請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33446
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝松蒼 | |
dc.contributor.author | Po-Ching Huang | en |
dc.contributor.author | 黃博靖 | zh_TW |
dc.date.accessioned | 2021-06-13T04:40:58Z | - |
dc.date.available | 2007-08-03 | |
dc.date.copyright | 2006-08-03 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-19 | |
dc.identifier.citation | Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M. 1996. Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16(2):287-295.
Angelov DN, Skouras E, Guntinas-Lichius O, Streppel M, Popratiloff A, Walther M, Klein J, Stennert E, Neiss WF. 1999. Contralateral trigeminal nerve lesion reduces polyneuronal muscle innervation after facial nerve repair in rats. Eur J Neurosci 11(4):1369-1378. Asawa T, Shindo M, Momoi H. 2004. Compound muscle action potentials during repetitive nerve stimulation. Muscle Nerve 29(5):724-728. Astrow SH, Pitaevski V, Herrera AA. 1996. Precision of reinnervation and synaptic remodeling observed in neuromuscular junctions of living frogs. J Neurosci 16(16):5130-5140. Becker E, Soler RM, Yuste VJ, Gine E, Sanz-Rodriguez C, Egea J, Martin-Zanca D, Comella JX. 1998. Development of survival responsiveness to brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5, but not to nerve growth factor, in cultured motoneurons from chick embryo spinal cord. J Neurosci 18(19):7903-7911. Bennett GJ, Xie YK. 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33(1):87-107. Bridge PM, Ball DJ, Mackinnon SE, Nakao Y, Brandt K, Hunter DA, Hertl C. 1994. Nerve crush injuries--a model for axonotmesis. Exp Neurol 127(2):284-290. Bromberg MB, Spiegelberg T. 1997. The influence of active electrode placement on CMAP amplitude. Electroencephalogr Clin Neurophysiol 105(5):385-389. Cai F, Tomlinson DR, Fernyhough P. 1998. Effect of sciatic nerve crush on local and target tissue production of neurotrophin-3 transcripts in rats. Neurosci Lett 252(1):45-48. Chiang HY, Chen CT, Chien HF, Hsieh ST. 2005a. Skin denervation, neuropathology, and neuropathic pain in a laser-induced focal neuropathy. Neurobiol Dis 18(1):40-53. Chiang HY, Chien HF, Shen HH, Yang JD, Chen YH, Chen JH, Hsieh ST. 2005b. Reinnervation of muscular targets by nerve regeneration through guidance conduits. J Neuropathol Exp Neurol 64(7):576-587. Chiang MC, Lin YH, Pan CL, Tseng TJ, Lin WM, Hsieh ST. 2002. Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy. Neurology 59(7):1094-1098. Chien HF, Tseng TJ, Lin WM, Yang CC, Chang YC, Chen RC, Hsieh ST. 2001. Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Acta Neuropathol (Berl) 102(5):455-461. De Koning P, Brakkee JH, Gispen WH. 1986. Methods for producing a reproducible crush in the sciatic and tibial nerve of the rat and rapid and precise testing of return of sensory function. Beneficial effects of melanocortins. J Neurol Sci 74(2-3):237-246. de Medinaceli L, Freed WJ, Wyatt RJ. 1982. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77(3):634-643. Decosterd I, Woolf CJ. 2000. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87(2):149-158. Diamond J, Holmes M, Coughlin M. 1992. Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat. J Neurosci 12(4):1454-1466. Dijkstra JR, Meek MF, Robinson PH, Gramsbergen A. 2000. Methods to evaluate functional nerve recovery in adult rats: walking track analysis, video analysis and the withdrawal reflex. J Neurosci Methods 96(2):89-96. Dohm S, Streppel M, Guntinas-Lichius O, Pesheva P, Probstmeier R, Walther M, Neiss WF, Stennert E, Angelov DN. 2000. Local application of extracellular matrix proteins fails to reduce the number of axonal branches after varying reconstructive surgery on rat facial nerve. Restor Neurol Neurosci 16(2):117-126. Dorfman LJ. 1984. The distribution of conduction velocities (DCV) in peripheral nerves: a review. Muscle Nerve 7(1):2-11. Ernfors P, Lee KF, Kucera J, Jaenisch R. 1994. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77(4):503-512. Evans DH, Murray JG. 1956. A study of regeneration in a motor nerve with a unimodal fiber diameter distribution. Anat Rec 126(3):311-333. Forman DS, Berenberg RA. 1978. Regeneration of motor axons in the rat sciatic nerve studied by labeling with axonally transported radioactive proteins. Brain Res 156(2):213-225. Forman DS, Wood DK, DeSilva S. 1979. Rate of regeneration of sensory axons in transected rat sciatic nerve repaired with epineurial sutures. J Neurol Sci 44(1):55-59. Franssen H, Wieneke GH. 1994. Nerve conduction and temperature: necessary warming time. Muscle Nerve 17(3):336-344. Goedert M, Otten U, Hunt SP, Bond A, Chapman D, Schlumpf M, Lichtensteiger W. 1984. Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia. Proc Natl Acad Sci U S A 81(5):1580-1584. Henderson CE, Camu W, Mettling C, Gouin A, Poulsen K, Karihaloo M, Rullamas J, Evans T, McMahon SB, Armanini MP, et al. 1993. Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363(6426):266-270. Hirata K, Kawabuchi M. 2002. Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration. Microsc Res Tech 57(6):541-547. Hsieh ST, Chiang HY, Lin WM. 2000. Pathology of nerve terminal degeneration in the skin. J Neuropathol Exp Neurol 59(4):297-307. Hsieh ST, Choi S, Lin WM, Chang YC, McArthur JC, Griffin JW. 1996. Epidermal denervation and its effects on keratinocytes and Langerhans cells. J Neurocytol 25(9):513-524. Hu D, Hu R, Berde CB. 1997. Neurologic evaluation of infant and adult rats before and after sciatic nerve blockade. Anesthesiology 86(4):957-965. Kawabuchi M, Zhou CJ, Wang S, Nakamura K, Liu WT, Hirata K. 2001. The spatiotemporal relationship among Schwann cells, axons and postsynaptic acetylcholine receptor regions during muscle reinnervation in aged rats. Anat Rec 264(2):183-202. Ko MH, Chen WP, Hsieh ST. 2002. Neuropathology of skin denervation in acrylamide-induced neuropathy. Neurobiol Dis 11(1):155-165. Ko MH, Chen WP, Lin-Shiau SY, Hsieh ST. 1999. Age-dependent acrylamide neurotoxicity in mice: morphology, physiology, and function. Exp Neurol 158(1):37-46. Kobayashi H, Hasegawa K, Tanaka M, Kikuno M. 1978. Changes in cholinesterase activity of muscle after crushing the sciatic nerve of rats. Experientia 34(6):750-751. Koirala S, Qiang H, Ko CP. 2000. Reciprocal interactions between perisynaptic Schwann cells and regenerating nerve terminals at the frog neuromuscular junction. J Neurobiol 44(3):343-360. Krarup C. 2004. Compound sensory action potential in normal and pathological human nerves. Muscle Nerve 29(4):465-483. Lago N, Navarro X. 2006. Correlation between target reinnervation and distribution of motor axons in the injured rat sciatic nerve. J Neurotrauma 23(2):227-240. Lancelotta MP, Sheth RN, Meyer RA, Belzberg AJ, Griffin JW, Campbell JN. 2003. Severity and duration of hyperalgesia in rat varies with type of nerve lesion. Neurosurgery 53(5):1200-1208; discussion 1208-1209. Lin WM, Hsieh ST, Huang IT, Griffin JW, Chen WP. 1997. Ultrastructural localization and regulation of protein gene product 9.5. Neuroreport 8(14):2999-3004. Liou JC, Fu WM. 1997. Regulation of quantal secretion from developing motoneurons by postsynaptic activity-dependent release of NT-3. J Neurosci 17(7):2459-2468. Lozeron P, Krarup C, Schmalbruch H. 2004. Regeneration of unmyelinated and myelinated sensory nerve fibres studied by a retrograde tracer method. J Neurosci Methods 138(1-2):225-232. Marshall LM, Sanes JR, McMahan UJ. 1977. Reinnervation of original synaptic sites on muscle fiber basement membrane after disruption of the muscle cells. Proc Natl Acad Sci U S A 74(7):3073-3077. McQuarrie IG, Grafstein B, Gershon MD. 1977. Axonal regeneration in the rat sciatic nerve: effect of a conditioning lesion and of dbcAMP. Brain Res 132(3):443-453. Mearow KM, Kril Y, Diamond J. 1993. Increased NGF mRNA expression in denervated rat skin. Neuroreport 4(4):351-354. Mitsui Y, Schmelzer JD, Zollman PJ, Kihara M, Low PA. 1999. Hypothermic neuroprotection of peripheral nerve of rats from ischaemia-reperfusion injury. Brain 122 ( Pt 1):161-169. Notermans NC, Franssen H, Wieneke GH, Wokke JH. 1994. Temperature dependence of nerve conduction and EMG in neuropathy associated with gammopathy. Muscle Nerve 17(5):516-522. O'Brien RA. 1978. Axonal transport of acetylcholine, choline acetyltransferase and cholinesterase in regenerating peripheral nerve. J Physiol 282:91-103. O'Malley JP, Waran MT, Balice-Gordon RJ. 1999. In vivo observations of terminal Schwann cells at normal, denervated, and reinnervated mouse neuromuscular junctions. J Neurobiol 38(2):270-286. Podhajsky RJ, Myers RR. 1995. A diffusion-reaction model of nerve regeneration. J Neurosci Methods 60(1):79-88. Robbins N, Polak J. 1988. Filopodia, lamellipodia and retractions at mouse neuromuscular junctions. J Neurocytol 17(4):545-561. Rochon D, Rousse I, Robitaille R. 2001. Synapse-glia interactions at the mammalian neuromuscular junction. J Neurosci 21(11):3819-3829. Rutkove SB. 2000. Pseudofacilitation: A temperature-sensitive phenomenon. Muscle Nerve 23(1):115-118. Sanes JR. 2003. The basement membrane/basal lamina of skeletal muscle. J Biol Chem 278(15):12601-12604. Seltzer Z, Dubner R, Shir Y. 1990. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43(2):205-218. Sjoberg J, Kanje M. 1990. The initial period of peripheral nerve regeneration and the importance of the local environment for the conditioning lesion effect. Brain Res 529(1-2):79-84. Sjoberg J, Kanje M, Edstrom A. 1988. Influence of non-neuronal cells on regeneration of the rat sciatic nerve. Brain Res 453(1-2):221-226. Stoll G, Muller HW. 1999. Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathol 9(2):313-325. Tjon ATAM, Lemkes HH, van der Kamp-Huyts AJ, van Dijk JG. 1996. Large electrodes improve nerve conduction repeatability in controls as well as in patients with diabetic neuropathy. Muscle Nerve 19(6):689-695. Toft PB, Fugleholm K, Schmalbruch H. 1988. Axonal branching following crush lesions of peripheral nerves of rat. Muscle Nerve 11(8):880-889. Valero-Cabre A, Navarro X. 2001. H reflex restitution and facilitation after different types of peripheral nerve injury and repair. Brain Res 919(2):302-312. Valero-Cabre A, Tsironis K, Skouras E, Navarro X, Neiss WF. 2004. Peripheral and spinal motor reorganization after nerve injury and repair. J Neurotrauma 21(1):95-108. Valero-Cabre A, Tsironis K, Skouras E, Perego G, Navarro X, Neiss WF. 2001. Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair. J Neurosci Res 63(2):214-223. van Dijk JG, van Benten I, Kramer CG, Stegeman DF. 1999. CMAP amplitude cartography of muscles innervated by the median, ulnar, peroneal, and tibial nerves. Muscle Nerve 22(3):378-389. van Dijk JG, van der Kamp W, van Hilten BJ, van Someren P. 1994. Influence of recording site on CMAP amplitude on its variation over a length of nerve. Muscle Nerve 17(11):1286-1292. Varejao ASP, Cabrita AM, Meek MF, Bulas-Cruz J, Melo-Pinto P, Raimondo S, Geuna S, Giacobini-Robecchi MG. 2004. Functional and Morphological Assessment of a Standardized Rat Sciatic Nerve Crush Injury with a Non-Serrated Clamp. J Neurotrauma 21(11):1652-1670. Verdu E, Navarro X. 1997. Comparison of immunohistochemical and functional reinnervation of skin and muscle after peripheral nerve injury. Exp Neurol 146(1):187-198. Vogelaar CF, Vrinten DH, Hoekman MF, Brakkee JH, Burbach JP, Hamers FP. 2004. Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome. Brain Res 1027(1-2):67-72. Wall PD, Devor M, Inbal R, Scadding JW, Schonfeld D, Seltzer Z, Tomkiewicz MM. 1979. Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain 7(2):103-111. Wang S, Kawabuchi M, Zhou CJ, Hirata K, Tan H, Kuraoka A. 2004. The spatiotemporal characterization of endplate reoccupation, with special reference to the superposition patterns of the presynaptic elements and the postsynaptic receptor regions during muscle reinnervation. J Peripher Nerv Syst 9(3):144-157. Wang T, Xie K, Lu B. 1995. Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci 15(7 Pt 1):4796-4805. Witzel C, Rohde C, Brushart TM. 2005. Pathway sampling by regenerating peripheral axons. J Comp Neurol 485(3):183-190. Wolthers M, Moldovan M, Binderup T, Schmalbruch H, Krarup C. 2005. Comparative electrophysiological, functional, and histological studies of nerve lesions in rats. Microsurgery 25(6):508-519. Wood SJ, Slater CR. 2001. Safety factor at the neuromuscular junction. Prog Neurobiol 64(4):393-429. Xie K, Wang T, Olafsson P, Mizuno K, Lu B. 1997. Activity-dependent expression of NT-3 in muscle cells in culture: implications in the development of neuromuscular junctions. J Neurosci 17(9):2947-2958. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33446 | - |
dc.description.abstract | 在研究動物體內神經再生的實驗中,有相當多不同的動物模式來觀察神經受損後的恢復情況,其目的則是欲以不同的動物模式去模擬神經受損的狀態,以觀察動物行為、細胞、甚或是分子的層級上的差異,希冀能對神經再生的機制有更進一步的了解。本實驗以夾傷的動物模式來觀察大鼠坐骨神經中運動與感覺神經的再生,時間點為手術後的12週與24週,並以手術對側為對照組。由電生理的檢查來看,運動神經的複合肌肉動作電位(CMAP, compound muscle action potential)的振幅從50.9 ± 10.4%(p<0.05)回復到78.2 ± 19.5%(p>0.05),而感覺神經動作電位(SNAP, sensory nerve action potential)則是由38.93 ± 6.5%(p<0.05)回復到85.6 ± 3.2%(p<0.05),顯示在手術後十二週到二十四週的時候運動神經與感覺神經都有繼續再生的現象,並於最後兩者有相似的再生程度。而從肌肉神經接點(NMJ, neuromuscular junction)的運動神經與乙醯膽酯酶的染色來看,肌肉中NMJ於術後十二週的神經分布已經與控制側類似;相對於此,足墊的表皮神經密度(END, epidermal nerve density)卻於術後二十四週時仍遠低於對側(1.9 ± 1.0 fibers/mm, p<0.05),這些結果顯示足墊的表皮中可能有某種抑制的分子阻擋表皮神經的再生,或是缺乏某種促進再生或引導的分子,導致皮膚感覺神經的效率比運動神經末稍差。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-13T04:40:58Z (GMT). No. of bitstreams: 1 ntu-95-R93446002-1.pdf: 1431877 bytes, checksum: 4611d483531c0d9f78af5e00ab174578 (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 一、摘要………………………………………………1
二、引言………………………………………………2 三、材料與方法………………………………………8 四、結果………………………………………………18 五、討論………………………………………………25 六、圖表與說明………………………………………34 七、參考資料…………………………………………56 | |
dc.language.iso | zh-TW | |
dc.title | 周邊神經損傷後,肌肉與皮膚神經再支配之比較 | zh_TW |
dc.title | Comparison of muscular and cutaneous reinnervation after nerve injury | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 閔明源,陳志成 | |
dc.subject.keyword | 坐骨神經,夾傷,截斷,神經再生,CMAP,SNAP,AChE,END, | zh_TW |
dc.subject.keyword | sciatic nerve,crush,transection,nerve regeneration,CMAP,SNAP,AChE,END, | en |
dc.relation.page | 63 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-19 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 解剖學研究所 | zh_TW |
顯示於系所單位: | 解剖學暨細胞生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-95-1.pdf 目前未授權公開取用 | 1.4 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。