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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37325完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 黃敏銓(Min-Chuan Huang) | |
| dc.contributor.author | Neng-Yu Lin | en |
| dc.contributor.author | 林能裕 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:24:29Z | - |
| dc.date.available | 2010-08-08 | |
| dc.date.copyright | 2008-08-08 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-21 | |
| dc.identifier.citation | 1. Mahal LK. Glycomics: towards bioinformatic approaches to understanding glycosylation. Anticancer Agents Med Chem 2008;8(1):37-51.
2. Kim YJ, Varki A. Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconj J 1997;14(5):569-76. 3. Patsos G, Robbe-Masselot C, Klein A, et al. O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines. Biochem Soc Trans 2007;35(Pt 5):1372-4. 4. Springer GF. T and Tn, general carcinoma autoantigens. Science 1984;224(4654):1198-206. 5. Campbell BJ, Finnie IA, Hounsell EF, Rhodes JM. Direct demonstration of increased expression of Thomsen-Friedenreich (TF) antigen in colonic adenocarcinoma and ulcerative colitis mucin and its concealment in normal mucin. J Clin Invest 1995;95(2):571-6. 6. Springer GF. Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy. J Mol Med 1997;75(8):594-602. 7. Yuan M, Itzkowitz SH, Boland CR, et al. Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry. Cancer Res 1986;46(9):4841-7. 8. Cao Y, Karsten UR, Liebrich W, Haensch W, Springer GF, Schlag PM. Expression of Thomsen-Friedenreich-related antigens in primary and metastatic colorectal carcinomas. A reevaluation. Cancer 1995;76(10):1700-8. 9. Jothy S. CD44 and its partners in metastasis. Clin Exp Metastasis 2003;20(3):195-201. 10. Heider KH, Kuthan H, Stehle G, Munzert G. CD44v6: a target for antibody-based cancer therapy. Cancer Immunol Immunother 2004;53(7):567-79. 11. Bresalier RS, Niv Y, Byrd JC, et al. Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis. J Clin Invest 1991;87(3):1037-45. 12. Nakamori S, Ota DM, Cleary KR, Shirotani K, Irimura T. MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 1994;106(2):353-61. 13. Karsten U, von Mensdorff-Pouilly S, Goletz S. What makes MUC1 a tumor antigen? Tumour Biol 2005;26(4):217-20. 14. Naor D, Wallach-Dayan SB, Zahalka MA, Sionov RV. Involvement of CD44, a molecule with a thousand faces, in cancer dissemination. Semin Cancer Biol 2008. 15. Glinsky VV, Glinsky GV, Rittenhouse-Olson K, et al. The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res 2001;61(12):4851-7. 16. Yu LG, Andrews N, Zhao Q, et al. Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. J Biol Chem 2007;282(1):773-81. 17. Ryder SD, Parker N, Ecclestone D, Haqqani MT, Rhodes JM. Peanut lectin stimulates proliferation in colonic explants from patients with inflammatory bowel disease and colon polyps. Gastroenterology 1994;106(1):117-24. 18. Huang MC, Chen HY, Huang HC, et al. C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. Oncogene 2006;25(23):3267-76. 19. Iwai T, Kudo T, Kawamoto R, et al. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. Proc Natl Acad Sci U S A 2005;102(12):4572-7. 20. Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM. Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem 2002;277(1):178-86. 21. Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci U S A 2002;99(26):16613-8. 22. Narimatsu Y, Ikehara Y, Iwasaki H, et al. Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc. Biochem Biophys Res Commun 2008;366(1):199-205. 23. Xia L, Ju T, Westmuckett A, et al. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J Cell Biol 2004;164(3):451-9. 24. Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome. Nature 2005;437(7063):1252. 25. Coppo R, Amore A. Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int 2004;65(5):1544-7. 26. Qin W, Zhou Q, Yang LC, et al. Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy. J Intern Med 2005;258(5):467-77. 27. Ju T, Lanneau GS, Gautam T, et al. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. Cancer Res 2008;68(6):1636-46. 28. Yoo NJ, Kim MS, Lee SH. Absence of COSMC gene mutations in breast and colorectal carcinomas. APMIS 2008;116(2):154-5. 29. Nakagoe T, Sawai T, Tsuji T, et al. The relationship between circulating sialyl Tn antigen and polypoid or nonpolypoid growth characteristics in colorectal cancer. J Cancer Res Clin Oncol 2000;126(9):542-8. 30. Ahmad I, Hoessli DC, Walker-Nasir E, Choudhary MI, Rafik SM, Shakoori AR. Phosphorylation and glycosylation interplay: protein modifications at hydroxy amino acids and prediction of signaling functions of the human beta3 integrin family. J Cell Biochem 2006;99(3):706-18. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37325 | - |
| dc.description.abstract | 在合成O-glycan 結構的過程中，Galβ1,3GalNAc稱為T antigen 或Core 1 structure，是一個根部的醣類結構，此結構在正常的表皮組織中會被其他糖類轉換酵素延伸為更長的醣類結構；而在許多的癌症中卻表現著大量的T antigen結構，而此結構被證明可以增加癌細胞轉移到肝臟的機率。C1GalT1是core 1 synthase會將UDP-Gal接到GalNAc-Ser/Thr的結構上形成T antigen；而C1GALT1-specific chaperone 1 (COSMC)是C1GalT1的專一性chaperone，使C1GalT1具有酵素活性所必須。T antigen結構在腫瘤中大量表現的機制目前還不清楚。我們推測COSMC可以調控大腸直腸癌細胞T antigen的表現並進而影響癌細胞的行為。在我的研究中發現，COSMC基因過量表現的百分比在較惡性Dukes’ C、D族群的病人中是增加的。當我們將COSMC基因轉染HCT116，可以發現細胞表面T antigen的表現量是顯著上升。更進一步的研究中發現，過量表現COSMC的癌細胞HCT116會促進其增生 (proliferation)、爬行 (migration)、入侵 (invasion)的能力，增強形成colony的能力。在免疫缺陷鼠(SCID mice)的腫瘤生成模式中，過量表現COSMC會促進腫瘤變大。這些發現表示COSMC可能在促進大腸直腸細胞癌化的過程中扮演著重要的角色。未來，在治療大腸直腸癌方面，COSMC亦有成為標靶藥物治療的潛力。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:24:29Z (GMT). No. of bitstreams: 1 ntu-97-R95446009-1.pdf: 1233091 bytes, checksum: c148c8cfc4c7cf74baacce7ef4015b46 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 口試委員會審定書…………………………………………i
誌謝…………………………………………………………ii 中文摘要……………………………………………………iii 英文摘要……………………………………………………iv 總目錄………………………………………………………v 圖目錄………………………………………………………vi 縮寫表………………………………………………………vii 前言…………………………………………………………1 實驗材料與方法……………………………………………5 結果…………………………………………………………16 討論…………………………………………………………23 參考文獻……………………………………………………27 | |
| dc.language.iso | zh-TW | |
| dc.subject | 大腸直腸癌 | zh_TW |
| dc.subject | 入侵 | zh_TW |
| dc.subject | 移行 | zh_TW |
| dc.subject | chaperone | en |
| dc.subject | C1GalT1C1 | en |
| dc.subject | Core 1 | en |
| dc.subject | T antigen | en |
| dc.title | C1GALT1-specific chaperone 1 促進大腸直腸癌細胞惡性行為 | zh_TW |
| dc.title | C1GALT1-specific chaperone 1 promotes malignant phenotypes of colon cancer cells | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李財坤(Tsai-Kun Li),李明學(Ming-Shyue Lee) | |
| dc.subject.keyword | 入侵,移行,大腸直腸癌, | zh_TW |
| dc.subject.keyword | C1GalT1C1,Core 1,T antigen,chaperone, | en |
| dc.relation.page | 42 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-07-22 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
| 顯示於系所單位： | 解剖學暨細胞生物學科所 | |
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|---|---|---|---|
| ntu-97-1.pdf 未授權公開取用 | 1.2 MB | Adobe PDF |
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