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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 謝學真 | |
| dc.contributor.author | Chen-Hsuan Hsieh | en |
| dc.contributor.author | 謝承軒 | zh_TW |
| dc.date.accessioned | 2021-06-13T04:48:03Z | - |
| dc.date.available | 2011-07-18 | |
| dc.date.copyright | 2006-07-18 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-07-17 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33572 | - |
| dc.description.abstract | 幾丁聚醣（chitosan）為幾丁質（chitin）去乙醯化後之天然多醣類高分子，具有無毒、抗菌、生物可降解及生物相容性。以幾丁聚醣所製備的顆粒也因此常被運用於生醫及藥學領域中。本研究將乳化法與冷凍凝膠法（emulsification/freeze-gelation method）結合，用於製備具多孔性質且無顆粒間凝聚現象之幾丁聚醣微粒。
在此乳化/冷凍凝膠製程中發現1.5％的Tween 80適合在低溫環境下作為界面活性劑以形成有機相與水相的乳化液。當乳化液旋轉攪拌流態穩定時，幾丁聚醣微粒會隨著轉速的提升使得粒徑減小且集中。以此新製程大量製備微粒後，微粒依舊十分穩定，顆粒間並無聚集現象的產生。以轉速300 rpm欲大量製備粒徑約集中在200μm之微粒用於微載體，經過50-80 mesh篩網濕篩後，仍具有45.3％的回收率，而粒徑則分布在198-288μm間。由SEM及冷凍切片的結果看來，所製備之幾丁聚醣微粒確實具有中空結構且表面亦具多孔性，也因有此特徵，當其水分飽和時，微粒的吸水能力約為本身質量之32倍，而體積膨潤度為356.3％，均遠較其他方法製程之微粒為高。將此微粒應用在以BSA為模式之蛋白質控制釋放上可發現微粒的大小明顯影響蛋白質之吸收率以及釋放速率。除此之外，將幾丁聚醣添加葡萄糖酸改質亦可成功以此新製程製備微粒。 本研究成功研發以乳化/冷凍凝膠法製備幾丁聚醣微粒之技術，此新製程的特色在於能製備表面具多孔性、內部具中空孔洞結構且具良好吸水能力之微粒，未來在微載體、藥物控制釋放或是吸水材料之應用上頗具進一步發展的潛力。 | zh_TW |
| dc.description.abstract | Chitosan, a natural carbohydrate biopolymer derived by deacetylation of chitin, is non-toxic, antiseptic, biodegradable and biocompatible. Chitosan microparticles have been used in various biomedical and pharmaceutical fields. In this study, porous chitosan microparticles without aggregation were prepared by a emulsification/freeze-gelation method.
In this method, Tween80 1.5% was found to be a suitable surfactant under low-temperature to form a emulsion made by organic phase and water phase. When the flow pattern of the rotating emulsion was steady, the size of the microparticles became smaller as the rotational speed increased. The use of this method for preparing the microparticles in large quantities was feasible, and no aggregation phenomenon was seen. The prepared microparticles had uniform size distribution (198-288 μm) and high mass recovery (45.3 %) after being sieved by a 50-80 mesh screen under wet condition. Results of SEM and cryosection micrographs demonostrated that the prepared particles had hollow structure and porous surface. Because of these characteristics, the water uptake capability of the particles was about 32 times of their mass and the swelling ratio was about 356.3%, much higher than the results reported in the past. The application of the particles in BSA release revealed that size of chitosan microparticles obviously influenced the protein absorption ratio and the rate of release. In addition, sugar-modified chitosan microparticles could be also prepared by this novel method. In this study, chitosan microparticles ware successfully prepared by this emulsification/freeze-gelation method. The prepared microparticles had porous surface, hollow structure and excellent water aborbability. These microparticles have application potential in microcarriers, drug controlled release or water-absorption materials. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T04:48:03Z (GMT). No. of bitstreams: 1 ntu-95-R93524036-1.pdf: 6023573 bytes, checksum: 480e5cf4a6faf27a21491c88af14a7a0 (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 致謝 I
中文摘要 III 英文摘要 V 目錄 VII 圖目錄 X 表目錄 XIII 縮寫與符號說明 XV 中英名詞對照 XVII 第一章 序論 1 1.1 研究背景 1 1.2 研究構想 3 第二章 文獻回顧 7 2.1 幾丁聚醣 7 2.1.1 幾丁聚醣的結構與性質 7 2.1.2 幾丁聚醣的應用 9 2.1.2.1 醫藥用品方面 9 2.1.2.2 美容、健康食品及其他方面 10 2.2 微粒的製備與應用 11 2.2.1 乳化法及衍生之改良製備方法 11 2.2.1.1 乳化之介紹 11 2.2.1.2 界面活性劑之分類 11 2.2.1.3 乳化液之穩定 15 2.2.1.4 乳化法及其衍生改良法之介紹 16 2.2.2 噴霧法、超音波霧化法、凝聚法及其他方法 22 2.2.3 微粒的應用 26 2.2.3.1 藥物控制釋放 26 2.2.3.2 基因治療 28 2.2.3.3 微載體 29 2.3 固定幾丁聚醣及多孔性基材之製備 30 2.3.1 相分離法 30 2.3.2 冷凍凝膠法 31 2.4 影響乳化法製成之幾丁聚醣顆粒型態的因素 32 2.4.1 相的體積比與界面活性劑的量 32 2.4.2 幾丁聚醣的濃度、分子量的影響 33 2.4.3 轉速的影響 33 2.4.4 其他因素的影響 33 第三章 實驗藥品、儀器與方法 37 3.1 實驗藥品 37 3.1.1 幾丁聚醣微粒製備藥品 37 3.1.2 幾丁聚醣微粒之控制釋放及改質 38 3.2 實驗儀器 39 3.2.1 一般儀器 39 3.2.2 幾丁聚醣微粒製備 39 3.2.3 幾丁聚醣微粒性質測試 40 3.2.4 幾丁聚醣微粒之大量製備、控制釋放及改質 41 3.3 實驗方法 42 3.3.1 乳化/冷凍凝膠法之裝置設備 42 3.3.2 幾丁聚醣微粒之製備條件分析 44 3.3.2.1 界面活性劑種類及用量之影響 44 3.3.2.2 乳化攪拌轉速之影響 45 3.3.3 幾丁聚醣微粒之應用 46 3.3.3.1 微粒大量製備之製程 46 3.3.3.2 幾丁聚醣微粒之控制釋放 46 3.3.3.3 幾丁聚醣微粒之改質 47 3.3.4 幾丁聚醣微粒之性質測試 48 3.3.4.1 幾丁聚醣微粒之型態、粒徑大小及分佈 48 3.3.4.2 幾丁聚醣微粒之Zeta電位 48 3.3.4.3 幾丁聚醣微粒之穩定性(stability) 49 3.3.4.4 幾丁聚醣微粒之SEM結構觀察 49 3.3.4.5 幾丁聚醣微粒之冷凍切片結構觀察 49 3.3.4.6 特定大小之幾丁聚醣比率 50 3.3.4.7 幾丁聚醣微粒之體積膨潤度 50 3.3.4.8 幾丁聚醣微粒之重量膨潤度(吸水能力) 51 3.3.4.9 幾丁聚醣微粒之BSA包覆率及釋放測試 52 3.3.4.10 傅立葉轉換紅外線光譜（FTIR）測定 52 第四章 結果與討論 55 4.1 乳化/冷凍凝膠法的裝置及操作探討 55 4.2 界面活性劑種類及添加量對微粒的影響 60 4.2.1 添加Tween20 60 4.2.1 添加Tween80 63 4.2.3 添加Span80 66 4.3 攪拌轉速對幾丁聚醣微粒的影響 71 4.4 幾丁聚醣微粒大量製備之探討 75 4.4.1 特定大小幾丁聚醣微粒之比率 75 4.4.2 幾丁聚醣微粒之粒徑分析、穩定性及Zeta電位 75 4.4.3 幾丁聚醣微粒之SEM及冷凍切片觀察 76 4.4.4 幾丁聚醣微粒之吸水能力及體積膨潤度 78 4.5 幾丁聚醣微粒之控制釋放應用 87 4.6 幾丁聚醣微粒之改質 89 第五章 結論與未來方向 93 5.1 結論 93 5.2 未來方向 95 參考文獻 97 | |
| dc.language.iso | zh-TW | |
| dc.title | 以乳化/冷凍凝膠法製備幾丁聚醣微粒及其特性分析與應用 | zh_TW |
| dc.title | Characterization and Application of Chitosan Microparticles Prepared by Emulsification/Freeze-gelation Method | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 王大銘,何明樺 | |
| dc.subject.keyword | 幾丁聚醣,微粒,乳化/冷凍凝膠法,冷凍凝膠法,乳化法, | zh_TW |
| dc.subject.keyword | chitosan,microparticles,emulsification/freeze-gelation method,freeze-gelaiton,emulsification,emulsion, | en |
| dc.relation.page | 102 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2006-07-17 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
| 顯示於系所單位： | 化學工程學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-95-1.pdf 目前未授權公開取用 | 5.88 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。