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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳玉怜 | |
dc.contributor.author | Chia-Ying Lin | en |
dc.contributor.author | 林佳穎 | zh_TW |
dc.date.accessioned | 2021-06-13T15:25:02Z | - |
dc.date.available | 2008-08-13 | |
dc.date.copyright | 2008-08-13 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-21 | |
dc.identifier.citation | 1. Antal-Szalmas P. Evaluation of CD14 in host defence. Eur J Clin Invest. 2000;30:167-179.
2. Arend WP, Gordon DF, Wood WM, Janson RW, Joslin FG, Jameel S. IL-1 beta production in cultured human monocytes is regulated at multiple levels. J Immunol. 1989;143:118-126. 3. Augustin HG. Translating angiogenesis research into the clinic: the challenges ahead. Br J Radiol. 2003;76 Spec No 1:S3-10. 4. Bannerman DD GS. Direct effects of endotoxin on the endothelium: barrier function and injury. Lab Invest. 1999;79:1191-1199. 5. Bao X, Liu C, Fang J, Li X. Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst. Carbohydr Res. 2001;332:67-74. 6. Barksby HE LS, Preshaw PM, Taylor JJ. The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol. . 2007;149:217-225. 7. Barnes MJ, Farndale RW. Collagens and atherosclerosis. Exp Gerontol. 1999;34:513-525. 8. Beasley D, McGuiggin ME, Dinarello CA. Human vascular smooth muscle cells produce an intracellular form of interleukin-1 receptor antagonist. Am J Physiol. 1995;269:C961-968. 9. Beg AA FT, Nantermet PV, Baldwin AS Jr. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol. . 1993;13:3301-3310. 10. Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol. 2000;12:20-26. 11. Bewick M, Conlon M, Lee H, Parissenti AM, Zhang L, Gluck S, LaFrenie RM. Evaluation of sICAM-1, sVCAM-1, and sE-Selectin levels in patients with metastatic breast cancer receiving high-dose chemotherapy. Stem Cells Dev. 2004;13:281-294. 12. Blankenberg S, Barbaux S, Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis. 2003;170:191-203. 13. Braun M, Pietsch P, Schror K, Baumann G, Felix SB. Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc Res. 1999;41:395-401. 14. Cai Q, Lanting L, Natarajan R. Growth factors induce monocyte binding to vascular smooth muscle cells: implications for monocyte retention in atherosclerosis. Am J Physiol Cell Physiol. 2004;287:C707-714. 15. Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, et al. Molecular cloning of the interleukin-1 beta converting enzyme. Science. 1992;256:97-100. 16. Champagne B, Tremblay P, Cantin A, St Pierre Y. Proteolytic cleavage of ICAM-1 by human neutrophil elastase. J Immunol. 1998;161:6398-6405. 17. Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem. 2004;12:5595-5601. 18. Chien CM, Cheng JL, Chang WT, Tien MH, Tsao CM, Chang YH, Chang HY, Hsieh JF, Wong CH, Chen ST. Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorg Med Chem. 2004;12:5603-5609. 19. Choi MS, Lee WH, Kwon EY, Kang MA, Lee MK, Park YB, Jeon SM. Effects of soy pinitol on the pro-inflammatory cytokines and scavenger receptors in oxidized low-density lipoprotein-treated THP-1 macrophages. J Med Food. 2007;10:594-601. 20. Chow JC YD, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem. 1999;274:10689-10692. 21. Clinton SK, Fleet JC, Loppnow H, Salomon RN, Clark BD, Cannon JG, Shaw AR, Dinarello CA, Libby P. Interleukin-1 gene expression in rabbit vascular tissue in vivo. Am J Pathol. 1991;138:1005-1014. 22. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D, Kyriakopoulos A. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol. 1993;171:223-229. 23. Dechend R, Maass M, Gieffers J, Dietz R, Scheidereit C, Leutz A, Gulba DC. Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis. Circulation. 1999;100:1369-1373. 24. Detmer K, Wang Z, Warejcka D, Leeper-Woodford SK, Newman WH. Endotoxin stimulated cytokine production in rat vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001;281:H661-668. 25. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996;87:2095-2147. 26. Dinarello CA, Wolff SM. The role of interleukin-1 in disease. N Engl J Med. 1993;328:106-113. 27. Doran AC, Meller N, McNamara CA. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:812-819. 28. Dripps DJ, Brandhuber BJ, Thompson RC, Eisenberg SP. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J Biol Chem. 1991;266:10331-10336. 29. Faure E, Equils O, Sieling PA, Thomas L, Zhang FX, Kirschning CJ, Polentarutti N, Muzio M, Arditi M. Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J Biol Chem. 2000;275:11058-11063. 30. Fenton MJ GD. LPS-binding proteins and receptors. J Leukoc Biol. 1998;64:25-32. 31. Ferroni P, Basili S, Davi G. Platelet activation, inflammatory mediators and hypercholesterolemia. Curr Vasc Pharmacol. 2003;1:157-169. 32. Galkina E, Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27:2292-2301. 33. Gallicchio M, Rosa AC, Dianzani C, Brucato L, Benetti E, Collino M, Fantozzi R. Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). Br J Pharmacol. 2008;153:870-878. 34. Gangloff SC, Hijiya N, Haziot A, Goyert SM. Lipopolysaccharide structure influences the macrophage response via CD14-independent and CD14-dependent pathways. Clin Infect Dis. 1999;28:491-496. 35. Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu C, Zhou S. Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. Immunol Invest. 2005;34:171-198. 36. Gao Y, Zhou S, Jiang W, Huang M, Dai X. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. 2003;32:201-215. 37. Geng Y, Valbracht J, Lotz M. Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest. 1996;98:2425-2430. 38. Gerthoffer WT. Mechanisms of vascular smooth muscle cell migration. Circ Res. 2007;100:607-621. 39. Haak-Frendscho M, Kino K, Sone T, Jardieu P. Ling Zhi-8: a novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression. Cell Immunol. 1993;150:101-113. 40. Hallegua DS, Weisman MH. Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases. Ann Rheum Dis. 2002;61:960-967. 41. Hegele RA. The pathogenesis of atherosclerosis. Clin Chim Acta. 1996;246:21-38. 42. Hillis GS. Soluble integrin adhesion receptors and atherosclerosis: much heat and a little light? J Hum Hypertens. 2003;17:449-453. 43. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA. Phylogenetic perspectives in innate immunity. Science. 1999;284:1313-1318. 44. Hsu HY, Hua KF, Lin CC, Lin CH, Hsu J, Wong CH. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. J Immunol. 2004;173:5989-5999. 45. Hsu HY, Wen MH. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem. 2002;277:22131-22139. 46. Hua KF, Hsu HY, Chao LK, Chen ST, Yang WB, Hsu J, Wong CH. Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression. J Cell Physiol. 2007;212:537-550. 47. Huo Y, Ley K. Adhesion molecules and atherogenesis. Acta Physiol Scand. 2001;173:35-43. 48. Huot J, Houle F, Marceau F, Landry J. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res. 1997;80:383-392. 49. Ip YT, Davis RJ. Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. Curr Opin Cell Biol. 1998;10:205-219. 50. Jawien J, Nastalek P, Korbut R. Mouse models of experimental atherosclerosis. J Physiol Pharmacol. 2004;55:503-517. 51. Kalayoglu MV BG. A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide. Infect Immun. 1998;66:5067-5072. 52. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995;270:16483-16486. 53. Kirii H, Niwa T, Yamada Y, Wada H, Saito K, Iwakura Y, Asano M, Moriwaki H, Seishima M. Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2003;23:656-660. 54. Kumar A, Middleton A, Chambers TC, Mehta KD. Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1beta- and tumor necrosis factor-alpha-induced low density lipoprotein receptor expression in HepG2 cells. J Biol Chem. 1998;273:15742-15748. 55. Kuvin JT, Kimmelstiel CD. Infectious causes of atherosclerosis. Am Heart J. 1999;137:216-226. 56. Kyriakis JM, Avruch J. Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays. 1996;18:567-577. 57. Lee HM, Kim HJ, Won KJ, Choi WS, Lee KY, Bae YM, Park PJ, Park TK, Lee YL, Lee CK, Kim B. Contribution of soluble intercellular adhesion molecule-1 to the migration of vascular smooth muscle cells. Eur J Pharmacol. 2008;579:260-268. 58. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135-1143. 59. Libby P, Warner SJ, Friedman GB. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest. 1988;81:487-498. 60. Lieu CW, Lee SS, Wang SY. The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. Anticancer Res. 1992;12:1211-1215. 61. Lin SJ, Yen HT, Chen YH, Ku HH, Lin FY, Chen YL. Expression of interleukin-1 beta and interleukin-1 receptor antagonist in oxLDL-treated human aortic smooth muscle cells and in the neointima of cholesterol-fed endothelia-denuded rabbits. J Cell Biochem. 2003;88:836-847. 62. Lin ZB. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. J Pharmacol Sci. 2005;99:144-153. 63. Liu-Wu Y, Hurt-Camejo E, Wiklund O. Lysophosphatidylcholine induces the production of IL-1beta by human monocytes. Atherosclerosis. 1998;137:351-357. 64. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241. 65. Makgoba MW, Sanders ME, Ginther Luce GE, Gugel EA, Dustin ML, Springer TA, Shaw S. Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity. Eur J Immunol. 1988;18:637-640. 66. Massberg S, Vogt F, Dickfeld T, Brand K, Page S, Gawaz M. Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells. Thromb Res. 2003;110:187-194. 67. Moyer CF, Sajuthi D, Tulli H, Williams JK. Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am J Pathol. 1991;138:951-960. 68. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-140. 69. Paul A, Wilson S, Belham CM, Robinson CJ, Scott PH, Gould GW, Plevin R. Stress-activated protein kinases: activation, regulation and function. Cell Signal. 1997;9:403-410. 70. Peppelenbosch MP, DeSmedt M, ten Hove T, van Deventer SJ, Grooten J. Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways. Blood. 1999;93:4011-4018. 71. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A. 1992;89:4471-4475. 72. Pinon P, Kaski JC. [Inflammation, atherosclerosis and cardiovascular disease risk: PAPP-A, Lp-PLA2 and cystatin C. New insights or redundant information?]. Rev Esp Cardiol. 2006;59:247-258. 73. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353. 74. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085-2088. 75. Poston RN, Haskard DO, Coucher JR, Gall NP, Johnson-Tidey RR. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol. 1992;140:665-673. 76. Preston A MR, Gibson BW, Apicella MA. The lipooligosaccharides of pathogenic gram-negative bacteria. Crit Rev Microbiol. 1996;22:139-180. 77. Price DT, Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med. 1999;107:85-97. 78. Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci U S A. 1987;84:2995-2998. 79. Raetz CR WC. Lipopolysaccharide endotoxins. Annu Rev Biochem. 2002;71:635-700. 80. Ramnath RD, Ng SW, Guglielmotti A, Bhatia M. Role of MCP-1 in endotoxemia and sepsis. Int Immunopharmacol. 2008;8:810-818. 81. Rauch BH, Muschenborn B, Braun M, Weber AA, Schror K. ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells. Eur J Pharmacol. 2007;577:54-57. 82. Read MA, Whitley MZ, Gupta S, Pierce JW, Best J, Davis RJ, Collins T. Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. J Biol Chem. 1997;272:2753-2761. 83. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler Thromb. 1994;14:141-147. 84. Rietschel ET BH. Bacterial endotoxins. Sci Am. . 1992;267:54-61. 85. Rietschel ET KT, Schade FU, Mamat U, Schmidt G, Loppnow H, Ulmer AJ, Zähringer U, Seydel U, Di Padova F, et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 1994;8:217-225. 86. Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol. 1999;66:876-888. 87. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999;340:115-126. 88. Ross R, Glomset JA. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973;180:1332-1339. 89. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004;323:133-141. 90. Sporri B, Bickel M, Limat A, Waelti ER, Hunziker T, Wiesmann UN. Juxtacrine stimulation of cytokine production in cocultures of human dermal fibroblasts and T cells. Cytokine. 1996;8:631-635. 91. Springer TA, Dustin ML, Kishimoto TK, Marlin SD. The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Annu Rev Immunol. 1987;5:223-252. 92. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W, Jr., Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb. 1994;14:840-856. 93. Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell. 1988;52:925-933. 94. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924. 95. Stoll LL DG, Weintraub NL. Potential role of endotoxin as a proinflammatory mediator of atherosclerosis. Arterioscler Thromb Vasc Biol. . 2004;24:2227-2236 96. Su X, Ao L, Zou N, Song Y, Yang X, Cai GY, Fullerton DA, Meng X. Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: An obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27. Biochim Biophys Acta. 2008;1783:1623-1631. 97. Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y, Yacoub MH. Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation. 2001;104:I308-I303. 98. Sweet MJ, Hume DA. Endotoxin signal transduction in macrophages. J Leukoc Biol. 1996;60:8-26. 99. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature. 1992;356:768-774. 100. Tso C, Martinic G, Fan WH, Rogers C, Rye KA, Barter PJ. High-density lipoproteins enhance progenitor-mediated endothelium repair in mice. Arterioscler Thromb Vasc Biol. 2006;26:1144-1149. 101. van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med. 1996;74:13-33. 102. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem. 2002;10:1057-1062. 103. Warner SJ, Auger KR, Libby P. Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells. J Exp Med. 1987;165:1316-1331. 104. Wautier JL, Wautier MP. Blood cells and vascular cell interactions in diabetes. Clin Hemorheol Microcirc. 2001;25:49-53. 105. Wei CY, Huang KC, Chou YH, Hsieh PF, Lin KH, Lin WW. The role of Rho-associated kinase in differential regulation by statins of interleukin-1beta- and lipopolysaccharide-mediated nuclear factor kappaB activation and inducible nitric-oxide synthase gene expression in vascular smooth muscle cells. Mol Pharmacol. 2006;69:960-967. 106. Wilkinson SG. Bacterial lipopolysaccharides--themes and variations. Prog Lipid Res. 1996;35:283-343. 107. Wu SQ, Aird WC. Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005;289:H873-885. 108. Yotsui T, Yasuda O, Kawamoto H, Higuchi M, Chihara Y, Umemoto E, Tanaka T, Miyasaka M, Rakugi H, Ogihara T. Aspirin prevents adhesion of T lymphoblasts to vascular smooth muscle cells. FEBS Lett. 2007;581:427-432. 109. Zapolska-Downar D, Zapolski-Downar A, Markiewski M, Ciechanowicz A, Kaczmarczyk M, Naruszewicz M. Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells. Atherosclerosis. 2001;155:123-130. 110. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471. 111. Zhou X, Lin J, Yin Y, Zhao J, Sun X, Tang K. Ganodermataceae: natural products and their related pharmacological functions. Am J Chin Med. 2007;35:559-574. 112. 李宜達. 探討丹蔘酚酸 B 對於內毒素處理人類主動脈平滑肌細胞和 apoE 缺陷小鼠表現 MMP-2 與 MMP-9 的影響及其機制. 國立陽明大學解剖暨細胞生物學研究所碩士論文 2005. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37344 | - |
dc.description.abstract | Ganoderma lucidum (Reishi; 靈芝) 長久以來被使用做保持健康長壽的漢方藥物,研究發現靈芝中有許多具有生物活性的成份,進而調控身體生理功能,目前已知靈芝有抗腫瘤以及免疫調節的作用。F3 (Fraction 3; EORP) 是從靈芝中萃取出的水溶性多醣體,研究證實,F3 可促使人類巨噬細胞表現細胞素 (cytokines),如:介白素-1 (interlukin-1β),增加體內免疫系統功能且增強抵抗力。動脈硬化屬於慢性發炎疾病,細胞素在發炎反應中扮演重要角色,因此本實驗主要探討利用 F3 處理,是否影響 LPS 刺激人類主動脈平滑肌細胞 ICAM-1 及 IL-1 的表現及其相關機制。
實驗結果顯示:以 F3 處理人類主動脈平滑肌細胞,可抑制細胞受到 LPS 刺激所產生的 ICAM-1 表現, 免疫細胞化學染色也觀察到相同結果,並且 F3 處理可降低因 LPS 所引發的單核球沾黏作用;然而,F3 卻可增加人類主動脈平滑肌細胞受 LPS 刺激所表現的 proIL-1 和 IL-1ra,且可促使細胞外 IL-1ra 表現量增加。此外,F3 可調控人類主動脈平滑肌細胞內因 LPS 刺激活化的 MAP kinases (ERK1/2、JNK 及 p38),F3 可抑制 ERK1/2 的活化,但會促進 JNK 及 p38 的活化。加入 MEK1 抑制劑 (PD98059) 後,以 LPS 刺激發現可抑制 ICAM-1 表現;加入 JNK 抑制劑 (SP600125) 可抑制因 LPS 刺激所表現的 proIL-1 和 IL-1ra。動物實驗方面,F3 與 LPS 短期刺激下,可降低 C57BL/6 小鼠體內 IL-1β和 IL-1ra 表現量;長期刺激下,F3 可降低因 LPS 刺激所表現的 IL-1β,卻可增加 IL-1ra 的表現量,利用 免疫組織化學染色觀察胸主動脈管壁 IL-1β和 IL-1ra 表現,發現也有相同結果。 由以上實驗結果推論:F3 可影響人類主動脈平滑肌細胞內 ERK1/2、JNK 磷酸化,而調控因 LPS 所誘發的 ICAM-1、proIL-1 和 IL-1ra ,並且降低發炎細胞 (如:單核球) 的沾黏,降低發炎細胞引發的組織發炎反應,F3 的餵食也可影響當動物體受 LPS 刺激時 IL-1 的表現,實驗證明 F3 可保護人類主動脈平滑肌細胞受 LPS 刺激後的發炎反應,降低血液中發炎細胞沾黏導致的發炎作用,也可透過調控動物體受 LPS 刺激後 IL-1 表現量的改變,以達到保護動物體避免受 LPS 感染而引發的血管病變。 | zh_TW |
dc.description.abstract | Ganoderma lucidum (Reishi, Ling-Zhi), a popular home remedy, has been known for its beneficial activities in human health and longevity for centuries. Accumulated studies attempting to understand the role of Reishi in regulating various body functions revealed that the crude or purified components of Reishi extracts possess anti-tumor and immunomodulating activities. A glucan-containing extract of Reishi-derived polysaccharides (EORP; F3) in human macrophages exerts immuno-modulating activities by stimulating the expression of interleukin-1β (IL-1β), a key mediator in chronic vascular inflammatory response. In the present study, we used F3 to test its functional role in LPS-treated smooth muscle cells, which play a key role in atherogenesis and restenosis. LPS treatment increased intercellular cell adhesion molecule-1 (ICAM-1) expression in a time- and dose-dependent manner in human aortic smooth muscle cells (HASMCs). Pretreatment with F3 significantly suppressed the LPS-induced expression of ICAM-1, and the effect was mediated by the inhibition of ERK phosphorylation. F3 also significantly reduced the binding of the human monocytic cell line, U937, to LPS-treated HASMCs. In addition, F3 could regulate the expression of IL-1βand IL-1 receptor antagonist (IL-1 Ra) in LPS-treated HASMCs as well as in plasma and vascular wall in LPS-treated C57BL6 mice by ELISA and Western blotting. These results suggest that F3 may play important roles in the protection of atherosclerosis and inflammatory responses. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T15:25:02Z (GMT). No. of bitstreams: 1 ntu-97-R95446002-1.pdf: 1441321 bytes, checksum: 1cd9e43eea53ce5f3a651953a2440f96 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 致謝 I
中文摘要 II Abstract IV 緒論 2 一、前言 2 二、動脈硬化 (atherosclerosis) 之成因 2 三、平滑肌細胞與動脈硬化之關係 4 四、細胞黏附因子與動脈硬化之關係 5 五、內毒素與動脈硬化之關係 6 六、介白素-1 (IL-1) 表現與動脈硬化之關係 7 七、Mitogen-activated protein kinases (MAPKs)與動脈硬化之關係 8 八、代表動脈硬化或發炎反應所採用動物模式 9 九、Ganoderma lucidum (靈芝) 之應用 10 十、研究動機 12 貳、實驗材料 13 叁、實驗方法 17 肆、實驗結果 28 伍、討論與結論 36 陸、附圖 41 柒、參考文獻 65 捌、附件 78 | |
dc.language.iso | zh-TW | |
dc.title | 靈芝多醣體對內毒素處理小鼠及人類主動脈平滑肌細胞之介白素-1表現的影響及其機轉 | zh_TW |
dc.title | The effects of Ganoderma lucidum polysaccharides regulated Interleukin-1 expression in Lipopolysaccharides-treated mice and human aortic smooth muscle cells and its mechanisms | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 王淑美,許先業,陳永祥 | |
dc.subject.keyword | 靈芝多醣體,介白素-1,人類主動脈平滑肌細胞, | zh_TW |
dc.subject.keyword | Ganoderma lucidum,polysaccharides,Interleukin-1,human aortic smooth muscle cells, | en |
dc.relation.page | 79 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2008-07-21 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
顯示於系所單位: | 解剖學暨細胞生物學科所 |
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