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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36034完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳秀男(Shiu-Nan Chen) | |
| dc.contributor.author | Shao-Yong Jhang | en |
| dc.contributor.author | 張劭墉 | zh_TW |
| dc.date.accessioned | 2021-06-13T07:50:05Z | - |
| dc.date.available | 2005-08-31 | |
| dc.date.copyright | 2005-07-28 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-26 | |
| dc.identifier.citation | 行政院衛生署統計室 (2003) 台灣地區死因統計結果摘要 (民國九十二年)。
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(2003) Hepatotoxicity andmechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit. Rev. Toxicol. 33(2): 105–136. Wisse, E., Knook, D.L. and Tamayo, R.P. (1983) Is cirrhosis of the liver experimentally produced by CCl4 an adequate model of human cirrhosis? Hepatology. 3(1): 112-120. Yoshitake, I., Ohishi, E., Sano, J., Mori, T. and Kubo, K. (1991) Effects of KF-14363 on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride. J. Pharmacobiodyn. 14(12): 679-685. Zhu, W. and Fung, P.C.W. (2000) The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice. Free Radical Biol. Med. 29(9): 870-880. Zhang, G.L., Wang, Y.H., Ni, W., Teng, H.L. and Lin, Z.B. (2002) Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. World J. Gastro. 8(4) :728-733. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36034 | - |
| dc.description.abstract | 本研究採用菇蕈多醣體 (mushroom β-Glucan) 為實驗材料，探討其對於四氯化碳 (CCl4) 誘導處理之大白鼠慢性肝損傷的影響。結果顯示大白鼠的體重變化率在三組實驗組與正對照組中，均比負對照組高且有顯著性差異 (p<0.05)；肝、腎臟器重量變化方面，負對照組明顯較高 (p<0.05)；在血清生化指標glutamate oxaloacetate transaminase (GOT) 與glutamate pyruvate transaminase (GPT) 方面，三種劑量多醣體處理組與正對照組，均比負對照組有顯著性的下降 (p<0.05)；肝臟蛋白質含量在負對照組有顯著性的下降 (p<0.01)，中、高劑量的多醣體處理組蛋白質含量則有顯著性的增加 (p<0.01)；在抗氧化酵素與物質方面，多醣體處理組均顯著的提升superoxide dismutase (SOD)、total sulfhydryl groups (TSH)、non-protein sulfhydryl groups (NPSH) 、protein sulfhydryl groups (PSH)、glutathione peroxidase (GPx) 、catalase (CAT) 活性與含量 (p<0.01)，並且具有劑量反應 (dose-dependent)。在肝均質液脂質過氧化程度方面，除了低劑量多醣體與負對照組沒有顯著性差異外 (p>0.01)，中、高劑量多醣體處理組和正對照組均與負對照組有顯著性差異 (p<0.01)。 | zh_TW |
| dc.description.abstract | This study attempts to investigate the effect of mushroom β-Glucan on the function of liver in experimental rats following the treatment of carbon tetrachloride (CCl4). The results, demonstrated that the body weight of three experimental groups and the positive control group were significantly (p<0.05) higher than that of the negative control rats. Comparatively, the liver and kidney weights of the negative control group were higher (p<0.05) than the other groups. The results showed that when β-Glucan and silymarin were used, biochemical values of liver including glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) were significantly lower (p<0.05) than those derived from the positive rats. In contrast, liver protein in the β-Glucan and silymarin treated rats was significantly higher (p<0.01) than that of the CCl4 treated animals. The present experiment also demonstrated that the activities of superoxide dismutase (SOD), total sulfhydryl groups (TSH), non-protein sulfhydryl groups (NPSP), protein sulfhydryl groups (PSH), glutathione peroxidase (GPx) and catalase (CAT) in the experimental rats were significantly (p<0.01) upgraded when β-Glucan and silymarin were used. In the experiment performed on the detection of lipid peroxidation in liver homogenate revealling that only medium and high dosage of β-Glucan treated and silymarin treated animals obtained a significant (p<0.01) activity comparing with the negative animals. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T07:50:05Z (GMT). No. of bitstreams: 1 ntu-94-R92b41027-1.pdf: 627797 bytes, checksum: d41dc7a6bdf88a8ce5f2d677cf818b74 (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 壹、前言..................................................3
貳、文獻整理..............................................4 2.1 肝臟損傷介紹..........................................4 2.2 活性氧衍生物 (ROS) 與自由基 (free radical)............4 2.3 體內的抗氧化物質......................................5 2.4 脂質過氧化反應 .......................................13 2.5 菇蕈類生理活性與保護肝臟能力探討 .....................15 2.6 實驗中使用造成肝臟損傷的藥劑介紹 .....................16 2.7 實驗中正對照組藥品介紹...............................18 參、材料與方法...........................................19 3.1 實驗動物.............................................19 3.2 菇蕈多醣體...........................................19 3.3 多醣體樣本濃度測定...................................19 3.4 投餵藥品的配製 .......................................20 3.4.1 多醣體水溶液的配製與給予..........................20 3.4.2 Silymarin水溶液的配製與給予.......................20 3.5 菇蕈多醣體水溶液對 CCl4 誘導的肝損傷之in vivo試驗....21 3.5.1 多醣體劑量選取.....................................21 3.5.2 實驗設計...........................................22 3.5.3 四氯化碳誘導大白鼠的肝損傷........................22 3.6 大白鼠基本數據 .......................................23 3.6.1 大白鼠體重變化情形.................................23 3.6.2大白鼠肝重、腎重與肝體比、腎體比....................23 3.6.3 大白鼠每日食物消耗量...............................24 3.7 測定血清中與肝傷害相關酵素活性.......................24 3.7.1 麩氨酸草乙酸轉氨酵素 (GOT) 測定....................24 3.7.2 麩氨酸丙氨基轉氨酵素 (GPT) 測定....................25 3.8肝臟中各種抗氧化成分與酵素活性之測定..................25 3.8.1 大白鼠的犧牲與內臟樣本的處理.......................25 3.8.2蛋白質濃度之測定....................................25 3.8.3 TSH 和 NPSH 濃度測定...............................26 3.8.4 Glutathione peroxidase (GPx) 活性分析..............28 3.8.5 Superoxide dismutase (SOD) 活性分析................29 3.8.6 Catalase (CAT) 活性分析............................30 3.8.7肝臟脂質過氧化程度測定 ..............................31 3.9 實驗數據與統計分析...................................32 肆、實驗結果.............................................33 4.1 多醣體含量測定 .......................................33 4.2 大白鼠基本數據 .......................................33 4.2.1大白鼠體重變化......................................33 4.2.2大白鼠肝重、腎重與肝體比、腎體比....................34 4.2.3大白鼠每日食物消耗量................................34 4.3 測定血清中與肝傷害相關之酵素活性.....................34 4.3.1 麩氨酸草乙酸轉氨酵素 (GOT) 測定....................34 4.3.2 麩氨酸丙氨基轉氨酵素 (GPT) 測定....................35 4.4 肝臟中各種與抗氧化功能相關之成分或酵素活性之測定.....35 4.4.1蛋白質濃度之測定....................................35 4.4.2 TSH 和 NPSH 濃度的測定.............................36 4.4.3 Glutathione peroxidase (GPx) 活性分析..............36 4.4.4 Superoxide dismutase (SOD) 活性分析................37 4.4.5 Catalase (CAT) 活性分析............................37 4.5 肝臟脂質過氧化測定...................................37 伍、討論.................................................38 陸、參考文獻.............................................44 表1 菇蕈多醣體樣品以酚硫酸法測定結果....................61 表2 各組平均GOT值 .......................................61 表3 各組平均GPT值 .......................................62 表4 各組平均TSH值、NPSH值及PSH值........................63 表5 各組平均 GPx 值、SOD 值及 CAT 值....................64 表6 肝臟均質液脂質過氧化程度............................65 圖1 葡萄糖標準曲線......................................66 圖2 各組大白鼠平均體重連續八週變化狀況..................67 圖3 八週中各組大白鼠體重成長率..........................68 圖4 肝臟重量............................................69 圖5 肝臟 / 100g體重之肝體比.............................70 圖6 腎臟重量............................................71 圖7 腎臟 / 100g體重之腎體比.............................72 圖8 大白鼠每日食物消耗量................................73 圖9 各組血清中平均GOT變化狀況...........................74 圖10 各組血清中GPT變化狀況...............................75 圖11 蛋白質標準曲線......................................76 圖12 大鼠肝臟中蛋白質之含量 ..............................77 圖13 大鼠肝臟均質液TSH濃度...............................78 圖14 大鼠肝臟均質液 NPSH 濃度............................79 圖15 大鼠肝臟均質液 PSH 濃度.............................80 圖16 大鼠肝臟均質液GPx 活性 ..............................81 圖17 大鼠肝臟均質液SOD活性...............................82 圖18 大鼠肝臟均質液CAT活性...............................83 圖19 大鼠肝臟均質液過氧化程度測定........................84 | |
| dc.language.iso | zh-TW | |
| dc.title | 菇蕈多醣體對四氯化碳誘導大白鼠肝損傷之修復效果評估 | zh_TW |
| dc.title | The Recovery Effect of Mushroom β-Glucan on Carbon Tetrachloride-induced Liver Injury Rats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 黃世鈴,冉繁華,王俊順 | |
| dc.subject.keyword | 菇蕈多醣體,四氯化碳,肝損傷,抗氧化, | zh_TW |
| dc.subject.keyword | β-glucan,carbon tetrachloride,liver injury,antioxidant, | en |
| dc.relation.page | 84 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-07-26 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
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