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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林嘉明 | |
| dc.contributor.author | I-ting Wang | en |
| dc.contributor.author | 王怡婷 | zh_TW |
| dc.date.accessioned | 2021-06-13T06:41:33Z | - |
| dc.date.available | 2005-08-12 | |
| dc.date.copyright | 2005-08-12 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-29 | |
| dc.identifier.citation | 1. Yang, T.T., Chen, C.C., and Lin, J.M., 2005. “Effect of Air Flow on Emission of Smoldering Incense.” Bulletin of Environmental Contamination and Toxicolgy, vol. 74, p 456 – 463.
2. World Health Organization Regional Office for Europe Copenhagen, 2000. “Air Quality Guidelines for Europe, 2nd edition ”, WHO Regional Publications, European Series, No. 91, Chapter I. Introduction, p 1 – 10. 3. 香港特別行政區政府室內空氣質素管理小組，2003。「辦公室及公眾場所室內空氣質素管理指引」，香港室內空氣品質管理指引，p ii – iii。 4. National Research Council (NRC), 1981. “Indoor Pollutants.” Committee on Indoor Pollutants, Board on Toxicology and Environmental Health Hazards, National Research Council. Executive summary, p 1- 15. 5. 行政院環保署，2001。「中華民國台灣地區空氣品質監測報告90年年報」。 6. 行政院環保署，2002。「中華民國台灣地區空氣品質監測報告91年年報」。 7. 行政院環保署，2003。「中華民國台灣地區空氣品質監測報告92年年報」。 8. 行政院環保署。空氣品質監測站網：http://taqm.epa.gov.tw/emc/default.aspx?mod=PsiAreaHourly 9. 中央研究院地球科學研究所，2003。「台灣地區臭氧與懸浮微粒預報模式建立及生成與傳輸機制分析-行政院環境保護署九十二年度專案計畫期末報告」。 10. U.S. Environmental Protection Agency, 2004. “Particulate Matters”, Six Common Air Pollutants, http://www.epa.gov/air/urbanair/pm/what1.html. 11. Canadian Medical Association, 1999, “Canadian Asthma Consensus Report, 1999.” Canadian Medical Association Journal, Supplement to CMAJ, vol. 161 (11 Suppl.), s 1 – 14. 12. Hodgson, M., 2002. “Indoor Environmental Exposure and Symptoms.” Environmental Health Perspectives, vol. 110, p 663 – 667. 13. Li, C.S., Ro, Y.S., 2000. “Indoor Characteristics of Polycyclic Aromatic Hydrocarbons in the Urban Atmosphere of Taipei.” Atmospheric Environment, vol. 34, p 611 – 620. 14. Schoental, R., Gibbard, S., 1967. “Carcinogens in Chinese Incense Smoke.” Nature, vol. 216, p 612. 15. Lowengart, R.A., Peters, J.M., Cicioni, C., Buckley, J., Bernstein, L., Preston-Martin, S., and Rappaport, E., 1987. “Childhood Leukemia and Parents’ Occupational and Home Exposure.” Journal of the National Cancer Institute, vol. 16, p 96 – 98. 16. Preston-Martin, S., Yu, M.C., Benton, B., and Henderson., B.E., 1982. “N-nitroso Compounds and Childhood Brain Tumors: A Case-Control Study.” Cancer Research, vol. 42 (12), p 5240 – 5245. 17. Jetter, J.J., Guo, Z., McBrian, J.A., Flynn, M.R., 2002. “Characterization of Emissions from Burning Incense.” The Science of the Total Environment, vol 295, p 51 – 67. 18. Rasmussen, R.E., 1987. “Mutagenic Activity of Incense Smoke in Salmonella typhimurium.” Bulletin of Environmental Contamination and Toxicology, vol. 38, p 827 – 833. 19. Sato, S., Makino, R., Takahashi, Y., Sugimura, T., and Miyazaki, T., 1980. “Mutagenicity of Smoke Condensates from Joss Sticks.” Mutation Research, vol. 77, p 31 – 36. 20. Löfroth, G., Stensman, C. and Brandohorst-Satzkorn, M., 1991. “Indoor Sources of Mutagenic Aerosol Particulate Matter: Smoking, Cooking and Incense Burning.” Mutation Research, vol. 261, p 21 – 28. 21. Lin, J.M., Wang, L.H., 1994. “Gaseous Aliphatic Aldehydes in Chinese Incense Smoke.” Bulletin of Environmental Contamination and Toxicology, vol. 53, p 374 – 381 22. Lee, R.S., Lin, J.M., 1996. “Gaseous Aliphatic Aldehydes in Smoke from Burning Raw Materials of Chinese Joss Sticks.” Bulletin of Environmental Contamination and Toxicology, vol. 57, p 361 – 366. 23. Chang, H.L., Kuo, M.L., Lin, J.M., 1997. “Mutagenic Activity of Incense Smoke in Comparison to Formaldehyde and Acetaldehyde in Salmonella typhimurium TA102.” Bulletin of Environmental Contamination and Toxicology, vol. 58, p 394 – 401. 24. Huynh, C.K., Salvolainen, H., Vu-Duc, T., Guillemin, M., and Iselin, F., 1991. “Impact of Thermal Proofing of a Church on Its Indoor Air Quality: the Combustion of Candles and Incense as a Source of Pollution.” The Science of the Total Environment, vol. 102, p 241 – 251. 25. Lin, T.C., Chang, F.H., Hsieh, J.H., Chao, H.R., Chao, M.R., 2002. “Characteristics of Polycyclic Aromatic Hydrocarbons and Total Suspended Particulate in Indoor and Outdoor Atmosphere of a Taiwanese Temple.” Journal of Hazardous Materials, A95, p 1 – 12. 26. Fang, G.C., Chang, C.N., Wu, Y.S., Yang, C.J., Chang, S.C., and Yang, I.L., 2002. “Suspended Particulate Variations and Mass Size Distributions of Incense Burning at Tzu Yun Yen Temple in Taiwan, Taichung.” The Science of the Total Environment, vol. 299, p 79 – 87. 27. Fang, G.C., Chang, C.N., Chu, C.C., Wu, Y.S., Fu, P.P.C., Chang, S.C., and Yang, I.L., 2003. “Fine (PM2.5), Coarse (PM2.5 – 10), and Metallic Elements of Suspended Particulates for Incense Burning at Tzu Yun Yen Temple in Taiwan.” Chemosphere, vol. 51, p 983 – 991. 28. Lung, S.C., Kao, M.C., Hu, S.C., 2003. “Contribution of Incense Burning to Indoor PM10 and Particle-bound Polycyclic Aromatic Hydrocarbons under Two Ventilation Conditions.” Indoor Air, vol. 13, Issue 2, p 194 – 199. 29. Lung, S.C. and Hu, S.C., 2003. “Generation Rates and Emission Factors of Particulate Matter and Particle-bound Polycyclic Aromatic Hydrocarbons of Incense sticks.” Chemosphere, vol. 50, Issue 5, p 673 – 679. 30. Morawska, L., Zhang, J., 2002. Combustion Sources of Particles. 1. Health Relevance and Source Signature. Chemosphere, vol. 49, p 1045 – 1058. 31. New York City Department of Health and Mental Hygiene and Agency for Toxic Substances and Disease Registry U.S. Department of Health and Human Services, 2001. “Final Technical Report of the Public Health Investigation to Assess Potential Exposures to Airborne and Settled Surface Dust in Residential Areas of Lower Manhattan.” p 2. 32. Gilmour, P.S., Morrison, E.R., Vickers, M.A., Ford, I., Ludlam, C.A., Greaves, M., Donaldson, K., MacNee, W., 2005. The Procoagulant Potential of Environmental Particles (PM10). Occupational and Environmental Medicine, vol. 62, p 164 – 171. 33. Atkinson, R.W., Anderson, H.R., Strachan, D.P., Bland, J.M., Bremmer, S.A., Ponce de Leon, A., 1999. “Short-term Associations between Outdoor Air Pollution and Visits to Accident and Emergency Departments in London for Respiratory Complaints.” European Respiratory Journal, vol. 13, p 257-265. 34. Salvi, S. S., Nordenhall, C., Blomberg, A., Rudell, B., Pourazar, J., Kelly, F. J., Wilson, S., Sandström, T., Holgate, S. T., and Frew, A. J., 2000. “Acute Exposure to Diesel Exhaust Increases IL-8 and GRO-a Production in Healthy Human Airways.” American Journal of Respiratory and Critical Care Medicine, vol. 161, p 550 – 557. 35. McClellan, R.O, 1987. Health Effects of Exposure to Diesel Exhaust Particles. Ann. Rev. Pharmacol. Toxicol., vol. 27, p 279 – 300. 36. Morawska, L., Jamriska, M., Bofinger, N.D., 1997. Size Characteristics and Ageing of the Environmental Tobacco Smoke. The Science of the Total Environment, vol. 196, p 43 – 55. 37. Pope III, C.A., Burnett, R.T., Thun, M.J., Calle, E.E., Krewski, D., Ito, K., Thurston, G.D., 2002. “Lung Cancer, Cardiopulmonary Mortality, and Long-term Exposure to Fine Particulate Air Pollution.” JAMA, vol. 287, no. 9, p 1132 – 1141. 38. Hoet, P.H.M., 2004. “Health Impact of Nanomaterials?” Nature, vol. 22, no. 1, correspondence. 39. Pedersen, E. K., Bjorseth, O., Syversen, T., Mathiesen, M., 2002. “Emissions from Heated Indoor Dust.” Environment International, vol. 27, p 579 – 587. 40. Mathiesen, M., Pedersen, E. K., Urfjell, B., Bjorseth, O., Syversen, T., 2003. “Emissions from heated indoor dust: an approach for sample preparation and in vitro toxicity testing.” Atmospheric Environment, vol. 37, p 4345 – 4352. 41. Mathiesen, M., Pedersen, E. K., Bjorseth, O., Egeberg, K.W., Syversen, T., 2004. “Heating of Indoor Dust Causes Reduction in Its Ability to Stimulate Release of IL-8 and TNF – in vitro Compared to Non-Heated Dust.” Indoor Air, vol. 14, p 226 – 234. 42. Saraf, A., Larsson, L., Larsson, B.M., Larsson, K., and Palmberg, L., 1999. “House Dust Induces IL-6 and IL-8 Response in A549 Epithelial Cells.” Indoor Air, vol. 9, p 219 – 225. 43. Lieber, M., Smith, B., Szakal, A., Nelson-Rees, W., Todaro, G., 1976. “A Continuous Tumor-Cell Line From a Human Lung Carcinoma with Properties of Type II Alveolar Epithelial Cells.” Int. J. Cancer, vol. 17, p 62 – 70. 44. 福井三郎，杉野幸夫編著，上野洋一郎編譯，1992 細胞培養，藝軒出版社，台北。 45. 陳嘉芬，2002。細胞生物學，藝軒出版社，台北。 46. Bell, R. David, 陳國榮，2003。生理學的基本概念，合記，臺北市。p 104 – 127。 47. 陳衍正，鄭尊仁，詹長權，1999。大氣懸浮微粒之細胞毒性研究 – 微粒粒徑與成分對A549細胞株釋放細胞激素之影響。台灣大學職業醫學與工業衛生研究所，碩士論文。 48. Roitt, I., Brostoff, J., Male, D., 丁慶雄等，1994。免疫學第三版，合記，臺北市。p 1.11 – 9.14。 49. Palmberg, Lena, Larsson, Britt-Marie, Malmberg, Per, and Larsson, Kjell, 1998. “Induction of IL-8 Production in Human Alveolar Macrophage and Human Bronchial Epithelial Cells in Vitro by Swine Dust.” Thorax, vol. 53, p 260 – 264. 50. Roitt, Ivan M. Ivan Maurice，王聖予，陳建和，2002。免疫學，藝軒出版社，台北。p 6 – 137。 51. 陳耀茂，1997。田口實驗計畫法Introduction to Design of Experiment，滄海書局，臺中市。 52. 丁志華，戴寶通，田口實驗計畫法簡介（I）毫微米通訊，第八卷第三期，p 7-11。 53. 林秀雄，1992。田口方法與低成本品質工程，新知企管，台北。 54. 劉克琪，1994。實驗設計與田口式品質工程，華泰，臺北市。 55. 高瑄玶，鄭尊仁，2003。臭氧及氣懸微粒對人體上皮細胞DNA傷害之研究。台灣大學職業醫學與工業衛生研究所，碩士論文。 56. COULTER, 1995. “N4 Plus Submicron Particle Sizer, Reference Manual.” 57. Endogen®, Instructions for Human IL-8 ELISA Kit, Prod. No. EH2IL8, EH2IL82, EH2IL85 Doc. No. 1349. 58. TSI, 2005. “Model 3936 Scanning Mobility Particle SizerTM (SMPS) Spectrometer Introduction Manual.” | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35122 | - |
| dc.description.abstract | 次微米微粒粒徑介於0.01 μm至1μm，如此細小的微粒可能深入人體呼吸系統的肺泡區域。造成急慢性健康效應，包括心血管疾病及慢性肺部疾病。本研究探討華人社會常使用的拜香，其燃燒產生的次微米微粒對肺部細胞可能造成的發炎反應。
研究設計採田口氏實驗設計法，試驗拜香種類、微粒粒徑、化學成分與微粒濃度等參數在不同組合下對A549人類肺部上皮細胞分泌出間白質 (Interleukin-8)的影響。 統計分析試驗數據指出，香種及微粒大小是影響細胞發炎程度的顯著參數。微粒愈小，A549類肺部上皮細胞發炎的程度愈嚴重 (p≦0.005)。 | zh_TW |
| dc.description.abstract | Submicron particles with particle size of 0.01 – 0.1 μm would reach alveolar region causing health effect including cardiovalular and lung diseases. The particles from burning incense with size of 0.08μm – 0.04μm supposedly would have cytotoxicity on respiratory system. The inflammatory response of A-549 cell-line to particles treated with different experiemental trials was observed. The experimental trials, designed by the Taguchi’s method, involve the parameters of brands of incense, particle size, time of heating particles as surrogate of chemicals embedded on particles, and concentration of particles. Interleukin-8 as endpoint of cellular inflammation was analyzed by ELISA.
As results, the inflammatory response significantly associated with the brand of incense as well as the particle size. The smaller particles would cause the more sever inflammatory response of the A-549 cell-line | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T06:41:33Z (GMT). No. of bitstreams: 1 ntu-94-R92844011-1.pdf: 887904 bytes, checksum: 73f09c74c40b4b7024122b641e8488f8 (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 摘 要 i
Abstract ii 誌 謝 iii 目 錄 iv 表目錄 v 圖目錄 vi 第一章 前言 1 第二章 文獻回顧 2 一、 空氣污染物相關介紹 2 二、 拜香燃燒煙介紹及相關健康影響研究 4 三、 次微米微粒相關研究 6 四、 體外暴露研究（In vitro study）-細胞培養技術 8 五、 A549類人類肺泡上皮細胞 9 六、 實驗設計法之論述 10 第三章 研究方法 13 一、 研究設計與架構 13 二、 進行步驟 16 第四章 結果 26 第五章 討論 28 參考文獻 32 附錄 61 附錄一 Scanning Mobility Particle Sizer測定原理 61 | |
| dc.language.iso | zh-TW | |
| dc.title | 拜香燃燒煙中次微米微粒之細胞毒性初探 | zh_TW |
| dc.title | Cytotoxicity of Submicron Particles from Burning Incense – A Preliminary Study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 鄭尊仁,龍世俊,洪益夫 | |
| dc.subject.keyword | 次微米微粒,拜香,發炎, | zh_TW |
| dc.subject.keyword | incense buring,submicron particle,inflammatory response, | en |
| dc.relation.page | 67 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-08-01 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境衛生研究所 | zh_TW |
| 顯示於系所單位： | 環境衛生研究所 | |
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