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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李繼忠 | |
dc.contributor.author | Chun-Chao Tsao | en |
dc.contributor.author | 曹均兆 | zh_TW |
dc.date.accessioned | 2021-06-13T07:53:15Z | - |
dc.date.available | 2011-08-22 | |
dc.date.copyright | 2011-08-22 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-20 | |
dc.identifier.citation | [1] Asboe-Hansen G. The mast cell. Cortisone action on connective tissue. Proc Soc Exp Biol 1952; 80: 677-679.
[2] Bailey DB, Rassnick KM, Kristal O, et al. Phase I dose escalation of single-agent vinblastine in dogs. J Vet Intern Med 2008; 22: 1397-1402. [3] Baxter JD, Harris AW, Tomkins GM, et al. Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Science 1971; 171: 189-191. [4] Baster JD, Tomkins GM. Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells. Proc Nat Acad Sci 1971; 68: 932-937. [5] Bloom F. Effects of cortisone on canine mast cell tumors (mastocytoma) of the dog. Proc Soc Exp Biol 1952; 80: 651-654. [6] Brodey RS, McGrath JT, Martin JE. Preliminary observations on the use of cortisone in canine mast cell sarcoma. J Am Vet Med Assoc 1953; 123: 391-393. [7] Cahalane AK, Payne S, Barber LG, et al. Prognostic factors for survival of dogs with inguinal and perineal mast cell tumors treated surgically with or without adjunctive treatment: 68 cases (1994-2002). J Am Vet Med Assoc 2004; 225: 401-408. [8] Camps-Palau MA, Leibman NF, Elmslie R, et al. Treatment of canine mast cell tumours with vinblastine, cyclophosphamide and prednisolone: 35 cases (1997-2004). Vet Comp Oncol 2007; 5: 156-167. [9] Chun R, Garrett LD, Vail DM. Cancer chemotherapy. Thamm DH, Vail DM. Mast cell tumors. In: Withrow SJ, MacEwen EG, eds. Small Animal Clinical Oncology, 4th ed. Philadelphia: WB Saunders; 2007: 185, 402-416. [10] Da silva CA, Kassel O, Mathieu E, et al. Inhibition by glucocorticoids of interleukin-1β-enhanced expression of the mast cell growth factor SCF. Br J Pharmacol 2002; 135: 1634-1640. [11] Davies DR, Wyatt KM, Jardine JE, et al. Vinblastine and prednisolone as adjunctive therapy for canine cutaneous mast cell tumors. J Am Anim Hosp Assoc 2004; 40: 124-130. [12] Dobson J, Cohen S, Gould S. Treatment of canine mast cell tumors with prednisolone and radiotherapy. Vet Comp Oncol 2004; 2: 132-141. [13] Dobson JM, Scase TJ. Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. J Small Anim Pract 2007; 48: 424-431. [14] Finotto S, Mekori YA, Metcalfe DD. Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems. J Clin Invest 1997; 99: 1721-1728. [15] Frimberger AE, Moore AS, LaRue SM, et al. Radiotherapy of incompletely resected, moderately differentiated mast cell tumors in the dogs: 37 cases (1989-1993). J Am Anim Hosp Assoc 1997; 33: 320-324. [16] Grant IA, Rodriguez CO, Kent MS, et al. A phase II clinical trial of vinorelbine in dogs with cutaneous mast cell tumors. J Vet Intern Med 2008; 22: 388-393. [17] Gerritsen RJ, Teske E, Kraus JS, et al. Multi-agent chemotherapy for mast cell tumours in the dog. Vet Quart 1998; 20: 28-31. [18] Hahn KA, King GK, Carreras JK. Efficacy of radiation therapy for incompletely resected grade III mast cell tumors in dogs: 31 cases (1987-1998). J Am Vet Med Assoc 2004; 224: 79-82. [19] Hayes A, Adams V, Smith K, et al. Vinblastine and prednisolone chemotherapy for surgically excised grade III canine cutaneous mast cell tumours. Vet Comp Oncol 2007; 5: 168-176. [20] Hosoya K, Kisseberth WC, Alvarez FJ, et al. Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors. J Am Anim Hosp Assoc 2009; 45: 14-18. [21] Hottendorf GH, Nielsen SW. Pathologic report of 29 necropsies on dogs with mastcytoma. Pathol Vet 1968; 5: 102-121. [22] Hume CT, Kiupel M, Rigatti L, et al. Outcomes of dogs with grade 3 mast cell tumors: 43 cases (1997-2007). J Am Anim Hosp Assoc 2011; 47: 37-44. [23] Kiupel M, Webster JD, Bailey KL, et al. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol 2011; 48: 147-155. [24] McCaw DL. Tumors of the skin, subcutis, and other soft tissues, section D: mast cell tumors. In: Henry CJ, Higginbotham ML, eds. Cancer Management in Small Animal Practice, 1st ed. Philadelphia: WB Saunders; 2010: 317-319. [25] McCaw DL, Miller MA, Bergman PJ, et al. Vincristine therapy for mast cell tumors in dogs. J Vet Intern Med 1997; 11: 375-378. [26] McCaw DL, Miller MA, Ogilvie GK, et al. Response of canine mast cell tumors to treatment with oral prednisolone. J Vet Intern Med 1994; 8: 406-408. [27] Mullins MN, Dernell WS, Withrow SJ, et al. Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneous mast cell tumors treated with surgery with and without adjuvant treatment: 54 cases (1998-2004). J Am Vet Med Assoc 2006; 228: 91-95. [28] Murphy S, Sparkes AH, Blunden AS, et al. Effects of stage and number of tumours on prognosis of dogs with cutaneous mast cell tumours. Vet Rec 2006; 158: 287-291. [29] North S, Banks T. Mast cell tumours. In: North S, Banks T, eds. Introduction to Small Animal Oncology, 1st ed. Philadelphia: WB Saunders; 2009: 183-196. [30] Patnaik AK, Ehler WJ, MacEwen EG. Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol 1984; 21: 469-474. [31] Plumb, DC. Prednisolone/prednisone. In: Plumb DC, ed. Plumb’s Veterinary Drug Handbook, 5th ed. Ames, lowa, Wiley-Blackwell; 2005: 937-948. [32] Poirier VJ, Adams WM, Forrest LJ, et al. Radiation therapy for incompletely excised grade II canine mast cell tumors. J Am Anim Hosp Assoc 2011; 42: 430-434. [33] Rassnick KM, Bailey DB, Flory AB, et al. Efficacy of vinblastine for treatment of canine mast cell tumors. J Vet Intern Med 2008; 22: 1390-1396. [34] Rassnick KM, Moore AS, Williams LE, et al. Treatment of canine mast cell tumors with CCNU (lomustine). J Vet Intern Med 1999; 13: 601-605. [35] Sfiligoi G, Rassnick KM, Scarlett JM, et al. outcome of dogs with mast cell tumors in the inguinal or perineal region versus other cutaneous locations: 124 cases (1990-2001). J Am Vet Med Assoc 2005; 226: 1368-1374. [36] Stanclift RM, Gilson SD. Evaluation of neoadjuvant prednisolone administration and surgical excision in treatment of cutaneous mast cell tumors in dogs. J Am Vet Med Assoc 2008; 232: 53-62. [37] Takahashi T, Kadosawa T, Nagase M, et al. Inhibitory effects of glucocorticoids on proliferation of canine mast cell tumor. J Vet Med Sci 1997; 59: 995-1001. [38] Taylor F, Gear R, Hoather T, et al. Chlorambucil an prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases. J Small Anim Pract 2009; 50: 284-289. [39] Thamm DH, Mauldin EA, Vail DM. Prednisolone and vinblastine chemotherapy for canine mast cell tumor-41cases (1992-1997). J Vet Intern Med 1999; 13: 491-497. [40] Thamm DH, Turek MM, Vail DM. Outcome and prognostic factors following adjuvant prednisolone/vinblastine chemotherapy for high-risk canine mast cell tumour: 61 cases. J Vet Med Sci 2006; 68: 581-587. [41] Trumel C, Bourges-Abella N, Touron C, et al. Adverse haematological effects of vinblastine, prednisolone and cimetidine treatment: a retrospective study in fourteen dogs with mast cell tumours. J Vet Med A Physiol Pathol Clin Med 2005; 52: 275-279. [42] Welle MM, Bley CR, Howard J, et al. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol 2008; 19:321-339. [43] Webster JD, Yuzbasiyan-Gurkan V, Thamm DH, et al. Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone. BMC Vet Res 2008; 4: 32. [44] White CR, Hohenhaus AE, Kelsey J, et al. Cutaneous MCTs: associations with spay/neuter status, breed, body size, and phylogenetic cluster. J Am Anim Hosp Assoc 2011; 47: 210-216. [45] Yoshikawa H, Nakajima Y, Tasaka K. glucocorticoid suppresses autocrine survival of mast cells by inhibiting IL-4 production and ICAM-1 expression. J Immunol 1999; 162: 6162-6170. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36184 | - |
dc.description.abstract | 肥大細胞瘤為犬隻中最常見的皮膚腫瘤,約佔所有犬隻皮膚腫瘤16到21%,現今大部份的治療方法為使用合併多種治療方法。在內科治療中,其中一個已被文獻證實有效對抗犬隻肥大細胞瘤的常用藥物為prednisolone,然而,目前尚未有文獻完整評估使用單一prednisolone治療犬隻肥大細胞瘤的臨床療效。本篇研究主要目的即為評估使用單一prednisolone治療犬隻肥大細胞瘤的治療效果,包括整體反應率、中位數反應持續時間、無疾病間隔時間以及治療無效時間。本實驗從2001到2010年總共有67隻狗,整體反應率為65% (38/67),其中部份消退為25隻、維持穩定疾病為11隻以及完全消退和疾病進展各為1隻,此反應率較先前的化學治療文獻研究(包括單一治療或合併治療藥物)皆為高。在38隻外觀可摸到腫瘤的犬隻中,中位數反應持續時間為39.5天,而中位數治療無效時間為66天;其他27外觀無明顯腫瘤的犬隻中,中位數無疾病間隔時間為54天,而中位數治療無效時間為67天,無論中位數反應持續時間或中位數無疾病間隔時間皆比先前文獻較為短。大致上而言,所有病畜對單一prednisolone治療的副作用皆能良好承受。腫瘤鄰近淋巴結狀態(p=0.04)和治療反應(p=0.013)為影響反應持續時間的重要因子;犬隻品種(p=0.043)為影響無疾病間隔時間的重要因子;至於外觀可摸到腫瘤的犬隻中,無統計上明顯差異的因子影響治療無效時間;但在外觀無明顯腫瘤的犬隻中,犬種(p=0.031)和治療反應(p=0.013)為影響治療無效時間的重要因子。另外在使用單一prednisolone治療與使用合併治療(prednisolone加cyclophosphamide和prednisolone加vinblastine)的治療效果比較中,在反應持續時間和治療無效時間皆無統計上差異性。由於使用單一prednisolone的治療效果為高整體反應率、短暫的反應持續時間和無疾病間隔時間,我們推論在進行大範圍手術切除犬隻肥大細胞瘤之前,為了達到足夠的手術範圍而使用單一prednisolone治療進行縮小腫瘤體積是一個有效的治療方法。然而,如果肥大細胞瘤的犬隻選擇使用化學治療作為長遠的治療方法,使用多重藥物合併治療則較使用單一prednisolone為較建議的治療方法選擇。 | zh_TW |
dc.description.abstract | Mast cell tumors (MCTs) are the most common cutaneous tumor in dogs, comprising 16-21 % of all cutaneous tumors. The treatment options of canine MCTs nowadays are mostly managed by combination protocols. Among internal medicine management, one commonly used drug is prednisolone, which is proven to have efficacy in treating canine MCTs in previous studies. However, no report to date has completely evaluated the response of single agent regimen of prednisolone as the choice of canine MCTs treatment. The aim of this study is to evaluate clinical response using single agent prednisolone in the treatment of canine MCTs, including overall response rate (ORR), median response duration (MRD), disease free interval (DFI), and time to treatment failure (TFF). 67 cases were collected into this study through 2001 to 2010.ORR was 65%. Of these cases (38/67), 25 was partial remission, 11 was stable disease, and other 2 were complete remission and progressive disease, respectively. It was higher than most previous clinical trials including single and combinational agent therapies. 38 cases had measurable disease, and the MRD was 39.5 days. Median TTF was 66 days. 27 cases (42%) had no measurable disease, and the median DFI was 54 days. Median TTF was 67 days. The MRD and median DFI were obvious shorter than others clinical reports. In general, the side effects of prednisolone treatment were well tolerated in present study. Regional lymph node status (p=0.04) and treatment response (p=0.013) were significant factors of response duration (RD). And breed of dogs was significant predictor of DFI (p=0.043). There were no significant factors for TTF of group that dogs with gross obvious tumors. But breed of dogs (p=0.031) and treatment response (p=0.013) were significant predictors of TTF of group that dogs without gross obvious tumors. There was no statistical difference of RD and TTF neither between the group that dogs treat with single agent prednisolone and the group that dogs treat with combinational prednisolone and cyclophosphamide or the group that dogs treat with single agent prednisolone and the group that dogs treat with combinational prednisolone and vinblastine. Owing to the characteristic of high response rate and short-term response duration and disease free interval in single agent prednisolone protocol, we conclude that it was an effective single regimen used in treat canine MCTs before wide-margin surgery in order to obtain adequate surgical margin. However, if patients of canine MCTs were treated with chemotherapy alone for long time, it had better choose multiple combinational protocols rather than single regimen of prednisolone. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T07:53:15Z (GMT). No. of bitstreams: 1 ntu-100-R97643012-1.pdf: 851881 bytes, checksum: 51e450674bfe0f3c7a5a316b4680152b (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 中文摘要 ii Abstract iv Contents vi List of figures viii List of tables x Chapter 1 Introduction 1 Chapter 2 Literatures review 3 2.1 The background of the prednisolone 3 2.2 The mechanism of prednisolone acts on canine mast cell tumors 4 2.3 The clinical usefulness of the prednisolone on canine mast cell tumors 6 Chapter 3 Aims 13 Chapter 4 Material and Methods 14 4.1 Patient selection 14 4.2 Initial evaluation 14 4.3 Treatment protocol 15 4.4 Assessment of response 16 4.5 Statistical analysis 18 Chapter 5 Result 20 5.1 Patient characteristics 20 5.2 Tumor details 21 5.3 Response to treatment 22 5.4 Factors evaluation 24 5.5 Compared with other treatment protocol groups 25 Chapter 6 Discussion 27 6.1 Treatment efficacy and side effects of single agent prednisolone 28 6.2 Influenced factors evaluation 31 6.3 Compared of treatment efficacy with other treatment groups 35 6.4 Limitations of this study 37 Chapter 7 Conclusion 40 Figures 42 Tables 57 References 69 | |
dc.language.iso | en | |
dc.title | 以回溯性研究方式評估使用單一prednisolone治療犬隻肥大細胞瘤的臨床療效 | zh_TW |
dc.title | Evaluation of Clinical Response Using Single Agent Prednisolone for the Treatment of Canine Mast Cell Tumor: A Retrospective Study | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 葉力森 | |
dc.contributor.oralexamcommittee | 林中天,廖泰慶 | |
dc.subject.keyword | Prednisolone,犬,犬隻肥大細胞瘤,回溯性研究,化學治療, | zh_TW |
dc.subject.keyword | Prednisolone,Dog,Canine mast cell tumors,Retrospective study,Chemotherapy, | en |
dc.relation.page | 73 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-20 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
顯示於系所單位: | 臨床動物醫學研究所 |
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