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標題: | 高強度聚焦超音波應用於子宮肌瘤熱治療之應用 High Intensity Focused Ultrasound for Uterine Fibroid Thermal Therapy |
作者: | Kuan-Chou Pan 潘冠州 |
指導教授: | 林文澧(Win-Li Lin) |
關鍵字: | 高能聚焦超音波,子宮肌瘤,皮膚燒灼傷,併發症, HIFU,uterine fibroid,skin burn,complication, |
出版年 : | 2006 |
學位: | 碩士 |
摘要: | 子宮肌瘤是女性最常見的骨盆腫瘤,嚴重時甚至可以影響到其之生育能力。針對子宮肌瘤的手術治療方式有子宮肌瘤切除術、子宮切除術和子宮纖維肌瘤栓塞術等,治療方式均屬於侵入性的治療,直至聚焦型超音波熱手術的出現。它除了可以提供非侵入式的治療外,並可以大大地減少術後併發症產生的機率以及術後病患臥床休養的時間。基於以上的優點,超音波熱手術是子宮肌瘤治療的理想方式,但是根據以往的臨床經驗,治療時間過長和治療所可能導致的表層皮膚燒傷,一直是亟待改善的問題。為此,本研究以一套具MRI相容性的超音波治療系統為基礎,進行簡化的雙層介質模擬子宮肌瘤之治療。此系統由四個換能器所組成,將換能器以30度的入射角配置,由四個分散的路徑對目標進行加熱,與目前所使用的單向入射路徑堆疊治療相比較,可以在相同的總功率輸出下,分散超音波行進路徑上表層皮膚所吸收的能量,同時在治療時予以較為低溫的去氣水進行表層皮膚的冷卻,期許能達到避免表層皮膚過熱的目標,若以對角線上的換能器同時驅動治療,亦可以減少所需要的治療時間。利用此系統的多向路徑入射治療與目前所使用的單向入射路徑堆疊治療模擬結果相比較,可以在較短的時間,減少表層皮膚溫度的升高,提供更為精準的加熱治療。 Uterine fibroids are the most common pelvic tumors in women and even it may affect fertility. The interventions for uterine fibroid are myomectomy, hysterectomy and uterine fibroid embolization (UFE). All of these surgical interventions are invasive until the exposure of focused ultrasound surgery. It can provide non-invasive intervention and largely decrease the probability of complications and post-operation bedrid time. Because of less invasive, focused ultrasound has become a promising tool for localized tumor therapy. Clinical tests, however, have shown that the main problems are long treatment time and skin burn which the ultrasound propagates through. In this study, based on a MRI compatible ultrasound treatment system, we carry out a simplified two - medium simulation for uterine fibroid intervention. The system is composed of four transducers which are oriented in an incident angle of 30 degrees to the skin – water interface to heat the target from four separate paths. Compared with single path stacking treatment which is used commonly on the present, using the system could disperse absorbed power in the skin under the condition of the same total power output. Soaking skin behind the target region in cooling degased water during operation aims to prevent over- heating in the skin. If the two transducers of the diagonal line operate simultaneously, it could lessen the treatment time. Compared with simulation results of multiple path treatment of our system and single path stacking treatment, multiple path treatment could provide precise heating intervention in a shorter time and diminish temperature elevation of the skin. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32775 |
全文授權: | 有償授權 |
顯示於系所單位: | 醫學工程學研究所 |
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