., T. A. Fehniger, and M. A. Caligiuri. 2001. The biology of human natural killer-cell subsets. Trends Immunol 22:633-640. 3. Caligiuri, M. A. 2008. Human natural killer cells. Blood 112:461-469. 4. Herberman, R. B., M. E. Nunn, and D. H. Lavrin. 1975. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer 16:216-229. 5. Herberman, R. B., M. E. Nunn, H. T. Holden, and D. H. Lavrin. 1975. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer 16:230-239. 6. Degli-Esposti, M. A., and M. J. Smyth. 2005. Close encounters of different kinds: dendritic cells and NK cells take centre stage. Nat Rev Immunol 5:112-124. 7. Strowig, T., F. Brilot, and C. Munz. 2008. Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 180:7785-7791. 8. Lanier, L. L. 1998. NK cell receptors. Annu Rev Immunol 16:359-393. 9. Hayakawa, Y., and M. J. Smyth. 2006. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol 176:1517-1524. 10. Janeway, C. A., Jr., and R. Medzhitov. 2002. Innate immune recognition. Annu Rev Immunol 20:197-216. 11. Bassing, C. H., W. Swat, and F. W. Alt. 2002. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109 Suppl:S45-55. 12. Farag, S. S., and M. A. Caligiuri. 2006. Human natural killer cell development and biology. Blood Rev 20:123-137. 13. Vivier, E., D. H. Raulet, A. Moretta, M. A. Caligiuri, L. Zitvogel, L. L. Lanier, W. M. Yokoyama, and S. Ugolini. 2011. Innate or adaptive immunity? The example of natural killer cells. Science 331:44-49. 14. Karre, K. 2008. Natural killer cell recognition of missing self. Nat Immunol 9:477-480. 15. Ljunggren, H. G., and K. Karre. 1990. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 11:237-244. 16. Fernandez, N. C., A. Lozier, C. Flament, P. Ricciardi-Castagnoli, D. Bellet, M. Suter, M. Perricaudet, T. Tursz, E. Maraskovsky, and L. Zitvogel. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5:405-411. 17. Yu, Y., M. Hagihara, K. Ando, B. Gansuvd, H. Matsuzawa, T. Tsuchiya, Y. Ueda, H. Inoue, T. Hotta, and S. Kato. 2001. Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. J Immunol 166:1590-1600. 18. Gerosa, F., B. Baldani-Guerra, C. Nisii, V. Marchesini, G. Carra, and G. Trinchieri. 2002. Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 195:327-333. 19. Granucci, F., I. Zanoni, N. Pavelka, S. L. Van Dommelen, C. E. Andoniou, F. Belardelli, M. A. Degli Esposti, and P. Ricciardi-Castagnoli. 2004. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med 200:287-295. 20. Andrews, D. M., A. A. Scalzo, W. M. Yokoyama, M. J. Smyth, and M. A. Degli-Esposti. 2003. Functional interactions between dendritic cells and NK cells during viral infection. Nat Immunol 4:175-181. 21. Ferlazzo, G., B. Morandi, A. D'Agostino, R. Meazza, G. Melioli, A. Moretta, and L. Moretta. 2003. The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells. Eur J Immunol 33:306-313. 22. Brillard, E., J. R. Pallandre, D. Chalmers, B. Ryffel, A. Radlovic, E. Seilles, P. S. Rohrlich, X. Pivot, P. Tiberghien, P. Saas, and C. Borg. 2007. Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes. Exp Hematol 35:416-425. 23. Nocentini, G., S. Ronchetti, S. Cuzzocrea, and C. Riccardi. 2007. GITR/GITRL: more than an effector T cell co-stimulatory system. Eur J Immunol 37:1165-1169. 24. Jinushi, M., T. Takehara, T. Tatsumi, S. Yamaguchi, R. Sakamori, N. Hiramatsu, T. Kanto, K. Ohkawa, and N. Hayashi. 2007. Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Immunology 120:73-82. 25. Gao, N., T. Dang, and D. Yuan. 2001. IFN-gamma-dependent and -independent initiation of switch recombination by NK cells. J Immunol 167:2011-2018. 26. Della Chiesa, M., M. Vitale, S. Carlomagno, G. Ferlazzo, L. Moretta, and A. Moretta. 2003. The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Eur J Immunol 33:1657-1666. 27. Iijima, N., Y. Yanagawa, J. M. Clingan, and K. Onoe. 2005. CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells. Int Immunol 17:1201-1212. 28. Jang, M. H., N. Sougawa, T. Tanaka, T. Hirata, T. Hiroi, K. Tohya, Z. Guo, E. Umemoto, Y. Ebisuno, B. G. Yang, J. Y. Seoh, M. Lipp, H. Kiyono, and M. Miyasaka. 2006. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 176:803-810. 29. Ohl, L., M. Mohaupt, N. Czeloth, G. Hintzen, Z. Kiafard, J. Zwirner, T. Blankenstein, G. Henning, and R. Forster. 2004. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279-288. 30. Rivas-Caicedo, A., G. Soldevila, T. I. Fortoul, A. Castell-Rodriguez, L. Flores-Romo, and E. A. Garcia-Zepeda. 2009. Jak3 is involved in dendritic cell maturation and CCR7-dependent migration. PLoS One 4:e7066. 31. Yanagihara, S., E. Komura, J. Nagafune, H. Watarai, and Y. Yamaguchi. 1998. EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol 161:3096-3102. 32. Lu, L., H. J. Kim, M. B. Werneck, and H. Cantor. 2008. Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A 105:19420-19425. 33. Lu, L., K. Ikizawa, D. Hu, M. B. Werneck, K. W. Wucherpfennig, and H. Cantor. 2007. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26:593-604. 34. Lunemann, A., J. D. Lunemann, S. Roberts, B. Messmer, R. Barreira da Silva, C. S. Raine, and C. Munz. 2008. Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. J Immunol 181:6170-6177. 35. Moretta, A., C. Bottino, M. Vitale, D. Pende, R. Biassoni, M. C. Mingari, and L. Moretta. 1996. Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 14:619-648. 36. Long, E. O. 1999. Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17:875-904. 37. Moretta, A., R. Biassoni, C. Bottino, D. Pende, M. Vitale, A. Poggi, M. C. Mingari, and L. Moretta. 1997. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 155:105-117. 38. Lanier, L. L., B. Corliss, and J. H. Phillips. 1997. Arousal and inhibition of human NK cells. Immunol Rev 155:145-154. 39. Moretta, A., C. Bottino, M. Vitale, D. Pende, C. Cantoni, M. C. Mingari, R. Biassoni, and L. Moretta. 2001. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 19:197-223. 40. Moretta, A., R. Biassoni, C. Bottino, M. C. Mingari, and L. Moretta. 2000. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis. Immunol Today 21:228-234. 41. Bottino, C., R. Biassoni, R. Millo, L. Moretta, and A. Moretta. 2000. The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering. Hum Immunol 61:1-6. 42. Sivori, S., M. Vitale, L. Morelli, L. Sanseverino, R. Augugliaro, C. Bottino, L. Moretta, and A. Moretta. 1997. p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med 186:1129-1136. 43. Pessino, A., S. Sivori, C. Bottino, A. Malaspina, L. Morelli, L. Moretta, R. Biassoni, and A. Moretta. 1998. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med 188:953-960. 44. Pende, D., S. Parolini, A. Pessino, S. Sivori, R. Augugliaro, L. Morelli, E. Marcenaro, L. Accame, A. Malaspina, R. Biassoni, C. Bottino, L. Moretta, and A. Moretta. 1999. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med 190:1505-1516. 45. Cantoni, C., C. Bottino, M. Vitale, A. Pessino, R. Augugliaro, A. Malaspina, S. Parolini, L. Moretta, A. Moretta, and R. Biassoni. 1999. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J Exp Med 189:787-796. 46. Orloff, D. G., C. S. Ra, S. J. Frank, R. D. Klausner, and J. P. Kinet. 1990. Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature 347:189-191. 47. Lanier, L. L., B. C. Corliss, J. Wu, C. Leong, and J. H. Phillips. 1998. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391:703-707. 48. Lanier, L. L., B. Corliss, J. Wu, and J. H. Phillips. 1998. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity 8:693-701. 49. Wu, J., Y. Song, A. B. Bakker, S. Bauer, T. Spies, L. L. Lanier, and J. H. Phillips. 1999. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285:730-732. 50. Bauer, S., V. Groh, J. Wu, A. Steinle, J. H. Phillips, L. L. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37584 | - |
dc.description.abstract | 自然殺手細胞(NK細胞)對於免疫系統之調控,以及在病毒與腫瘤之對抗中均扮演著極為重要的角色。然而目前的研究對於犬的自然殺手細胞卻瞭解不多。我們先前的發表首度發現犬周邊血液淋巴球中CD5低表現量(CD5lo)細胞,具有明顯自然殺手細胞之特性,且被認為是犬NK細胞內非常重要的族群。此族群有別於其他已發現之哺乳類動物的NK細胞,因其具有T細胞特徵性之分子標記CD3、CD8和α/βTCR,此一發現使得犬隻NK細胞在比較免疫學中成為極為特殊的存在。本文針對犬NK細胞的深入研究則顯示,原本僅具微弱毒殺能力且表現型為CD21-與CD5lo-ne之細胞群,在與CD5lo細胞共同培養後,竟會產生高度NK細胞專一性的細胞毒殺能力。而該現象僅限於CD5lo細胞,其他如CD5hi、CD21+和嗜中性細胞皆無法增加其毒殺能力。以高階細胞流式分選儀將CD5lo-ne細胞區分成CD5- 和CD5hi兩族群進一步作測試,結果顯示CD5-細胞在去除CD5lo細胞單獨培養之情況下,不論是否經過IL-2刺激其細胞毒殺能力都偏低(當E/T ration 50:1,毒殺能力為4.16±3.51%)。相較於兩者共同培養時,CD5-細胞的NK細胞毒殺能力則明顯被誘發(當E/T ration 50:1,毒殺能力為22.42±18.07%)。而CD5lo-ne細胞的另一組成者CD5hi細胞,以同樣的實驗方法,縱使有CD5lo細胞存在也不具有細胞毒殺能力(當E/T ration 50:1,毒殺能力為3.60±2.92% or 3.07±2.08%)。使用更精細的細胞分選並進行NK細胞毒殺能力之測試結果顯示,CD5-細胞中的CD5-CD21-細胞是在CD5lo細胞誘發下,主要具有NK細胞毒殺力的細胞。這是第一篇報告證明,NK細胞可誘發其他具自然殺手細胞潛質之細胞族群表現出NK細胞毒殺能力。在米格魯犬中,除了先前已發現的CD5lo細胞外,CD5-CD21-細胞在經由CD5lo細胞之誘發下亦能產生NK細胞活性。 | zh_TW |
dc.description.abstract | Natural killer (NK) cells play important roles in both early protection against viruses or tumor cells and in regulating immune functions. However, only a few studies have focused on the characterization of canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes with low surface CD5 density (CD5lo) are closely associated with NK cell characteristics, and are considered to be an important NK population. NK cells in most mammals do not express T cell markers. However, CD5lo cells expressed surface molecules such as CD3, CD8, and α/βTCR, making canines a unique model to study comparative immunology in NK cells.
In this study, we discovered that although CD5lo (CD5lo-ne) and CD21 double negative cells were originally low in NK cytotoxicity, they became highly activated in NK cytotoxicity when cultured with CD5lo NK cells. The cytotoxicity was not activated as in the culture of other types of cells, such as CD5hi cells and CD21+. The CD5lo-ne population comprises CD5- and CD5hi cells, which were sorted separately by fluorescent density with a FACSAria TM flow cytometer. We first tested CD5- cells and found that these cells were initially low in NK cytotoxicity or after being cultured in IL-2 when CD5lo cells were absent in the culture (4.16±3.51% at ET ratio of 50:1), but as CD5lo cells were added in similar medium, the NK activity became greatly enhanced (22.42±18.07at ET ratio of 50:1). The other population of CD5lo-ne, CD5hi cells, was always NK inactive, no matter whether or not it was cultured alone or with CD5lo cells (3.60±2.92% or 3.07±2.08% at ET ratio of 50:1). We further verified that CD5- cells carrying no CD21 surface molecules, i.e. CD5/CD21 double negative cells were the cell type in CD5- cells population whose NK cytotoxicity was activated by CD5lo cells. This is the first report to present that NK cells enhanced NK-inert cells to become NK cytotoxic. It also concluded that in beagles, besides CD5lo cells, CD5/CD21 double negative cells also exhibited NK activity. However, it depended on the presence of CD5lo cells | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T15:33:45Z (GMT). No. of bitstreams: 1 ntu-100-R97629006-1.pdf: 3274909 bytes, checksum: a8575ccdd0a1f10a135c999755248cc4 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | Contents
口試委員會審定書.......Ⅰ 誌謝...................Ⅱ 中文摘要...............Ⅲ Abstract...............Ⅳ Abbreviation...........Ⅵ Contents...............Ⅷ Chapter 1 Literature review…………………………………………1 1 NK cell immune activities………………………………1 1.1 Innate immunity……………………………………………2 1.2 Adaptive immunity…………………………………………3 2 NK cell receptors…………………………………………………………………3 2.1 Inhibitory receptors……………………………………4 2.1.1 KIR…………………………………………………………4 2.1.2 Ly49………………………………………………………6 2.1.3 CD94/NKD2D…………………………………………………6 2.2 Activating receptors……………………………………7 2.2.1 Natural cytotoxicity receptors (NCR)………………7 2.2.2 NKG2D………………………………………………………9 2.2.3 2B4(CD244)…………………………………………………11 2.2.4 CD16 and CD56………………………………………………12 3 NK cell function…………………………………………13 3.1 Cytokines and chemokines………………………………14 3.2 NK cell-mediated killing………………………………14 3.2.1 Granule-dependent exocytosis pathway………………14 3.2.2 Fas-FasL intercellular linkage-mediated killing.16 4 Natural killer cell subpopulation…………………16 5 Canine natural killer cell……………………………17 6 Conclusion…………………………………………………19 Chapter 2 Introduction………………………………………………20 Chapter 3 Materials & Methods……………………………………23 1 Preparation of canine peripheral blood lymphocytes……………………………………………………………23 2 Lymphokime-activated killer cells preparation…23 3 Isolation of CD5hi, CD5lo, and CD5- cells………23 4 NK cytotoxicity assay…………………………………24 5 Phenotype analysis of CD5- cells in PBLs and LAKs……………………………………………………………………24 6 RNA extraction and cDNA prepaionrat……………25 7 Quantitative RT-PCR……………………………………25 8 Statistical Analysis…………………………………26 Chapter 4 Results…………………………………………………27 1 CD3- cells had NK cytotoxic activity………………27 2 CD5lo-ne cells were NK activity……………………27 3 CD5lo cells were involved in the NK cytotoxic activation of CD5lo-ne cells……………………………………28 4 Phenotyping canine CD5- cells………………………29 5 mRNA expressions of NK cells associated surface markers…………………………………………………………………29 6 mRNA expressions of cytokines………………………30 7 CD5-CD21- cells became NK cytotoxic as CD5lo cells were present………………………………………………30 Chapter 5 Discussion……………………………………………32 Tables…………………………………………………………………38 Table 1 List of antibodies used for surface phenotype assay…………………………………………………………………38 Table 2 Sequences of PCR primers………………………………38 Table 3 The expression percentage of surface molecules in CD5- cells from PBLs and LAKs………………………………39 Figures………………………………………………………………40 Fig. 1 CD3- cells have NK cytotoxicty ability when PBLs directly…………………………………………………………40 Fig. 2 Different culture condition of CD5lo-ne cells have different……………………………………………………42 Fig. 3 CD5- cells isolate from LAKs have NK cytotoxic abilities……………………………………………………44 Fig. 4 CD5- cells have NK cytotoxic abilities when CD5lo cells are present…………………………………………45 Fig. 5 Phenotypes of CD5- cells of canine PBLs………………47 Fig. 6 Phenotypes of CD5- cells of canine LAKs………………48 Fig. 7 Canine NK-related gene expressed in CD5-,CD5lo, and CD5hi cells……………………………………………………………49 Fig. 8 Cytokine gene expressed in CD5-, CD5lo and CD5hi cells………………………………………………………………49 Fig. 9 NK cytotoxicity of CD5-CD21- (non-T non-B) cells cultured with CD5lo cells………………………………………50 References……………………………………………………………51 | |
dc.language.iso | en | |
dc.title | 犬CD5lo細胞誘發CD5-CD21-細胞的自然殺手細胞
之細胞毒殺能力 | zh_TW |
dc.title | Induction of NK cytotoxicity of canine CD5/CD21 double negative cells by CD5lo NK cells | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 廖泰慶 | |
dc.contributor.oralexamcommittee | 林大盛,廖光文,王愈善 | |
dc.subject.keyword | 犬自然殺手細胞, | zh_TW |
dc.subject.keyword | canine natural killer cells,peripheral blood lymphocytes (PBLs),lymphokine-activated killers (LAKs),CD5lo cells,CD5- cells,non-T non-B,natural cytotoxicity, | en |
dc.relation.page | 70 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-10 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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