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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 李繼忠 | |
dc.contributor.author | Ber-In Lee | en |
dc.contributor.author | 李柏穎 | zh_TW |
dc.date.accessioned | 2021-05-13T08:36:15Z | - |
dc.date.available | 2017-12-30 | |
dc.date.available | 2021-05-13T08:36:15Z | - |
dc.date.copyright | 2016-08-24 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-16 | |
dc.identifier.citation | 1. Adams, W. M., Bjorling, D. E., McAnulty, J. F., 2005. Outcome of Accelerated Radiotherapy Alone or Accelerated Radiotherapy Followed by Exenteration of the Nasal Cavity in Dogs with Intranasal Neoplasia: 53 Cases (1990-2002). Journal of the American Veterinary Medical Association 227, 936-941.
2. Adams, W. M., Kleiter, M. M., Thrall, D. E., Klauer, J. M., Forrest, L. J., LaDue, T. A., Havighurst, T. C., 2009. Prognostic Significance of Tumor Histology and Computed Tomographic Staging for Radiation Treatment Response of Canine Nasal Tumors. Veterinary Radiology & Ultrasound 50, 330-335. 3. Adams, W. M., Miller, P. E., Vail, D. M., Forrest, L. J., MacEwen, E. G., 1998. An Accelerated Technique for Irradiation of Malignant Canine Nasal and Paranasal Sinus Tumors. Veterinary Radiology & Ultrasound 39, 475-481. 4. Adams, W. M., Withrow, S. J., Walshaw, R., Turrell, J. M., Evans, S. M., Walker, M. A., Kurzman, I. D., 1987. Radiotherapy of Malignant Nasal Tumors in 67 Dogs. Journal of the American Veterinary Medical Association 191, 311-315. 5. Beck, J. A., Hunt, G. B., Goldsmid, S. E., Swinney, G. R., 1999. Nasopharyngeal Obstruction Due to Cystic Rathke's Clefts in Two Dogs. Australian Veterinary Journal 77, 94-96. 6. Begg, A. C., Hofland, I., Van Glabekke, M., Bartelink, H., Horiot, J. C., 1992. Predictive Value of Potential Doubling Time for Radiotherapy of Head and Neck Tumor Patients: Results from the Eortc Cooperative Trial 22851. Seminars in Radiation Oncology 2, 22-25. 7. Belshaw, Z., Constantio-Casas, F., Brearley, M. J., Dunning, M. D., Holmes, M. A., Dobson, J. M., 2011. Cox-2 Expression and Outcome in Canine Nasal Carcinomas Treated with Hypofractionated Radiotherapy. Veterinary and Comparative Oncology 9, 141-148. 8. Bommarito, D. A., Kent, M. S., Selting, K. A., Henry, C. J., Lattimer, J. C., 2010. Reirradiation of Recurrent Canine Nasal Tumors. Veterinary Radiology & Ultrasound 52, 207-212. 9. Bowles, K., Desandre-Robinson, D., Kubicek, L., Lurie, D., Milner, R., Boston, S. E., 2014. Outcome of Definitive Fractionated Radiation Followed by Exenteration of the Nasal Cavity in Dogs with Sinonasal Neoplasia: 16 Cases. Veterinary and Comparative Oncology. 10. Bradley, P. A., Harvey, C. E., 1973. Intra-Nasal Tumors in Dog - Evaluation of Prognosis. Journal of Small Animal Practice 14, 459-467. 11. Buchholz, J., Hagen, R., Leo, C., Ebling, A., Roos, M., Kaser-Hotz, B., Bley, C. R., 2009. 3d Conformal Radiation Therapy for Palliative Treatment of Canine Nasal Tumors. Veterinary Radiology & Ultrasound 50, 679-683. 12. Bukowski, J. A., Wartenberg, D., Goldschmidt, M., 1998. Environmental Causes for Sinonasal Cancers in Pet Dogs, and Their Usefulness as Sentinels of Indoor Cancer Risk. Journal of Toxicology and Environmental Health 54, 579-591. 13. Burrow, R. D., 2004. A Nasal Dermoid Sinus in an English Bull Terrier. Journal of the American Veterinary Medical Association 45, 572-574. 14. Cancedda, S., Sabattini, S., Bettini, G., Leone, V. F., Laganga, P., Rossi, F., Terragni, R., Gnudi, G., Vignoli, M., 2015. Combination of Radiation Therapy and Firocoxib for the Treatment of Canine Nasal Carcinoma. Veterinary Radiology & Ultrasound 56, 335-343. 15. Clendenin, M. A., Conrad, M. C., 1979. Collateral Vessel Development after Chronic Bilateral Common Carotid Artery Occlusion in the Dog. American Journal of Veterinary Research 40, 1244-1248. 16. Cook, W. R., 1964. Observations on the Upper Respiratory Tract of the Dog and Cat. Journal of Small Animal Practice 5, 309-329. 17. Correa, S. S., Mauldin, G. N., Mauldin, G. E., Patnaik, A. K., 2003. Efficacy of Cobalt-60 Radiation Therapy for the Treatment of Nasal Cavity Nonkeratinizing Squamous Cell Carcinoma in the Dog. Journal of the American Veterinary Medical Association 39, 86-89. 18. Delmage, D. A., 1973. Some Conditions of Nasal Chambers of Dog and Cat. Veterinary Record 92, 437-442. 19. Deveau, M. A., Gutierrez, A. N., Mackie, T. R., Tome, W. A., Forrest, L. J., 2010. Dosimetric Impact of Daily Setup Variations During Treatment of Canine Nasal Tumors Using Intensity-Modulated Radiation Therapy. Veterinary Radiology & Ultrasound 51, 90-96. 20. Drees, R., Forrest, L. J., Chappell, R., 2009. 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Prognosis of Canine Patients with Nasal Tumors According to Modified Clinical Stages Based on Computed Tomography: A Retrospective Study. Journal of Veterinary Medical Science 70, 207-212. 30. Kubicek, L., Milner, R., An, Q., Kow, K., 2016. Outcomes and Prognostic Factors Associated with Canine Sinonasal Tumors Treated with Curative Intent Cone-Based Stereotactic Radiosurgery (1999-2013). Veterinary Radiology & Ultrasound 57, 331-340. 31. LaDue, T., Klein, M. K., 2001. Toxicity Criteria of the Veterinary Radiation Therapy Oncology Group. Veterinary Radiology & Ultrasound 42, 475-476. 32. LaDue, T. A., Dodge, R., Page, R. L., Price, G. S., Hauck, M. L., Thrall, D. E., 1999. Factors Influencing Survival after Radiotherapy of Nasal Tumors in 130 Dogs. Veterinary Radiology & Ultrasound 40, 312-317. 33. Laing, E. J., Binnington, A. G., 1988. Surgical Therapy of Canine Nasal Tumors: A Retrospective Study (1982-1986). Canadian Veterinary Journal 29, 809-813. 34. Lana, S. E., Dernell, W. S., Lafferty, M. H., Withrow, S. J., LaRue, S. M., 2004. Use of Radiation and a Slow-Release Cisplatin Formulation for Treatment of Canine Nasal Tumors. Veterinary Radiology & Ultrasound 45, 577-581. 35. Lana, S. E., Dernell, W. S., LaRue, S. M., Lafferty, M. J., Douple, E. B., Brekke, J. H., Withrow, S. J., 1997. Slow Release Cisplatin Combined with Radiation for the Treatment of Canine Nasal Tumors. Veterinary Radiology & Ultrasound 38, 474-478. 36. Langova, V., Mutsaers, A. J., Phillips, B., Straw, R., 2004. Treatment of Eight Dogs with Nasal Tumours with Alternating Doses of Doxorubicin and Carboplatin in Conjunction with Oral Piroxicam. Australian Veterinary Journal 82, 676-680. 37. Lawrence, J. A., Forrest, L. J., Turek, M. M., Miller, P. E., Mackie, T. R., Jaradat, H. A., Vail, D. M., Dubielzig, R. R., Chappell, R., Mehta, M. P., 2010. Proof of Principle of Ocular Sparing in Dogs with Sinonasal Tumors Treated with Intensity-Modulated Radiation Therapy. Veterinary Radiology & Ultrasound 51, 561-570. 38. LeBlanc, A. K., LaDue, T. A., Turrel, J. M., Klein, M. K., 2004. Unexpected Toxicity Following Use of Gemcitabine as a Radiosensitizer in Head and Neck Carcinomas: A Veterinary Radiation Therapy Oncology Group Pilot Study. Veterinary Radiology & Ultrasound 45, 466-470. 39. Lobetti, R. G., 2009. A Retrospective Study of Chronic Nasal Disease in 75 Dogs. Journal of the South African Veterinary Association 80, 224-228. 40. MacEwen, E., Withrow, S., Patnaik, A., 1977. Nasal Tumors in the Dog: Retrospective Evaluation of Diagnosis, Prognosis, and Treatment. Journal of the American Veterinary Medical Association 170, 45-48. 41. Madewell, B. R., Priester, W. A., Gillette, E. L., Snyder, S. P., 1976. Neoplasms of the Nasal Passages and Paranasal Sinuses in Domesticated Animals as Reported by 13 Veterinary Colleges. American Journal of Veterinary Research 37, 851-856. 42. Maruo, T., Shida, T., Fukuyama, Y., Hosaka, S., Noda, M., Ito, T., Sugiyama, H., Ishikawa, T., Madarame, H., 2011. Retrospective Study of Canine Nasal Tumor Treated with Hypofractionated Radiotherapy. Journal of Veterinary Medical Science 73, 193-197. 43. Mason, S. L., Maddox, T. W., Lillis, S. M., Blackwood, L., 2013. Late Presentation of Canine Nasal Tumours in a Uk Referral Hospital and Treatment Outcomes. Journal of Small Animal Practice 54, 347-353. 44. McDonald, C., Looper, J., Greene, S., 2012. Response Rate and Duration Associated with a 4gy 5 Fraction Palliative Radiation Protocol. Veterinary Radiology & Ultrasound 53, 358-364. 45. McEntee, M. C., Page, R. L., Heidner, G. L., Cline, J. M., Thrall, D. E., 1991. A Retrospective Study of 27 Dogs with Intranasal Neoplasms Treated with Cobalt Radiation. Veterinary Radiology & Ultrasound 32, 135-139. 46. Meler, E., Dunn, M., Lecuyer, M., 2008. A Retrospective Study of Canine Persistent Nasal Disease: 80 Cases (1998-2003). Canadian Veterinary Journal 49, 71-76. 47. Mellanby, R. J., Stevenson, R. K., Herrtage, M. E., White, R. a. S., Dobson, J. M., 2002. Long-Term Outcome of 56 Dogs with Nasal Tumours Treated with Four Doses of Radiation at Intervals of Seven Days. Veterinary Record 151, 253-257. 48. Moore, M. P., Gavin, P. R., Kraft, S. L., Dehaan, C. E., Leathers, C. W., Dorn, R. V., 1991. Mr, Ct and Clinical-Features from 4 Dogs with Nasal Tumors Involving the Rostral Cerebrum. Veterinary Radiology & Ultrasound 32, 19-25. 49. Morris, J. S., Dunn, K. J., Dobson, J. M., White, R. a. S., 1994. Effects of Radiotherapy Alone and Surgery and Radiotherapy on Survival of Dogs with Nasal Tumours. Journal of the American Veterinary Medical Association 35, 567-573. 50. Nadeau, M.-E., Kitchell, B. E., Rooks, R. L., LaRue, S. M., 2004. Cobalt Radiation with or without Low-Dose Cisplatin for Treatment of Canine Naso-Sinus Carcinomas. Veterinary Radiology & Ultrasound 45, 362-367. 51. Norris, A. M., 1979. Intranasal Neoplasms in the Dog. Journal of the American Veterinary Medical Association 15, 231-236. 52. Northrup, N. C., Etue, S. M., Ruslander, D. M., Rassnick, K. M., Hutto, D. L., Bengtson, A., Rand, W., Moore, A. S., 2001. Retrospective Study of Orthovoltage Radiation Therapy for Nasal Tumors in 42 Dogs. Journal of Veterinary Internal Medicine 15, 183-189. 53. Owen, L. N. 1980. Tnm Classification of Tumours in Domestic Animal (Geneva : World Health Organization). 54. Patnaik, A. K., 1989. Canine Sinonasal Neoplasms: Clinicopathological Study of 285 Cases. Journal of the American Veterinary Medical Association. 55. Rancilio, N. J., Custead, M. R., Poulson, J. M., 2016. Radiation Therapy Communication-Reirradiation of a Nasal Tumor in a Brachycephalic Dog Using Intensity Modulated Radiation Therapy. Veterinary Radiology & Ultrasound. 56. Rassnick, K. M., Goldkamp, C. E., Erb, H. N., Scrivani, P. V., Njaa, B. L., Gieger, T. L., Turek, M. M., Mcniel, E. A., Proulx, D. R., Chun, R., Mauldin, G. E., Phillips, B. S., Kristal, O., 2006. Evaluation of Factors Associated with Survival in Dogs with Untreated Nasal Carcinomas: 139 Cases (1993-2003). Journal of the American Veterinary Medical Association 229, 401-406. 57. Reif, J. S., Bruns, C., Lower, K. S., 1998. Cancer of the Nasal Cavity and Paranasal Sinuses and Exposure to Environmental Tobacco Smoke in Pet Dogs. American Journal of Epidemiology 147, 488-492. 58. Reif, J. S., Cohen, D., 1971. The Environmental Distribution of Canine Respiratory Tract Neoplasms. Archives of Environmental Health: An International Journal 22, 136-140. 59. Rogers, K., Walker, M., Helman, R., 1995. Squamous Cell Carcinoma of the Canine Nasal Cavity and Frontal Sinus: Eight Cases. Journal of the American Veterinary Medical Association 32, 103-110. 60. Rudd, R. G., Richardson, D. C., 1985. A Diagnostic and Therapeutic Approach to Nasal Disease in Dogs. The Compendium on continuing education for the practicing veterinarian (USA). 61. Russo, M., Lamb, C. R., Jakovljevic, S., 2000. Distinguishing Rhinitis and Nasal Neoplasia by Radiography. Veterinary Radiology & Ultrasound 41, 1-7. 62. Saunders, J. H., Van Bree, H., Gielen, I., De Rooster, H., 2003. Diagnostic Value of Computed Tomography in Dogs with Chronic Nasal Disease. Veterinary Radiology & Ultrasound 44, 409-413. 63. Sones, E., Smith, A., Schleis, S., Brawner, W., Almond, G., Taylor, K., Haney, S., Wypij, J., Keyerleber, M., Arthur, J., Hamilton, T., Lawrence, J., Gieger, T., Sellon, R., Wright, Z., 2012. Survival Times for Canine Intranasal Sarcomas Treated with Radiation Therapy: 86 Cases (1996-2011). Veterinary Radiology & Ultrasound 54, 194-201. 64. Strasser, J. L., Hawkins, E. C., 2005. Clinical Features of Epistaxis in Dogs: A Retrospective Study of 35 Cases (1999-2002). Journal of the American Veterinary Medical Association 41, 179-184. 65. Stunzi, H., Hauser, B., 1976. Tumours of the Nasal Cavity. Bulletin of the World Health Organization 53, 257-263. 66. Tan-Coleman, B., Lyons, J., Lewis, C., Rosenberg, M., Ruiz, A., 2012. Prospective Evaluation of a 5 × 4 Gy Prescription for Palliation of Canine Nasal Tumors. Veterinary Radiology & Ultrasound 54, 89-92. 67. Theon, A. P., Madewell, B. R., Harb, M. F., Dungworth, D. L., 1993. Megavoltage Irradiation of Neoplasms of the Nasal and Paranasal Cavities in 77 Dogs. Journal of the American Veterinary Medical Association 202, 1469-1475. 68. Thrall, D. E., Harvey, C. E., 1983. Radiotherapy of Malignant Nasal Tumors in 21 Dogs. Journal of the American Veterinary Medical Association 183, 663-666. 69. Thrall, D. E., McEntee, M. C., Novotney, C., Hauck, M. L., Page, R. L., 1993. A Boost Technique for Irradiation of Malignant Canine Nasal Tumors. Veterinary Radiology & Ultrasound 34, 295-300. 70. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/3728 | - |
dc.description.abstract | 鼻腔腫瘤在狗是不常發生的惡性腫瘤,局部侵犯性強但在診斷時甚少發生轉移。 使用經驗性口服藥物通常會暫時改善鼻腔腫瘤的臨床症狀,但症狀還是會間歇性的反覆出現。鼻腔腫瘤的治療主要以局部控制為主,未接受治療的中位存活時間約為3.1個月。除了一般的規律分次性放射治療,低分次性放射治療療程較不密集,主要為了緩解影響病患生活品質的臨床症狀。
回溯國立台灣大學附設動物醫院於2011至2015年的病例,共有35隻患犬符合經病理學確診或臨床上強烈懷疑鼻腔腫瘤的病患。15隻患犬接受低分次性強度調控放射治療被歸類為放療組,非放療組有20隻患犬,其中17隻接受除了放射治療以外的治療方式,3隻沒有接受任何治療。 本研究大部分患犬臨床分期較末期(82.8%為第三或第四期),先前文獻末期病患比例較低,本研究治療成果與先前病患接受放射治療或化學治療的文獻不相上下。與非放療組相比,放療組患犬有顯著較長的無疾病進展期與存活時間。非放療組9隻患犬有接受化學治療,與同組沒接受化學治療的患犬的生存時間有顯著差異。 以多變數分析各因子與疾病進展的關係時,臉部變形 (P=0.012)與是否接受放療 (P=0.014)仍具顯著差異,危害比分別是3.741、0.347。以多變數分析各因子與生存時間的關係時,只有是否接受放療 (P=0.005)仍具顯著差異,危害比是0.259。 這是第一篇犬隻鼻腔腫瘤以低分次性強度調控放射治療的研究。即使本研究大部分患犬臨床分期較末期,經過低分次性強度調控放射治療後可以獲得一段可觀的無疾病進展期與存活時間。本研究的結果也指出當鼻腔腫瘤的患犬無法接受放射治療時,傳統的化學治療仍然可以提供病患一些幫助。 | zh_TW |
dc.description.abstract | Canine nasal tumors is an uncommon malignancy, usually have a locally invasive behavior and rarely metastasis at the time of diagnosis. Clinical signs of nasal neoplasia usually are intermittent and progressive when empirical therapy administered. Treatment options of nasal tumors focus on local control. The MST of untreated canine nasal carcinoma is about 3.1 months. Besides regular fractionated radiation therapy for canine nasal tumors, coarse fractionated radiation therapy is less intensive and mainly focus on relieving clinical signs that affects patient’s quality of life.
The medical records of histologically confirmed or clinically highly suspected nasal malignancy from 2011 to 2015 at National Taiwan University Veterinary Hospital were reviewed and 35 of client-owned dogs met the inclusion criteria. 15 patients treated with hypofractionated intensity-modulated radiation therapy (IMRT) were assigned to RT group. Non-RT group consisted of 20 patients either with treatment except RT (n=17) or no treatment (n=3) for further comparison. From the result of present study where most patients were advanced stage (82.8% are stage III and IV), our treatment outcome was comparable with previous studies of radiation therapy or chemotherapy in canine nasal tumor patients even though lower ratio of late stage patients were presented in most of the studies. Progression free interval and overall survival were significant longer in RT group when compared with non-RT group. In non-RT group, receiving chemotherapy (n=9) offered significant longer overall survival when compared with those patients that only received palliative oral medications. Facial deformity (P=0.012) and received radiation therapy or not (P=0.014) remained statistically significant in multivariable analysis of progression free interval. Hazard ratio of facial deformity and received radiation therapy or not was 3.741, and 0.347, respectively. Only received radiation therapy or not (P=0.005) remained statistically in multivariable analysis of overall survival. Hazard ratio of received radiation therapy or not was 0.259. This is the first IMRT study delivers weekly fractionated radiation therapy in canine nasal tumor patients. From the result of present study where most patients were in late stage, a durable progression free interval and comparable survival was obtained from our radiation treatment procedure. The result from present study also indicate that if radiation therapy is not an amenable option, traditional chemotherapy can still offer some benefit to canine nasal tumor patients. | en |
dc.description.provenance | Made available in DSpace on 2021-05-13T08:36:15Z (GMT). No. of bitstreams: 1 ntu-105-R02643002-1.pdf: 1207568 bytes, checksum: 24560f73a299bc70033d939447ac6a98 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 中文摘要 iii ABSTRACT v CONTENTS vii List of Tables x List of Figures xi Chapter 1 Literature review 1 1.1 Canine nasal tumor 1 1.2 Non-radiation therapy in canine nasal tumors 5 1.2.1 Surgery 5 1.2.2 Palliative medical treatment 5 1.2.3 Chemotherapy 6 1.3 Radiation therapy in canine nasal tumors 6 1.3.1 Combination of radiation therapy and surgery 6 1.3.2 Regular fractionated radiation therapy 8 1.3.3 Concurrent chemoradiation therapy (CCRT) 9 1.3.4 Hypofractionated radiation therapy 10 Chapter 2 Introduction 12 Chapter 3 Materials and Methods 13 3.1 Patient selection 13 3.2 Tumor staging 13 3.3 Medications 14 3.4 RT procedure 14 3.5 Treatment response and side effects 16 3.6 Statistic analysis 17 Chapter 4 Result 20 4.1 Demographic 20 4.2 Non-radiation therapy group 21 4.2.1 Treatment and toxicity 22 4.2.2 Treatment response 22 4.2.3 Correlated factors of clinical improvement in non-RT group 23 4.2.4 Kaplan-Meier of PFI and OS in non-RT group 24 4.3 Hypofractionated radiation therapy group 25 4.3.1 Treatment and toxicity 26 4.3.2 Treatment response 27 4.3.3 Correlated factors of treatment response in RT group 28 4.3.4 Kaplan-Meier of PFI and OS in RT group 28 4.4 Compare two study groups 29 4.4.1 PFI Kaplan-Meier curve of RT and non-RT group 29 4.4.2 OS Kaplan-Meier curve of RT and non-RT group 30 4.4.3 Univariable analysis 31 4.4.4 Multivariable analysis 32 Chapter 5 Discussion 33 5.1 Efficacy 33 5.2 Influential and prognostic factors evaluation 36 5.3 Treatment failure and retreatment 41 5.4 Limitation of this study 44 Chapter 6 Conclusion 45 Tables 46 Figures 65 REFERENCE 87 | |
dc.language.iso | en | |
dc.title | ⽐較使⽤低分次性強度調控放射治療與傳統治療在末期⽝⿐腔腫瘤之效果 | zh_TW |
dc.title | Comparison of Hypofractionated Intensity-Modulated Radiation Therapy Versus Traditional Treatment Modalities in Advanced Stage of Canine Nasal Tumors | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 季匡華,廖泰慶,林辰栖 | |
dc.subject.keyword | ??腔腫瘤,強度調控放射治療,低分次性放射治療,末期, | zh_TW |
dc.subject.keyword | Canine nasal tumor,IMRT,Hypofractionated RT,Advanced stage, | en |
dc.relation.page | 95 | |
dc.identifier.doi | 10.6342/NTU201602570 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2016-08-17 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
顯示於系所單位: | 臨床動物醫學研究所 |
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