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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林璧鳳(Bi-Fong Lin) | |
dc.contributor.author | Wen-Yin Lo | en |
dc.contributor.author | 羅文音 | zh_TW |
dc.date.accessioned | 2021-06-13T04:23:01Z | - |
dc.date.available | 2010-08-27 | |
dc.date.copyright | 2006-07-28 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-23 | |
dc.identifier.citation | 「保健食品」跨部會整合推動委員會 (2005)。93年度「保健食品研究開發」計畫第二次進度報告,190-197。
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33045 | - |
dc.description.abstract | 本研究主要探討山藥對發炎相關疾病的影響,首先以細胞培養探討台農二號山藥 ( Dioscorea alata L. cv. Tainung No.2 ) 乙酸乙酯 ( EA ) 萃取物對巨噬細胞株RAW 264.7及小鼠初代細胞免疫調的作用。發現山藥EA萃物能顯著降低巨噬細胞及小鼠初代腹腔細胞IL-6的分泌,也顯著降低小鼠初代脾臟細胞IFN-、IL-4及IL-10的分泌。在體外試驗初步觀察到山藥EA萃物具有抗發炎的潛力及調節免疫反應的效果。接著分別探討攝食熟山藥粉及山藥EA萃物對致敏小鼠過敏性氣喘的影響。BALB/c小鼠7周大時,以卵蛋白 ( ovalbumin, OVA ) 伴隨氫氧化鋁為佐劑隔週腹腔致敏以誘發其過敏體質,三次致敏之後,以OVA特異性抗體IgE含量將小鼠分為四組,分別為餵食AIN-76飼料的控制組、AIN-76飼料含0.9% 熟台農二號熟山藥粉的DA-cook組,每天管餵100 g或200 g台農二號山藥乙酸乙酯萃物的DAEA-1X組及DAEA-2X組。餵食期間以OVA做二次吸入性致敏,餵食10天後,以methacholine (Mch) 刺激小鼠進行呼吸道阻力 (AHR) 測試,結果發現,DAEA-2X組、DA-cook組及DAEA-1X組分別在25 mg/mL及50 mg/mL Mch刺激下,呼吸阻力係數PEnh值顯著低於控制組。餵食達15天後犧牲小鼠,採集血液、肺氣管沖洗液與培養脾臟及腹腔細胞。結果顯示, DA-cook組、DAEA-1X組、DAEA-2X組的脾臟細胞在OVA刺激之下,其Th2細胞激素IL-4與IL-5分泌量顯著低於控制組,腹腔細胞分泌的IL-6則有降低的趨勢。並且,肺氣管沖洗液中總細胞數目、嗜伊紅白血球及嗜中性白血球的比例、Th2 細胞激素IL-4、IL-5,IL-10,IL-13與促發炎細胞激素IL-6,PGE2含量,皆明顯低於控制組。此外,血清中總IgE生成量也顯著低於控制組。由以上結果可知,台農二號山藥能夠降低過敏小鼠Th2細胞激素的分泌、減少過敏性抗體IgE的生成、並降低促發炎介質的分泌,因此有助於減緩過敏性氣喘的症狀,深具開發的潛力。 | zh_TW |
dc.description.abstract | The purpose of this study is to evaluate whether the yam may possess an immunomodulation effect. First, the effect of ethyl acetate extract of Taiwanese Yam ( Dioscorea alata L. cv. Tainung No.2 ) ( DAEA ) on in vitro cytokines secretions by RAW 264.7 cell and primary macrophages and splenocytes from BALB/c mice was investigated. The results showed that 50 g/mL and 40 g/mL DAEA significantly inhibited IL-6 secretion in LPS-stimulated RAW264.7 and primary macrophages. ConA-stimulated IFN-, IL-4, IL-10 secretions under DAEA treatment also significantly reduced. Therefore, yam may have an anti-inflammatory and immunoregulatory effect.
Based on the results from cell culture experiments, we further used an in vivo OVA-sensitized mouse model to evaluate the effect of yam on allergic asthma. Female BALB/c mice were first sensitized with ovalbumin (OVA) in Al(OH)3 adjuvant intraperitoneally. After three times of sensitization, mice were divided into four groups by OVA-IgE titers. Four groups of mice were either fed an AIN-76 diet ( control ), AIN-76 diet containing 0.9% cooked yam ( DA-cook ), tube-feeding of 100 ( DAEA-1X ) or 200 g ( DAEA-2X ) EA extracts of yam per day. During the feeding period, mice were challenged with OVA aerosol twice to induce bronchoconstriction. The results showed that DA-cook, DAEA-1X and DAEA-2X groups significantly attenuated methacholine-induced airway hyperresponsiveness. After feeding for fifteen days, mice were sacrificed for further analysis. Compared to the control group, the DA-cook, DAEA-1X and DAEA-2X groups inhibited Th2 cytokines such as IL-4, IL-5, IL-10 secretions by splenocytes and suppressed the IgE productions in serum. The count of total cells and the distribution of eosinoiphil and neutrophil in bronchoalveolar fluid (BALF) were decreased in the DA-cook, DAEA-1X and DAEA-2X groups. The Th2 cytokines and inflammatory indicators of BALF such as IL-4, IL-5, IL-6, IL10, IL-13, PGE2 were all lessened by yam-feeding groups. In conclusion, these results suggest yam extract could alleviate allergic asthma through suppression of Th2 cytokines, pro-inflammatory mediators and serum IgE levels. Dioscorea alata L. cv. Tainung No.2 used in this study may be beneficial for patient of allergic asthma and it need to be further studied. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T04:23:01Z (GMT). No. of bitstreams: 1 ntu-95-R93b47302-1.pdf: 3173280 bytes, checksum: c78d9d11cb2f429ba99812fe5824554f (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 中文摘要……………………………………………………………………………..Ⅰ
英文摘要…………………………………………………………..…………………Ⅱ Abbreviation………………………………………………………………………....Ⅳ 第一章 序論 第一節 文獻回顧 一、過敏性氣喘 (一) 過敏反應之簡介…………………………………………………..1 (二) 氣喘疾病的定義…………………………………………………..2 (三) 過敏性氣喘的致病機轉及簡介 1. 參與過敏性氣喘之細胞……………………..………………..3 2. 過敏性氣喘中細胞激素之網絡………………………………5 二、山藥 (一) 簡介………………………………………………………………..8 (二) 山藥的生理機能…………………………………………………..9 三、中草藥在過敏疾病的研究現況………………………………………...14 第二節 研究動機與目的……………………………………………………...16 第三節 研究架構……………………………………………………………...17 第二章 以體外模式探討山藥萃物的免疫調節作用 第一節 前言…………………………………………………………………...18 第二節 材料與方法 一、山藥乙酸乙酯萃物製備……………………………………………….20 二、RAW 264.7 小鼠巨噬細胞株…………………………………………20 三、免疫初代細胞來源 (一) 腹腔細胞的取得與培養…………………………………………21 (二) 脾臟細胞之取得與培養…………………………………………22 四、細胞存活分析…………………………………………………………..23 五、細胞激素分泌量的測定………………………………………………..23 六、統計分析………………………………………………………………..25 第三節 結果 一、RAW 264.7細胞 (一) 細胞存活率………………………………………………………26 (二) 促發炎細胞激素的分泌…………………………………………26 二、初代腹腔細胞培養 (一) 細胞存活率………………………………………………………26 (二) 促發炎細胞激素的分泌…………………………………………26 三、初代脾臟細胞培養 (一) 細胞存活率………………………………………………………27 (二) 促發炎細胞激素的分泌…………………………………………27 第四節 討論 一、山藥EA萃物對免疫細胞的影響………………………………………36 二、劑量換算………………………………………………………………...37 第三章 餵食山藥對過敏性氣喘的影響 第一節 前言………………………………………………………………..….39 第二節 材料與方法 一、實驗材料置備 (一) 台農二號山藥乙酸乙酯萃取物……………………………….…41 (二) 台農二號山藥蒸熟山藥粉…………………………………….…41 二、動物實驗設計 (一) 實驗流程及分組………………………………………………….41 (二) 動物飼養…………………………………………………………43 (三) 致敏操作…………………………………………………………44 三、動物犧牲和實驗材料收集與分析 (一) 血液樣品的收集…………………………………………………45 (二) 血清特異性抗體IgE、IgG1、IgG2a 測定……………………45 (三) 呼吸道阻力測定方法……………………………………………46 (四) 動物犧牲…………………………………………………………48 (五) 肺氣管沖洗液 ( Bronchoalveolar lavage fluid, BALF ) 細胞之取得與處理……………………………………………………...48 (六) 肺沖洗液細胞表面標記分析……………………………………49 (七) 腹腔細胞的取得與培養…………………………………………50 (八) 脾臟細胞之取得與培養…………………………………………51 (九) 脾臟細胞增生測定………………………………………………51 (十) 非特異性抗體測定………………………………………………52 (十一) 細胞激素分泌量的測定………………………………………53 (十二) PGE2分析……………………………………………………..53 (十三) histamine………………………………………………………54 (十四) 脂質過氧化產物 (TBARS) 分析……………………………54 四、統計分析………………………………………………………………..55 第三節 結果 一、體重及攝食量………………………………………………………….56 二、器官相對重量………………………………………………………….56 三、OVA特異性抗體IgE、IgG1、IgG2a的比較……………………….56 四、血清中總抗體IgE、IgG、IgA、IgM的比較………………………..57 五、脾臟細胞激素………………………………………………………….57 六、腹腔細胞激素…………………………………………………………..58 七、呼吸道阻力……………………………………………………………..58 八、肺氣管沖洗液 (BALF)中白血球變化…………………………………59 九、肺氣管沖洗液中細胞表面標記………………………………………..59 十、肺氣管沖洗液 (BALF) 中各項指標變化 (一) 促發炎細胞激素…………………………………………………59 (二) Th1/Th2細胞激素……………………………………………….60 (三) 發炎介質…………………………………………………………60 十一、脾臟細胞增生能力…………………………………………………..60 十二、脂質過氧化產物測定………………………………………………..60 第四節 討論 一、過敏性氣喘動物實驗模式…………………………………………….80 二、於致敏體質下餵食山藥對小鼠全身性 ( systemic ) 免疫反應之影響 …………………………………………………………………………...82 三、於致敏體質下餵食山藥對小鼠呼吸道發炎之影響………………….82 四、於致敏體質下餵食山藥對小鼠血清中各抗體生成之影響………….84 五、於致敏體質下餵食山藥對小鼠體內抗氧化效果之影響…………….85 第四章 討論與總結 第一節 綜合討論 一、細胞模式與動物模式之一致性………………………………………86 二、動物實驗各組結果比較.............................…………………………86 三、細胞模式換算動物模式劑量之適當性………………………………87 四、具有減緩呼吸道發炎作用的中草藥及植物食材之比較……………87 五、山藥減緩過敏性氣喘之可能的途徑…………………………………88 六、雌激素與植物雌激素的作用…………………………………………89 七、山藥EA萃物減緩發炎反應之可能機制…………………………….90 第二節 總結…………………………………………………………………96 第五章 參考文獻………………………………………………………………….97 | |
dc.language.iso | zh-TW | |
dc.title | 以卵蛋白致敏小鼠模式探討攝食山藥對過敏性氣喘的影響 | zh_TW |
dc.title | The effect of yam feeding on allergic asthma in OVA-sensitized mouse model | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳文惠(Wen-Huey Wu),吳文勉(Wen-Mein Wu),江伯倫(Bor-Luen Chiang),黃青真(Ching-Jang Huang) | |
dc.subject.keyword | 山藥,氣喘,細胞激素,呼吸道發炎, | zh_TW |
dc.subject.keyword | yam,asthma,cytokine,IgE, | en |
dc.relation.page | 113 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-23 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
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