請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/3718
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李心予 | |
dc.contributor.author | Ya-Yun Chan | en |
dc.contributor.author | 詹雅雲 | zh_TW |
dc.date.accessioned | 2021-05-13T08:36:11Z | - |
dc.date.available | 2018-08-25 | |
dc.date.available | 2021-05-13T08:36:11Z | - |
dc.date.copyright | 2016-08-25 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-16 | |
dc.identifier.citation | 5 References
1. Kewley, R.J., M.L. Whitelaw, A. Chapman-Smith, The mammalian basic helix–loop–helix/PAS family of transcriptional regulators. The International Journal of Biochemistry & Cell Biology, 2004. 36(2): p. 189-204. 2. Bersten, D.C., et al., bHLH-PAS proteins in cancer. Nat Rev Cancer, 2013. 13(12): p. 827-41. 3. Ellen C. HENRY, T.A.G., Transformation of the arylhydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased afinityfor2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem, 1993. 249: p. 95-101. 4. Perdew, G.H., Association of the Ah Receptor with the 90-kDa Heat Shock Protein. Biochem. 263(25): p. 13802-13805. 5. Qiang Ma, J.P.W., Jr., A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Biological chemistry, 1997. 272(4): p. 8878–8884. 6. Shetty, P.V., B.Y. Bhagwat, and W.K. Chan, p23 enhances the formation of the aryl hydrocarbon receptor–DNA complex. Biochemical Pharmacology, 2003. 65(6): p. 941-948. 7. III, M.B.C.a.C.A.M., Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling. Cell Stress & Chaperones, 2004. 9(1): p. 4-20. 8. MURRAY WHITELAW, I.P., ANNA WILHELMSSON, JAN-AKE GUSTAFSSON, AND LORENZ POELLINGER, Ligand-Dependent Recruitment of the Arnt Coregulator Determines DNA Recognition by the Dioxin Receptor. MOLECULAR and CELLULAR BIOLOGY, 1993. 13: p. 2504-2514. 9. SCOTT E. HEID, R.S.P., HOLLIE I. SWANSON, Role of Heat Shock Protein 90 Dissociation in Mediating Agonist-Induced Activation of the Aryl Hydrocarbon Receptor. MOLECULAR PHARMACOLOGY, 1999. 57: p. 82–92. 10. James P. Whitlock, J., INDUCTION OF CYTOCHROME P4501A1. Annu. Rev. Pharmacol. Toxicol., 1991. 39: p. 103–25. 11. Daniel W. Nebert, A.L.R., Matthew Z. Dieter, Willy A. Solis, Yi Yang and Timothy P. Dalton, Role of the Aromatic Hydrocarbon Receptor and [Ah] Gene Battery in the Oxidative Stress Response, Cell Cycle Control, and Apoptosis. Biochemical Pharmacology, 2000. 59: p. 65–85. 12. Swanson, H.I., DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation. Chemico-Biological Interactions, 2002. 141: p. 63–76. 13. Mandal, P.K., Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. J Comp Physiol B, 2005. 175(4): p. 221-30. 14. Busbee, P.B., et al., Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders. Nutr Rev, 2013. 71(6): p. 353-69. 15. Adachi, J., et al., Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J Biol Chem, 2001. 276(34): p. 31475-8. 16. Song, J., et al., A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A, 2002. 99(23): p. 14694-9. 17. Wincent, E., et al., The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J Biol Chem, 2009. 284(5): p. 2690-6. 18. DiNatale, B.C., et al., Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci, 2010. 115(1): p. 89-97. 19. Nguyen, N.T., et al., Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research. Front Immunol, 2014. 5: p. 551. 20. Opitz, C.A., et al., An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature, 2011. 478(7368): p. 197-203. 21. Jin, D.Q., et al., 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells. Neurosci Lett, 2004. 363(1): p. 69-72. 22. Marlowe, J.L., et al., The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression. J Biol Chem, 2004. 279(28): p. 29013-22. 23. Jennifer L. Marlowe, Y.F., Xiaoqing Chang, Li Peng, Erik S. Knudsen, Ying Xia, and Alvaro Puga, The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis. Molecular Biology of the Cell, 2008. 19: p. 3263–3271. 24. Yuichi WATABE, N.N., Masakatsu TEZUKA, and Shigeki SHIMBA, Aryl Hydrocarbon Receptor Functions as a Potent Coactivator of E2F1- Dependent Trascription Activity. Biol. Pharm. Bull., 2010. 33(3): p. 389—397. 25. Wu, P.Y., et al., Aryl hydrocarbon receptor downregulates MYCN expression and promotes cell differentiation of neuroblastoma. PLoS One, 2014. 9(2): p. e88795. 26. Richard B. Emmons1, D.D., Patricia A. Estes2, Paula Kiefel1, Jack T. Mosher2, Margaret Sonnenfeld2, Mary P. Ward2, Ian Duncan1 and Stephen T. Crews2,, The Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. Development, 1999. 126: p. 3937-3945. 27. SANDRA L. PETERSEN, M.A.C., SHARON A. MARCONI, CLIFFORD D. CARPENTER, LAURA S. LUBBERS, AND MICHAEL D. MCABEE, Distribution of mRNAs Encoding the Arylhydrocarbon Receptor, Arylhydrocarbon Receptor Nuclear Translocator, and Arylhydrocarbon Receptor Nuclear Translocator-2 in the Rat Brain and Brainstem. THE JOURNAL OF COMPARATIVE NEUROLOGY, 2000. 427: p. 428–439. 28. Hahn, M.E., Aryl hydrocarbon receptors: diversity and evolution. Chemico-Biological Interactions, 2002. 141: p. 131-160. 29. Huang, X., J.A. Powell-Coffman, and Y. Jin, The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans. Development, 2004. 131(4): p. 819-28. 30. Kim, M.D., L.Y. Jan, and Y.N. Jan, The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Genes Dev, 2006. 20(20): p. 2806-19. 31. Collins, L.L., et al., 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol Sci, 2008. 103(1): p. 125-36. 32. Quintana, F.J., Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor. Semin Immunopathol, 2013. 35(6): p. 627-35. 33. Murray, I.A., A.D. Patterson, and G.H. Perdew, Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat Rev Cancer, 2014. 14(12): p. 801-14. 34. Prendergast, G.C., et al., IDO2 in Immunomodulation and Autoimmune Disease. Front Immunol, 2014. 5: p. 585. 35. Pedro Fernandez-Salguero, T.P., David M. Hilbert, Timothy McPhail, Susanna S. T. Lee, Shioko Kimura, Daniel W. Nebert, Stuart Rudikoff, Jerrold M. Ward, FrankJ.Gonzalez, Immune system impairment and hepatic fibrosis in mice lacking the dioxin- binding Ah receptor. Science, 1995. 268: p. 722–726. 36. JENNIFER V. SCHMIDT, JANARDAN K. REDDY, M. CELESTE SIMONt, AND CHRISTOPHERA.BRADFIELD, Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Pharmacology, 1996. 93: p. 6731-6736. 37. Junsei Mimura1, K.Y., Kenji Nakamura, Masanobu Morita1, Toshio N. Takagi2, Kazuki Nakao3, Masatsugu Ema1, Kazuhiro Sogawa1, Mineo Yasuda2, Motoya Katsuki3 and Yoshiaki Fujii-Kuriyama1, Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes to Cells, 1997. 2: p. 645 – 654. 38. Jamie C. Benedict, T.-M.L., I. K. Loeffler, Richard E. Peterson, and Jodi A. Flaws, Physiological Role of the Aryl Hydrocarbon Receptor in Mouse Ovary Development. TOXICOLOGICAL SCIENCES, 2000. 56: p. 382–388. 39. Billiard, S.M., et al., The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicol Sci, 2006. 92(2): p. 526-36. 40. Goodale, B.C., et al., AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. PLoS One, 2012. 7(1): p. e29346. 41. Chevallier, A., et al., Oculomotor deficits in aryl hydrocarbon receptor null mouse. PLoS One, 2013. 8(1): p. e53520. 42. Garner, L.V., D.R. Brown, and R.T. Di Giulio, Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquat Toxicol, 2013. 142-143: p. 336-46. 43. Latchney, S.E., et al., Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory. J Neurochem, 2013. 125(3): p. 430-45. 44. Wang, Q., et al., Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environ Health Perspect, 2013. 121(11-12): p. 1334-43. 45. Xie, H.Q., et al., AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro. Environ Health Perspect, 2013. 121(5): p. 613-8. 46. Aluru, N., M.J. Jenny, and M.E. Hahn, Knockdown of a zebrafish aryl hydrocarbon receptor repressor (AHRRa) affects expression of genes related to photoreceptor development and hematopoiesis. Toxicol Sci, 2014. 139(2): p. 381-95. 47. Kim, S.Y., et al., Deletion of aryl hydrocarbon receptor AHR in mice leads to subretinal accumulation of microglia and RPE atrophy. Invest Ophthalmol Vis Sci, 2014. 55(9): p. 6031-40. 48. Karchner, S.I., D.G. Franks, and M.E. Hahn, AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes. Biochem J, 2005. 392(Pt 1): p. 153-61. 49. Fraccalvieri, D., et al., Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry, 2013. 52(4): p. 714-25. 50. Kubota, A., et al., Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2. Toxicol Appl Pharmacol, 2011. 253(3): p. 244-52. 51. Bugel, S.M., L.A. White, and K.R. Cooper, Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). Aquat Toxicol, 2013. 126: p. 1-8. 52. Wang, W.D., et al., Aryl hydrocarbon receptor 2 mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos. Aquat Toxicol, 2015. 159: p. 13-22. 53. Incardona, J.P., et al., Aryl Hydrocarbon Receptor–Independent Toxicity of Weathered Crude Oil during Fish Development. Environmental Health Perspectives, 2005. 113(12): p. 1755-1762. 54. Incardona, J.P., et al., Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism. Toxicol Appl Pharmacol, 2006. 217(3): p. 308-21. 55. Jonsson, M.E., et al., Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci, 2007. 100(1): p. 180-93. 56. Lanham, K.A., et al., A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity. PLoS One, 2011. 6(12): p. e28020. 57. Van Tiem, L.A. and R.T. Di Giulio, AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). Toxicol Appl Pharmacol, 2011. 254(3): p. 280-7. 58. Timme-Laragy, A.R., S.I. Karchner, and M.E. Hahn, Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology. Methods Mol Biol, 2012. 889: p. 51-71. 59. Wincent, E., et al., Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol, 2016. 110-111: p. 117-29. 60. ERIC A. ANDREASEN, M.E.H., WARREN HEIDEMAN, RICHARD E. PETERSON, ROBERT L. TANGUAY, The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor. Mol Pharmacol, 2002. 62: p. 234–249. 61. Eric A. Andreasen, J.M.S., Robert L. Tanguay, John J. Stegeman, Warren Heideman, Richard E. Peterson, Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure. TOXICOLOGICAL SCIENCES, 2002. 68: p. 403–419. 62. Wang, B.J., et al., Establishment of a cell-free bioassay for detecting dioxin-like compounds. Toxicol Mech Methods, 2013. 23(6): p. 464-70. 63. Shackleton, C.H., et al., The corticosteroid metabolic profile of the mouse. Steroids, 2008. 73(11): p. 1066-76. 64. Langlois, V.S., et al., Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase. Gen Comp Endocrinol, 2010. 166(3): p. 489-97. 65. Tokarz, J., et al., Zebrafish and steroids: what do we know and what do we need to know? J Steroid Biochem Mol Biol, 2013. 137: p. 165-73. 66. Haggstrom, M., Diagram of the pathways of human steroidogenesis. Wikiversity Journal of Medicine, 2014. 1(1). 67. Traish, A.M., et al., Adverse effects of 5alpha-reductase inhibitors: What do we know, don't know, and need to know? Rev Endocr Metab Disord, 2015. 16(3): p. 177-98. 68. R. C. MELCANGI, F.C., M. BALLABIO,A. POLETTI,P. CASTANO, L. MARTINI, Testosterone 5 alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axons. Steroid Biochem., 1988. 31: p. 173-179. 69. F. CELOTTI, R.C.M., P. NEGRI-CEsIand A. POLETT, TESTOSTERONE METABOLISM IN BRAIN CELLS AND MEMBRANES. Steroid Biochem. Molec. Biol., 1991. 40: p. 673-678. 70. Angelo Poletti, F.C., Cristiano Rumio, Monica Rabuffetti, Luciano Martini, Identification of type 1 5h-reductase in myelin membranes of male and female rat brain. Molecular and Cellular Endocrinology, 1997. 129: p. 181–190. 71. Tsuruo, Y., Topography and function of androgen-metabolizing enzymes in the central nervous system. Anatomical Science International, 2005. 80: p. 1-11. 72. Saalmann, Y.B., et al., Cellular distribution of the GABAA receptor-modulating 3alpha-hydroxy, 5alpha-reduced pregnane steroids in the adult rat brain. J Neuroendocrinol, 2007. 19(4): p. 272-84. 73. Pesaresi, M., et al., Dihydroprogesterone increases the gene expression of myelin basic protein in spinal cord of diabetic rats. J Mol Neurosci, 2010. 42(2): p. 135-9. 74. Azzouni, F., et al., The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. Adv Urol, 2012. 2012: p. 530121. 75. Campagnoni, J.M.V.a.A.T., Translational Regulation by Steroids. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1990. 265(25): p. 20314-20320. 76. R. C. MELCANGI, V.M., I. CAVARRETTA, L. MARTINI, F. PIVA, AGE-INDUCED DECREASE OF GLYCOPROTEIN PO AND MYELIN BASIC PROTEIN GENE EXPRESSION IN THE RAT SCIATIC NERVE. REPAIR BY STEROID DERIVATIVES. Neuroscience, 1998. 85(2): p. 569–578. 77. Higashi, T., et al., Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS. Steroids, 2007. 72(13): p. 865-74. 78. Melcangi, R.C., L.M. Garcia-Segura, and A.G. Mensah-Nyagan, Neuroactive steroids: state of the art and new perspectives. Cell Mol Life Sci, 2008. 65(5): p. 777-97. 79. Pelletier, G., Steroidogenic Enzymes in the Brain: Morphological Aspects. 2010. 181: p. 193-207. 80. Diotel, N., et al., The brain of teleost fish, a source, and a target of sexual steroids. Front Neurosci, 2011. 5: p. 137. 81. Kelleher, M.A., J.J. Hirst, and H.K. Palliser, Changes in neuroactive steroid concentrations after preterm delivery in the Guinea pig. Reprod Sci, 2013. 20(11): p. 1365-75. 82. Brunton, P.J., J.A. Russell, and J.J. Hirst, Allopregnanolone in the brain: protecting pregnancy and birth outcomes. Prog Neurobiol, 2014. 113: p. 106-36. 83. Jenkins, S.I., et al., Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS Chem Neurosci, 2014. 5(1): p. 51-63. 84. Melcangi, R.C., S. Giatti, and L.M. Garcia-Segura, Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features. Neurosci Biobehav Rev, 2015. 85. Raphael, A.R. and W.S. Talbot, New insights into signaling during myelination in zebrafish. Curr Top Dev Biol, 2011. 97: p. 1-19. 86. Crawford, A.H., C. Chambers, and R.J. Franklin, Remyelination: the true regeneration of the central nervous system. J Comp Pathol, 2013. 149(2-3): p. 242-54. 87. Barateiro, A. and A. Fernandes, Temporal oligodendrocyte lineage progression: in vitro models of proliferation, differentiation and myelination. Biochim Biophys Acta, 2014. 1843(9): p. 1917-29. 88. From, R., et al., Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate. Glia, 2014. 62(4): p. 649-65. 89. Ackerman, S.D. and K.R. Monk, The scales and tales of myelination: using zebrafish and mouse to study myelinating glia. Brain Res, 2015. 90. Lyons, D.A. and W.S. Talbot, Glial cell development and function in zebrafish. Cold Spring Harb Perspect Biol, 2015. 7(2): p. a020586. 91. Ravanelli, A.M. and B. Appel, Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment. Genes Dev, 2015. 29(23): p. 2504-15. 92. Czopka, T., Insights into mechanisms of central nervous system myelination using zebrafish. Glia, 2016. 64(3): p. 333-49. 93. Marinelli, C., et al., Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage. Front Cell Neurosci, 2016. 10: p. 27. 94. Fernandez, M., et al., A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain. J Neurochem, 2010. 115(4): p. 897-909. 95. Duarte, J.H., et al., Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS One, 2013. 8(11): p. e79819. 96. Rouse, M., et al., Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells. Br J Pharmacol, 2013. 169(6): p. 1305-21. 97. Yang, E.J., et al., Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin. Toxicol Sci, 2016. 151(1): p. 35-43. 98. Wang, B.J., et al., Establishment of a bioluminescence-based bioassay for the detection of dioxin-like compounds. Toxicol Mech Methods, 2013. 23(4): p. 247-54. 99. Cheung, Y.T., et al., Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology, 2009. 30(1): p. 127-35. 100. Sato, T., M. Takahoko, and H. Okamoto, HuC:Kaede, a useful tool to label neural morphologies in networks in vivo. Genesis, 2006. 44(3): p. 136-42. 101. St John, J.A. and B. Key, HuC-eGFP mosaic labelling of neurons in zebrafish enables in vivo live cell imaging of growth cones. J Mol Histol, 2012. 43(6): p. 615-23. 102. CHARLES B. KIMMEL, W.W.B., SETH R. KIMMEL, BONNIE ULLMANN, AND and T.F. SCHILLING, Stages of embryonic development of the zebrafish. Dev Dyn, 1995. 203: p. 255-310. 103. Wang, W.D., et al., Phenylthiourea as a weak activator of aryl hydrocarbon receptor inhibiting 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 transcription in zebrafish embryo. Biochem Pharmacol, 2004. 68(1): p. 63-71. 104. Inoue, D. and J. Wittbrodt, One for all--a highly efficient and versatile method for fluorescent immunostaining in fish embryos. PLoS One, 2011. 6(5): p. e19713. 105. Nuti, R., et al., Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR). J Chem Inf Model, 2014. 54(12): p. 3373-83. 106. McInnes, K.J., et al., 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. J Biol Chem, 2004. 279(22): p. 22908-12. 107. Vogeli, I., et al., Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo. J Endocrinol, 2013. 219(2): p. 119-29. 108. Togo Ikuta, H.E., Taro Tachibana, Yoshihiro Yoneda, and Kaname Kawajiri, Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1998. 273(January 30): p. 2895–2904. 109. M. S. Denison, S.H.-P., The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals. Bull. Environ. Contam. Toxicol., 1998(61): p. 557-568. 110. Scott R. Nagy, G.L., Kit S. Lam, and Michael S. Denison, Identification of Novel Ah Receptor Agonists Using a High-Throughput Green Fluorescent Protein-Based Recombinant Cell Bioassay. Biochemistry, 2002. 41: p. 861-868. 111. Huang, T.C., et al., Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR. FEBS Lett, 2011. 585(22): p. 3582-6. 112. Janardhanan, R., N.L. Banik, and S.K. Ray, N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53. Biochem Pharmacol, 2009. 78(9): p. 1105-14. 113. L. A. Benjamin, R.C.M., and D. A. Hart, Effect of retinoic acid on human neuroblastoma: Correlation between morphological differentiation and changes in plasminogen activator and inhibitor activity. cancer chemother pharmacol, 1989. 25: p. 25-31. 114. Dong, W., et al., Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci, 2004. 77(1): p. 109-16. 115. Sheridan, G.K. and K.J. Murphy, Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biol, 2013. 3(12): p. 130181. 116. Zhang, J., et al., Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase. Neuron, 2014. 82(1): p. 195-207. 117. Baalman, K., et al., Axon initial segment-associated microglia. J Neurosci, 2015. 35(5): p. 2283-92. 118. Morris, G.P., et al., Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiol Learn Mem, 2013. 105: p. 40-53. 119. Nayak, D., T.L. Roth, and D.B. McGavern, Microglia development and function. Annu Rev Immunol, 2014. 32: p. 367-402. 120. Arno, B., et al., Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex. Nat Commun, 2014. 5: p. 5611. 121. Eric A. Andreasen, J.M.S., Robert L. Tanguay, John J. Stegeman, Warren Heideman, and Richard E. Peterson, Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure. science, 2002. 68: p. 403-419. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/3718 | - |
dc.description.abstract | 戴奧辛經由芳香烴接受器 (aryl hydrocarbon receptor, AHR) 調控不同的訊號傳遞路徑影響細胞的行為,例如,胚胎發育,腫瘤生成以及發炎反應。然而能與芳香烴接受器結合並影響細胞的生理反應之內生性配體仍有待更多發現與深深入研究。藉由本實驗室所開發之戴奧辛檢測法,我們在斑馬魚胚胎中找到可能的芳香烴接受器內生性配體,四氫皮質甾酮 (Tetrahydrocorticosterone, THB),於此研究當中,我們希望能進一步透過四氫皮質甾酮所激活的芳香烴接受器的功能。在細胞實驗中四氫皮質甾酮可以誘導芳香烴接受器進入細胞核,並且激活下游基因CYP1A1的表現。在我們先前的研究中,證實芳香烴接受器大量表達會導致神經纖維母細胞瘤細胞分化; 而四氫皮質甾酮也同樣展現其促進神經纖維母細胞瘤細胞神經分化的潛力。動物實驗則顯示四氫皮質甾酮透過斑馬魚的芳香烴接受器2 (AHR2)提高芳香烴接受器標的之zCYP1A、髓鞘相關的zMBP以及zOLIG2的表現。此外,我們也發現四氫皮質甾酮透過芳香烴接受器2參與了早期的神經發育,以及不同的神經細胞群系如寡突膠細胞、星狀膠細胞以及小膠質細胞等的分化。由以上結果,我們認為四氫皮質甾酮乃一內生性的芳香烴接受器配體,並且在神經分化的過程中扮演了關鍵的角色。 | zh_TW |
dc.description.abstract | Activation of aryl hydrocarbon receptor (AHR) by xenobiotic toxic chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin regulates a variety of cellular processes, for example, embryogenesis, tumorigenesis and inflammation. However, the identity of endogenous ligands activating AHR remains unclear. To explore the possibilities, previously developed cell free bioassay for dioxin-like compounds in our laboratory was applied and Tetrahydrocorticosterone (THB) was identified from zebrafish embryos as a potential AHR ligand. In this study, we aim to investigate the functions of THB in AHR activation and further physiological effects. In vitro studies revealed that THB induces AHR translocation into nucleus and activates the expression of downstream cytochrome P450 1A1 (CYP1A1). THB also demonstrated potential to promote neuronal differentiation in neuroblastoma (NB) cells, which corresponds to our previous studies that AHR overexpression lead to NB cells differentiation. On the other hand, In vivo studies indicated that THB treatment enhances AHR-target zCYP1A, myelin-associated myelin basic protein (zMBP) and oligodendrocyte transcription factor 2 (zOLIG2) expression via AHR2-dependent pathway in zebrafish. Moreover, we found that THB is involved in early neurogenesis and neuronal differentiation of oligodendrocyte, astrocyte and microglia via AHR2 pathway. Therefore, our results strongly suggest that THB is an endogenous AHR ligand, and plays a critical role during neuronal differentiation. | en |
dc.description.provenance | Made available in DSpace on 2021-05-13T08:36:11Z (GMT). No. of bitstreams: 1 ntu-105-R03b21027-1.pdf: 55647800 bytes, checksum: 54872a9a0c68daf7a369b92e24f72422 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | ⼝試委員審定書........................................................................................................................... i
致謝................................................................................................................................................ ii 中⽂摘要........................................................................................................................................iii Abstract........................................................................................................................iv Contents........................................................................................................................v 1 Introduction...............................................................................................................1 1.1 Aryl Hydrocarbon Receptor (AHR).......................................…………………..1 1.2 Endogenous ligands and physiological roles of AHR..........................................1 1.3 AHR and neural differentiation/ development.....................................................2 1.4 Functional characterization between AHRs.........................................................2 1.5 5 α︎-reduced Tetrahydrocorticosterone (THB) and central nervous system..........3 1.6 Myelination and neuronal differentiation.............................................................4 2 Materials and Methods.............................................................................................5 2.1 Cell culture...........................................................................................................5 2.2 Zebrafish embryo preparation for extraction.......................................................5 2.3 Cell-free dioxin assay preparation.......................................................................6 2.4 Dioxin bioassay detection....................................................................................6 2.5 HPLC fraction......................................................................................................7 2.6 LC-ESI-MS..........................................................................................................7 2.7 Chemical preparation...........................................................................................8 2.8 Neuroblastoma differentiation assay....................................................................8 2.9 Zebrafish maintenance and embryos collection...................................................8 2.10 Gene knockdown by antisense morpholino injection........................................9 2.11 Drug Exposure....................................................................................................9 2.12 mRNA extraction................................................................................................9 2.13 Reverse-transcription and Quantitative real-time PCR....................................10 2.14 Western Blot.....................................................................................................11 2.15 Immunocytochemistry (ICC) and Fluorescence imaging................................12 2.16 Immunohistochemistry (IHC) and Fluorescence imaging...............................13 2.17 Microscopy and image analysis.......................................................................14 2.18 Statistical analysis............................................................................................15 3 Results......................................................................................................................16 3.1 Identification of endogenous dioxin-like compounds from zebrafish embryo extract using a novel AHR-base cell free bioassay..................................................16 3.2 THB is a novel AHR endogenous ligand...........................................................17 3.3 THB reveals the potential of neuronal differentiation........................................18 3.4 THB-activated signal pathway is AHR2-dependent..........................................19 3.5 THB is involved in early neurogenesis..............................................................19 3.6 THB regulates oligodendrocytes lineage via AHR2-dependent pathway..........20 3.7 THB affects microglia, astrocyte and neuron lineage via AHR2-dependent pathway.....................................................................................................................21 4 Conclusions and Discussions..................................................................................22 5 Reference..................................................................................................................24 6 Figures......................................................................................................................39 7 Tables........................................................................................................................60 8 Supplemental Figures.............................................................................................61 | |
dc.language.iso | en | |
dc.title | 芳香烴接受器2之內生性配體於斑馬魚神經分化的角色 | zh_TW |
dc.title | The Roles of Endogenous Ligand for Aryl Hydrocarbon Receptor 2 during Neural Differentiation in Zebrafish | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 廖永豐,許文明,黃元勵 | |
dc.subject.keyword | 芳香烴接受器,芳香烴接受器配體,神經分化,芳香烴接受器2,斑馬魚, | zh_TW |
dc.subject.keyword | AHR,AHR ligand,neuronal differentiation,AHR2,zebrafish, | en |
dc.relation.page | 61 | |
dc.identifier.doi | 10.6342/NTU201602857 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2016-08-18 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生命科學系 | zh_TW |
顯示於系所單位: | 生命科學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-105-1.pdf | 54.34 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。