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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林文澧(Win-Li Lin) | |
dc.contributor.author | Cheng-Shiao Ho | en |
dc.contributor.author | 何乘孝 | zh_TW |
dc.date.accessioned | 2021-06-13T04:15:12Z | - |
dc.date.available | 2008-07-28 | |
dc.date.copyright | 2006-07-28 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-25 | |
dc.identifier.citation | 參考文獻
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32770 | - |
dc.description.abstract | 本研究的目的為探討圓柱型相位陣列超音波換能器搭配多聚焦點模式掃描之加熱策略應用於乳癌熱手術之可行性。在本研究中,乳房被一個驅動頻率為1MHz的圓柱型相位陣列超音波換能器所環繞,半徑為10㎝、高2㎝,而其包含了200個獨立驅動的單元晶片。為了避免在治療時傷害過多的正常組織,一個1㎝×1㎝的目標區域被選定為單一治療單元。若是目標區域的大小大於單一治療單元的大小,則會將目標區域切割為數個子治療單元,並依序分別進行加熱,並且在各個子治療單元之間給予冷卻的時間,以降低對周圍的正常組織之傷害。同時亦討論治療參數:目標溫度(Ttgt)、血液灌流率以及目標區域之大小之影響。除此之外,也針對一個淺層乳房腫瘤(腫瘤邊界距離皮膚約5㎜)在不同周圍冷卻水初始水溫下之治療情形進行探討。模擬結果顯示,目標溫度的高低(Ttgt)會影響燒灼區域的大小,而較高的血液灌流率則會使加熱時間顯著的延長。基於圓柱型相位陣列超音波換能器擁有較大的聲窗口搭配上周圍冷卻水所帶來的冷卻效應,由模擬結果可以得知,以本系統進行淺層乳房腫瘤治療時,可以在目標區域產生一個可接受的燒灼結果,而不會有皮膚過熱或燒傷的現象。本研究中所提出的圓柱型相位陣列超音波換能器系統以及加熱策略為乳房腫瘤之熱手術提供了一個有效的治療方法,並且可以大幅減低肋骨以及皮膚發生過熱的情形。 | zh_TW |
dc.description.abstract | The purpose of this study is to investigate the feasibility of a cylindrical ultrasound phased-array with multiple-focus scanning strategy to produce a uniform heating for breast thermal therapy. In this study, a breast is surrounded by a 1-MHz cylindrical ultrasound phased-array consisting of 200 elements with a radius of 10 cm and a height of 2 cm. To prevent overheating in the normal tissue, a scanning heating region of 1㎝×1㎝ was selected as a single heating unit. Planning target volume larger than this size would be divided into several sub-heating units, and then be treated sequentially with cooling phase between heating sub-units to prevent overheating in the surrounding normal tissue. Parameters such as the target temperature(Ttgt), blood perfusion rate and the size of the planning target volume are evaluated. Furthermore, a case of superficial breast tumor (The distance from tumor boundary to the skin is about 5㎜.) was simulated with different surrounding water temperature:37 and 20℃. Simulation results show that the target temperature affects the thermal lesion size and the blood perfusion rate increases the heating time significantly. Due to large acoustic window and the effect of surrounding cooling water, the lesion was well produced in the desired region without skin overheating. This method provides effective heating for breast tumor thermal therapy while preventing overheating the ribs and skin. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T04:15:12Z (GMT). No. of bitstreams: 1 ntu-95-R93548042-1.pdf: 3012758 bytes, checksum: 536e6a33a78e78f5cc9e1cffc85e73db (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 目錄
第一章 序論 1 1.1乳癌 1 1.2 超音波熱治療的歷史回顧 5 1.3 超音波高溫熱治療與熱手術 6 1.4 超音波熱治療與熱手術在乳癌上的應用 7 1.5 研究動機與研究目的 10 第二章 理論分析與模擬方法 12 2.1 引言 12 2.2 超音波之物理特性 13 2.3 組織之聲學特性 13 2.4 雷利-薩瑪菲爾德繞射積分式 16 2.5 聚焦點分佈控制 17 2.6 超音波能量在組織中的吸收 19 2.7 溫度場之計算 20 2.8 熱劑量之計算 21 2.9 乳房模型之聲學與熱傳參數 23 第三章 系統架構、治療規劃與加熱策略 24 3.1 引言 24 3.2 治療系統架構 25 3.3加熱策略與治療規劃 26 第四章 模擬結果 30 4.1 圓柱型相位陣列超音波換能器之聚焦點分佈情形 30 4.2單一治療單元之加熱 – 目標溫度(TTGT)之影響 32 4.3單一治療單元之加熱 – 血液灌流率之影響 35 4.4多治療單元之加熱結果 39 4.5多治療單元之加熱結果(偏離乳房中心3㎝) 42 4.6多治療平面之加熱結果(偏離乳房中心3㎝) 44 4.7淺層乳房腫瘤治療之加熱結果 47 第五章 討論 53 5.1系統與加熱策略之探討 53 5.2多治療平面與多治療單元之探討 54 5.3淺層乳房腫瘤治療之探討 54 第六章 結論 55 第七章 未來展望 56 參考文獻 57 圖目錄 圖1.1 全世界最常發生的幾種癌症之發生率與致死率 1 圖1.2 乳房之解剖構造示意圖 2 圖1.3 細胞存活率與熱劑量(EQUIVALENT-MINUTES AT 43℃,TD43)之關係圖 5 圖1.4 高強度聚焦型超音波(HIFU)原理示意圖 6 圖 1.5 單一元素的球面聚焦型超音波換能器與定位系統 7 圖1.6 多元素之相位陣列式超音波換能器與定位系統 8 圖1.7 MR-GUIDED FOCUSED ULTRASOUND SURGERY SYSTEM :EXABLATE 2000 8 圖1.8 單一元素的球面聚焦型換能器搭配超音波影像監控系統 9 圖1.9 半球型191個元素之相位陣列超音波換能器 9 圖2.1 超音波於介質介面所產生的折射與反射現象示意圖 15 圖2.2 雷利-薩瑪菲爾德繞射積分式示意圖 16 圖3.1 治療系統架構示意圖 25 圖3.2 肋骨內之能量吸收率與入射角之關係圖 26 圖3.3 加熱策略示意圖 28 圖3.4 單一治療平面與多治療平面治療不同體積腫瘤之示意圖 29 圖4.1 (A)單一聚焦點之強度場分佈圖(B)驅動訊號之相位與振幅強度 30 圖4.2(A)多聚焦點之強度場分佈圖(B)驅動訊號之相位與振幅強度 31 圖4.3 三種TTGT在加熱過程中組織最高溫度隨時間之變化圖 32 圖4.4 加熱結束瞬間之溫度場分佈圖 33 圖4.5 單一治療單元加熱後冷卻至43℃所形成之熱劑量240分鐘輪廓圖 34 圖4.6 三種血液灌流率在加熱過程中組織最高溫度隨時間之變化圖 35 圖4.7 三種血液灌流率條件所形成之等熱劑量面圖 36 圖4.8 在三種血液灌流率條件下於三個軸向上之熱劑量分佈對數曲線圖 37 圖4.9 加熱大目標區域過程中組織最高溫度隨時間之變化圖 39 圖4.10 治療位於乳房中心之大目標區域所形成之等熱劑量面圖 40 圖4.11加熱偏離乳房中心三公分之大目標區域(單一治療平面)過程中組織最高溫度隨時間之變化圖 42 圖4.12 治療偏離乳房中心三公分之大目標區域所形成的等熱劑量面圖(綠色為TD240分鐘、紅色為TD100分鐘、黃色為TD10分鐘),(A)為立體圖,(B)為立體俯視圖(C)為立體側視圖(Y=0),(D)為立體側視圖(X=0)。 43 圖4.13 加熱偏離乳房中心三公分之大目標區域(多治療平面)過程中組織最高溫度隨時間之變化圖 44 圖4.14 治療偏離乳房中心三公分之大目標區域(多治療平面)所形成的等熱劑量面圖(綠色為TD240分鐘、紅色為TD100分鐘、黃色為TD10分鐘),(A)為立體圖,(B)為立體俯視圖(C)為立體側視圖(Y=0),(D)為立體側視圖(X=0)。 45 圖4.15淺層乳房腫瘤加熱過程中組織最高溫度隨時間之變化圖 48 圖4.16 淺層乳房腫瘤加熱結束瞬間之溫度場分佈圖,冷卻水之初始水溫分別為(A)37℃ (B)20℃ 49 圖4.17 淺層乳房腫瘤在不同冷卻水之初始水溫狀況下,治療結束時在三個切面上(Z=-3.5㎝,X=3㎝,Y=0㎝,由上而下)之熱劑量(TD=240、100、10 MIN.)輪廓圖。冷卻水之初始水溫分別為(A-C)37℃,(D-F)20℃。粗黑色弧線為皮膚之邊界。 50 圖4.18 淺層乳房腫瘤在不同冷卻水之初始水溫狀況下,加熱結束時在X軸上之溫度分佈曲線圖。冷卻水之初始水溫分別為:37℃(紅線)、20℃(藍線)。黑色垂直實線表示皮膚之範圍,黑色垂直虛線表示目標區域範圍(X=3.3㎝~4.3㎝)。 51 圖4.19 淺層乳房腫瘤在不同冷卻水之初始水溫狀況下,治療結束時在X軸上之熱劑量分佈曲線圖。冷卻水之初始水溫分別為:37℃(紅線)、20℃(藍線)。黑色垂直實線表示皮膚之範圍,黑色垂直虛線表示目標區域範圍(X=3.3㎝ ~ 4.3㎝)。黑色水平虛線表示了熱劑量240分鐘的區域。 52 表目錄 表2.1 哺乳類動物組織之聲學特性於溫度37℃,頻率1MHZ的條件下 14 表2.2 各種組織加熱至壞死所需之熱劑量門檻值 22 表2.3 模擬中所使用之乳房組織之聲學與熱傳參數 23 表4.1 不同血液灌流率所造成的治療結果 38 表4.2各子治療單元加熱與單元之間的冷卻時間 40 表4.3偏離乳房中心之各子治療單元加熱與單元之間的冷卻時間 43 表4.4偏離乳房中心之各治療平面與各子治療單元加熱與單元之間的冷卻時間 45 表4.5 不同初始溫度之冷卻水所造成對於乳房淺層腫瘤之治療結果 47 | |
dc.language.iso | zh-TW | |
dc.title | 圓柱型相位陣列超音波換能器應用於乳癌熱手術之研究 | zh_TW |
dc.title | Investigation of Using a Cylindrical Ultrasound Phased-Array for Breast Tumor Thermal Surgery | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 陳永耀(Yung-Yaw Chen) | |
dc.contributor.oralexamcommittee | 陳文翔(Wen-Shiang Chen),江惠華(Hui-Hua Chiang) | |
dc.subject.keyword | 圓柱型相位陣列超音波換能器,乳癌,熱手術, | zh_TW |
dc.subject.keyword | Cylindrical Ultrasound Phased-Array,Breast Tumor,Thermal Surgery, | en |
dc.relation.page | 62 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-25 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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