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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 戴政 | |
dc.contributor.author | Hsiu-Hui Chang | en |
dc.contributor.author | 張秀慧 | zh_TW |
dc.date.accessioned | 2021-06-13T08:13:23Z | - |
dc.date.available | 2010-08-03 | |
dc.date.copyright | 2005-08-03 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-20 | |
dc.identifier.citation | Benjamini Y, Hochberg Y, Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Statist. Soc. 1995, B 57: 259-300
Camp NJ. Genomwide transmission/disequilibrium testing- consideration of the genotypic relative risks at disease loci. Am J Hum Genet. 1997, 61:1424-1430. Elston RC (1992) Designs for the global search of the human genome by linkage analysis. In: Proceedings of the XVIth International Biometric Conference. Halmilton, New Zealand, December 7-11. Ruakura Agricultural Center, Hamilton, New Zealand, 39-51 Elston RC (1994) P-values, power and pitfalls in the linkage analysis of psychiatric disorders. In: Gershon ES, Cloninger CR, Barrett JE (eds) Genetic approaches to mental disorders. American psychiatric Press, Washington DC, 3-21 Elston RC, Guo X, Williams LV. Two-stage global search designs for linkage analysis using pairs of affected relatives. Genet Epidemiol. 1996;13(6):535-558. Guo X, Elston RC. Two-stage global search designs for linkage analysis I: use of the mean statistic for affected sib pairs. Genet Epidemiol. 2000;18(2):97-110. Guo X, Elston RC. Two-stage global search designs for linkage analysis II: including discordant relative pairs in the study. Genet Epidemiol. 2000;18(2):111-127. Guo X, Elston RC. One-stage versus two-stage strategies for genome scans. Adv Genet. 2001;42:459-471. Haldane JBS. The combination of linkage values, and the calculation of distances between loci of linked factors. J. Genet. 1919, 8:299-309. Hochberg, Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika, 1988, 75, 800-802. Hoh J, Wille A, Zee R, Cheng S, Reynolds R, Lindpaintner K, Ott J. Selecting SNPs in two-stage analysis of disease association data: a model-free approach. Ann Hum Genet. 2000, 64(Pt 5):413-417. Holm, S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics, 1979 .6, 65-70. Holmans P, Craddock N. Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis. Am J Hum Genet. 1997, 60(3):657-666. Huttley GA, Smith MW, Carrington M, O'Brien SJ. A scan for linkage disequilibrium across the human genome. Genetics. 1999, 152(4):1711-1722. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999, 22(2):139-144. Lee WC, Yen YC. Admixture mapping using interval transmission/disequilibrium tests. Ann Hum Genet. 2003, 67 (Pt 6):580-588. Lewontin RC. The interaction of selection and linkage. II. Optimim models. Genetics. 1964, 50:757-782. Morton RS. Late congenital syphilitic nerve deafness. Br J Vener Dis. 1955, 31(4):242-244. Ott J, Hoh J. Statistical approaches to gene mapping. Am J Hum Genet. 2000, 67:289-294. Peterson AC, Di Rienzo A, Lehesjoki AE, de la Chapelle A, Slatkin M, Freimer NB. The distribution of linkage disequilibrium over anonymous genome regions. Hum Mol Genet. 1995, 4(5):887-894. Pritchard JK, Przeworski M. Linkage disequilibrium in humans: models and data. Am J Hum Genet. 2001, 69(1):1-14. Epub 2001 Jun 14. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996, 13;273(5281):1516-1517. Sham PC, Curtis D. An extended transmission/ disequilibrium test (TDT) for multi-allele marker loci. Ann. Hum. Genet. 1995, 59,323-336 Sobell JL, Heston LL, Sommer SS (1993) Novel association approach for determining the genetic predisposition to schizophrenia: case-control resource and testing of a candidate gene. Am J Med Genet. 1993, 48(1):28-35. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 1993, 52(3):506-516. Stephens JC, Briscoe D, O'Brien SJ. Mapping by admixture linkage disequilibrium in human populations: limits and guidelines. Am J Hum Genet. 1994, 55(4):809-824. Taillon-Miller P, Bauer-Sardina I, Saccone NL, Putzel J, Laitinen T, Cao A, Kere J, Pilia G, Rice JP, Kwok PY. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet. 2000, 25(3):324-328. Xiong M, Jin L. Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods. Am J Hum Genet. 1999, 64(2):629-640. 戴政 遺傳流行病學—基因定位之遺傳設計與分析方法。藝軒,台北, 2002。 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36735 | - |
dc.description.abstract | 做基因全體逐點搜尋 (genomewide scan) 時,需事先針對所有的標識基因做完基因型判定 (genotyping),再針對每一個標識基因逐點作連鎖分析,觀察標識基因和疾病間的相關以推測疾病基因座可能的位置。由於基因全體逐點搜尋需要大量的標識基因,若每一標識基因都做基因型定位,會耗費許多時間與金錢成本,使眾多研究者卻步。本研究目的在於提出一個搜尋策略,期望只需做一部份的基因型分析就可發現疾病基因座的可能位置,以節省研究經費與成本。本搜尋策略是以可調適方法並利用傳遞不平衡檢定 (TDT) 來找尋疾病基因座位置。可調適方法是指將所有標識基因分成數個步驟分批以TDT檢定,於前一步驟中已達門檻顯著水準 (SLST) 之標識基因附近再多選取幾個標識基因續做分析,若達更嚴格的停止標準顯著水準 (SLSS) 則可停止搜尋策略。透過模擬結果,本搜尋策略平均約可節省一半的標識基因,即可正確發現和疾病基因有連鎖的標識基因座,顯示本策略是一個有效的基因全體逐點搜尋方法。 | zh_TW |
dc.description.abstract | Linkage analysis has been considered as a major instrument for gene mapping. When performing a genomewide scan, there requires a large number of markers being genotyped in advance and then being analyzed to find the candidate markers linked with the disease gene. To save the cost in labor and time, here we propose an adaptive stepwise selection strategy with the use of transmission/disequilibrium test that may only need to analyze a part of the whole markers to catch the disease gene. We have used computer simulation to investigate the efficiency of the adaptive genomewide scan strategy. In general, the results show that the strategy does not need to genotype all the markers and can still efficiently locate the gene. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T08:13:23Z (GMT). No. of bitstreams: 1 ntu-94-R92842018-1.pdf: 526755 bytes, checksum: bfa6baa30c2aef2a79fc9662ca6fb315 (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | 目 錄
第一章 緒論 1 第一節 研究背景 1 第二節 文獻探討 4 第二章 統計方法 9 第一節 研究假設 9 第二節 傳遞不平衡連鎖檢定 (TDT) 9 第三節 基因搜尋分析策略 11 1. 顯著水準 、 之訂定 16 2. 擴展窗內之標識基因數目之訂定 17 第三章 模擬結果 23 第一節 模擬設定 23 第二節 模擬結果 30 1. 平均個數與平均節省效率:在不同遺傳模式之下 30 2. 平均個數與平均節省效率:疾病基因座位置 33 3. 平均個數與平均節省效率:基因圖譜的密度 34 4. 定位錯誤率 35 5. 遺漏率 35 6. 定位準確率 38 第四章 結論與討論 41 參考文獻 45 附錄一、表 49 附錄二、平均使用標識基因個數_Acc 59 附錄三、平均節省效率:以平均使用標識基因個數_Acc為基礎 66 附錄四、遺漏率 72 附錄五、定位準確率 85 | |
dc.language.iso | zh-TW | |
dc.title | 遺傳連鎖分析之可調適全基因組掃描策略 | zh_TW |
dc.title | An Adaptive Genomewide Scan Strategy in Linkage Analysis | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蕭朱杏,沈葆聖,鄭光甫,高振宏 | |
dc.subject.keyword | 傳遞不平衡檢定,基因定位,效率,基因型判定,連鎖分析, | zh_TW |
dc.subject.keyword | transmission/disequilibrium test,gene mapping,efficiency,linkage analysis,genotyping, | en |
dc.relation.page | 97 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-20 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 流行病學研究所 | zh_TW |
顯示於系所單位: | 流行病學與預防醫學研究所 |
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