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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蔡向榮(Hsiang-Jung Tsai) | |
dc.contributor.author | Hsiao-Yun Tsai | en |
dc.contributor.author | 蔡筱芸 | zh_TW |
dc.date.accessioned | 2021-06-13T04:19:54Z | - |
dc.date.available | 2008-07-28 | |
dc.date.copyright | 2006-07-28 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-22 | |
dc.identifier.citation | 吳光華, 楊佩英, 唐家琪. 2001. 八種重要傳染病的防治. 人民軍醫出版社, 北京.
林文助, 郭振欽, 張賜海, 黃榮作, 何新奇, 黃天福, 郭白井. 1990. 台南地區野鼠密度測定及其族群變動. 行政院農委會台南區農業改良場研究彚報 25:84-90. 林鼎翔. 2001. 台灣地區漢他病毒流行病學調查. 行政院衛生署九十年度研究計畫結果報告. 金權, 林惠足. 1996. 台閩地區漢他病毒之調查研究. 行政院衛生署八十五年度研究計畫結果報告. 金權, 林進三, 連日清. 1995. 台閩地區漢他病毒之調查研究. 行政院衛生署八十四年度研究計畫結果報告. 陳彥君. 1986. 嘉義地區農地野鼠之族群動態研究. 東海大學生物學研究所碩士論文 楊宗泓. 1998. 利用基因序列比對分析台灣本土的漢他病毒. 國立台灣大學流行病學研究所碩士論文 Abbott, K. D., T. G. Ksiazek, and J. N. Mills. 1999. Long-term hantavirus persistence in rodent populations in central Arizona. Emerg Infect Dis 5:102-112. Aberle, S. W., P. Lehner, M. Ecker, J. H. Aberle, K. Arneitz, G. Khanakah, A. Radda, I. Radda, T. Popow-Kraupp, C. Kunz, and F. X. Heinz. 1999. Nephropathia epidemica and Puumala virus in Austria. Eur J Clin Microbiol Infect Dis 18:467-472. Ahlm, C., K. Wallin, A. Lundkvist, F. Elgh, P. Juto, M. Merza, and A. Tarnvik. 2000. Serologic evidence of Puumala virus infection in wild moose in northern Sweden. Am J Trop Med Hyg 62:106-111. Ahn, C., J. T. Cho, J. G. Lee, C. S. Lim, Y. Y. Kim, J. S. Han, S. Kim, and J. S. Lee. 2000. Detection of Hantaan and Seoul viruses by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP) in renal syndrome patients with hemorrhagic fever. Clin Nephrol 53:79-89. Aitichou, M., S. S. Saleh, A. K. McElroy, C. Schmaljohn, and M. S. Ibrahim. 2005. Identification of Dobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR. J Virol Methods 124:21-26. Antic, D., C. Y. Kang, K. Spik, C. Schmaljohn, O. Vapalahti, and A. Vaheri. 1992. Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses. Virus Res 24:35-46. Arthur, R. R., R. S. Lofts, J. Gomez, G. E. Glass, J. W. Leduc, and J. E. Childs. 1992. Grouping of hantaviruses by small (S) genome segment polymerase chain reaction and amplification of viral RNA from wild-caught rats. Am J Trop Med Hyg 47:210-224. Avsic-Zupanc, T., A. Toney, K. Anderson, Y. K. Chu, and C. Schmaljohn. 1995. Genetic and antigenic properties of Dobrava virus: a unique member of the Hantavirus genus, family Bunyaviridae. J Gen Virol 76 ( Pt 11):2801-2808. Baxi, M., D. McRae, S. Baxi, I. Greiser-Wilke, S. Vilcek, K. Amoako, and D. Deregt. 2006. A one-step multiplex real-time RT-PCR for detection and typing of bovine viral diarrhea viruses. Vet Microbiol. (article in press) Boone, J. D., K. C. McGwire, E. W. Otteson, R. S. DeBaca, E. A. Kuhn, and S. C. St Jeor. 2002. Infection dynamics of Sin Nombre virus after a widespread decline in host populations. Am J Trop Med Hyg 67:310-318. Boone, J. D., E. W. Otteson, K. C. McGwire, P. Villard, J. E. Rowe, and S. C. St Jeor. 1998. Ecology and demographics of hantavirus infections in rodent populations in the Walker River Basin of Nevada and California. Am J Trop Med Hyg 59:445-451. Botten, J., K. Mirowsky, D. Kusewitt, M. Bharadwaj, J. Yee, R. Ricci, R. M. Feddersen, and B. Hjelle. 2000. Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus). Proc Natl Acad Sci USA 97:10578-10583. Botten, J., K. Mirowsky, D. Kusewitt, C. Ye, K. Gottlieb, J. Prescott, and B. Hjelle. 2003. Persistent Sin Nombre virus infection in the deer mouse (Peromyscus maniculatus) model: sites of replication and strand-specific expression. J Virol 77:1540-1550. Botten, J., K. Mirowsky, C. Ye, K. Gottlieb, M. Saavedra, L. Ponce, and B. Hjelle. 2002. Shedding and intracage transmission of Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus) model. J Virol 76:7587-7594. Brummer-Korvenkontio, M., A. Vaheri, T. Hovi, C. H. von Bonsdorff, J. Vuorimies, T. Manni, K. Penttinen, N. Oker-Blom, and J. Lahdevirta. 1980. Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis 141:131-134. Bustin, S. A. 2000. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25:169-193. Calisher, C. H., J. J. Root, J. N. Mills, J. E. Rowe, S. A. Reeder, E. S. Jentes, K. Wagoner, and B. J. Beaty. 2005. Epizootiology of Sin Nombre and El Moro Canyon hantaviruses, southeastern Colorado, 1995-2000. J Wildl Dis 41:1-11. CDC. 1994. Laboratory Management of Agents Associated with Hantavirus Pulmonary Syndrome: Interim Biosafety Guidelines. Morbidity and Mortality Weekly Report 43 RR7:1-7. Chen, H. X., F. X. Qiu, B. J. Dong, S. Z. Ji, Y. T. Li, Y. Wang, H. M. Wang, G. F. Zuo, X. X. Tao, and S. Y. Gao. 1986. Epidemiological studies on hemorrhagic fever with renal syndrome in China. J Infect Dis 154:394-398. Childs, J. E., T. G. Ksiazek, C. F. Spiropoulou, J. W. Krebs, S. Morzunov, G. O. Maupin, K. L. Gage, P. E. Rollin, J. Sarisky, R. E. Enscore. 1994. Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169:1271-1280. Chin, C., T. S. Chiueh, W. C. Yang, T. H. Yang, C. M. Shih, H. T. Lin, K. C. Lin, J. C. Lien, T. F. Tsai, S. L. Ruo, S. T. Nichol, T. G. Ksiazek, P. E. Rollin, C. J. Peters, T. N. Wu, and C. Y. Shen. 2000. Hantavirus infection in Taiwan: the experience of a geographically unique area. J Med Virol 60:237-247. Chow, L., P. Y. Shu, J. H. Huang, H. C. Wang, S. F. Chang, H. Y. Lu, and T. H. Lin. 2005. A retrospective study of hantavirus infection in Kinmen, Taiwan. J Microbiol Immunol Infect 38:343-349. Compton, S. R., R. O. Jacoby, F. X. Paturzo, and A. L. Smith. 2004. Persistent Seoul virus infection in Lewis rats. Arch Virol 149:1325-1339. Cvetko, L., N. Turk, A. Markotic, Z. Milas, J. Margaletic, M. Miletic-Medved, A. Plyusnin, G. Baranton, D. Postic, and T. Avsic-Zupanc. 2006. Short report: dual infections with Puumala virus and Leptospira interrogans serovar lora in a bank vole (Clethrionomys glareolus). Am J Trop Med Hyg 74:612-614. David, M. K., and M. H. Peter. 2001. Bunyavirade. In Fields' virology. Lippincott Williams & Wilkins, Philadelphia, pp. 1581-1633. Dekonenko, A., M. S. Ibrahim, and C. S. Schmaljohn. 1997. A colorimetric PCR-enzyme immunoassay to identify hantaviruses. Clin Diagn Virol 8:113-121. Drosten, C., S. Gunther, W. Preiser, S. van der Werf, H. R. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R. A. Fouchier, A. Berger, A. M. Burguiere, J. Cinatl, M. Eickmann, N. Escriou, K. Grywna, S. Kramme, J. C. Manuguerra, S. Muller, V. Rickerts, M. Sturmer, S. Vieth, H. D. Klenk, A. D. Osterhaus, H. Schmitz, and H. W. Doerr. 2003. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348:1967-1976. Duchin, J. S., F. T. Koster, C. J. Peters, G. L. Simpson, B. Tempest, S. R. Zaki, T. G. Ksiazek, P. E. Rollin, S. Nichol, and E. T. Umland. 1994. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med 330:949-955. Elgh, F., A. Lundkvist, O. A. Alexeyev, H. Stenlund, T. Avsic-Zupanc, B. Hjelle, H. W. Lee, K. J. Smith, R. Vainionpaa, D. Wiger, G. Wadell, and P. Juto. 1997. Serological diagnosis of hantavirus infections by an enzyme-linked immunosorbent assay based on detection of immunoglobulin G and M responses to recombinant nucleocapsid proteins of five viral serotypes. J Clin Microbiol 35:1122-1130. Engelthaler, D. M., D. G. Mosley, J. E. Cheek, C. E. Levy, K. K. Komatsu, P. Ettestad, T. Davis, D. T. Tanda, L. Miller, J. W. Frampton, R. Porter, and R. T. Bryan. 1999. Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners region, United States. Emerg Infect Dis 5:87-94. Garin, D., C. Peyrefitte, J. M. Crance, A. Le Faou, A. Jouan, and M. Bouloy. 2001. Highly sensitive Taqman PCR detection of Puumala hantavirus. Microbes Infect 3:739-745. Giulietti, A., L. Overbergh, D. Valckx, B. Decallonne, R. Bouillon, and C. Mathieu. 2001. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25:386-401. Glass, G. E., J. E. Childs, G. W. Korch, and J. W. LeDuc. 1988. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect 101:459-472. Gonzalez-Scarano, F., R. S. Janssen, J. A. Najjar, N. Pobjecky, and N. Nathanson. 1985. An avirulent G1 glycoprotein variant of La Crosse bunyavirus with defective fusion function. J Virol 54:757-763. Gonzalez-Scarano, F., R. E. Shope, C. E. Calisher, and N. Nathanson. 1982. Characterization of monoclonal antibodies against the G1 and N proteins of LaCrosse and Tahyna, two California serogroup bunyaviruses. Virology 120:42-53. Groen, J., M. N. Gerding, J. G. Jordans, J. P. Clement, J. H. Nieuwenhuijs, and A. D. Osterhaus. 1995. Hantavirus infections in The Netherlands: epidemiology and disease. Epidemiol Infect 114:373-383. Groen, J., G. van der Groen, G. Hoofd, and A. Osterhaus. 1989. Comparison of immunofluorescence and enzyme-linked immunosorbent assays for the serology of Hantaan virus infections. J Virol Methods 23:195-203. Gubler, D. J., P. Reiter, K. L. Ebi, W. Yap, R. Nasci, and J. A. Patz. 2001. Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases. Environ Health Perspect 109 Suppl 2:223-233. Hart, C. A., and M. Bennett. 1999. Hantavirus infections: epidemiology and pathogenesis. Microbes and Infection 1:1299-1237. Heyman, P., R. Van Mele, F. De Jaegere, J. Klingstrom, C. Vandenvelde, A. Lundkvist, F. Rozenfeld, and M. Zizi. 2002. Distribution of hantavirus foci in Belgium. Acta Trop 84:183-188. Hinojosa, P. M., C. E. Villagra, R. J. Mora, and L. Maier. 2006. [Identification of infectious agents in cases suspicious of Hantavirus infection but with negative serology.]. Rev Med Chil 134:332-338. Hinson, E. R., M. F. Hannah, D. E. Norris, G. E. Glass, and S. L. Klein. 2006. Social status does not predict responses to Seoul virus infection or reproductive success among male Norway rats. Brain Behav Immun 20:182-190. Hinson, E. R., S. M. Shone, M. C. Zink, G. E. Glass, and S. L. Klein. 2004. Wounding: the primary mode of Seoul virus transmission among male Norway rats. Am J Trop Med Hyg 70:310-317. Howard, C. 2005. Viral Haemorrhagic Fever. ELSEVIER, San Diego. Huang, C., W. P. Campbell, R. Means, and D. M. Ackman. 1996. Hantavirus S RNA sequence from a fatal case of HPS in New York. J Med Virol 50:5-8. Ishii, S. 1942. Study on song-go fever. Jpn Army Med J 355:1755-1758 Kanerva, M., J. Mustonen, and A. Vaheri. 1998. Pathogenesis of puumala and other hantavirus infections. Rev Med Virol 8:67-86. Kariwa, H., M. Fujiki, K. Yoshimatsu, J. Arikawa, I. Takashima, and N. Hashimoto. 1998. Urine-associated horizontal transmission of Seoul virus among rats. Arch Virol 143:365-374. Kariwa, H., M. Kimura, S. Yoshizumi, J. Arikawa, K. Yoshimatsu, I. Takashima, and N. Hashimoto. 1996. Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats. Arch Virol 141:2327-2338. Kawamura, K., X. K. Zhang, J. Arikawa, I. Takashima, K. Dempo, and N. Hashimoto. 1991. Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses. Acta Virol 35:54-63. Kim, E. C., I. S. Kim, Y. Choi, S. G. Kim, and J. S. Lee. 1994. Rapid differentiation between Hantaan and Seoul viruses by polymerase chain reaction and restriction enzyme analysis. J Med Virol 43:245-248. Kingsford, L., L. D. Ishizawa, and D. W. Hill. 1983. Biological activities of monoclonal antibodies reactive with antigenic sites mapped on the G1 glycoprotein of La Crosse virus. Virology 129:443-455. Kitamura, T., C. Morita, T. Komatsu, K. Sugiyama, J. Arikawa, S. Shiga, H. Takeda, Y. Akao, K. Imaizumi, A. Oya, N. Hashimoto, and S. Urasawa. 1983. Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jpn J Med Sci Biol 36:17-25. Klein, S. L. 2000. The effects of hormones on sex differences in infection: from genes to behavior. Neurosci Biobehav Rev 24:627-638. Klein, S. L., B. H. Bird, and G. E. Glass. 2000. Sex differences in Seoul virus infection are not related to adult sex steroid concentrations in Norway rats. J Virol 74:8213-8217. _____. 2001. Sex differences in immune responses and viral shedding following Seoul virus infection in Norway rats. Am J Trop Med Hyg 65:57-63. Klein, S. L., A. L. Marson, A. L. Scott, G. Ketner, and G. E. Glass. 2002. Neonatal sex steroids affect responses to Seoul virus infection in male but not female Norway rats. Brain Behav Immun 16:736-746. Klempa, B., E. Fichet-Calvet, E. Lecompte, B. Auste, V. Aniskin, H. Meisel, C. Denys, L. Koivogui, J. ter Meulen, and D. H. Kruger. 2006. Hantavirus in African wood mouse, Guinea. Emerg Infect Dis 12:838-840. Klingstrom, J., K. I. Falk, and A. Lundkvist. 2005. Delayed viremia and antibody responses in Puumala hantavirus challenged passively immunized cynomolgus macaques. Arch Virol 150:79-92. Klingstrom, J., P. Heyman, S. Escutenaire, K. B. Sjolander, F. De Jaegere, H. Henttonen, and A. Lundkvist. 2002a. Rodent host specificity of European hantaviruses: evidence of Puumala virus interspecific spillover. J Med Virol 68:581-588. Klingstrom, J., A. Plyusnin, A. Vaheri, and A. Lundkvist. 2002b. Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques. J Virol 76:444-449. Korch, G. W., J. E. Childs, G. E. Glass, C. A. Rossi, and J. W. LeDuc. 1989. Serologic evidence of hantaviral infections within small mammal communities of Baltimore, Maryland: spatial and temporal patterns and host range. Am J Trop Med Hyg 41:230-240. Ksiazek, T. G., C. J. Peters, P. E. Rollin, S. Zaki, S. Nichol, C. Spiropoulou, S. Morzunov, H. Feldmann, A. Sanchez, A. S. Khan. 1995. Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 52:117-123. Kuenzi, A. J., R. J. Douglass, C. W. Bond, C. H. Calisher, and J. N. Mills. 2005. Long-term dynamics of Sin Nombre viral RNA and antibody in deer mice in Montana. J Wildl Dis 41:473-481. Kutyavin, I. V., I. A. Afonina, A. Mills, V. V. Gorn, E. A. Lukhtanov, E. S. Belousov, M. J. Singer, D. K. Walburger, S. G. Lokhov, A. A. Gall, R. Dempcy, M. W. Reed, R. B. Meyer, and J. Hedgpeth. 2000. 3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures. Nucleic Acids Res 28:655-661. Lanciotti, R. S., and A. J. Kerst. 2001. Nucleic acid sequence-based amplification assays for rapid detection of West Nile and St. Louis encephalitis viruses. J Clin Microbiol 39:4506-4513. Lednicky, J. A. 2003. Hantaviruses. a short review. Arch Pathol Lab Med 127:30-35. Lee, C. W., and D. L. Suarez. 2004. Application of real-time RT-PCR for the quantitation and competitive replication study of H5 and H7 subtype avian influenza virus. J Virol Methods 119:151-158. Lee, H. W., L. J. Baek, and K. M. Johnson. 1982. Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J Infect Dis 146:638-644. Lee, H. W., P. W. Lee, L. J. Baek, C. K. Song, and I. W. Seong. 1981a. Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg 30:1106-1112. Lee, H. W., P. W. Lee, and K. M. Johnson. 1978. Isolation of the etiologic agent of Korean Hemorrhagic fever. J Infect Dis 137:298-308. Lee, M., B. K. Kim, S. Kim, S. Park, J. S. Han, S. T. Kim, and J. S. Lee. 1989. Coagulopathy in hemorrhagic fever with renal syndrome (Korean hemorrhagic fever). Rev Infect Dis 11 Suppl 4:S877-883. Lee, P. W., H. L. Amyx, C. J. Gibbs, Jr., D. C. Gajdusek, and H. W. Lee. 1981b. Propagation of Korean hemorrhagic fever virus in laboratory rats. Infect Immun 31:334-338. Lee, P. W., C. J. Gibbs, Jr., D. C. Gajdusek, C. M. Hsiang, and G. D. Hsiung. 1980. Identification of epidemic haemorrhagic fever with renal syndrome in China with Korean haemorrhagic fever. Lancet 1:1025-1026. Lokugamage, N., H. Kariwa, K. Lokugamage, M. A. Iwasa, T. Hagiya, K. Yoshii, A. Tachi, S. Ando, H. Fukushima, K. Tsuchiya, T. Iwasaki, K. Araki, K. Yoshimatsu, J. Arikawa, T. Mizutani, K. Osawa, H. Sato, and I. Takashima. 2004. Epizootiological and epidemiological study of hantavirus infection in Japan. Microbiol Immunol 48:843-851. Lundkvist, A., S. Bjorsten, and B. Niklasson. 1993a. Immunoglobulin G subclass responses against the structural components of Puumala virus. J Clin Microbiol 31:368-372. Lundkvist, A., J. Horling, and B. Niklasson. 1993b. The humoral response to Puumala virus infection (nephropathia epidemica) investigated by viral protein specific immunoassays. Arch Virol 130:121-130. Lundkvist, A., M. Hukic, J. Horling, M. Gilljam, S. Nichol, and B. Niklasson. 1997. Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. J Med Virol 53:51-59. Mackay, I. M., K. E. Arden, and A. Nitsche. 2002. Real-time PCR in virology. Nucleic Acids Res 30:1292-1305. Martinez, V. P., C. Bellomo, J. San Juan, D. Pinna, R. Forlenza, M. Elder, and P. J. Padula. 2005. Person-to-person transmission of Andes virus. Emerg Infect Dis 11:1848-1853. McKee, K. T., Jr., G. R. Kim, D. E. Green, and C. J. Peters. 1985. Hantaan virus infection in suckling mice: virologic and pathologic correlates. J Med Virol 17:107-117. Meyer, B. J., and C. Schmaljohn. 2000. Accumulation of terminally deleted RNAs may play a role in Seoul virus persistence. J Virol 74:1321-1331. Mills, J. N., J. M. Johnson, T. G. Ksiazek, B. A. Ellis, P. E. Rollin, T. L. Yates, M. O. Mann, M. R. Johnson, M. L. Campbell, J. Miyashiro, M. Patrick, M. Zyzak, D. Lavender, M. G. Novak, K. Schmidt, C. J. Peters, and J. E. Childs. 1998. A survey of hantavirus antibody in small-mammal populations in selected United States National Parks. Am J Trop Med Hyg 58:525-532. Mills, J. N., T. G. Ksiazek, C. J. Peters, and J. E. Childs. 1999. Long-term studies of hantavirus reservoir populations in the southwestern United States: a synthesis. Emerg Infect Dis 5:135-142. Murphy, F. 1999. Bunyaviridae. In Veterinary Virology. ACADEMIC, London, pp. 460-482 Myhrman, G. 1951. Nephropathia epidemica a new infectious disease in northern Scandinavia. Acta Med Scand 140:52-56. Nemirov, K., H. K. Andersen, H. Leirs, H. Henttonen, A. Vaheri, A. Lundkvist, and A. Plyusnin. 2004. Saaremaa hantavirus in Denmark. J Clin Virol 30:254-257. Nemirov, K., O. Vapalahti, A. Lundkvist, V. Vasilenko, I. Golovljova, A. Plyusnina, J. Niemimaa, J. Laakkonen, H. Henttonen, A. Vaheri, and A. Plyusnin. 1999. Isolation and characterization of Dobrava hantavirus carried by the striped field mouse (Apodemus agrarius) in Estonia. J Gen Virol 80 ( Pt 2):371-379. Nemirov, K., O. Vapalahti, A. Papa, A. Plyusnina, A. Lundkvist, A. Antoniadis, A. Vaheri, and A. Plyusnin. 2003. Genetic characterization of new Dobrava hantavirus isolate from Greece. J Med Virol 69:408-416. Nichol, S. T., C. F. Spiropoulou, S. Morzunov, P. E. Rollin, T. G. Ksiazek, H. Feldmann, A. Sanchez, J. Childs, S. Zaki, and C. J. Peters. 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262:914-917. Nitatpattana, N., T. Henrich, S. Palabodeewat, W. Tangkanakul, D. Poonsuksombat, G. Chauvancy, P. Barbazan, S. Yoksan, and J. P. Gonzalez. 2002. Hantaan virus antibody prevalence in rodent populations of several provinces of northeastern Thailand. Trop Med Int Health 7:840-845. Olsson, G. E., N. White, C. Ahlm, F. Elgh, A. C. Verlemyr, P. Juto, and R. T. Palo. 2002. Demographic factors associated with hantavirus infection in bank voles (Clethrionomys glareolus). Emerg Infect Dis 8:924-929. Ozoemena, L. C., P. D. Minor, and M. A. Afzal. 2004. Comparative evaluation of measles virus specific TaqMan PCR and conventional PCR using synthetic and natural RNA templates. J Med Virol 73:79-84. Papa, A., A. M. Johnson, P. C. Stockton, M. D. Bowen, C. F. Spiropoulou, S. Alexiou-Daniel, T. G. Ksiazek, S. T. Nichol, and A. Antoniadis. 1998. Retrospective serological and genetic study of the distribution of hantaviruses in Greece. J Med Virol 55:321-327. Parrington, M. A., and C. Y. Kang. 1990. Nucleotide sequence analysis of the S genomic segment of Prospect Hill virus: comparison with the prototype Hantavirus. Virology 175:167-175. Plyusnin, A., J. Horling, M. Kanerva, J. Mustonen, Y. Cheng, J. Partanen, O. Vapalahti, S. K. Kukkonen, J. Niemimaa, H. Henttonen, B. Niklasson, A. Lundkvist, and A. Vaheri. 1997. Puumala hantavirus genome in patients with nephropathia epidemica: correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents. J Clin Microbiol 35:1090-1096. Plyusnina, A., I. N. Ibrahim, I. Winoto, K. R. Porter, I. B. Gotama, A. Lundkvist, A. Vaheri, and A. Plyusnin. 2004. Identification of Seoul hantavirus in Rattus norvegicus in Indonesia. Scand J Infect Dis 36:356-359. Poon, L. L., K. H. Chan, O. K. Wong, W. C. Yam, K. Y. Yuen, Y. Guan, Y. M. Lo, and J. S. Peiris. 2003. Early diagnosis of SARS coronavirus infection by real time RT-PCR. J Clin Virol 28:233-238. Puthavathana, P., H. W. Lee, and C. Y. Kang. 1992. Typing of Hantaviruses from five continents by polymerase chain reaction. Virus Res 26:1-14. Ravkov, E. V., P. E. Rollin, T. G. Ksiazek, C. J. Peters, and S. T. Nichol. 1995. Genetic and serologic analysis of Black Creek Canal virus and its association with human disease and Sigmodon hispidus infection. Virology 210:482-489. Rawlings, J. A., N. Torrez-Martinez, S. U. Neill, G. M. Moore, B. N. Hicks, S. Pichuantes, A. Nguyen, M. Bharadwaj, and B. Hjelle. 1996. Cocirculation of multiple hantaviruses in Texas, with characterization of the small (S) genome of a previously undescribed virus of cotton rats (Sigmodon hispidus). Am J Trop Med Hyg 55:672-679. Reynes, J. M., J. L. Soares, T. Hue, M. Bouloy, S. Sun, S. L. Kruy, F. Flye Sainte Marie, and H. Zeller. 2003. Evidence of the presence of Seoul virus in Cambodia. Microbes Infect 5:769-773. Richard, M. E. 1996. Tha Bunyaviridae. Plenum Press, New York. Rossi, C., C. Schmaljohn, J. Meegan, and J. LeDuc. 1990. Diagnostic potential of a baculovirus-expressed nucleocapsid protein for hantavirus. Arch Virol Suppl 1:19-28. Rowe, J. E., S. C. St Jeor, J. Riolo, E. W. Otteson, M. C. Monroe, W. W. Henderson, T. G. Ksiazek, P. E. Rollin, and S. T. Nichol. 1995. Coexistence of several novel hantaviruses in rodents indigenous to North America. Virology 213:122-130. Ruo, S. L., Y. L. Li, Z. Tong, Q. R. Ma, Z. L. Liu, Y. W. Tang, K. L. Ye, J. B. McCormick, S. P. Fisher-Hoch, and Z. Y. Xu. 1994. Retrospective and prospective studies of hemorrhagic fever with renal syndrome in rural China. J Infect Dis 170:527-534. Sakuntabhai, A., C. Turbpaiboon, I. Casademont, A. Chuansumrit, T. Lowhnoo, A. Kajaste-Rudnitski, S. M. Kalayanarooj, K. Tangnararatchakit, N. Tangthawornchaikul, S. Vasanawathana, W. Chaiyaratana, P. T. Yenchitsomanus, P. Suriyaphol, P. Avirutnan, K. Chokephaibulkit, F. Matsuda, S. Yoksan, Y. Jacob, G. M. Lathrop, P. Malasit, P. Despres, and C. Julier. 2005. A variant in the CD209 promoter is associated with severity of dengue disease. Nat Genet 37:507-513. Salazar-Bravo, J., B. Armien, G. Suzan, A. Armien, L. A. Ruedas, M. Avila, Y. Zaldivar, J. M. Pascale, F. Gracia, and T. L. Yates. 2004. Serosurvey of wild rodents for hantaviruses in Panama, 2000-2002. J Wildl Dis 40:103-109. Sambrook, J., and D. W. Russell. 2001. Molecular Cloning. Cold Spring Harbor, New York. Schmaljohn, C., and B. Hjelle. 1997. Hantaviruses: a global disease problem. Emerg Infect Dis 3:95-104. Schmaljohn, C., and S. Nichol. 2001. Hantaviruses. Curr Top Microbiol Immunol 256:1-191. Schmaljohn, C. S., Y. K. Chu, A. L. Schmaljohn, and J. M. Dalrymple. 1990. Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants. J Virol 64:3162-3170. Schmaljohn, C. S., G. B. Jennings, J. Hay, and J. M. Dalrymple. 1986. Coding strategy of the S genome segment of Hantaan virus. Virology 155:633-643. Schmidt, J., B. Jandrig, B. Klempa, K. Yoshimatsu, J. Arikawa, H. Meisel, M. Niedrig, C. Pitra, D. H. Kruger, and R. Ulrich. 2005. Nucleocapsid protein of cell culture-adapted Seoul virus strain 80-39: analysis of its encoding sequence, expression in yeast and immuno-reactivity. Virus Genes 30:37-48. Schubert, J., F. Tollmann, and B. Weissbrich. 2001. Evaluation of a pan-reactive hantavirus enzyme immunoassay and of a hantavirus immunoblot for the diagnosis of nephropathia epidemica. J Clin Virol 21:63-74. Shi, X., C. McCaughey, and R. M. Elliott. 2003. Genetic characterisation of a Hantavirus isolated from a laboratory-acquired infection. J Med Virol 71:105-109. Sjolander, K. B., F. Elgh, H. Kallio-Kokko, O. Vapalahti, M. Hagglund, V. Palmcrantz, P. Juto, A. Vaheri, B. Niklasson, and A. Lundkvist. 1997. Evaluation of serological methods for diagnosis of Puumala hantavirus infection (nephropathia epidemica). J Clin Microbiol 35:3264-3268. Smadel, J. E. 1953. Epidemic hemorrhagic fever. Am J Public Health 43:1327-1330. Song, G., C. Wang, H. Liao, z. Qiu, G. Gao, L. Du, N. Zhao, j. Xu, and B. Kong. 1982. Isolation of EHF-related agent from Rattus norvegicus captured in patients' home. in endemic area of the mild type of hemorrhagic fever. Aeta Microbiol Sin 22:373-377. Song, J. W., L. J. Baek, K. J. Song, A. Skrok, J. Markowski, J. Bratosiewicz-Wasik, R. Kordek, P. P. Liberski, and R. Yanagihara. 2004. Characterization of Tula virus from common voles (microtus arvalis) in Poland: evidence for geographic-specific phylogenetic clustering. Virus Genes 29:239-247. Song, J. W., A. Gligic, and R. Yanagihara. 2002. Identification of Tula hantavirus in Pitymys subterraneus captured in the Cacak region of Serbia-Yugoslavia. Int J Infect Dis 6:31-36. Song, J. W., K. J. Song, L. J. Baek, B. Frost, M. Poncz, and K. Park. 2005. In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry. Exp Mol Med 37:121-127. Suarez, O. V., G. R. Cueto, R. Cavia, I. E. Gomez Villafane, D. N. Bilenca, A. Edelstein, P. Martinez, S. Miguel, C. Bellomo, K. Hodara, P. J. Padula, and M. Busch. 2003. Prevalence of infection with hantavirus in rodent populations of central Argentina. Mem Inst Oswaldo Cruz 98:727-732. Suzan, G., G. Ceballos, J. Mills, T. G. Ksiazek, and T. Yates. 2001. Serologic evidence of hantavirus infection in sigmodontine rodents in Mexico. J Wildl Dis 37:391-393. Takakura, A., K. Goto, T. Itoh, K. Yoshimatsu, I. Takashima, and J. Arikawa. 2003. Establishment of an enzyme-linked immunosorbent assay for detection of hantavirus antibody of rats using a recombinant of nucleocapsid protein expressed in Escherichia coli. Exp Anim 52:25-30. Tanishita, O., Y. Takahashi, Y. Okuno, M. Tamura, H. Asada, J. R. Dantas, Jr., T. Yamanouchi, K. Domae, T. Kurata, and K. Yamanishi. 1986. Persistent infection of rats with haemorrhagic fever with renal syndrome virus and their antibody responses. J Gen Virol 67 ( Pt 12):2819-2824. Temonen, M., J. Mustonen, H. Helin, A. Pasternack, A. Vaheri, and H. Holthofer. 1996. Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: an immunohistochemical study. Clin Immunol Immunopathol 78:47-55. Teo, I. A., J. W. Choi, J. Morlese, G. Taylor, and S. Shaunak. 2002. LightCycler qPCR optimisation for low copy number target DNA. J Immunol Methods 270:119-133. Van Loock, F., I. Thomas, J. Clement, S. Ghoos, and P. Colson. 1999. A case-control study after a hantavirus infection outbreak in the south of Belgium: who is at risk? Clin Infect Dis 28:834-839. Vapalahti, K., M. Paunio, M. Brummer-Korvenkontio, A. Vaheri, and O. Vapalahti. 1999. Puumala virus infections in Finland: increased occupational risk for farmers. Am J Epidemiol 149:1142-1151. Vapalahti, O., H. Kallio-Kokko, E. M. Salonen, M. Brummer-Korvenkontio, and A. Vaheri. 1992. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J Gen Virol 73 ( Pt 4):829-838. Vapalahti, O., J. Mustonen, A. Lundkvist, H. Henttonen, A. Plyusnin, and A. Vaheri. 2003. Hantavirus infections in Europe. Lancet Infect Dis 3:653-661. Wang, H., K. Yoshimatsu, H. Ebihara, M. Ogino, K. Araki, H. Kariwa, Z. Wang, Z. Luo, D. Li, C. Hang, and J. Arikawa. 2000. Genetic diversity of hantaviruses isolated in china and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus. Virology 278:332-345. Ward, C. L., M. H. Dempsey, C. J. Ring, R. E. Kempson, L. Zhang, D. Gor, B. W. Snowden, and M. Tisdale. 2004. Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol 29:179-188. Weidmann, M., P. Schmidt, M. Vackova, K. Krivanec, P. Munclinger, and F. T. Hufert. 2005. Identification of genetic evidence for dobrava virus spillover in rodents by nested reverse transcription (RT)-PCR and TaqMan RT-PCR. J Clin Microbiol 43:808-812. Wells, R. M., S. Sosa Estani, Z. E. Yadon, D. Enria, P. Padula, N. Pini, J. N. Mills, C. J. Peters, and E. L. Segura. 1997. An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Hantavirus Pulmonary Syndrome Study Group for Patagonia. Emerg Infect Dis 3:171-174. Wilhelm, J., and A. Pingoud. 2003. Real-time polymerase chain reaction. Chembiochem 4:1120-1128. Xiao, S. Y., Y. K. Chu, F. K. Knauert, R. Lofts, J. M. Dalrymple, and J. W. LeDuc. 1992. Comparison of hantavirus isolates using a genus-reactive primer pair polymerase chain reaction. J Gen Virol 73 ( Pt 3):567-573. Xiao, S. Y., J. W. Leduc, Y. K. Chu, and C. S. Schmaljohn. 1994. Phylogenetic analyses of virus isolates in the genus Hantavirus, family Bunyaviridae. Virology 198:205-217. Yoshimatsu, K., J. Arikawa, M. Tamura, R. Yoshida, A. Lundkvist, B. Niklasson, H. Kariwa, and I. Azuma. 1996. Characterization of the nucleocapsid protein of Hantaan virus strain 76-118 using monoclonal antibodies. J Gen Virol 77 ( Pt 4):695-704. Zeier, M., M. Handermann, U. Bahr, B. Rensch, S. Muller, R. Kehm, W. Muranyi, and G. Darai. 2005. New ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention--a review. Virus Genes 30:157-180. Zeitz, P. S., J. C. Butler, J. E. Cheek, M. C. Samuel, J. E. Childs, L. A. Shands, R. E. Turner, R. E. Voorhees, J. Sarisky, P. E. Rollin. 1995. A case-control study of hantavirus pulmonary syndrome during an outbreak in the southwestern United States. J Infect Dis 171:864-870. Zoller, L., S. Yang, P. Gott, E. K. Bautz, and G. Darai. 1993. Use of recombinant nucleocapsid proteins of the Hantaan and nephropathia epidemica serotypes of Hantaviruses as immunodiagnostic antigens. J Med Virol 39:200-207. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32949 | - |
dc.description.abstract | 漢他病毒屬於布尼亞病毒科之漢他病毒屬,人類感染後依據病毒種類不同會有出血熱腎症候群或漢他病毒肺症候群。嚙齒類動物為漢他病毒的自然保毒宿主,且每種漢他病毒有其專一性宿主。而人類則為意外宿主,是藉由吸入、食入或接觸到來自於嚙齒類動物的唾液、尿液或糞便之病毒懸浮氣膠而感染。本研究藉巢式反轉錄酶聚合酶鏈反應與間接免疫螢光法調查鼠類感染漢他病毒的盛行率,以窺探台灣各地區鼠類漢他病毒感染的情況,提供防疫之參考。另外,由於鼠類感染漢他病毒後會持續性帶原,本論文亦藉由即時定量聚合酶鏈反應檢測鼠隻各臟器中的病毒量高低,以及比較在自然宿主與過剩宿主 (spillover host) 間是否有差異。盛行率調查結果得知台灣鼠類感染病毒株為首爾型漢他病毒,彼此之核酸序列之相似性達 95.8-100 %,總盛行率為 24.69 % (79/320),以溝鼠為主要宿主,但是亦有錢鼠、黃胸鼠、鬼鼠等過剩宿主的發現。季節分佈為全年皆有,但多集中於春天、秋天與冬天 (但未達統計學上顯著差異,P>0.05)。台灣南部與外島地區的帶原率高於東部地區 (但未達統計學上顯著差異,P>0.05)。病毒於臟器的分布以肺臟為主要儲存場所,平均病毒量為 6.308 x 103 ± 4.110 x 101 copies/mg,但低於前人以人工感染漢他病毒肺症候群無名病毒實驗的病毒量。且過剩宿主體內的病毒量少於專一性宿主,符合漢他病毒感染專一性宿主可能為長期共同演化而來,非常適應於其宿主體內之推測。 | zh_TW |
dc.description.abstract | Hantaviruses, which belonged to the family Bunyaviridae and genus Hantavirus, cause two serious and often fatal human diseases, namely hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in Americas. In nature, hantaviruses are exclusively maintained in the populations of their specific rodent hosts and cause a persistent, asymptomatic infection. Humans, as accidental hosts, become infected by inhaling or ingesting or contacting with virus contaminated aerosol generated from urine, feces, and/or saliva shedded by infected rodents. To provide the basic epidemiological information for the disease control, we use nested reverse transcription polymerase chain reaction (RT-PCR) and immunoflurescence assay to investigate the hantavirus infection rate in rodent population in Taiwan. Since rodents are persistent infected with hantavirus, we used the real-time quantitative polymerase chain reaction to evaluate the virus load in various tissues, and compared the viral load between the nature hosts and spillover hosts. The hantavirus strains prevalent in Taiwan were Seoul virus (SEOV), and the sequence homology among the SEOV strains were found to be 95.8-100 %. There were a total of 320 rodents captured and the virus prevalence was 24.69 %. Rattus norvegicus was the most common carrier and other spillover hosts included Suncus murinus or Rattus flavipectus or Bandicota indica. The hantavirus could be detected all the year round but especially common in the spring, fall and winter, although such a difference was not statistically significant (P>0.05). The hantavirus prevalence in rodent in Southern Taiwan and offshore islets was much higher than in Eastern Taiwan, although such a difference was not statistically significant (P>0.05). By real time RT-PCR, lungs of the carrier rodent had the highest mean viral load (6.308 x 103 ± 4.110 x 101 copies/mg), however, it was lower than the virus load of previous study using Sin Nombre virus (SNV) in experimentally infected rodents. It is suggested that the virus load in the experimental infection model is different from the nature infection. The viral load in the spillover host is lower than that in the nature host, suggesting further support on the notion that hantavirus co-evolved with their specific hosts over a very long time. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T04:19:54Z (GMT). No. of bitstreams: 1 ntu-95-R93629037-1.pdf: 1372001 bytes, checksum: 4c703809361654666a86c778c2c6eddd (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 致謝 I
中文摘要 II 英文摘要 III 名詞定義 V 目錄 VI 表次 IX 圖次 X 第一章 前言 - 1 - 第二章 文獻探討 - 2 - 第一節 漢他病毒發現歷史- 2 - 第二節 病毒學 - 3 - 2.2.1 漢他病毒分類 - 3 - 2.2.2 漢他病毒形態與特性 - 4 - 2.2.3 漢他病毒基因結構 - 4 - 2.2.4 漢他病毒致病機轉 - 6 - 第三節 漢他病毒的傳播途徑 - 6 - 第四節 漢他病毒與宿主種類 - 7 - 第五節 漢他病毒引起的相關疾病及臨床症狀 -11 - 2.5.1 漢他病毒出血熱與腎病症候群 (HFRS) - 12 - 2.5.2 漢他病毒肺症候群 (HPS) - 13 - 第六節 實驗室診斷 - 13 - 2.6.1 血清抗體檢測 - 14 - 2.6.1.1 酵素連結免疫吸附法 (ELISA) - 14 - 2.6.1.2 間接免疫螢光法 (IFA) - 14 - 2.6.2 病毒檢測 - 14 - 2.6.2.1 反轉錄聚合酶鏈反應 (RT-PCR) - 14 - 2.6.2.2 即時定量聚合酶鏈反應 (real-time quantitative PCR) - 15 - 2.6.2.2.1 Real-time quantitative PCR 技術的偵測原理 - 15 - 2.6.2.2.2 Real-time quantitative PCR 技術的應用 - 16 - 第七節 漢他病毒的流行病學 - 21 - 第八節 各國鼠類漢他病毒盛行率調查 - 22 - 第三章 材料與方法 - 25 - 第一節 實驗目的 - 25 - 第二節 實驗設計與流程圖 - 25 - 第三節 檢體來源 - 26 - 第四節 漢他病毒引子 (primer) 及探針 (probe) 之選擇與設計 - 27 - 第五節 檢測漢他病毒核酸 - 29 - 3.5.1 病毒核酸萃取 - 29 - 3.5.2 反轉錄反應 (reverse transcription; RT) - 29 - 3.5.3 巢式聚合酶鏈反應 (nested polymerase chain reaction; nPCR) - 30 - 3.5.3.1 檢測首爾型 (Seoul) 漢他病毒 - 30 - 3.5.3.2 檢測漢灘型 (Hantaan) 漢他病毒 - 30 - 3.5.4 電泳分析聚合酶鏈反應 - 31 - 3.5.5 陽性結果之判讀 - 31 - 第六節 即時定量聚合酶鏈反應 - 33 - 3.6.1 陽性對照之製備 - 33 - 3.6.1.1 PCR 產物之純化 - 33 - 3.6.1.2 接合作用 (ligation) - 34 - 3.6.1.3 轉形作用 (transformation) - 34 - 3.6.1.4 選殖質體之抽取與確認 - 34 - 3.6.1.5 限制酶切割與定序確認重組之質體DNA - 36 - 3.6.2 標準曲線之建立 - 36 - 3.6.3 各臟器核酸之萃取與cDNA 之合成 - 39 - 3.6.4 Real-time PCR 之定量分析 - 39 - 第七節 基因片段之序列比對分析 - 39 - 第八節 RT-nPCR 與Real-time PCR 敏感性試驗 - 42 - 第九節 間接免疫螢光法 (indirect immunofluorescene assay; IFA) - 42 - 第四章 結果 - 44 - 第一節 捕獲鼠隻樣本分佈- 44 - 第二節 以RT-nPCR 檢測漢他病毒核酸 - 44 - 4.2.1 肺臟檢體之首爾型漢他病毒盛行率 - 44 - 4.2.1 肺臟檢體之漢灘型漢他病毒檢測 - 52 - 第三節 以real-time quantitative PCR 定量漢他病毒核酸 - 52 - 4.3.1 敏感性試驗 - 52 - 4.3.2 臟器定量 - 54 - 第四節 以IFA 檢測鼠類感染漢他病毒之抗體盛行率 - 56 - 第五節 漢他病毒S片段基因之序列比對分析 - 57 - 第五章 討論 - 59 - 參考文獻 - 67 - 附錄一 鼠類基本資料與定量數據 - 81 - 附錄二 鼠類樣本原始資料 - 85 - | |
dc.language.iso | zh-TW | |
dc.title | 以即時定量聚合酶鏈反應、巢氏反轉錄酶聚合酶鏈反應與間接免疫螢光法調查臺灣地區野鼠感染漢他病毒的盛行率 | zh_TW |
dc.title | Prevalence of Hantavirus Infection in Rodent Populations in Taiwan Determined by Real-time Quantitative PCR, Nested RT-PCR and Indirect Immunofluorescene Assay | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 潘銘正(Ming-Jeng Pan) | |
dc.contributor.oralexamcommittee | 張照勤,張紹光,王汎熒 | |
dc.subject.keyword | 漢他病毒, | zh_TW |
dc.subject.keyword | Hantavirus, | en |
dc.relation.page | 93 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-24 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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