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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林俊彬 | |
| dc.contributor.author | Hong-Jiun Chen | en |
| dc.contributor.author | 陳虹君 | zh_TW |
| dc.date.accessioned | 2021-06-13T02:02:16Z | - |
| dc.date.available | 2007-11-10 | |
| dc.date.copyright | 2007-07-12 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-09 | |
| dc.identifier.citation | Abe T ,Tachibana Y, Uemtsu T, Iwamoto M (1995). J Chem Soc Chem Commun:1617.
Absi EG, Addy M, Adams D (1987). Dentine hypersensitivity, a study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine. J Clin Periodontol 14:280-284. Absi EG, Addy M, Adams D. Dentine hypersensitivity (1989). The development and evaluation of a replica technique to study sensitive and non-sensitive cervical dentine. J Clin Periodontol 16:190-195. Addy M, Absi EG, Adams D. Dentine hypersensitivity (1987). The effects in vitro of acids and dietary substances on root-planed and burred dentine. J Clin Periodontol 14:247-249. Addy M. Etiology and clinical implications of dentine hypersensitivity (1990). Dent Clin North Am 34:503-514. Addy M, Urquhart E (1992). Dentin hypersensitivity: its prevalence, etiology and clinical management. Dent Update 19:407-408,410-412. Addy M, Embery G, Edgar WM, Orchardson R (2000). Tooth wear and sensitivity: Clinical advances in restorative dentistry. London:Martin Dunitz 239-248. Addy M, Hunter ML (2003). Can tooth brushing damage your health? Effects on oral and dental tissues. Int Dent J 53(supplement3):177-186. Aw TC, Lepe X, Johnson GH, Mancl L (2004). One-year clinical evaluation of an ethanol-based and a solvent-free dentin adhesive. Am J Dent 7:451-456. Berman LH. Dentinal sensation and hypersensitivity (1985). A review of mechanisms and treatment alternatives. J Periodontol 56:216-222. Bonin P, Boivin R, Poulard J (1991). Dentinal permeability of the dog canine after exposure of a cervical cavity to the beam of a CO2 laser. J Endodon 116-118. Boremer H, Deutscher K, Blencke B, Pfeil E and Strunz V (1977). Properties of the bioactive implant material. Ceravital. Sci Ceram 9:219-255. Brännström M (1963). A hydrodynamic mechanism in the transmission of pain-producing stimuli through dentine. Anderson DJ, ed. Sensory mechanisms in dentine, England: Pergamon 73-79. Brännström M. Dentin sensitivity and aspiration of odontoblasts (1963). J Am Dent Asso 66:366-370. Brännström M (1986). The hydrodynamic theory of dentinal pain: sensation in preparations, caries, and the dentinal crack syndrome. J Endodon 12:453-457. Camps J, About I, Van Meerbeek B, Franquin JC (2002). Efficiency and cytotoxicity of resin-based desensitizing agents. Am J Dent 15:300-304. Canadian Advisory Board on Dentin Hypersensitivity (2003). Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc 69:221-226. Cant NW, Hall WK (1997). J Phys Chem 75:2914. Charkraborty B, Pulikottil AC, Viswanathan B (1994). Catal Lett 39:63. Cherng AM, Chow LC, Takagi S (2004). Reduction in dentin permeability using mildly supersaturated calcium phosphate solutions. Arch Oral Biol 49:91-98. Chersoni S, Suppa P, Grandini S, Goracci C, Monticelli F, Yiu C, Huang C, Prati C, Breschi L, Ferrari M, Pashley DH, Tay FR (2004). In vivo and in vitro permeability of one-step self-etch adhesives. J Dent Res 83:459-464. Ciaramicoli MT, Carvalho RCR, Eduardo CP (2003). Treatment of cervical dentin hypersensitivity using neodymium:yttrium-aluminum-garnet laser. Clinical evaluation. Lasers Surg Med 33:358-362. Clark DC, Hanley JA, Geoghegan S, Vinet D (1985). The effectiveness of a fluoride varnish and a desensitizing toothpaste in treating dentinal hypersensitivity. J Periodontal Res 20:212-219. Corona SAM, Nascimento TND, Catirse ABE, Lizarelli RFZ, Dinelli W, Palma DRG (2003). Clinical evaluation of low-level laser therapy and fluoride varnish for treating cervical dentinal hypersensitivity. J Oral Rehabil 30:1183-1189. Dababneh R, Khouri A, Addy M (1999). Dentine hypersensitivity: an enigma? A review of terminology, epidemiology, mechanisms, aetiology and management. Br Dent J 187:606-611. Dayton RE, DeMarco TJ, Swedlow D (1974). Treatment of hypersensitive root surfaces with dental adhesive materials. J Periodontol 45:873. Davidson DF, Suzuki M (1997). The Gluma bonding system: a clinical evaluation of its various components for the treatment of hypersensitive root dentin. J Can Dent Assoc 63:38-41. Davis WB, Winter PJ (1980). The effect of abrasion on enamel and dentine and exposure to dietary acid. Br Dent J 148:253–256. Dentsply (1999). Seal & Protect™ Training Manual 13. Dowell P, Addy M (1983). Dentine Hypersensitivity – A review. J Clin Periodontol 10:341-363. Duran I, Sengun A (2004). The long-term effectiveness of five current desentizing products on cervical dentin sensitivity. J Oral Rehabil 31:351-356. Fearnhead RW (1961). The neurohistology of human dentine. Proc R Soc Med 54:877-884. Felton DA, Bergenholtz G, Kanoy BE (1991). Evaluation of the desensitizing effect of Gluma Dentin Bond on teeth prepared for complete-coverage restorations. Int J Prosthodont 4:292-298. Fayad MI, Carter JM, & Liebow C (1996). Transient effects of low-energy CO2 laser irradiation on dentinal impedance: Implications for treatment of hypersensitive teeth. J Endodon 22:526–531. Fischer C, Fischer RG, Wennberg A (1992). Prevalence and distribution of cervical dentin hypersensitivity in a population in Rio de Janeiro. Brazil J Dent 20:272. Flynn J, Galloway R, Orchardson R (1985). The incidence of ‘hypersensitive’ teeth in the west of Scotland. J Dent 13:230-236. Freedman G. Dentistry today 2000;First Impressions Gillam DG, Khan N, Mordan NJ, Barber PM (1999). Scanning electron microscopy investigation of selected desensitizing agents in the dentin disc model. Endod Dent Traumatol 15:198-204. Gillam DG, Aris A, Bulman JS, Newman HN, Ley F (2002). Dentine hypersensitivity in subjects recruited for clinical trials: clinical evaluation, prevalence and intra-oral distribution. J Oral Rehabil 29:226-231. Greenhill JD, Pashley DH (1981). The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. J Dent Res 60:686-698. Grossman, LI (1935). A systematic method for the treatment of hypersensitive dentin. J Am Dent Assoc 22:592-602. Gwinnett AJ (1984). Smear layer: Morphological considerations. Oper Dent 3:3-12. Haruta M, Yamada N, Kobatashi T, and Iijima S (1989). J Catal 115:301. Hench LL, Splinder RJ, Allen WC, Green TK (1972). Bonding mechanism at the interface of the ceramic prosthetic materials. J Biomed Mater Res 2:117-141. Hench LL (1991). Bioceramics: From Concept to Clinic. J Am Ceram Soc 74:1487-1510. Holmberg K (2002). Surfactants and polymers in aqueous solution. Wiley Press, England. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R (1997). Guidelines for the design and conduct of clinical trials on dentin hypersensitivity. J Clin Periodontal 24:808-813. Irwin CR, McCusker P (1997). Prevalence of dentine hypersensitivity in a general dental population. J Ir Dent Assoc 43:7-9. Ishikawa S (1969). A clinico-histological study on the hypersensitivity of dentine. J Japan Stomatol Soc 36:68-88. Ishikawa K, Suge T, Yoshiyama M et al (1994). Occlusion of dentinal tubules with calcium phosphate using acidic calcium phosphate solution followed by neutralization. J Dent Res 73:1197-1204. Jarvis D, MacIver MB, Tanelian DL (1990).Electrophysiologic recording and thermodynamic modeling demonstrate that helium-neon laser irradiation does not affect peripheral Adeltaor C-fiber nociceptors. Pain 43:235-242. Jensen ME ,Doering JV (1987). A comparative study of two clinical techniques for treatment of root surface hypersensitivity. Gen Dent 35:128-132. Kimura Y, Wilder-Smith P, Yonaga K, Matsumoto K (2000). Treatment of dentine hypersensitivity by lasers: a review. J Clin Periodontol 27:715-721. Kishore A, Mehrotra KK, Saimbi CS (2002). Effectiveness of desensitizing agents. J Endodon 28:34-35. Kokubo T, Ito S, Huang ZT, Hayashi T, Sakka S, Kitsugi T, Yamamuro T (1990). Ca,P-rich layer formed on high-strength bioactive glass-ceramic A-W. J Biomed Mater Res 24:331-343. Kolker JL, Vargas MA, Armstrong SR, Dawson DV (2002). Effect of desensitizing agents on dentin permeability and dentin tubule occlusion. J Adhes Dent 4:211-221. Krauser JT (1986). Hypersensitivity teeth. Part I: Etiology. J Prosthet Dent 56:153-156. Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC and Beck JS (1992). Nature 359:710. Kumar R, Prakash KH, Cheang P, Khor KA (2004). Temperature driven morphological changes of chemically precipitated hydroxyapatite nanoparticles. Langmuir 20:5196-5200. Lan WH, Liu HC. Sealing of human dentinal tubules by Nd:YAG laser (1995). J Clin Laser Med Surg 13:329-333. Lan WH., Liu HC, Lin CP (1999). The combined occluding effect of sodium fluoride varnish and Nd:YAG laser irradiation on human dentinal tubules. J Endodon 25:424–426. Lee BS, Chang CW, Chen WP, Lan WH, Lin CP (2004). In vitro study of dentin hypersensitivity treated by Nd:YAP laser and bioglass. Dent Mater xx:1-9. Lin CP, Lee BS, Kok SH, Lan WH (2000). Treatment of tooth fracture by medium energy CO2 laser and DP-bioactive glass paste: Thermal behavior and phase transformation of human tooth enamel and dentin after irritation by CO2 laser. J Mater Sci: Mater Med 11:373-381. Lin CP, Tseng YC, Lin FH, Kok SH, Liao JD, Lan WH (2001).Treatment of tooth fracture by medium-energy CO2 laser and DP-bioactive glass paste: the interaction of enamel and DP-bioactive glass paste during irradiation by CO2 laser. Biomaterials 22:489-496. Liu HC, Lan WH (1994). The combined effectiveness of the semiconductor laser with Duraphat in the treatment of dentin hypersensitivity. J Clin Laser Med Surg 12:315-319. Liu HC, Lan WH, Hsieh CC (1998). Prevalence and distribution of cervical dentin hypersensitivity in a population in Taipei, Taiwan. J Endodon 24:45-47. Low T (1981). The treatment of hypersensitive cervical abrasion cavities using ASPA cement. J Oral Rehabil 8:81-89. McBain JW (1932). The sorption of gases and vapours by solids, rutledge and sons. London ch5. Maiman TH (1960). Stimulated optical radiation in ruby. Nature 187,493–494. Matsumoto K, Funai H, Shirasuka T, Wakabayashi H (1985). Effects of Nd:YAG- laser in treatment of cervical hypersensitive dentine. Japanese Journal of Conservative Dentistry 28:760–765. Markowitz K, Billotto G, Kim S (1991). Decreasing intradental nerve activity in the cat with potassium and divalent cations. Arch Oral Biol 36:1-7. Matthews B, Vongsavan N (1994). Interactions between neural and hydrodynamic mechanisms in dentine and pulp. Arch Oral Biol 39:87S-95S. Minkov B, Marmari I, Gedalia I, Garfunkel A (1975). The effectiveness of sodium fluoride treatment with and without iontophoresis on the reduction of hypersensitive dentin. J Periodontol 46:246-249. Moritz A, Gutknecht N, Schoop U, Goharkhay K, Ebrahim D, Wernisch J, Sperr W (1996). The advantage of CO2-treated dental necks, in comparison with a standard method: results of an in vivo study. J Clin Laser Med Surg 14:27-32. Muzzin KB, Johnson R(1989) Effects of potassium oxalate on dentin hypersensitivity in vivo. J Periodontol 60:151-158. Myers TD, McDaniel JD (1991). The pulsed Nd:YAG dental laser: review of clinical applications. J Calif Dent Assoc;19:25-30. Nagata T, Ishida H, Shinohara H, Nishikawa S, Kasahara S, Wakano Y, Daigen S, Troullos ES (1994). Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. J Clin Periodontol 21:217-221. Närhi MVO, Haegerstam G (1983). Interdental nerve activity induced by reduced pressure applied to exposed dentin in the cat. Acta Physiol 119:381-386. Neumann R, Khenkin K (1996). Chem Commun 23:2643. Orchardson R, Collins WJN (1984). Clinical features of hypersensitive' (HS) dentine. J Dent Res 63:521. Orchardson R, Collins WJN (1987). Clinical features of hypersensitive teeth. Br Dent J 162:253-256. Orchardson R, Peacock JM, & Whitters CJ (1997). Effect of pulsed Nd:YAG laser radiation on action potential conduction in isolated mammalian spinal nerves. Lasers Surg Med 21:142–148. Orchardson R, Cadden SW (2001). An update on the physiology of the dentine-pulp complex. Dent Update 28:200-209. Orchardson R, Gillam DG (2006). Managing dentin hypersensitivity. J Am Dent Assoc 137:990-998;quiz 1028-1029. Outhwaite WC, Mckenzie DM, Pashley DH (1974). A versatile split-chamber device for studying dentin permeability. J Dent Res 53:1503. Pashley DH, Livingston MJ, Greenhill JD, Reeder OW, Homer J (1978). Effects of the degree of tubule occlusion on the permeability of human dentine in vitro. Arch Oral Biol 23:1127-1133. Pashley DH, Thompson SM, and Stewart FP (1983). Dentin permeability: effects of temperature on hydraulic conductance. J Dent Res 62:956-959. Pashley DH. Dentin-predentin complex and its permeability: physiologic overview (1985). J Dent Res 64:613-620. Pashley DH, Galloway SE (1985). The effects of oxalate treatment on the smear layer of ground surfaces of human dentin. Arch oral Biol 30:731-737. Pashley DH, O'Meara JA, Williams EC, Kepler EE (1985). Dentin permeability: effects of cavity varnishes and bases. J Prosthet Dent. 53:511-516. Pashley DH (1986). Sensitivity of dentin to chemical stimuli. Endod Dent Traumatol 2:130-137. Pashley DH (1994). Dentin permeability and its role in the pathobiology of dentin sensitivity. Arch oral Biol 39:73s-80s. Powell LV, Gordon GE, Johnson GH (1990). Sensitivity restored of ClassV abrasion/erosion lesions. J Am Dent Assoc 121:694-696. Rapp R, Avery JK, Strachan DS (1967). The distribution of nerves in human primary teeth. Anat Rec159:89-103. Rees JS, Addy M (2002). A cross-sectional study of dentine hypersensitivity. J Clin Periodontol 29:997-1003. Rimondini L, Baroni C, Carrassi A (1995). Ultrastructure of hypersensitive and non-sensitive dentine. A study on replica models. J Clin Periodontol 22:899-902. Rochkind S, Nissan M, Razon N, Schwartz M, Bartal A (1986). Electrophysiological effect of HeNe laser on normal and injured sciatic nerve in the rat. Acta Neurochir (Wien) 83:125-130. Sayari A (1996). Chem mater 8:1840. Sena FJ (1990). Dentin permeability in assessing therapeutic agents. Dent Clin North Am 34:475-490. Scherman A, Jacobsen PL (1992). Managing dentin hypersensitivity: what treatment to recommend to patients. J Am Dent Assoc 123:57-61. Schwarz F, Arweiler N, George T, Reich E (2002). Desensitizing effects of an Er:YAG laser on hypersensitive dentin. J Clin Periodontol 29:211-215. Shono Y, Terashita M, Shimada J, Kozono Y, Carvalho RM, Russell CM, Smith RG (1997). Gingival recession. Reappraisal of an enigmatic condition and a new index for monitoring. J Clin Periodontol 24:201-205. Suda R, Andoh Y, Shionome M et al (1990). Clinical evaluation of the sedative effect of HEMA solution on the hypersensitivity of dentin. Dent Mater J 9:163-166. Suge T, Ishikawa K, Kawasaki A, Yoshiyama M, Asoaka K, Ebisu S (1995). Duration of dentinal tubule occlusion formed by calcium phosphate precipitation method: in vitro evaluation using synthetic saliva. J Dent Res 74:1709-1714. Tavares M, Depaola PF, Soparkar P (1994). Using a fluoride-releasing resin to reduce cervical sensitivity. J Am Dent Assoc 125:1337-1342. Tay FR, Pashley DH, Mak YF, Carvalho RM, Lai SCN, Suh BI (2003). Integrating oxalate desensitizers with total-etch two-step adhesive. J Dent Res 82:703-707. Tilliss TS, Keating JG (2002). Understanding and managing dentin hypersensitivity. J Dent Hygiene 76:296-310. Trowbridge HO, Silver DR (1990). A review of current approaches to in-office management of tooth hypersensitivity. Dent Clin Nor Am 34:561-581. Tsang SC, davis JJ, Green MLH., Hill HAO, Leung YC, Sadler PJ (1995). J Chem Soc Chem Commun 1803. Turkun LS (2005). The clinical performance of one- and two-step self-etching adhesive systems at one year. J Am Dent Assoc 136:656-664. Wakabayashi H, Hamba M, Matsumoto K, Tachibana H (1993). Effect of irradiation by semiconductor laser on responses evoked in trigeminal caudal neurons by tooth pulp stimulation. Lasers Surg Med 13:605-610. Walters PA (2005). Dentinal hypersensitivity: a review. J Contemp Dent Pract 6:107-117. Watanabe H, Nakamura Y, Wakabayashi H & Matsumoto K (1991). Study on laser transmission through tooth structures by 40 mW Ga-Al-As semiconductor laser. J Jpn Endodon Assoc 12:40–44. Watson PJ (1984). Gingival recession. J Dent 12:29-35. Wu CG, Bein T (1994). Conducting polyaniline filaments in a mesoporous channel host. Science 264:1757-1759. Wu CG, Bein T (1994). Conducting carbon wires in ordered nanometer-sized channels. Science 266:1013-1015. Wu CG ,Bein T (1994). Chem Mater 6:1109. Wylie SG, Wilson PR (1994). An investigation into the pressure transmitted to the pulp chamber on crown cementation: a laboratory study. J Dent Res 73:1684-1689. Yates R, Owens J, Jackson R, Newcombe RG, Addy M (1998). A split-mouth placebo-controlled study to determine the effect of amorphous calcium phosphate in the treatment of dentine hypersensitivity. J Clin Periodontol 25:687-692. Yiu CKY, Hiraishi N, Chersoni S, Breschi L, Ferrari Marco, Prati C, King NNM, Pashley DH, Tay FR (2006). Single-bottle adhesives behave as permeable membranes after polymerisation. II. Differential permeability reduction with an oxalate desensitizer. J Dent 34:106-116. Yonaga K, Kimura Y, Matsumoto K (1999) Treatment of cervical dentin hypersensitivity by various methods using pulsed Nd:YAG laser. J Clin Laser Med Surg 17:205-210. Yoshiyama M, Ozaki K, Ebisu S (1992). Morphological characterization of hypersensitive human radicular dentin and the effect of a light-curing resin liner on tubular occlusion. Proc Finn Dent Soc 88 Suppl 1:337-344. Zhang C, Matsumoto K, Kimura Y, Harashima T, Takeda FH, Zhou H (1998). Effects of CO2 laser in treatment of cervical dentinal hypersensitivity. J Endondon 24:595-597. 張俊偉 (2000). 應用生醫陶瓷玻璃及雷射於牙本質過敏症治療之研究. 台大臨床牙醫學研究所碩士論文 陳朝楠 (2002). 合成高均勻度之中孔洞氧化矽球. 成大化學系研究所碩士論文 陳東文 (2002). 以油界面活性劑水微乳液為模板製備囊泡狀中孔洞材料. 成大化學系研究所碩士論文 陳永志、陳姿秀、陳致源 (2002). 溶膠凝膠法之研究與技術發展近況(上). 工業材料雜誌 3月,206期:169-178. 潘易霜 (2006). 金屬氧化物在氧化矽表面的修飾及中孔碳材合成. 成大化學系研究所碩士論文 黃淑娟 (2002). 奈米粉體製成技術. 化工資訊 4月:34-38 康舒涵 (2006). 以溶膠-凝膠技術研發孔洞材料應用於治療牙本質過敏症. 台大臨床牙醫學研究所碩士論文 蔡心儀 (2001). 研發生醫玻璃製劑於治療牙本質過敏症之研究. 台大臨床牙醫學研究所碩士論文 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/30371 | - |
| dc.description.abstract | 在牙科臨床的經驗中，牙本質過敏症是常見的主訴，並且往往無法完全消除症狀，雖然有相當多的市售牙本質黏著劑及去敏感劑號稱效果卓著，但在臨床使用上仍無法達到立即或是持久之療效。本團隊研發之DP-生醫玻璃已證實可有效進入並封閉牙本質小管，惟其反應需三天以上，於臨床應用上有困難。使用奈米技術可製成粒徑小且具有孔洞之材料，藉由高表面積可提升材料反應能力，因此我們以含浸法製成奈米孔洞材料，以期達到縮短反應時間與方便臨床使用之目標；並且使用液體流動模組測試牙本質滲透性，評估不同材料對牙本質的封閉效果。本研究首先製作含氧化鈣中孔洞二氧化矽的粉末，將之與30 %磷酸使用不同水粉比調拌，然後觀察製劑的狀態變化。經由穿透式電子顯微鏡觀察，此孔洞材料呈現均勻之圓球體，平均直徑小於50 nm，並且具有15 nm 之孔洞，的確為體積十分微小之孔洞奈米顆粒；以不同水粉比混合磷酸與含氧化鈣中孔洞二氧化矽，分別將液狀至膠狀而至固態所歷經時間，進行記錄與觀察，最後依據可操作時間長短以及磷酸使用量，選定水粉比3：1 (mL/g) 作為本研究之調配方式。接下來運用二種方法來評估去敏感材料對牙本質小管的封閉效果，第一種方式為直接測試牙本質滲透性，本團隊參考Pashley 的水力導率概念，自行架設液體流動模組，透過量測液體流速，比較不同材料減少牙本質滲透性之能力；而另一種衡量牙本質封閉程度之方式，即為大家常用的電子顯微鏡觀察法，檢視小管堵塞物質進入小管之深度，以及與管周牙本質之密合程度。本研究比較市售材料、DP-生醫玻璃及含氧化鈣中孔洞二氧化矽三種材料，其中含氧化鈣中孔洞二氧化矽表現最優異，能使牙本質滲透性降低至19.1 %，並且在掃描式電子顯微鏡觀察下，結晶可深達牙本質小管100 μm 以上，並且與管壁之間完全密合。本研究也測試牙本質小管朝外壓力存在與否，對於三種材料封閉小管能力之影響，而由結果發現，市售材料、DP-生醫玻璃和含氧化鈣中孔洞二氧化矽都沒有表現出顯著差異。
結論：(1)利用含氧化鈣中孔洞二氧化矽奈米複合材料，與磷酸混合後，能有效且快速封閉牙本質小管，具有治療牙本質過敏症之潛力。(2)在本研究中，無論模擬之牙髓腔壓力是否存在，對受測材料皆未有顯著影響，但在壓力存在下，牙本質滲透性有較高之趨勢。(3)合併使用電子顯微鏡觀察及液體流動模組測試滲透性，能使牙本質封閉效果之評估，得到更完整更明確的結果。 | zh_TW |
| dc.description.abstract | Dentin hypersensitivity is a common complaint in dental clinics. The clinical experiences and investigations have exhibited the inefficiency of the commercialized dentin sealants. Our previous investigation proved that DP-bioglass mixed with 30 % phosphoric acid could form well-occlusive, recrystallized precipitants deep into the dentinal tubules. Because more than 3 days were needed for crystal formation,DP-bioglass has not been practical for clinical use.
In this research, a nano-sized biomaterial was synthesized using mesoporous silica as the carrier, and the nano@CaO mesoporous silica was prepared via an impregnation technique. TEM observation of nano@CaO mesoporous silica showed homogenous spherical particles with about 50 nm in diameter. Because of the small size and large surface-volume ratio, the reaction time of crystal formation was shortened that made more practical for clinical use. We prepared the nano@CaO mesoporous silica paste by mixing nano@CaO mesoporous silica powder and 30 % phosphoric acid in different liquid/powder ratios. Then, we observed the changes of the conditions of these agents. We examined the efficacy of three desensitizing materials for occlusion of dentinal tubules. We measured the fluid flow rate to compare the effects of different materials on dentin permeability with a fluid flow model. We also compared the depth and the sealing quality of the plugs or precipitants penetrating into dentinal tubules with SEM observation. The results revealed that nano@CaO mesoporous silica decreased the dentin permeability most to the lowest level (19.1 %) among three tested materials, and the SEM showed the best sealing ability and deep penetration (> 100 μm) of the crystal precipitants. We also tested the efficacy of three desensitizing agents with or without pressure, and all of Seal & Protect, DP-bioglass, and nano@CaO mesoporous silica did not exhibit significant difference. In conclusion: (1) The nano@CaO mesoporous silica could react with 30 % phosphoric acid quickly and occlude the dentinal tubules well. This porous material had the potential in treatment of dentin hypersensitivity clinically. (2) None of the tested materials in this research exhibited significant difference in reducing dentin permeability whether the pulp pressure existed or not. (3) We compared the efficacy of different desensitizing agents by combination of SEM observation and dentin permeability with a fluid flow model. It provided more appropriate results to evaluate the occlusion of dentinal tubules. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T02:02:16Z (GMT). No. of bitstreams: 1 ntu-96-P93422006-1.pdf: 7986049 bytes, checksum: da1a90920cc03dc19daecb52d6403d28 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 中文摘要------------------------------------------------------------------------------------------i
Abstract------------------------------------------------------------------------------------------iii 目錄-----------------------------------------------------------------------------------------------v 圖次--------------------------------------------------------------------------------------------viii 表次-----------------------------------------------------------------------------------------------x 第一章 前言-------------------------------------------------------------------------------------1 第二章 文獻回顧-------------------------------------------------------------------------------4 2.1 牙本質過敏症的定義-------------------------------------------------------------------4 2.2 牙本質過敏症盛行率-------------------------------------------------------------------4 2.3 牙本質過敏症致病因-------------------------------------------------------------------5 2.3.1 牙本質曝露-------------------------------------------------------------------------5 2.3.2 牙本質小管開口通暢-------------------------------------------------------------6 2.4 牙本質過敏症的機制-------------------------------------------------------------------6 2.4.1 神經支配理論----------------------------------------------------------------------7 2.4.2 造牙本質細胞感覺接受器理論-------------------------------------------------7 2.4.3 流體力學理論----------------------------------------------------------------------7 2.5 牙本質滲透性--------------------------------------------------------------------------8 2.6 牙本質過敏症治療材料與方法-----------------------------------------------------10 2.6.1 化學性減敏方法------------------------------------------------------------------10 2.6.2 物理性減敏方法------------------------------------------------------------------13 2.7 生醫玻璃的應用-----------------------------------------------------------------------16 2.8 孔洞材料原理--------------------------------------------------------------------------17 2.8.1 中孔洞分子篩---------------------------------------------------------------------17 2.8.2 界面活性劑與微胞的形成----------------------------------------------------18 2.8.3 微乳液------------------------------------------------------------------------------19 2.8.4 中孔洞分子篩的性質與應用---------------------------------------------------19 2.9 奈米孔洞材料：含氧化鈣中孔洞二氧化矽--------------------------------------20 2.9.1 中孔洞二氧化矽模板------------------------------------------------------------20 2.9.2 結合金屬氧化物與中孔洞二氧化矽------------------------------------------21 第三章 動機與目的-----------------------------------------------------------------------------23 第四章 材料與方法-----------------------------------------------------------------------------24 4.1 製備去敏感材料-----------------------------------------------------------------------24 4.1.1 DP-生醫玻璃粉末之製作--------------------------------------------------------24 4.1.2 DP-生醫玻璃製劑之準備--------------------------------------------------------24 4.1.3 含氧化鈣中孔洞二氧化矽之製作---------------------------------------------25 4.1.4 含氧化鈣中孔洞二氧化矽製劑之準備---------------------------------------26 4.2 建立液體流動模組--------------------------------------------------------------------26 4.3 觀察及比較不同去敏感材料對牙本質小管封閉效果---------------------------27 4.3.1 牙本質試片之製備---------------------------------------------------------------27 4.3.2 評估去敏感材料對牙本質滲透性影響---------------------------------------27 4.3.3 掃描式電子顯微鏡之觀察------------------------------------------------------28 4.3.4 統計與資料分析------------------------------------------------------------------29 第五章 結果------------------------------------------------------------------------------------31 5.1 含氧化鈣中孔洞二氧化矽製劑之準備--------------------------------------------31 5.2 觀察及比較不同去敏感材料對牙本質小管封閉效果--------------------------31 5.2.1 牙本質滲透性之測試------------------------------------------------------------31 5.2.2 掃描式電子顯微鏡之觀察-----------------------------------------------------32 第六章 討論------------------------------------------------------------------------------------35 第七章 結論------------------------------------------------------------------------------------45 第八章 未來研究方向------------------------------------------------------------------------46 參考文獻----------------------------------------------------------------------------------------48 圖 次 圖4-1 液體流動模組以氮氣瓶為壓力來源---------------------------------------56 圖4-2 具壓力計與壓力閥之不鏽鋼儲水槽---------------------------------------56 圖4-3 經由T 型管連接針筒以打入氣泡至管線中------------------------------57 圖4-4 以觀察玻璃管之氣泡移動來偵側液體流速------------------------------57 圖4-5 模組的玻璃管末端連接金屬圓盤------------------------------------------58 圖4-6 用以放置牙本質試片之金屬圓盤------------------------------------------58 圖4-7 牙本質試片以牙髓側面向壓力來源置入金屬圓盤---------------------59 圖4-8 露出直徑5 mm 之牙本質以塗抹測試材料-------------------------------59 圖4-9 以壓克力板測試模組是否有滲漏------------------------------------------60 圖5-1a 含氧化鈣中孔洞二氧化矽在TEM 下的觀察 (8000X)------------------61 圖5-1b 含氧化鈣中孔洞二氧化矽在TEM 下的觀察 (200000X)---------------61 圖5-2 含氧化鈣中孔洞二氧化矽與磷酸混合瞬間產生大量氣泡------------62 圖5-3 含氧化鈣中孔洞二氧化矽與磷酸混合初期呈現液狀------------------62 圖5-4 含氧化鈣中孔洞二氧化矽製劑之膠狀時期------------------------------63 圖5-5 含氧化鈣中孔洞二氧化矽製劑逐漸喪失操作性------------------------63 圖5-6 含氧化鈣中孔洞二氧化矽製劑最後形成固態---------------------------64 圖5-7 不同水粉比之含氧化鈣中孔洞二氧化矽製劑隨時間的狀態變化---65 圖5-8 各測試材料在壓力有無下之表現------------------------------------------65 圖5-9a Seal & Protect 在無壓力下塗布牙本質之封閉效果 (橫切面1000X)-66 圖5-9b Seal & Protect 在無壓力下塗布牙本質之封閉效果 (縱切面1000X)-66 圖5-9c Seal & Protect 在無壓力下塗布牙本質之封閉效果 (縱切面2000X)-67 圖5-9d Seal & Protect 在無壓力下塗布牙本質之封閉效果 (縱切面5000X)-67 圖5-10a Seal & Protect 在壓力下塗布牙本質之封閉效果 (橫切面1000X)---68 圖5-10b Seal & Protect 在壓力下塗布牙本質之封閉效果 (縱切面1000X)---68 圖5-11a DP-bioglass 在無壓力下塗布牙本質之封閉效果 (橫切面1000X)---69 圖5-11b DP-bioglass 在無壓力下塗布牙本質之封閉效果 (縱切面1000X)---69 圖5-11c DP-bioglass 在無壓力下塗布牙本質之封閉效果 (縱切面2000X)---70 圖5-12a DP-bioglass 在壓力下塗布牙本質之封閉效果 (橫切面1000X)------71 圖5-12b DP-bioglass 在壓力下塗布牙本質之封閉效果 (縱切面1000X)------71 圖5-12c DP-bioglass 在壓力下塗布牙本質之封閉效果 (縱切面2000X)------72 圖5-13a nano@CaO mesoporous silica 在無壓力下塗布牙本質之封閉效果 (橫 切面1000X)---------------------------------------------------------------------73 圖5-13b nano@CaO mesoporous silica 在無壓力下塗布牙本質之封閉效果 (縱 切面1000X)---------------------------------------------------------------------73 圖5-13c nano@CaO mesoporous silica 在無壓力下塗布牙本質之封閉效果 (縱 切面2000X)---------------------------------------------------------------------74 圖5-14a nano@CaO mesoporous silica 在壓力下塗布牙本質之封閉效果 (橫切 面1000X)------------------------------------------------------------------------75 圖5-14b nano@CaO mesoporous silica 在壓力下塗布牙本質之封閉效果 (橫切 面1000X)------------------------------------------------------------------------75 圖5-14c nano@CaO mesoporous silica 在壓力下塗布牙本質之封閉效果 (縱切 面2000X)------------------------------------------------------------------------76 圖5-14d nano@CaO mesoporous silica 在壓力下塗布牙本質之封閉效果 (縱切 面5000X)------------------------------------------------------------------------76 表 次 表4-1 本研究所使用去敏感劑之成分及使用方式------------------------------77 表4-2 本研究所使用之化學藥品---------------------------------------------------78 表4-3 本研究所使用之相關儀器---------------------------------------------------79 表 5-1 牙本質經Seal & Protect，DP-bioglass 及nano@CaO mesoporous silica 處理後之滲透性變化----------------------------------------------------------80 表5-2 在液體流動模組未開啟壓力下塗布Seal & Protect，DP-bioglass 及 nano@CaO mesoporous silica，牙本質滲透性統計分析結果-----------80 表5-3 在液體流動模組壓力開啟下塗布Seal & Protect，DP-bioglass 及 nano@CaO mesoporous silica，牙本質滲透性統計分析結果----------81 | |
| dc.language.iso | zh-TW | |
| dc.subject | 氧化鈣 | zh_TW |
| dc.subject | 液體流動模組 | zh_TW |
| dc.subject | 生醫玻璃 | zh_TW |
| dc.subject | 牙本質過敏症 | zh_TW |
| dc.subject | 中孔洞 | zh_TW |
| dc.subject | 牙本質滲透性 | zh_TW |
| dc.subject | mesoporous | en |
| dc.subject | dentin permeability | en |
| dc.subject | dentin hypersensitivity | en |
| dc.subject | fluid flow model | en |
| dc.subject | bioglass | en |
| dc.subject | CaO | en |
| dc.title | 研發含氧化鈣中孔洞二氧化矽治療牙本質過敏症：以液體流動模組評估效果 | zh_TW |
| dc.title | Development of nano@CaO mesoporous silica for treatment of dentin hypersensitivity:permeability assessment by fluid flow model | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林弘萍,李伯訓 | |
| dc.subject.keyword | 中孔洞,氧化鈣,生醫玻璃,液體流動模組,牙本質過敏症,牙本質滲透性, | zh_TW |
| dc.subject.keyword | mesoporous,CaO,bioglass,fluid flow model,dentin hypersensitivity,dentin permeability, | en |
| dc.relation.page | 81 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-09 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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