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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李百祺 | |
| dc.contributor.author | Li-Yen Chen | en |
| dc.contributor.author | 陳立言 | zh_TW |
| dc.date.accessioned | 2021-06-13T04:13:39Z | - |
| dc.date.available | 2006-07-31 | |
| dc.date.copyright | 2006-07-31 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-07-25 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32695 | - |
| dc.description.abstract | 小動物模型常作為邁入臨床研究前，進行疾病研究、基因體研究、藥物發展等相關醫療技術研究的實驗主體；而高解析度、高靈敏度、非侵入式小動物成像系統，將有助於上述研究的發展。另一方面，藉由結合不同成像原理的多重影像系統，能同時獲得不同的影像資訊，進而比較生物體內不同的功能參數。本研究結合高頻超音波影像以及微正子斷層掃描影像的目的就是希望達到上述的目標。在進行影像系統結合前，必須先進行影像定位的工作，將要結合的影像系統成像的相對應影像資訊，能在正確的影像空間位置上顯示。由於影像系統彼此的系統架構和成像原理皆不相同，因此必須針對不同的系統結合配對，設計適當的影像定位方式。本研究的目標，是希望能夠建立高頻超音波和微正子斷層掃描進行結合時的醫學影像定位方式。我們採用定位點定位，作為決定空間轉換矩陣的依據，並使用orthogonal Procrustes algorithm，作為本研究進行影像定位的演算法，來決定影像變化只有位移和旋轉的剛體定位。定位裝置材料方面，以瓊膠分別作為製作定位固定裝置和仿體的材質，然後在相同定位點位置上，放置直徑0.425~0.600 mm的玻璃珠和1 μl [18F]FDG核醫藥物，作為能同時成像於兩種影像上的定位點。另外，考慮系統解析度、實驗製作方式和演算法參數數目等因素，研究中使用的定位點數目為六點。實驗過程中，將定位裝置與小動物固定後，分別依序完成超音波系統和微正子系統成像，再來選取影像上定位點位置，進行影像空間轉換式的運算，最後轉換影像，完成影像定位流程。在目前的成果中，仿體實驗方面，我們獲得定位點誤差為0.68 mm和標的點誤差為1.05 mm的實驗結果；小動物實驗方面，我們得到定位點誤差為0.31 mm的初步融合影像；以上誤差皆小於微正子斷層掃描的影像解析度。進一步的討論中，首先根據四種不同的定位點擺放方式與實驗限制，決定採用擺放在腫瘤上方單側的方法。接著比較使用三到六點定位點數目的定位結果；隨著定位點數目增加，標的點誤差也會隨之降低。最後比較使用剛體定位和非剛體定位的結果；結果顯示，將定位點擺放在腫瘤上方單側的方式，會使得採用非剛體定位的標的點誤差增加。總結來說，我們利用定位點定位和剛體定位方式，順利地將高頻超音波系統和微正子斷層掃描系統進行結合後得到初步的融合影像。在未來工作方面，希望能運用本研究提出的定位方式，將高頻超音波彩色都卜勒影像提供的腫瘤內微血液循環資訊，與微正子斷層掃描影像提供的腫瘤內藥物代謝資訊進行結合。未來亦希望，結合兩個系統的成像技術與醫療技術，讓觀察及治療的功能同時運作，幫助研究人員進行癌症治療等相關研究。 | zh_TW |
| dc.description.abstract | Small animal models have been used extensively in disease research, genomics research, drug development, and developmental biology. A non-invasive, small animal imaging system with high spatial resolution and high sensitivity is beneficial to the research above mentioned. On the other hand, multi-modality medical imaging can provide complementary image information and is of further importance. The purpose of this research is thus to combine high-frequency ultrasonic imaging and micro-PET imaging. To achieve this goal, image registration is a critical stag. In particular, our goal is to establish an appropriate image registration algorithm for US/PET multi-modality small animal imaging. In this study, rigid body transformation with exogenous markers is employed. We place a glass bead with 0.425~0.600 mm diameter and 1 μl [18F]FDG in the same marker position so that the markers can appear in two imaging systems. With the process of rigid-body image registration, we get the preliminary image, and fiducial registration error is 0.31 mm in small animal experiments. The fiducial registration error is 0.68 mm and target registration error is 1.05 mm in phantom experiments. Target registration error decreases with the increasing of the number of markers. On the other hand, target registration error increases with using non-rigid registration because of the marker placement scheme employed in this study. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T04:13:39Z (GMT). No. of bitstreams: 1 ntu-95-R93921047-1.pdf: 1504244 bytes, checksum: fbb1364d976e70ebec4ce25a8352a833 (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 第一章 緒論………………………………………………………....1
1.1 多重醫學影像系統………………………………………………...3 1.1.1 高頻超音波影像………………………………………………..6 1.1.2 微正子斷層掃描影像…………………………………………..7 1.2 影像定位…………………………………………………………...9 1.3 研究動機與目標…………………………...….………….............11 1.4 論文架構………………………………………………………….12 第二章 醫學影像定位……………………….……………..…..13 2.1 影像定位標的方式………………………………..………...……13 2.1.1 定位點標的法………………………………...………..……...13 2.1.2 表面輪廓標的法………………………………………………15 2.1.3 影像像素強度相似度標的法…………………………………16 2.2 影像定位演算法……………………..………………………...…18 2.2.1 剛體定位演算法………………………………………………18 2.2.2 非剛體定位演算法……………………………………………21 2.1.2.1 仿射轉換…………….……………...……………………21 2.1.2.2 薄板曲尺轉換……….…………………...………………23 2.3 本研究影像定位方法………..…………………………...………25 2.4 剛體定位演算法……………..…………………………...………26 第三章 實驗方法與結果………………………………….…...28 3.1 實驗架構以及流程………………………………...……………..28 3.1.1 定位裝置製作…………………………………………………28 3.1.1.1 小動物模型…………………………………...…………28 3.1.1.2 小動物定位裝置製作……………………...……………29 3.1.1.3 測試仿體定位裝置製作………………………...………31 3.1.1.4 定位點放置位置及數目限制…………………...………32 3.1.2 影像系統成像………………………………………………...33 3.1.3 影像定位融合………………………………………………...34 3.1.3.1 影像定位前處理…………………………………….......35 3.1.3.2 影像定位…………………………………………...…....36 3.1.3.2.1 選取定位點位置…………………………..……….36 3.1.3.2.2 求取剛體定位轉換矩陣以及影像空間轉換…..….37 3.1.3.3 影像融合……………………………….…..……………38 3.2 實驗結果………………………………………….…..………….40 3.2.1 小動物初步融合影像結果………………….………………..40 3.2.2 定位結果準確性評估………………………….……………..46 第四章 討論…………...……………………………………....…..49 4.1 不同定位點擺放位置結果之比較……………………………....49 4.2決定定位點位置方式之比較…………………………………….57 4.2.1 定位點於超音波影像上位置判定方式……………………...57 4.2.2 定位點於正子斷層掃描影像上位置判定方式……………...64 4.3 不同數目定位點定位結果之比較………………………………69 4.4 不同定位點演算法定位結果之比較……………………………71 第五章 結論與未來工作………………..……………………..73 5.1 結論……………………………………………………………....73 5.2 未來工作…………………………………………………………75 第六章 參考文獻…........................................................................77 附錄A…………………………………………………………………82 附錄B…………………………………………………………………87 | |
| dc.language.iso | zh-TW | |
| dc.subject | 標的點誤差 | zh_TW |
| dc.subject | 高頻超音波影像 | zh_TW |
| dc.subject | 微正子斷層掃描影像 | zh_TW |
| dc.subject | 醫學影像定位 | zh_TW |
| dc.subject | 剛體定位 | zh_TW |
| dc.subject | 定位點誤差 | zh_TW |
| dc.subject | High-frequency Ultrasonic Imaging | en |
| dc.subject | Target Registration Error | en |
| dc.subject | Fiducial Registration Error | en |
| dc.subject | Rigid-body Image Registration | en |
| dc.subject | Medical Image Registration | en |
| dc.subject | Micro-PET Imaging | en |
| dc.title | 結合高頻超音波影像與微正子斷層掃描影像之醫學影像定位研究 | zh_TW |
| dc.title | Image registration for US/PET multi-modality small animal imaging | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳中明,陳志成,郭益源,沈哲州 | |
| dc.subject.keyword | 高頻超音波影像,微正子斷層掃描影像,醫學影像定位,剛體定位,定位點誤差,標的點誤差, | zh_TW |
| dc.subject.keyword | High-frequency Ultrasonic Imaging,Micro-PET Imaging,Medical Image Registration,Rigid-body Image Registration,Fiducial Registration Error,Target Registration Error, | en |
| dc.relation.page | 89 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2006-07-25 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 電機工程學研究所 | zh_TW |
| 顯示於系所單位： | 電機工程學系 | |
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