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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 王正一 | |
| dc.contributor.author | Ping-Shan Lai | en |
| dc.contributor.author | 賴秉杉 | zh_TW |
| dc.date.accessioned | 2021-06-13T06:34:59Z | - |
| dc.date.available | 2010-10-24 | |
| dc.date.copyright | 2006-02-07 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-01-17 | |
| dc.identifier.citation | Reference
CHAPTER 1 1. Mrsny, R. J. The colon as a site for drug delivery. Journal of Controlled Release 1992, 22 (1), 15-34. 2. Rubinstein, A. Approaches and opportunities in colon-specific drug-delivery. Critical Reviews in Therapeutic Drug Carrier Systems 1995, 12 (2-3), 101-149. 3. Watts, P. J.; Illum, L. Colonic drug delivery. Drug Development and Industrial Pharmacy 1997, 23 (9), 893-913. 4.Esfand, R.; Tomalia, D. A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discovery Today 2001, 6 (8), 427-436. 5. Tomalia, D. A.; Naylor, A. M.; Goddard, W. A. Starburst dendrimers - molecular-level control of size, shape, surface-chemistry, topology, and flexibility from atoms to macroscopic matter. Angewandte Chemie-International Edition in English 1990, 29 (2), 138-175. 6. Pai, C.L. Studies on the intracellular trafficking and subcellular distribution of PAMAM dendrimer; Graduated thesis 2004, National Taiwan University. 7. Wang, T.W. Effects of PAMAM dendrimers on the endosomal/lysosomal pH, Graduated thesis 2004, National Taiwan University. 8. Ochsner, M. Photophysical and photobiological processes in the photodynamic therapy of tumours. Journal of Photochemistry and Photobiology B-Biology 1997, 39 (1), 1-18. 9. Berg, K.; Selbo, P. K.; Prasmickaite, L.; Tjelle, T. E.; Sandvig, K.; Moan, D.; Gaudernack, G.; Fodstad, O.; Kjolsrud, S.; Anholt, H.; Rodal, G. H.; Rodal, S. K.; Hogset, A. Photochemical internalization: A novel technology for delivery of macromolecules into cytosol. Cancer Research 1999, 59 (6), 1180-1183. CHAPTER 2 1. Mrsny, R. J. The colon as a site for drug delivery. Journal of Controlled Release 1992, 22 (1), 15-34. 2. Watts, P. J.; Illum, L. Colonic drug delivery. Drug Development and Industrial Pharmacy 1997, 23 (9), 893-913. 3. Yu, D. K.; Morrill, B.; Eichmeier, L. S.; Lanman, R. C.; Lanman, M. B.; Giesing, D. H.; Weir, S. J. Pharmacokinetics of 5-aminosalicylic acid from controlled-release capsules in man. European Journal of Clinical Pharmacology 1995, 48 (3-4), 273-277. 4. Vazquez, B.; Gurruchaga, M.; Goni, I.; Narvarte, E.; Roman, J. S. A pH-sensitive hydrogel based on poly(ethoxy triethylene glycol monomethacrylate). Polymer 1995, 36 (17), 3327-3333. 5. Akala, E. O.; Kopeckova, P.; Kopecek, J. Novel pH-sensitive hydrogels with adjustable swelling kinetics. Biomaterials 1998, 19 (11-12), 1037-1047. 6. Brondsted, H.; Andersen, C.; Hovgaard, L. Crosslinked dextran - a new capsule material for colon targeting of drugs. Journal of Controlled Release 1998, 53 (1-3), 7-13. 7. Park, H.; Robinson, J. R. Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels. Pharmaceutical Research 1987, 4 (6), 457-464. 8. Blanco, M. D.; Garcia, O.; Trigo, R. M.; Teijon, J. M.; Katime, I. 5-fluorouracil release from copolymeric hydrogels of itaconic acid monoester .1. Acrylamide-co-monomethyl itaconate. Biomaterials 1996, 17 (11), 1061-1067. 9. Sakurada, Y.; Sueoka, A.; Kawahashi, M. Blood purification device using membranes derived from poly(vinyl-alcohol), and copolymer of ethylene and vinyl alcohol. Polymer Journal 1987, 19 (5), 501-513. 10. Lin, D. T.; Cheng, L. P.; Kang, Y. J.; Chen, L. W.; Young, T. H. Effects of precipitation conditions on the membrane morphology and permeation characteristics. Journal of Membrane Science 1998, 140 (2), 185-194. 11. Young, T. H.; Huang, J. H.; Hung, S. H.; Hsu, J. P. The role of cell density in the survival of cultured cerebellar granule neurons. Journal of Biomedical Materials Research 2000, 52 (4), 748-753. 12. Young, T. H.; Yao, C. H.; Sun, J. S.; Lai, C. P.; Chen, L. W. The effect of morphology variety of EVAL membranes on the behavior of myoblasts in vitro. Biomaterials 1998, 19 (7-9), 717-724. 13. Kondoh, A.; Makino, K.; Matsuda, T. 2-Dimensional artificial extracellular-matrix - bioadhesive peptide-immobilized surface design. Journal of Applied Polymer Science 1993, 47 (11), 1983-1988. 14. Skoog, D. A.; West, D. M. Analytical Chemistry, 5th Edition; Saunders: London, 1990. 15. Smith, K. A.; Colton C.K.; Merrill, E. W.; Evans, L. B. Convective transport in a batch dialyzer. Determination of the true membrane permeability from a single measurement. AIChE Symp. Ser. 1968, 64, 45. 16. American Hostipal Formulary Service Drug Information, American Society of Hospital Pharmacists: MD, 1993. 17. Nelson, D. L.; Cox, M. M. Lehninger, A. L. Principles of Biochemistry, 3rd Edition; Worth Publishers Inc.: New York, 2000. 18. Crank, J. The Mathematics of Diffusion, Oxford University Press: London, 1975. CHAPTER 3 1. Pinedo, H. M.; Peters, G. F. J. Fluorouracil - biochemistry and pharmacology. Journal of Clinical Oncology 1988, 6 (10), 1653-1664. 2. Isacoff, W. H.; Borud, K. Chemotherapy for the treatment of patients with metastatic colorectal cancer: An overview. World Journal of Surgery 1997, 21 (7), 748-762. 3. Loehrer, P. J.; Turner, S.; Kubilis, P.; Hui, S.; Correa, J.; Ansari, R.; Stephens, D.; Woodburn, R.; Meyer, S. A prospective randomized trial of fluorouracil versus fluorouracil plus cisplatin in the treatment of metastatic colorectal-cancer - A hoosier oncology group trial. Journal of Clinical Oncology 1988, 6 (4), 642-648. 4. Poon, M. A.; Oconnell, M. J.; Moertel, C. G.; Wieand, H. S.; Cullinan, S. A.; Everson, L. K.; Krook, J. E.; Mailliard, J. A.; Laurie, J. A.; Tschetter, L. K.; Wiesenfeld, M. Biochemical modulation of fluorouracil - Evidence of significant improvement of survival and quality of life in patients with advanced colorectal-carcinoma. Journal of Clinical Oncology 1989, 7 (10), 1407-1418. 5. Milano, G.; Roman, P.; Khater, R.; Frenay, M.; Renee, N.; Namer, M. Dose versus pharmacokinetics for predicting tolerance to 5-day continuous infusion of 5-FU. International Journal of Cancer 1988, 41 (4), 537-541. 6. Bleiberg, H. Colorectal cancer - Is there an alternative to 5-FU? European Journal of Cancer 1997, 33 (4), 536-541. 7. Lin, F. H.; Lee, Y. H.; Jian, C. H.; Wong, J. M.; Shieh, M. J.; Wang, C. Y. A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier. Biomaterials 2002, 23 (9), 1981-1987. 8. Mrsny, R. J. The colon as a site for drug delivery. Journal of Controlled Release 1992, 22 (1), 15-34. 9. Rubinstein, A. Approaches and opportunities in colon-specific drug-delivery. Critical Reviews in Therapeutic Drug Carrier Systems 1995, 12 (2-3), 101-149. 10. Watts, P. J.; Illum, L. Colonic drug delivery. Drug Development and Industrial Pharmacy 1997, 23 (9), 893-913. 11. Akala, E. O.; Kopeckova, P.; Kopecek, J. Novel pH-sensitive hydrogels with adjustable swelling kinetics. Biomaterials 1998, 19 (11-12), 1037-1047. 12. Blanco, M. D.; Garcia, O.; Trigo, R. M.; Teijon, J. M.; Katime, I. 5-fluorouracil release from copolymeric hydrogels of itaconic acid monoester. Biomaterials 1996, 17 (11), 1061-1067. 13. Brondsted, H.; Andersen, C.; Hovgaard, L. Crosslinked dextran - a new capsule material for colon targeting of drugs. Journal of Controlled Release 1998, 53 (1-3), 7-13. 14. Changez, M.; Burugapalli, K.; Koul, V.; Choudhary, V. The effect of composition of poly(acrylic acid)-gelatin hydrogel on gentamicin sulphate release: in vitro. Biomaterials 2003, 24 (4), 527-536. 15. Shieh, M. J.; Lai, P. S.; Young, T. H. 5-aminosalicylic acid permeability enhancement by a pH-sensitive EVAL membrane. Journal of Membrane Science 2002, 204 (1-2), 237-246. 16. Vazquez, B.; Gurruchaga, M.; Goni, I.; Narvarte, E.; Roman, J. S. A pH-sensitive hydrogel based on poly(ethoxy triethylene glycol monomethacrylate). Polymer 1995, 36 (17), 3327-3333. 17. Sakurada, Y.; Sueoka, A.; Kawahashi, M. Blood purification device using membranes derived from poly(vinyl-alcohol) and copolymer of ethylene and vinyl alcohol. Polymer Journal 1987, 19 (5), 501-513. 18. Lin, D. T.; Cheng, L. P.; Kang, Y. J.; Chen, L. W.; Young, T. H. Effects of precipitation conditions on the membrane morphology and permeation characteristics. Journal of Membrane Science 1998, 140 (2), 185-194. 19. Young, T. H.; Chuang, W. Y.; Wei, C. W.; Tang, C. Y. Investigation of the drug distribution and release characteristics from particulate membranes. Journal of Membrane Science 2001, 191 (1-2), 199-205. 20. Young, T. H.; Hu, W. W. Covalent bonding of lysine to EVAL membrane surface to improve survival of cultured cerebellar granule neurons. Biomaterials 2003, 24 (8), 1477-1486. 21. Young, T. H.; Lin, C. W.; Cheng, L. P.; Hsieh, C. C. Preparation of EVAL membranes with smooth and particulate morphologies for neuronal culture. Biomaterials 2001, 22 (13), 1771-1777. 22. Young, T. H.; Huang, J. H.; Hung, S. H.; Hsu, J. P. The role of cell density in the survival of cultured cerebellar granule neurons. Journal of Biomedical Materials Research 2000, 52 (4), 748-753. 23. Luo, R. L.; Young, T. H.; Sun, Y. M. Structure formation and characterization of EVAL membranes with cosolvent of isopropanol and water. Polymer 2003, 44 (1), 157-166. 24. Smith, K. A.; Colton C.K.; Merrill, E. W.; Evans, L. B. Convective transport in a batch dialyzer. Determination of the true membrane permeability from a single measurement. AIChE Symp. Ser. 1968, 64, 45. 25. Mosmann, T. Rapid colorimetric assay for cellular growth and survival - Application to proliferation and cyto-toxicity assays. Journal of Immunological Methods 1983, 65 (1-2), 55-63. 26. Katime, I.; Parada, L. G.; Meaurio, E.; Cesteros, L. C. Poly(N,N-dimethylacrylamide)/copolymers of vinyl alcohol blends: effect of the comonomer. Polymer 2000, 41 (4), 1369-1375. 27. Dong, J.; Ozaki, Y.; Nakashima, K. Infrared, Raman, and near-infrared spectroscopic evidence for the coexistence of various hydrogen-bond forms in poly(acrylic acid). Macromolecules 1997, 30 (4), 1111-1117. 28. Peppas, N. A.; Bures, P.; Leobandung, W.; Ichikawa, H. Hydrogels in pharmaceutical formulations. European Journal of Pharmaceutics and Biopharmaceutics 2000, 50 (1), 27-46. CHAPTER 4 1. Endo, Y.; Mitsui, K.; Motizuki, M.; Tsurugi, K. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes - the site and the characteristics of the modification in 28-S ribosomal-RNA caused by the toxins. Journal of Biological Chemistry 1987, 262 (12), 5908-5912. 2. Barbieri, L.; Battelli, M. G.; Stirpe, F. Ribosome-inactivating proteins from plants. Biochimica et Biophysica Acta 1993, 1154 (3-4), 237-282. 3. Wang, P.; Tumer, N. E. Pokeweed antiviral protein cleaves double-stranded supercoiled DNA using the same active site required to depurinate rRNA. Nucleic Acids Research 1999, 27 (8), 1900-1905. 4. Ferreras, J. M.; Barbieri, L.; Girbes, T.; Battelli, M. G.; Rojo, M. A.; Arias, F. J.; Rocher, M. A.; Soriano, F.; Mendez, E.; Stirpe, F. Distribution and properties of major ribosome-inactivating proteins (28-S ribosomal-RNA N-glycosidases) of the plant saponaria-officinalis l (Caryophyllaceae). Biochimica et Biophysica Acta 1993, 1216 (1), 31-42. 5. Flavell, D. J.; Boehm, D. A.; Noss, A.; Warnes, S. L.; Flavell, S. U. Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin. British Journal of Cancer 2001, 84 (4), 571-578. 6. Wu, M. Enhancement of immunotoxin activity using chemical and biological reagents. British Journal of Cancer 1997, 75 (9), 1347-1355. 7. Barth, R. F.; Yang, W. L.; Adams, D. M.; Rotaru, J. H.; Shukla, S.; Sekido, M.; Tjarks, W.; Fenstermaker, R. A.; Ciesielski, M.; Nawrocky, M. M.; Coderre, J. A. Molecular targeting of the epidermal growth factor receptor for neutron capture therapy of gliomas. Cancer Research 2002, 62 (11), 3159-3166. 8. Esfand, R.; Tomalia, D. A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discovery Today 2001, 6 (8), 427-436. 9. Patri, A. K.; Majoros, I. J.; Baker, J. R. Dendritic polymer macromolecular carriers for drug delivery. Current Opinion in Chemical Biology 2002, 6 (4), 466-471. 10. Tomalia, D. A.; Naylor, A. M.; Goddard, W. A. Starburst dendrimers - molecular-level control of size, shape, surface-chemistry, topology, and flexibility from atoms to macroscopic matter. Angewandte Chemie-International Edition in English 1990, 29 (2), 138-175. 11. Bielinska, A.; Kukowska, L.; Johnson, J.; Tomalia, D. A.; Baker, J. R. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res 1996, 24 (11), 2176-2182. 12. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. Journal of Controlled Release 2000, 65 (1-2), 271-284. 13. Malik, N.; Evagorou, E. G.; Duncan, R. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anti-Cancer Drugs 1999, 10 (8), 767-776. 14. Berg, K.; Selbo, P. K.; Prasmickaite, L.; Tjelle, T. E.; Sandvig, K.; Moan, D.; Gaudernack, G.; Fodstad, O.; Kjolsrud, S.; Anholt, H.; Rodal, G. H.; Rodal, S. K.; Hogset, A. Photochemical internalization: A novel technology for delivery of macromolecules into cytosol. Cancer Research 1999, 59 (6), 1180-1183. 15. Prasmickaite, L.; Hogset, A.; Selbo, P. K.; Engesaeter, B. O.; Hellum, M.; Berg, K. Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy. British Journal of Cancer 2002, 86 (4), 652-657. 16. Selbo, P. K.; Sandvig, K.; Kirveliene, V.; Berg, K. Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization. Biochimica et Biophysica Acta-General Subjects 2000, 1475 (3), 307-313. 17. Engesaeter, B. O.; Bonsted, A.; Berg, K.; Hogset, A.; Engebraten, O.; Fodstad, O.; Curiel, D. T.; Maelandsmo, G. M. PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles. Cancer Gene Therapy 2005, 12 (5), 439-448. 18. Folini, M.; Berg, K.; Millo, E.; Villa, R.; Prasmickaite, L.; Daidone, M. G.; Benatti, U.; Zaffaroni, N. Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase. Cancer Research 2003, 63 (13), 3490-3494. 19. Selbo, P. K.; Sivam, G.; Fodstad, O.; Sandvig, K.; Berg, K. Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin. International Journal of Cancer 2000, 87 (6), 853-859. 20. Lou, P. J.; Lai, P. S.; Shieh, M. J.; MacRobert, A. J.; Berg, K.; Bown, S. G. Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization. International Journal of Cancer 2006, revised. 21. Kamata, N.; Chida, K.; Rikimaru, K.; Horikoshi, M.; Enomoto, S.; Kuroki, T. Growth-inhibitory effects of epidermal growth-factor and overexpression of its receptors on human squamous-cell carcinomas in culture. Cancer Research 1986, 46 (4), 1648-1653. 22. Ko, J. Y.; Lee, T. C.; Hsiao, C. F.; Lin, G. L.; Yen, S. H.; Chen, K. Y.; Hsiung, C. A.; Chen, P. J.; Hsu, M. M.; Jou, Y. S. Definition of three minimal deleted regions comprehensive allelotyping and mutational of FHIT, p16(INK4a), and p19(ARF) genes in nasopharyngeal carcinoma. Cancer 2002, 94 (7), 1987-1996. 23. Mosmann, T. Rapid colorimetric assay for cellular growth and survival - application to proliferation and cyto-toxicity assays. Journal of Immunological Methods 1983, 65 (1-2), 55-63. 24. Demoy, M.; Minko, T.; Kopeckova, P.; Kopecek, J. Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. Journal of Controlled Release 2000, 69 (1), 185-196. 25. Minko, T.; Kopeckova, P.; Kopecek, J. Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. International Journal of Cancer 2000, 86 (1), 108-117. 26. Minko, T.; Kopeckova, P.; Kopecek, J. Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharmaceutical Research 1999, 16 (7), 986-996. 27. Arpicco, S.; Dosio, F.; Bolognesi, A.; Lubelli, C.; Brusa, P.; Stella, B.; Ceruti, M.; Cattel, L. Novel poly(ethylene glycol) derivatives for preparation of ribosome-inactivating protein conjugates. Bioconjugate Chemistry 2002, 13 (4), 757-765. 28. Wiley, R. G.; Oeltmann, T. N.; Lappi, D. A. Immunolesioning - Selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Research 1991, 562 (1), 149-153. 29. Pasqualucci, L.; Wasik, M.; Teicher, B. A.; Flenghi, L.; Bolognesi, A.; Stirpe, F.; Polito, L.; Falini, B.; Kadin, M. E. Antitumor-activity of anti-Cd30 immunotoxin (ber-H2 saporin) in-vitro and in severe combined immunodeficiency sisease mice xenografted with human CD30(+) anaplastic large-cell lymphoma. Blood 1995, 85 (8), 2139-2146. 30. Battelli, M. G.; Buonamici, L.; Bolognesi, A.; Stirpe, F. In-vivo and in-vitro uptake of an anti-CD30/saporin immunotoxin by rat-liver parenchymal and nonparenchymal cells. Hepatology 1994, 20 (4), 940-947. 31. Blasi, F.; Vassalli, J. D.; Dano, K. Urokinase-type plasminogen-activator - proenzyme, receptor, and inhibitors. Journal of Cell Biology 1987, 104 (4), 801-804. 32. Ippoliti, R.; Lendaro, E.; Benedetti, P. A.; Torrisi, M. R.; Belleudi, F.; Carpani, D.; Soria, M. R.; Fabbrini, M. S. Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism. Faseb Journal 2000, 14 (10), 1335-1344. 33. Fabbrini, M. S.; Carpani, D.; BelloRivero, I.; Soria, M. R. The amino-terminal fragment of human urokinase directs a recombinant chimeric toxin to target cells: internalization is toxin mediated. Faseb Journal 1997, 11 (13), 1169-1176. 34. Provoda, C. J.; Stier, E. M.; Lee, K. D. Tumor cell killing enabled by listeriolysin O-liposome-mediated delivery of the protein toxin gelonin. Journal of Biological Chemistry 2003, 278 (37), 35102-35108. 35. Poma, A.; Cesare, P.; Marcozzi, G.; Spano, L. Nuclear damage induced by liposomes containing FITC-labeled saporin on human melanoma cells in vitro. Journal of Liposome Research 2001, 11 (1), 91-102. 36. Mcintosh, D. P.; Heath, T. D. Liposome-Mediated Delivery of Ribosome Inactivating Proteins to Cells-Invitro. Biochimica et Biophysica Acta 1982, 690 (2), 224-230. 37. Dosio, F.; Brusa, P.; Delprino, L.; Grosa, G.; Ceruti, M.; Cattel, L. A new approach in the synthesis of immunotoxins - ribosome-inactivating protein noncovalently bound to monoclonal-antibody. Journal of Pharmaceutical Sciences 1994, 83 (2), 206-211. 38. Lambert, J. M.; Senter, P. D.; Yauyoung, A.; Blattler, W. A.; Goldmacher, V. S. Purified immunotoxins that are reactive with human lymphoid-cells - monoclonal-antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins. Journal of Biological Chemistry 1985, 260 (22), 2035-2041. 39. Thorpe, P. E.; Brown, A. N. F.; Ross, W. C. J.; Cumber, A. J.; Detre, S. I.; Edwards, D. C.; Davies, A. J. S.; Stirpe, F. Cyto-toxicity acquired by conjugation of an anti-Thy1.1 monoclonal-antibody and the ribosome-inactivating protein, gelonin. European Journal of Biochemistry 1981, 116 (3), 447-454. 40. Landers, J. J.; Cao, Z. Y.; Lee, I.; Piehler, L. T.; Myc, P. P.; Myc, A.; Hamouda, T.; Galecki, A. T.; Baker, J. R. Prevention of influenza pneumonitis by sialic acid-conjugated dendritic polymers. Journal of Infectious Diseases 2002, 186 (9), 1222-1230. 41. Kichler, A.; Leborgne, C.; Coeytaux, E.; Danos, O. Polyethylenimine-mediated gene delivery: a mechanistic study. Journal of Gene Medicine 2001, 3 (2), 135-144. 42. Sonawane, N. D.; Szoka, F. C.; Verkman, A. S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. Journal of Biological Chemistry 2003, 278 (45), 44826-44831. 43. Delius, M.; Adams, G. Shock wave permeabilization with ribosome inactivating proteins: A new approach to tumor therapy. Cancer Research 1999, 59 (20), 5227-5232. 44. Kodama, T.; Doukas, A. G.; Hamblin, M. R. Delivery of ribosome-inactivating protein toxin into cancer cells with shock waves. Cancer Letters 2003, 189 (1), 69-75. 45. Bagga, S.; Seth, D.; Batra, J. K. The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities. Journal of Biological Chemistry 2003, 278 (7), 4813-4820. 46. Jans, D. A.; Hubner, S. Regulation of protein transport to the nucleus: Central role of phosphorylation. Physiological Reviews 1996, 76 (3), 651-685. CHAPTER 5 1. Lu, Z. R.; Kopeckova, P.; Kopecek, J. Polymerizable Fab ' antibody fragments for targeting of anticancer drugs. Nature Biotechnology 1999, 17 (11), 1101-1104. 2. Satchi-Fainaro, R.; Puder, M.; Davies, J. W.; Tran, H. T.; Sampson, D. A.; Greene, A. K.; Corfas, G.; Folkman, J. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nature Medicine 2004, 10 (3), 255-261. 3. Patri, A. K.; Majoros, I. J.; Baker, J. R. Dendritic polymer macromolecular carriers for drug delivery. Current Opinion in Chemical Biology 2002, 6 (4), 466-471. 4. Sahoo, S. K.; Labhasetwar, V. Nanotech approaches to delivery and imaging drug. Drug Discovery Today 2003, 8 (24), 1112-1120. 5. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. Journal of Controlled Release 2000, 65 (1-2), 271-284. 6. Malik, N.; Evagorou, E. G.; Duncan, R. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anti-Cancer Drugs 1999, 10 (8), 767-776. 7. David, A.; Kopeckova, P.; Minko, T.; Rubinstein, A.; Kopecek, J. Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells. European Journal of Cancer 2004, 40 (1), 148-157. 8. Duncan, R.; Gac-Breton, S.; Keane, R.; Musila, R.; Sat, Y. N.; Satchi, R.; Searle, F. Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. Journal of Controlled Release 2001, 74 (1-3), 135-146. 9. Ulbrich, K.; Etrych, T.; Chytil, P.; Pechar, M.; Jelinkova, M.; Rihova, B. Polymeric anticancer drugs with pH-controlled activation. International Journal of Pharmaceutics 2004, 277 (1-2), 63-72. 10. Yoo, H. S.; Lee, E. A.; Park, T. G. Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages. Journal of Controlled Release 2002, 82 (1), 17-27. 11. Pan, D.; Turner, J. L.; Wooley, K. L. Folic acid-conjugated nanostructured materials designed for cancer cell targeting. Chemical Communications 2003, (19), 2400-2401. 12. Hoffman, A. S.; Stayton, P. S.; Press, O.; Murthy, N.; Lackey, C. A.; Cheung, C.; Black, F.; Campbell, J.; Fausto, N.; Kyriakides, T. R.; Bornstein, P. Design of 'smart' polymers that can direct intracellular drug delivery. Polymers for Advanced Technologies 2002, 13 (10-12), 992-999. 13. Jones, R. A.; Cheung, C. Y.; Black, F. E.; Zia, J. K.; Stayton, P. S.; Hoffman, A. S.; Wilson, M. R. Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles. Biochemical Journal 2003, 372, 65-75. 14. Etrych, T.; Jelinkova, M.; Rihova, B.; Ulbrich, K. New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. Journal of Controlled Release 2001, 73 (1), 89-102. 15. Kovar, M.; Kovar, L.; Subr, V.; Etrych, T.; Ulbrich, K.; Mrkvan, T.; Loucka, J.; Rihova, B. HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro. Journal of Controlled Release 2004, 99 (2), 301-314. 16. Schoenmakers, R. G.; van de Wetering, P.; Elbert, D. L.; Hubbell, J. A. The effect of the linker on the hydrolysis rate of drug-linked ester bonds. Journal of Controlled Release 2004, 95 (2), 291-300. 17. Ulbrich, K.; Subr, V. Polymeric anticancer drugs with pH-controlled activation. Advanced Drug Delivery Reviews 2004, 56 (7), 1023-1050. 18. Berg, K.; Selbo, P. K.; Prasmickaite, L.; Tjelle, T. E.; Sandvig, K.; Moan, D.; Gaudernack, G.; Fodstad, O.; Kjolsrud, S.; Anholt, H.; Rodal, G. H.; Rodal, S. K.; Hogset, A. Photochemical internalization: A novel technology for delivery of macromolecules into cytosol. Cancer Research 1999, 59 (6), 1180-1183. 19. Engesaeter, B. O.; Bonsted, A.; Berg, K.; Hogset, A.; Engebraten, O.; Fodstad, O.; Curiel, D. T.; Maelandsmo, G. M. PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles. Cancer Gene Therapy 2005, 12 (5), 439-448. 20. Folini, M.; Berg, K.; Millo, E.; Villa, R.; Prasmickaite, L.; Daidone, M. G.; Benatti, U.; Zaffaroni, N. Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase. Cancer Research 2003, 63 (13), 3490-3494. 21. Prasmickaite, L.; Hogset, A.; Selbo, P. K.; Engesaeter, B. O.; Hellum, M.; Berg, K. Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy. British Journal of Cancer 2002, 86 (4), 652-657. 22. Selbo, P. K.; Sandvig, K.; Kirveliene, V.; Berg, K. Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization. Biochimica et Biophysica Acta-General Subjects 2000, 1475 (3), 307-313. 23. Lou, P. J.; Lai, P. S.; Shieh, M. J.; MacRobert, A. J.; Berg, K.; Bown, S. G. Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization. International Journal of Cancer 2005, revised. 24. Bae, Y.; Fukushima, S.; Harada, A.; Kataoka, K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change. Angewandte Chemie-International Edition 2003, 42 (38), 4640-4643. 25. Mosmann, T. Rapid colorimetric assay for cellular growth and survival - application to proliferation and cyto-toxicity assays. Journal of Immunological Methods 1983, 65 (1-2), 55-63. 26. Altan, N.; Chen, Y.; Schindler, M.; Simon, S. M. Defective acidification in human breast tumor cells and implications for chemotherapy. Journal of Experimental Medicine 1998, 187 (10), 1583-1598. 27. Demoy, M.; Minko, T.; Kopeckova, P.; Kopecek, J. Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. Journal of Controlled Release 2000, 69 (1), 185-196. 28. Minko, T.; Kopeckova, P.; Kopecek, J. Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. International Journal of Cancer 2000, 86 (1), 108-117. 29. Minko, T.; Kopeckova, P.; Kopecek, J. Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharmaceutical Research 1999, 16 (7), 986-996. 30. Kamada, H.; Tsutsumi, Y.; Yoshioka, Y.; Yamamoto, Y.; Kodaira, H.; Tsunoda, S.; Okamoto, T.; Mukai, Y.; Shibata, H.; Nakagawa, S.; Mayumi, T. Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy. Clinical Cancer Research 2004, 10 (7), 2545-2550. 31. Omelyanenko, V.; Kopeckova, P.; Gentry, C.; Kopecek, J. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. Journal of Controlled Release 1998, 53 (1-3), 25-37. 32. Rihova, B.; Etrych, T.; Pechar, M.; Jelinkova, M.; Stastny, M.; Hovorka, O.; Kovar, M.; Ulbrich, K. Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes. Journal of Controlled Release 2001, 74 (1-3), 225-232. 33. Etrych, T.; Chytil, P.; Jelinkova, M.; Rihova, B.; Ulbrich, K. Synthesis of HPMA copolymers containing doxorubicin bound via a hydrazone linkage. Effect of spacer on drug release and in vitro cytotoxicity. Macromolecular Bioscience 2002, 2 (1), 43-52. 34. Langer, M.; Kratz, F.; Rothen-Rutishauser, B.; Wunderli-Allenspach, H.; Beck-Sickinger, A. G. Novel peptide conjugates for tumor-specific chemotherapy. Journal of Medicinal Chemistry 2001, 44 (9), 1341-1348. 35. Rodrigues, P. C. A.; Beyer, U.; Schumacher, P.; Roth, T.; Fiebig, H. H.; Unger, C.; Messori, L.; Orioli, P.; Paper, D. H.; Mulhaupt, R.; Kratz, F. Acid-sensitive polyethylene glycol conjugates of doxorubicin: Preparation, in vitro efficacy and intracellular distribution. Bioorganic & Medicinal Chemistry 1999, 7 (11), 2517-2524. 36. Hudde, T.; Rayner, S. A.; Comer, R. M.; Weber, M.; Isaacs, J. D.; Waldmann, H.; Larkin, D. F.; George, A. J. Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium. Gene Ther 1999, 6 (5), 939-943. 37. Esfand, R.; Tomalia, D. A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discovery Today 2001, 6 (8), 427-436. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/34810 | - |
| dc.description.abstract | 藥物傳輸系統的開發與設計一直以來都是相當熱門的課題，除了利用高分子作為藥物包覆材料外，近年來奈米藥物載體也逐漸受到重視。
本論文分為兩部分，第一部份是利用高分子薄膜技術發展大腸藥物釋放系統，以解決大腸標的給藥的臨床問題。此部分分為兩個研究主題：1. 利用化學修飾技術將甘胺酸接枝於聚乙烯乙烯醇薄膜上，2. 將聚丙烯酸與聚乙烯乙烯醇摻合後製膜，使其具有酸鹼敏感特性，以利大腸藥物釋放。 第二部分是利用樹枝狀高分子作為藥物載體，結合光化學內化技術達到藥物傳輸的目的。此部分同樣分為兩個研究主題：1. 將毒素(saporin)與樹枝狀高分子鍵結，並合併光化學內化(photochemical internalization)技術探討毒素進入癌細胞的情形及毒殺效果。2. 將化療藥物小紅莓(doxorubicin)利用不同鍵結接至樹枝狀高分子表面，並探討不同光化學內化技術對於藥物釋放及細胞毒性的影響。 本研究成功地開發出具酸鹼敏感性的聚乙烯乙烯醇薄膜，並適合用於大腸標的給藥；此外，我們也利用奈米高分子鍵結及光化學內化技術，成功地將不易進入細胞的毒素變成大量進入細胞，並具有良好的細胞毒殺效果；同時我們也發現如果利用酸鹼敏感性的鍵結進行藥物釋放，在合併「後」光化學內化技術能有較好的細胞毒殺效果。 綜上所述，本研究成果將有助於開發大腸藥物給藥系統及奈米光化學給藥技術，期望未來能應用於在臨床醫學上。 | zh_TW |
| dc.description.abstract | In recent years, there has been a rapid growth in the area of drug delivery, facilitated by novel technologies such as smart polymer and nanotechnology that has become a promising field in pharmaceutical sciences.
This dissertation was divided into two parts. The first part is to develop the polymeric membranes for colonic drug delivery to resolve the difficulties of clinical treatment. There are two topics of research in this part. The first topic is to prepare the pH-sensitive membrane for colon-specific drug delivery via glycine-immobilized poly(ethylene-co-vinyl alcohol) (EVAL) membrane. Another topic is to blend the EVAL with poly(acrylic aicd) for colonic drug release. The second part of the dissertation is to investigate the drug delivery systems of nanocarriers combined with photochemical internalization (PCI). This part also contains two topics of research. The first topic is to develop the toxin delivery system by the dendrimer conjugation and PCI treatment. The second one is to investigate the effects of the linkage between dendrimer and doxorubicin combined with PCI strategies on drug release and cytotoxicity. In this study, the pH-sensitive polymeric membranes were successfully prepared for colonic drug delivery. Moreover, the cell uptake and cytotoxicity of saporin were improved significantly by dendrimer conjugation combined with PCI technology. We also found out the ‘light after’ PCI treatment was more efficient than the ‘light before’ PCI treatment in releasing DOX from the pH-cleavable conjugates, resulted in more nuclear accumulation of DOX and more cell death after treatment. In summary, the results were very helpful for the development of colonic drug delivery system and nano-photochemical-induced drug delivery in clinical treatment. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T06:34:59Z (GMT). No. of bitstreams: 1 ntu-95-F89548003-1.pdf: 790885 bytes, checksum: 35b6764798090fd6effdad5f57683a94 (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 中文摘要..................................1
ABSTRACT..................................2 CHAPTER 1 ................................3 GENERAL INTRODUCTION......................3 REFERENCE .................................5 CHAPTER 2.... ............................6 ABSTRACT..................................7 1. INTRODUCTION...........................8 2. MATERIALS AND METHODS..................9 2.1. MATERIALS............................9 2.2. MEMBRANE PREPARATION.................9 2.3. SURFACE MODIFICATION.................9 2.4. SCANNING ELECTRON MICROSCOPY........10 2.5. ATTENUATED TOTAL REFLECTION/FOURIER TRANSFORM INFRARED SPECTROSCOPY..............................10 2.6. X-RAY PHOTOELECTRON SPECTROSCOPY (XPS)......10 2.7. SWELLING BEHAVIOR....................11 2.8. NEUTRALIZATION TITRATION.............11 2.9. PERMEABILITY OF 5-ASA................12 3. RESULTS AND DISCUSSION.................13 3.1. MEMBRANE MORPHOLOGY..................13 3.2. SURFACE MODIFICATION.................13 3.3. SWELLING BEHAVIOR....................14 3.4. 5-ASA PERMEABILITY...................14 5. REFERENCE..............................29 CHAPTER 3.................................32 ABSTRACT..................................33 1. INTRODUCTION...........................34 2. MATERIALS AND METHODS..................36 2.1. MATERIALS............................36 2.2. MEMBRANE PREPARATION.................36 2.3. FTIR SPECTROSCOPY....................37 2.4. SWELLING BEHAVIOR OF THE MEMBRANE....37 2.5. 5-FU PERMEATION ACROSS THE MEMBRANE..38 2.6. VIABILITY OF CACO-2 CELLS............38 3. RESULTS AND DISCUSSION.................40 3.1. MEMBRANE MORPHOLOGY..................40 3.2. INTERACTION BETWEEN PAA AND EVAL IN THE BLENDED MEMBRANES .................................40 3.3. SWELLING RATIO OF THE MEMBRANE.......42 3.4. 5-FU PERMEABILITY ACROSS THE MEMBRANE...42 3.5. VIABILITY OF CACO-2 CELLS............46 4. CONCLUSION.............................47 5. REFERENCE..............................58 CHAPTER 4.................................62 ABSTRACT..................................63 1. INTRODUCTION...........................64 2. MATERIALS AND METHODS..................66 2.1. MATERIALS............................66 2.2. LIGHT DELIVERY SYSTEM................66 2.3. CELL LINES...........................66 2.4. SYNTHESIS OF THE PAMAM-SAPORIN CONJUGATES.....67 2.5. CELLULAR UPTAKE OF SAPORIN AND PAMAM-SAPORIN..67 2.6. TREATMENT WITH SAPORIN, SAPORIN CONJUGATES, PHOTODYNAMIC THERAPY (PDT), AND PCI.......68 2.7. CYTOTOXICITY ASSAY...................68 2.8. CONFOCAL MICROSCOPY..................68 3. RESULTS AND DISCUSSION.................70 3.1. CONJUGATION TO PAMAM DENDRIMER ENHANCED THE CYTOTOXICITY OF SAPORIN...................70 3.2. CELLULAR UPTAKE OF SAPORIN IS SIGNIFICANTLY IMPROVED AFTER CONJUGATION TO THE PAMAM DENDRIMER..70 3.3. CYTOTOXICITY OF SAPORIN AND PAMAM-SAPORIN CAN BE FURTHER ENHANCED BY PCI...................71 3.4. INTRACELLULAR DISTRIBUTION OF SAPORIN AND PAMAM-SAPORIN AFTER PCI.........................72 4. CONCLUSION.............................76 5. REFERENCE..............................82 CHAPTER 5................................ 89 ABSTRACT..................................90 1. INTRODUCTION...........................91 2. MATERIALS AND METHODS..................93 2.1. MATERIALS............................93 2.2. LIGHT DELIVERY SYSTEM................93 2.3. SYNTHESIS OF THE PAMAM-DOX CONJUGATES....93 2.4. CELL LINES AND CULTURE CONDITIONS....94 2.5. CELL VIABILITY ASSAY.................94 2.6. CYTOTOXICITY OF DOX, PAMAM-DOX CONJUGATES, PHOTODYNAMIC THERAPY (PDT), AND PCI.......95 2.7. CONFOCAL MICROSCOPY..................96 3. RESULTS AND DISCUSSION.................97 3.1. CYTOTOXICITY OF FREE DOX, PAMAM-AMIDE-DOX, AND PAMAM-HYD-DOX...................................97 3.2. EFFECTS OF PCI ON THE CYTOTOXICITY OF FREE DOX, PAMAM-AMIDE-DOX, AND PAMAM-HYD-DOX..............97 3.3. INTRACELLULAR DISTRIBUTION OF FREE DOX AND PAMAM-DOX CONJUGATES................................98 3.4. INTRACELLULAR DISTRIBUTION OF FREE DOX AND PAMAM-DOX CONJUGATES IN CELLS TREATED WITH ‘LIGHT AFTER’ PCI...99 3.5. INTRACELLULAR DISTRIBUTION OF FREE DOX AND PAMAM-DOX CONJUGATES IN CELLS TREATED WITH ‘LIGHT BEFORE’ PCI..99 4. CONCLUSION............................103 5. REFERENCE.............................112 CHAPTER 6 CONCLUSION...............................118 CHAPTER 7 FUTURE WORK..............................119 | |
| dc.language.iso | en | |
| dc.subject | 大腸藥物傳輸 | zh_TW |
| dc.subject | 光化學內化 | zh_TW |
| dc.subject | 樹枝狀高分子 | zh_TW |
| dc.subject | 酸鹼敏感性 | zh_TW |
| dc.subject | 高分子薄膜 | zh_TW |
| dc.subject | dendrimer | en |
| dc.subject | photochemical internalization | en |
| dc.subject | Colonic drug delivery | en |
| dc.subject | polymeric membrane | en |
| dc.subject | pH-sensitive | en |
| dc.title | 高分子薄膜及奈米粒子於藥物傳輸之應用 | zh_TW |
| dc.title | Application of polymeric membranes and nanoparticles on drug delivery | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.coadvisor | 謝銘鈞 | |
| dc.contributor.oralexamcommittee | 王盈錦,蔡新,謝松蒼,楊台鴻 | |
| dc.subject.keyword | 大腸藥物傳輸,高分子薄膜,酸鹼敏感性,樹枝狀高分子,光化學內化, | zh_TW |
| dc.subject.keyword | Colonic drug delivery,polymeric membrane,pH-sensitive,dendrimer,photochemical internalization, | en |
| dc.relation.page | 119 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2006-01-17 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| Appears in Collections: | 醫學工程學研究所 | |
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