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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林文澧 | |
dc.contributor.author | Jhao-Syong Chen | en |
dc.contributor.author | 陳昭雄 | zh_TW |
dc.date.accessioned | 2021-06-13T07:04:52Z | - |
dc.date.available | 2005-07-29 | |
dc.date.copyright | 2005-07-29 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-27 | |
dc.identifier.citation | Barnett SB: Ultrasound. Nonthermal issues: cavitation--its nature, detection and measurement. Ultrasound Med Biol 1998, 24 Suppl 1:S11-21.
Bacon DR:Characteristics of a PVDF Membrane Hydrophone for Use in the Rang 1-100MHz. IEEE Transactions on Ultrasonics, on Sonics and Ultrasonics.SU-29:18-28 Chapelon JY, Ribault M, Vernier F, Souchon R, Gelet A: Treatment of localised prostate cancer with transrectal high intensity focused ultrasound. Eur J Ultrasound 1999, 9(1):31-38. Chavrier F, Chapelon JY, Gelet A, Cathignol D: Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles. J Acoust Soc Am 2000, 108(1):432-440. Holt RG, Roy RA: Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med Biol 2001, 27(10):1399-1412. Hynynen K: The threshold for thermally significant cavitation in dog's thigh muscle in vivo. Ultrasound Med Biol 1991, 17(2):157-169. Hynynen K, Damianou CA, Colucci V, Unger E, Cline HH, Jolesz FA: MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies. J Magn Reson Imaging 1995, 5(3):259-266. Ivey JA, Gardner EA, Fowlkes JB, Rubin JM, Carson PL: Acoustic generation of intra-arterial contrast boluses. Ultrasound Med Biol 1995, 21(6):757-767. Kossoff G :Analysis of focusing action of spherically curved transducer Ultrasound Med Biol 1979,5:359-65. Lynn G.J., Zwemer R.L, Chick A.J., Miller A.E.: A new method for the generation and use of focused ultrasound in experimental biology.J. Gen. Physiol.1946,vol.26:179-193. Malcolm AL, ter Haar GR: Ablation of tissue volumes using high intensity focused ultrasound. Ultrasound Med Biol 1996, 22(5):659-669. Martin CJ, Gregory DW, Hodgkiss M: The effects of ultrasound in vivo on mouse liver in contact with an aqueous coupling medium. Ultrasound Med Biol 1981, 7(3):253-265. Melodelima D, Chapelon JY, Theillere Y, Cathignol D: Combination of thermal and cavitation effects to generate deep lesions with an endocavitary applicator using a plane transducer: ex vivo studies. Ultrasound Med Biol 2004, 30(1):103-111. Morton KI, Ter Haar GR, Stratford IJ, Hill CR: Subharmonic emission as an indicator of ultrasonically-induced biological damage. Ultrasound Med Biol 1983, 9(6):629-633. Sanghvi NT, Hawes RH: High-intensity focused ultrasound. Gastrointest Endosc Clin N Am 1994, 4(2):383-395. Sokka SD, King R, Hynynen K: MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Phys Med Biol 2003, 48(2):223-241. Takegami K, Kaneko Y, Watanabe T, Maruyama T, Matsumoto Y, Nagawa H: Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound. Ultrasound Med Biol 2004, 30(10):1419-1422. Tang H, Wang CC, Blankschtein D, Langer R: An investigation of the role of cavitation in low-frequency ultrasound-mediated transdermal drug transport. Pharm Res 2002, 19(8):1160-1169. ter Haar G: High intensity ultrasound. Semin Laparosc Surg 2001, (1):77-89. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35686 | - |
dc.description.abstract | 本篇論文主要在探討,空蝕化現象(Cavitation)對焦斑(Lesion)形成的影響。我們使用不同高低頻(1.155KHz+0.577MHz 1.155MHz+28KHz),以及波源輻照特性(0.577MHz為聚焦型換能器,28KHz為平面型換能器)的搭配去對仿體與豬肉組織進行燒灼,比較經超音波燒灼後,焦斑的大小和差異。從實驗結果可以發現,高頻結合聚焦型低頻超音波產生的焦斑,可以做到區域性增強加熱並保護重要組織的功能;高頻結合平面型低頻超音波產生的焦斑,可在組織深部變長變寬而不會造成前場過熱。我們利用水診器(Hydrophone)去測量子諧波訊號(Sub-harmonic)的方式驗證空蝕化現象是否真的發生。未來在臨床治療運用上,如果可以適當的利用這兩種治療策略,便可以有效地增進整體熱治療的效果。 | zh_TW |
dc.description.abstract | This study is focused on the effect of cavitation on the process of thermal lesions formation. Different frequencies (1.155MHz + 0.577MHz,1.155MHz + 28KHz) and different types of transducers (focused transducer for 0.577MHz frequency, plan transducer for 28KHz frequency) were applied for heating phantoms and porcine muscle tissue. The differences in size and shape of the formed lesions were compared. The experimental results showed that the combination of high frequency and low-frequency focused transducer produced thermal lesion locally. On the other hand, the combination of high frequency and low-frequency plane transducer produced lager and wider lesion without over heating. The existence of cavitation was monitored by detecting the emitting signals using a hydrophone placed inside the tested samples. If use these novel strategies properly, the efficiency of thermal therapy in the clinical application would be enhanced. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T07:04:52Z (GMT). No. of bitstreams: 1 ntu-94-R92548043-1.pdf: 2333575 bytes, checksum: a1c8a2d5234ef67eb6ff67d7dd974849 (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | 誌謝 I
摘要 II Abstract III 目錄 IV 圖目錄 VI 表目錄 VIII 第一章 緒論 1 1-1 引言1 1-2 超音波與生物物質相互作用的基本原理1 1-2-1 機械效應1 1-2-2 熱效應2 1-2-3 空蝕化效應2 1-3 超音波空蝕化現象的實質3 1-4 文獻回顧4 1-5 研究目的5 1-6 論文架構7 第二章 設備和材料 8 2-1 研究設備8 2-2 系統架構9 2-3 超音波換能器和匹配電路10 2-3-1 1.155MHz換能器與其匹配電路10 2-3-2 0.577MHz換能器與其匹配電路11 2-3-3 28KHz探頭與電源系統12 2-4 材料的使用13 2-4-1 仿體製作13 2-4-2 離體(in vitro)豬肉的使用15 2-5 統計方法15 第三章 實驗準備 16 3-1 實驗設計16 3-2 實驗參數控制17 3-2-1 HIFU燒灼用換能器:1.155MHz換能器17 3-2-2 產生空蝕化效應換能器:0.577MHz聚焦式換能器17 3-2-3 產生空蝕化效應換能器:28KHz平面式換能器17 3-3 比較高頻與低頻換能器對仿體燒灼後焦斑的型態18 3-4 超音波壓力場之量測20 第四章 實驗結果--雙聚焦超音波系統 21 4-1 仿體實驗21 4-2 豬肉組織實驗29 4-3 子諧波訊號的量測33 4-4 討論36 第五章 實驗結果--混頻超音波系統 38 5-1 仿體實驗38 5-2 豬肉組織實驗41 5-3 低頻28KHz對豬肉組織進行燒灼時的溫度量測53 5-4 子諧波訊號的量測54 5-5 討論56 第六章 結論與未來工作 58 參考文獻 59 | |
dc.language.iso | zh-TW | |
dc.title | 利用低頻超音波產生空蝕化現象強化高頻熱效應之研究 | zh_TW |
dc.title | Cavitation-Enhanced Ultrasound Thermal Therapy
By Dual Frequencies | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳永耀,陳文翔,王士豪,江惠華 | |
dc.subject.keyword | 聚焦型超音波,空蝕化現象,雙頻,子諧波訊號,仿體, | zh_TW |
dc.subject.keyword | Focused Ultrasound,Cavitation,Dual Frequencies,Sub-harmonic,Phantom, | en |
dc.relation.page | 60 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-27 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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