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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/30505完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鍾孝文 | |
| dc.contributor.author | Chun-Jung Juan | en |
| dc.contributor.author | 阮春榮 | zh_TW |
| dc.date.accessioned | 2021-06-13T02:05:41Z | - |
| dc.date.available | 2012-07-16 | |
| dc.date.copyright | 2007-07-16 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-02 | |
| dc.identifier.citation | Chapter 1
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Wong EC, Buxton RB, Frank LR. Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 1998; 39:702-708. 34. An H, Lin W. Impact of intravascular signal on quantitative measures of cerebral oxygen extraction and blood volume under normo- and hypercapnic conditions using an asymmetric spin echo approach. Magn Reson Med 2003; 50:708-716. 35. Liu YJ, Juan CJ, Chen CY, et al. Are the local blood-oxygenation-level-dependent (BOLD) signals caused by neural stimulation response dependent on global BOLD signal induced by hypercapnia i | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/30505 | - |
| dc.description.abstract | 神經活動牽涉到能源的需求與能源的供應。當神經活化時，所需的能源包括葡萄糖及氧氣會經由大腦微循環調控所增加的腦血流所供應。然而，除了神經活活之外，大腦微循環還受到神經活化之外許多因素的調控，其中包括二氧化碳。因此經由神經活化所造成的大腦微循環調控很可能會受到外加二氧化碳的影響及遮蔽。在本本論文中，我們主要探討吸入之二氧化碳對於大腦主要血管以及大腦微循環調控以及對於視覺刺激之功能性磁振造影研究的影響。
此外，我們也特別研發並提出一個混合的磁振造影波序。該磁振造影波序的優點在於可以在一次的實驗中，同步並且準確的測量大腦血流體積、大腦血流量、以及大腦血流含氧程度。實驗的結果與先前功能性磁振造影研究、正子攝影研究、以及生理學對於大腦微循環調控研究結果相符合。 | zh_TW |
| dc.description.abstract | The neural activity involves energy demand and energy supply. During neural activation, the energy source glucose and oxygen are supplied by increase cerebral blood flow via a regulation of the cerebral microcirculatory units. In addition to neural activation, the cerebral microcirculation is regulated by many other factors including CO2. It is very likely that the neural activation related cerebral microcirculatory regulation is overwhelmed by the external CO2 perturbation. In this thesis, we explore the effect of inhaled CO2 on cerebral vascular and microcirculatory regulations and on the visual fMRI study.
Specially, we propose a hybrid pulse sequence that allows accurate measurement of cerebral blood volume, cerebral blood flow and cerebral blood oxygenation simultaneously. Experimental results are consistent with prior fMRI and PET studies and the basic understanding of cerebral microcirculatory regulation on physiology. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T02:05:41Z (GMT). No. of bitstreams: 1 ntu-96-D92921024-1.pdf: 2427299 bytes, checksum: 09b793612296e7d3ac21b7064b1864fe (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | Table of contents:
論文致謝 中文摘要 Abstract Chapter 1 A physiological review of the cerebral hemodynamic regulation 1-1 1.1 Regulation of cerebral vascular tone ………………………….. 1-2 1.2 Autoregulation of cerebral circulation …………………………. 1-8 1.3 Effect of CO2 on cardiac and cerebrovascular hemodynamics 1-10 1.4 Effect of neural activity on cerebrovascular hemodynamics…. 1-16 1.5 Cerebral vasomotor reactivity ………………………………….. 1-17 Reference …………………………………………………………………… 1-20 Chapter 2 A study investigating the relationship between fBOLD and hBOLD signals in the fMRI experiment 2-1 2.1 Background and purpose ………………………………………. 2-2 2.2 Materials and methods …………………………………………. 2-4 2.3 Results …………………………………………………………… 2-10 2.4 Discussion ……………………………………………………….. 2-16 2.5 Conclusion ……………………………………………………….. 2-23 2.6 Publication ……………………………………………………….. 2-24 Reference …………………………………………………………………… 2-25 Chapter 3 A study investigating the cerebral arterial and venous vasomotor reactivity using phase-contrast magnetic resonance imaging technique 3-1 3.1 Background and purpose ………………………………………. 3-2 3.2 Materials and methods …………………………………………. 3-4 3.3 Results …………………………………………………………… 3-15 3.4 Discussion ……………………………………………………….. 3-28 3.5 Conclusion ……………………………………………………….. 3-33 3.6 Publication ……………………………………………………….. 3-34 Reference …………………………………………………………………… 3-35 Chapter 4 A study investigating cerebral vasomotor reactivity and fMRI experiment using CO2 challenge and a triple function mapping MR sequence 4-1 4.1 Background and purpose ………………………………………. 4-2 4.2 Sequence development 4-11 4.3 Studies …………………………………………. 4-17 4.3.1 Measurement of T1 relaxation times of gray matter, white matter and blood 4-20 4.3.2 Visual fMRI studies 4-23 4.3.3 Bipolar crasher gradients fMRI studies 4-26 4.3.4 Hypercapnic studies 4-36 4.4 Discussion……………………………………………………… 4-44 4.5 Conclusion ……………………………………………………….. 4-52 4.6 Publication ……………………………………………………….. 4-53 Reference …………………………………………………………………… 4-54 | |
| dc.language.iso | en | |
| dc.subject | 高血碳酸 | zh_TW |
| dc.subject | 血管運動反應度(VMR) | zh_TW |
| dc.subject | 磁振造影(MRI) | zh_TW |
| dc.subject | 大腦血流量(CBF) | zh_TW |
| dc.subject | 大腦血流體積(CBV) | zh_TW |
| dc.subject | 大腦血流含氧程度(CBO) | zh_TW |
| dc.subject | 功能性磁振造影(fMRI) | zh_TW |
| dc.subject | cerebral blood flow (CBF) | en |
| dc.subject | magnetic resonance imaging (MRI) | en |
| dc.subject | vasomotor reactivity (VMR) | en |
| dc.subject | hypercapnia | en |
| dc.subject | functional MRI (fMRI) | en |
| dc.subject | cerebral blood volume (CBV) | en |
| dc.subject | cerebral blood oxygenation (CBO) | en |
| dc.title | 吸入二氧化碳對於功能性磁振造影、腦血管反應度、大腦血流量、大腦血流體積以及大腦血流含氧程度測量的影響 | zh_TW |
| dc.title | Impact of Inhaled CO2 on fMRI Experiments and Measurements of Cerebral Vasomotor Reactivity, Cerebral Blood Flow, Cerebral Blood Volume and Cerebral Blood Oxygenation | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 葉子成,高怡宣,劉鶴齡,許元昱,黃騰毅,劉益瑞,林益如 | |
| dc.subject.keyword | 大腦血流量(CBF),大腦血流體積(CBV),大腦血流含氧程度(CBO),功能性磁振造影(fMRI),高血碳酸,磁振造影(MRI),血管運動反應度(VMR), | zh_TW |
| dc.subject.keyword | cerebral blood flow (CBF),cerebral blood oxygenation (CBO),cerebral blood volume (CBV),functional MRI (fMRI),hypercapnia,magnetic resonance imaging (MRI),vasomotor reactivity (VMR), | en |
| dc.relation.page | 146 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-03 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 電機工程學研究所 | zh_TW |
| 顯示於系所單位： | 電機工程學系 | |
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